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Abbreviation : EADs
Long Form : early afterdepolarizations
No. Year Title Co-occurring Abbreviation
2022 A Novel In Silico Electromechanical Model of Human Ventricular Cardiomyocyte. DADs
2022 Aging-associated susceptibility to stress-induced ventricular arrhythmogenesis is attenuated by tetrodotoxin. VF
2022 Altered Expression of Zonula occludens-1 Affects Cardiac Na+ Channels and Increases Susceptibility to Ventricular Arrhythmias. ZO-1
2022 Chronic Administration of COVID-19 Drugs Fluvoxamine and Lopinavir Shortens Action Potential Duration by Inhibiting the Human Ether-à-go-go-Related Gene and Cav1.2. COVID-19, FLV, hiPSC-CMs, L-VOCC, LPV
2022 Initiation of ventricular arrhythmia in the acquired long QT syndrome. aLQTS, APs, LQTS, PVCs, VGs
2022 Mechanism of Danhong Injection in the Treatment of Arrhythmia Based on Network Pharmacology, Molecular Docking, and In Vitro Experiments. DHI, hiPSC-CMs, qRT-PCR
2022 Rate dependence of early afterdepolarizations in the His-Purkinje system: A simulation study. ---
2022 Real-Time Interactive Simulations of Complex Ionic Cardiac Cell Models in 2D and 3D Heart Structures with GPUs on Personal Computers. ---
2022 Vicious LQT induced by a combination of factors different from hERG inhibition. APD, ECG, hERG, LQT, TdP, VF
10  2021 A computational model of pig ventricular cardiomyocyte electrophysiology and calcium handling: Translation from pig to human electrophysiology. AP, DADs
11  2021 A mathematical model of hiPSC cardiomyocytes electromechanics. AP, CaT, CE, hiPSC-CMs
12  2021 Arrhythmogenic Mechanisms in Hypokalaemia: Insights From Pre-clinical Models. APD, CV, DADs, ERP
13  2021 Cardiomyocyte Na+ and Ca2+ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors. APD, CaMKII, CPVT, DADs, HF, hiPSC-CMs, INaL, LQT, ROS, RyRs, STV
14  2021 Dynamical analysis of early afterdepolarization patterns in a biophysically detailed cardiac model. APs
15  2021 Human-induced pluripotent stem cell-derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs. AP, FMO, LQTS3
16  2021 In Vitro Safety "Clinical Trial" of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy. AZM, HCQ, MPS
17  2021 Ion Channel Impairment and Myofilament Ca2+ Sensitization: Two Parallel Mechanisms Underlying Arrhythmogenesis in Hypertrophic Cardiomyopathy. HCM
18  2021 Mechanisms of phase-3 early afterdepolarizations and triggered activities in ventricular myocyte models. TAs
19  2021 Pathological activation of CaMKII induces arrhythmogenicity through TRPM4 overactivation. APs, PLA
20  2021 Rutaecarpine targets hERG channels and participates in regulating electrophysiological properties leading to ventricular arrhythmia. acLQTS, DF, PSs, Rut, Thr, Tyr, VA, VF
21  2021 Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current. ---
22  2020 Antiarrhythmic effect of crotonoside by regulating sodium and calcium channels in rabbit ventricular myocytes. APA, APD, APs, ATX-II, Cro, DADs, INa, INaL, RMP
23  2020 Arrhythmogenic late Ca2+ sparks in failing heart cells and their control by action potential configuration. ---
24  2020 Canard analysis reveals why a large Ca2+ window current promotes early afterdepolarizations in cardiac myocytes. ---
25  2020 Circadian Rhythms of Early Afterdepolarizations and Ventricular Arrhythmias in a Cardiomyocyte Model. SCD
26  2020 Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia. APD, ATX-II, WT
27  2020 Eleutheroside B, a selective late sodium current inhibitor, suppresses atrial fibrillation induced by sea anemone toxin II in rabbit hearts. AF, APD, APD90, AS, ATX-II, DADs, EB, ECG, INaL, MAP, TAs, VF
28  2020 Inhibition of cardiac potassium currents by oxidation-activated protein kinase A contributes to early afterdepolarizations in the heart. APs, Ito, KI, PKA I, RI, ROS, VEH, WT
29  2020 Intercellular Sodium Regulates Repolarization in Cardiac Tissue with Sodium Channel Gain of Function. APD, GOF
30  2020 Ion currents, action potentials, and noradrenergic responses in rat pulmonary vein and left atrial cardiomyocytes. APD, LA, NA, PV
31  2020 Isoliensinine Eliminates Afterdepolarizations Through Inhibiting Late Sodium Current and L-Type Calcium Current. AP, APA, APD, DADs, IL, INaT, RMP
32  2020 Late INa Blocker GS967 Supresses Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 2. PVTs
33  2020 Mechanisms of Premature Ventricular Complexes Caused by QT Prolongation. PVCs, RG
34  2020 Role of Oxidation-Dependent CaMKII Activation in the Genesis of Abnormal Action Potentials in Atrial Cardiomyocytes: A Simulation Study. SR
35  2020 Thioridazine Induces Cardiotoxicity via Reactive Oxygen Species-Mediated hERG Channel Deficiency and L-Type Calcium Channel Activation. ER, hiPSC-CMs, NAC, NRVMs, ROS, THIO
36  2020 Validation of quantitative measure of repolarization reserve as a novel marker of drug induced proarrhythmia. APD, hiPSC-CM, RRC, VF
37  2019 Action potential response of human induced-pluripotent stem cell derived cardiomyocytes to the 28 CiPA compounds: A non-core site data report of the CiPA study. ---
38  2019 Dynamic clamping human and rabbit atrial calcium current: narrowing ICaL window abolishes early afterdepolarizations. AF, AP, ICaL,D-C
39  2019 Early afterdepolarizations in cardiac action potentials as mixed mode oscillations due to a folded node singularity. CiPA
40  2019 Global Sensitivity Analysis of Ventricular Myocyte Model-Derived Metrics for Proarrhythmic Risk Assessment. GSA, TdP
41  2019 Implication of frequency-dependent protocols in antiarrhythmic and proarrhythmic drug testing. SV
42  2019 Mutation-specific differences in arrhythmias and drug responses in CPVT patients: simultaneous patch clamp and video imaging of iPSC derived cardiomyocytes. AP, CPVT, DADs, E3D
43  2019 Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1. EMW, LQT1, LSGS, MAPs, RSGS, TdP, VF
44  2019 SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells. ---
45  2019 The necessity of implantable cardioverter defibrillators in patients with Kearns-Sayre syndrome - systematic review of the articles. AVB, CAVB, CRT-D, ICD, KSS, PMIs, PMVT, VF
46  2019 Why pacing frequency affects the production of early afterdepolarizations in cardiomyocytes: An explanation revealed by slow-fast analysis of a minimal model. ---
47  2018 Afterdepolarizations and triggered activity as a mechanism for clinical arrhythmias. APD, DADs, LQT, PES, SR
48  2018 Antioxidant defense and protection against cardiac arrhythmias: lessons from a mammalian hibernator (the woodchuck). CaMKII, SCD
49  2018 Autonomic conflict exacerbates long QT associated ventricular arrhythmias. LQTS, VNS, VT
50  2018 Caveolin-3 Microdomain: Arrhythmia Implications for Potassium Inward Rectifier and Cardiac Sodium Channel. APD, DADs, LQT9
51  2018 Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo. APD, CAVB, DHE, hiPSC-CMs
52  2018 Determinants of early afterdepolarization properties in ventricular myocyte models. ---
53  2018 Distinct Occurrence of Proarrhythmic Afterdepolarizations in Atrial Versus Ventricular Cardiomyocytes: Implications for Translational Research on Atrial Arrhythmia. APD90, DADs, sAPs
54  2018 Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator. TdP
55  2018 Fragmented endocardial signals and early afterdepolarizations during torsades de pointes tachycardia. AVB, ECG, EGMs, RV, TdP
56  2018 Mitochondrial Ca2+ Influx Contributes to Arrhythmic Risk in Nonischemic Cardiomyopathy. HF
57  2018 NCX-Mediated Subcellular Ca2+ Dynamics Underlying Early Afterdepolarizations in LQT2 Cardiomyocytes. LQT2
58  2018 Paradoxical Effects of Sodium-Calcium Exchanger Inhibition on Torsade de Pointes and Early Afterdepolarization in a Heart Failure Rabbit Model. APD, TdP
59  2018 Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia. CAVB, GS967, sEB, SR, TdP
60  2018 Simultaneous recordings of action potentials and calcium transients from human induced pluripotent stem cell derived cardiomyocytes. AP, CaT90, DADs, hiPSC-CMs
61  2018 Tetrodotoxin-sensitive Navs contribute to early and delayed afterdepolarizations in long QT arrhythmia models. 4-AP, APD, ATX-II, CPVT, DADs, LQT
62  2018 Transient Outward K+ Current (Ito) Underlies the Right Ventricular Initiation of Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long-QT Syndrome Type 1. LQT1, PVT, RV
63  2017 A model of cardiac ryanodine receptor gating predicts experimental Ca2+-dynamics and Ca2+-triggered arrhythmia in the long QT syndrome. LQT2, LQTS, SR, TdP
64  2017 Barbaloin inhibits ventricular arrhythmias in rabbits by modulating voltage-gated ion channels. APD, APs, DADs, ICa.L, INa.L, RRD
65  2017 Congenital Long QT syndrome and torsade de pointes. APD, LQTS, TdP
66  2017 Dynamics of sodium current mediated early afterdepolarizations. Ca
67  2017 Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets. AADs, CaMKII
68  2017 Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes. AP, APD
69  2017 Hysteretic Dynamics of Multi-Stable Early Afterdepolarisations with Repolarisation Reserve Attenuation: A Potential Dynamical Mechanism for Cardiac Arrhythmias. AP, APD
70  2017 Icariin, a Novel Blocker of Sodium and Calcium Channels, Eliminates Early and Delayed Afterdepolarizations, As Well As Triggered Activity, in Rabbit Cardiomyocytes. APA, APDs, APs, ATX-II, DADs, LAMs, LVMs, RMP, TAs
71  2017 Myofilament protein dynamics modulate EAD formation in human hypertrophic cardiomyopathy. HCM, MEF, SCD, SL
72  2017 Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies. CiPA, ICH
73  2017 Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment. CiPA, TdP
74  2017 Period doubling cascades of limit cycles in cardiac action potential models as precursors to chaotic early Afterdepolarizations. APs, PD
75  2017 Pro-arrhythmic effects of low plasma [K+] in human ventricle: An illustrated review. ---
76  2017 Revealing the Concealed Nature of Long-QT Type 3 Syndrome. LQT3
77  2017 Severe Proarrhythmic Potential of the Antiemetic Agents Ondansetron and Domperidone. VT
78  2017 Sex and regional differences in rabbit right ventricular L-type calcium current levels and mathematical modelling of arrhythmia vulnerability. ---
79  2017 Simulation study of the ionic mechanisms underlying Torsade de Pointes in a 2D cardiac tissue. INaCa, LQTS2, PVC, SCR, TdP
80  2017 Study of factors affecting the progression and termination of drug induced Torsade de pointes in two dimensional cardiac tissue. GJC, ICaL, SLS, TdP
81  2016 A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. AP
82  2016 Assessment of drug-induced proarrhythmia: The importance of study design in the rabbit left ventricular wedge model. TdP
83  2016 Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging. AP, CiPA, CMs, TdP
84  2016 Divergent electrophysiologic profile of fluconazole and voriconazole in an experimental whole-heart model of proarrhythmia. ---
85  2016 Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve. VW
86  2016 Early Afterdepolarizations with Growing Amplitudes via Delayed Subcritical Hopf Bifurcations and Unstable Manifolds of Saddle Foci in Cardiac Action Potential Dynamics. ---
87  2016 Electrophysiological properties of iPS cell-derived cardiomyocytes from a patient with long QT syndrome type 1 harboring the novel mutation M437V of KCNQ1. APD, iPSC, LQT1
88  2016 Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction. hiPSC-CMs
89  2016 Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation. AP, TdP
90  2016 Severe proarrhythmic potential of risperidone compared to quetiapine in an experimental whole-heart model of proarrhythmia. ---
91  2016 Spontaneous initiation of premature ventricular complexes and arrhythmias in type 2 long QT syndrome. ICa,L, PVCs, RG
92  2016 Tolterodine reduces veratridine-augmented late INa, reverse-INCX and early afterdepolarizations in isolated rabbit ventricular myocytes. APD, EAD, INa.T, Tol, VER
93  2015 A Comparative Study of Early Afterdepolarization-Mediated Fibrillation in Two Mathematical Models for Human Ventricular Cells. AP
94  2015 A Computational Study of the Factors Influencing the PVC-Triggering Ability of a Cluster of Early Afterdepolarization-Capable Myocytes. PVCs, RR
95  2015 Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes. AF
96  2015 Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytes. AP, Ca, DADs
97  2015 Cardiac fibrosis as a determinant of ventricular tachyarrhythmias. VT/VF
98  2015 Cytosolic calcium changes affect the incidence of early afterdepolarizations in canine ventricular myocytes. AP, APD
99  2015 Electrophysiological properties under heart failure conditions in a human ventricular cell: a modeling study. AP, APD, HF, OVVR, RMP, SS
100  2015 Mechanistic Investigation of the Arrhythmogenic Role of Oxidized CaMKII in the Heart. CaM, ROS