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Abbreviation : EC
Long Form : enterochromaffin
No. Year Title Co-occurring Abbreviation
2020 Modified Liu-Jun-Zi decoction alleviates visceral hypersensitivity in functional dyspepsia by regulating EC cell-5HT3r signaling in duodenum. 5-HT, 5HT3r, ELISA, FD, HE, IF, IHC, MLJZ, PAX4, qPCR, TPH1, TRPA1, TRPC4
2019 A novel serotonin-containing tuft cell subpopulation in mouse intestine. DCLK1, SERT, TPH
2019 Characterization of Serotonin Signaling Components in Patients with Inflammatory Bowel Disease. 5-HTR, 5-HTT, 5-HTTLPR, CD, HC, IBD, PPP, qPCR, TPH
2019 Deoxycholic acid activates colonic afferent nerves via 5-HT3 receptor-dependent and -independent mechanisms. DCA, DRG, NG
2019 Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. IBS, ISCs, NGF, NMS, TrkA
2019 Enterochromaffin cell hyperplasia in the gut: Factors, mechanism and therapeutic clues. 5-HT, CRF, NGF
2019 Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis. TPH1
2019 PDGFRalpha expression as a novel therapeutic marker in well-differentiated neuroendocrine tumors. ---
2019 Quercetin Attenuates Visceral Hypersensitivity and 5-Hydroxytryptamine Availability in Postinflammatory Irritable Bowel Syndrome Rats: Role of Enterochromaffin Cells in the Colon. 5-HT, IBS, PI-IBS, TPH
10  2019 Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells whilerepressing genetic programs controllingserotonin production. EECs, PE
11  2019 Serotonin 3 receptor signaling regulates 5-fluorouracil-mediated apoptosis indirectly via TNF-alpha production by enhancing serotonin release from enterochromaffin cells. 5-FU, BM, WT
12  2019 Sugar Responses of Human Enterochromaffin Cells Depend on Gut Region, Sex, and Body Mass. BMI
13  2019 TLR2 Plays a Pivotal Role in Mediating Mucosal Serotonin Production in the Gut. ---
14  2018 A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release. EE
15  2018 Analgesic effects of electroacupuncture at ST25 and CV12 in a rat model of postinflammatory irritable bowel syndrome visceral pain. 5-HIAA, AWR, EA, EMG, PI-IBS, TNBS, TPH
16  2018 Augmented capacity for peripheral serotonin release in human obesity. TPH1
17  2018 Effects of Obesity and Gastric Bypass Surgery on Nutrient Sensors, Endocrine Cells, and Mucosal Innervation of the Mouse Colon. EEC, GPCRs, PGP, RYGB
18  2018 Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites. ---
19  2018 Immunohistochemical detection of the vomiting-inducing monoamine neurotransmitter serotonin and enterochromaffin cells in the intestines of conventional or gnotobiotic (Gn) pigs infected with porcine epidemic diarrhea virus (PEDV) and serum cytokine responses of Gn pigs to acute PEDV infection. Gn, PEDV, PIH
20  2018 Mature enteroendocrine cells contribute to basal and pathological stem cell dynamics in the small intestine. EECs, ISCs
21  2018 Modulation of the immune response by helminths: a role for serotonin? ---
22  2018 Olfactory receptors expressed in various non-olfactory tissues. OR
23  2018 Possible anti-inflammatory role of Zingiberis processum rhizoma, one component of the Kampo formula daikenchuto, against neutrophil infiltration through muscarinic acetylcholine receptor activation. 5-HT4R, alpha7nAChR, DKT, IM, KO, mAChR, POI, TRPA1, ZPR
24  2018 The Onset and Progression of Chronic Colitis Parallels Increased Mucosal Serotonin Release via Enterochromaffin Cell Hyperplasia and Downregulation of the Serotonin Reuptake Transporter. SERT, UC
25  2018 The touchy business of gastrointestinal (GI) mechanosensitivity. GI, ICC
26  2018 Whole Cell Electrophysiology of Primary Cultured Murine Enterochromaffin Cells. CFP, GI
27  2017 A model of the enteric neural circuitry underlying the generation of rhythmic motor patterns in the colon: the role of serotonin. CMMCs, EMNs, IMNs, IPANs, NO
28  2017 Analgesic activity of cynaropicrinon on post-inflammatory irritable bowel syndrome visceral hypersensitivity in a rat model. 5-HT, PI-IBS, TNBS
29  2017 Diverse Effects of Gut-Derived Serotonin in Intestinal Inflammation. 5-HT, ENS, GI, IBD
30  2017 Effects of electroacupuncture at ST25 and BL25 in a Sennae-induced rat model of diarrhoea-predominant irritable bowel syndrome. EA, GI, IBS-D, TPH
31  2017 Enteric serotonin and oxytocin: endogenous regulation of severity in a murine model of necrotizing enterocolitis. NEC, OT, TPH1
32  2017 Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways. ---
33  2017 Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. GI
34  2017 Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4. GI
35  2017 Regional differences in nutrient-induced secretion of gut serotonin. GI, SCFAs
36  2017 Regulation of gut luminal serotonin by commensal microbiota in mice. GF, SPF
37  2017 Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release. GI
38  2017 The Anti-Inflammatory Effect of Guchangzhixie-Pill by Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in an Ulcerative Colitis Rat Model. DAI, GCZX-pill, IBD, MPO, MS, TPH, UC
39  2017 The Diverse Metabolic Roles of Peripheral Serotonin. GI
40  2017 The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon. GI
41  2017 Topographic distribution pattern of morphologically different G cells in the murine antral mucosa. G cells
42  2017 Zingiberis Siccatum Rhizoma, the active component of the Kampo formula Daikenchuto, induces anti-inflammatory actions through alpha7 nicotinic acetylcholine receptor activation. CD68, DKT, IM, nAChR, POI, TRPA1, ZSR
43  2016 Ageing and gastrointestinal sensory function: altered colonic mechanosensory and chemosensory function in the aged mouse. DRG
44  2016 Carbonyl stress-induced 5-hydroxytriptamine secretion from RIN-14B, rat pancreatic islet tumor cells, via the activation of transient receptor potential ankyrin 1. 5-HT, IBS, MG, TRPA1
45  2016 Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa. EE, ISH
46  2016 Helional induces Ca2+ decrease and serotonin secretion of QGP-1 cells via a PKG-mediated pathway. OR, PKG
47  2016 Identification of 5-hydroxytryptamine-producing cells by detection of fluorescence in paraffin-embedded tissue sections. 5-HT
48  2016 Interplay between mast cells, enterochromaffin cells, and sensory signaling in the aging human bowel. SP-IR
49  2016 Mechanosensory Signaling in Enterochromaffin Cells and 5-HT Release: Potential Implications for Gut Inflammation. IBD, MS
50  2016 Oridonin Alleviates Visceral Hyperalgesia in a Rat Model of Postinflammatory Irritable Bowel Syndrome: Role of Colonic Enterochromaffin Cell and Serotonin Availability. IFN, IL, PI-IBS, TNF, TPH
51  2016 Polyclonal Crypt Genesis and Development of Familial Small Intestinal Neuroendocrine Tumors. ACECs, ISC, SI-NETs
52  2016 Rotavirus and Serotonin Cross-Talk in Diarrhoea. RRV, RV, siRNANSP4
53  2016 Sex-related differences in small intestinal transit and serotonin dynamics in high-fat-diet-induced obesity in mice. CD, DAT, GI, HFD, SERT
54  2015 An Endogenous Tachykinergic NK2/NK3 Receptor Cascade System Controlling the Release of Serotonin from Colonic Mucosa. 5-HT, IBS, PYY
55  2015 Anticolitis activity of Chinese herbal formula yupingfeng powder via regulating colonic enterochromaffin cells and serotonin. 5-HT, MPO, TNBS, YPF
56  2015 Distinct action of the alpha-glucosidase inhibitor miglitol on SGLT3, enteroendocrine cells, and GLP1 secretion. alpha-GI, GLP-1, KATP, phospho-CaMK2, SGLT1
57  2015 Gastric mucosal protection by aegle marmelos against gastric mucosal damage: role of enterochromaffin cell and serotonin. AM, MUI
58  2015 Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. CR, GF, GI, HM, SCFAs
59  2015 Human gastroenteropancreatic expression of melatonin and its receptors MT1 and MT2. GI, IR
60  2015 Research Resource: A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells. CHGA, GI, hr
61  2015 Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability. ---
62  2015 The role of serotonin and its receptors in activation of immune responses and inflammation. 5-HT, CNS, GI
63  2014 5-HT7 receptor signaling: improved therapeutic strategy in gut disorders. CNS, IBD, IBS
64  2014 Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. 5-HT, CRD, TRPA1
65  2014 Mucosal adenosine triphosphate mediates serotonin release from ileal but not colonic guinea pig enterochromaffin cells. ATP
66  2014 Overexpression of gastric leptin precedes adipocyte leptin during high-fat diet and is linked to 5HT-containing enterochromaffin cells. 5-HT, CI
67  2014 [Neuroendocrine neoplasms of the distal jejunum and ileum]. ENETS, NEN
68  2013 Histomorphology and immunohistochemistry of the lower esophageal sphincter of the least shrew (Cryptotis parva). ECJ, LES
69  2013 Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells. LDCVs
70  2013 IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut. GI, IL-13
71  2013 Important role of mucosal serotonin in colonic propulsion and peristaltic reflexes: in vitro analyses in mice lacking tryptophan hydroxylase 1. 5-HT, CMMCs
72  2013 Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. 5-HTP, DNBS, DSS, GI, IL, rmIL-13, WT
73  2013 Role of serotonin 5-HT₃ receptors in intestinal inflammation. GI
74  2013 Serotonin and the 5-HT7 receptor: the link between hepatocytes, IGF-1 and small intestinal neuroendocrine tumors. ---
75  2013 Serotonin in blood: assessment of its origin by concomitant determination of beta-thromboglobulin (platelets) and chromogranin A (enterochromaffin cells). beta-TG, CgA
76  2013 The stimulatory adenosine receptor ADORA2B regulates serotonin (5-HT) synthesis and release in oxygen-depleted EC cells in inflammatory bowel disease. HRE
77  2012 Differential signal pathway activation and 5-HT function: the role of gut enterochromaffin cells as oxygen sensors. HIF-1alpha, HRE
78  2012 JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats. PI-IBS, TNBS
79  2012 Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats. AWR, MPO, PI-IBS, TNBS
80  2012 Serotonin and GI Disorders: An Update on Clinical and Experimental Studies. GI
81  2012 Serotonin availability in rat colon is reduced during a Western diet model of obesity. CF, SS, WD
82  2012 Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. GI, TPH1
83  2012 The clinical implications and biologic relevance of neurofilament expression in gastroenteropancreatic neuroendocrine neoplasms. GEP-NENs, INA, MAPK
84  2012 The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. IBD
85  2011 A Western diet increases serotonin availability in rat small intestine. CF, SERT, SS, SS, TPH1, WD
86  2011 Activation of Type 1 CRH receptor isoforms induces serotonin release from human carcinoid BON-1N cells: an enterochromaffin cell model. 5-HT, Ucn
87  2011 Combined effect of early life stress and acute stress on colonic sensory and motor responses through serotonin pathways: differences between proximal and distal colon in rats. NMS, WAS
88  2011 Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. ENCDCs, ENS, SERT, TPH1
89  2011 Intestinal glucose-induced calcium-calmodulin kinase signaling in the gut-brain axis in awake rats. 5-HT, GI, pCaMKII, SGLT-3
90  2011 Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells? 5-HT
91  2011 Postnatal development of the serotonin signaling system in the mucosa of the guinea pig ileum. 5-HIAA, GI, HPLC, SERT
92  2011 Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting. NTS, RV
93  2011 Serotonin-producing enterochromaffin cell tumors of the pancreas: clinicopathologic study of 15 cases and comparison with intestinal enterochromaffin cell tumors. ---
94  2010 Analysis of real-time serotonin (5-HT) availability during experimental colitis in mouse. DSS, SERT
95  2010 Corticotropin releasing factor in the rat colon: expression, localization and upregulation by endotoxin. i.p, RT-PCR
96  2010 Electrochemical measurements of serotonin (5-HT) release from the guinea pig mucosa using continuous amperometry with a boron-doped diamond microelectrode. BDD, GI, IBS
97  2010 Increased immunoendocrine cells in intestinal mucosa of postinfectious irritable bowel syndrome patients 3 years after acute Shigella infection--an observation in a small case control study. 5-HT, DC, IEL, PI-IBS, PYY, SC
98  2010 Pathology of gastrointestinal disorders. ECL, GCP, NEC, NETs
99  2010 Serotonin release and uptake in the gastrointestinal tract. EE, GI
100  2010 Simultaneous measurement of serotonin and melatonin from the intestine of old mice: the effects of daily melatonin supplementation. ---