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Abbreviation : FADD
Long Form : Fas-associated death domain
No. Year Title Co-occurring Abbreviation
2019 A Suicide Switch Directly Eliminates Intracellular scFv Oligomers in the Cytoplasm of Mammalian Cells. scFv
2019 An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRalpha Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma. GBM, PDGFRalpha, TNF
2019 Atrazine induces necroptosis by miR-181-5p targeting inflammation and glycometabolism in carp lymphocytes. ATR, CYLD, miRNAs, MLKL, RIP1, RIP3
2019 Connexin 43 dephosphorylation contributes to arrhythmias and cardiomyocyte apoptosis in ischemia/reperfusion hearts. Cx43, Fas, I/R, S282A
2019 FADD-deficient mouse embryonic fibroblasts undergo RIPK1-dependent apoptosis and autophagy after NB-UVB irradiation. MEFs, NB-UVB, ROS, UVB, WT
2019 Foxo3a-dependent miR-633 regulates chemotherapeutic sensitivity in gastric cancer by targeting Fas-associated death domain. DOX, FOXO3a, miRNAs
2019 H19 suppresses the growth of hepatoblastoma cells by promoting their apoptosis via the signaling pathways of miR-675/FADD and miR-138/PTK2. FAK, HBV, HIFIA, IHC, PTK2, TUNEL
2019 Identification of potential binding pocket on viral oncoprotein HPV16 E6: a promising anti-cancer target for small molecule drug discovery. HPV
2019 Lactobacillus plantarum C88 protects against aflatoxin B1-induced liver injury in mice via inhibition of NF-kappaB-mediated inflammatory responses and excessive apoptosis. ALP, ALT, AST, Fas, IFN-gamma, IkappaB, IL-1beta, NF-kappaB, TLR2, TNF-alpha, TRADD
10  2019 Molecular cloning and characterization of FADD from the manila clam Ruditapes philippinarum. ---
11  2019 PEA-15 C-Terminal Tail Allosterically Modulates Death-Effector Domain Conformation and Facilitates Protein-Protein Interactions. CS, DED, DISC, DRS, ERK, NMR, PEA-15
12  2019 Protective effect of remifentanil on myocardial ischemia-reperfusion injury through Fas apoptosis signaling pathway. CK, CK-MB, ELISA, FasL, IL-6, IR, IR, LDH, MDA, RFT, RFT, RT-PCR, SD, sham, SOD, TNF-alpha, TUNEL
13  2019 Rs217727 polymorphism in H19 promotes cell apoptosis by regulating the expressions of H19 and the activation of its downstream signaling pathway. HCC, miR, PCR, UTR
14  2019 SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis. CP, IL-6, NF-kappaB, PSCs, SPOP
15  2019 The classical NLRP3 inflammasome controls FADD unconventional secretion through microvesicle shedding. IL-1beta
16  2019 The first cloned sea cucumber FADD from Holothuria leucospilota: Molecular characterization, inducible expression and involvement of apoptosis. LPS, ORF, UTR
17  2019 Ulmus macrocarpa Hance improves benign prostatic hyperplasia by regulating prostatic cell apoptosis. Bax, Bcl-2, BOO, BPH, DHT, FasL, LUTS, PCNA, TP, UMH
18  2019 ZBP1 mediates interferon-induced necroptosis. IFNs, ISG, ND, RIPK1, SIRS
19  2019 [Effect of enalapril on apoptosis of renal tubular epithelial cells in renal interstitial fibrosis in rats]. APAF-1, CHOP, UUO
20  2019 [Herbal cake-partitioned moxibustion improves intestinal epithelial barrier dysfunction by suppressing TNF-alpha-mediated apoptosis pathway of intestinal epithelium in rats with Crohn's disease]. CD, Moxi, RIP1, TNF, TNFR1
21  2018 A Novel AKT Activator, SC79, Prevents Acute Hepatic Failure Induced by Fas-Mediated Apoptosis of Hepatocytes. DISC, FLICE
22  2018 A protective role for FADD dominant negative (FADD-DN) mutant in trinitrochlorobenzene (TNCB)-induced murine contact hypersensitivity reactions. CHS, FADD-DN, TNCB
23  2018 Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer. CTL, HNSCCs, TNF
24  2018 Cadmium-induced apoptosis in neuronal cells is mediated by Fas/FasL-mediated mitochondrial apoptotic signaling pathway. Bax, Bcl-2, Cd, FasL, MMP
25  2018 Combined effects of 17beta-estradiol and exercise training on cardiac apoptosis in ovariectomized rats. Bad, Bax, Bcl-2, Bcl-xL, ERalpha, ERbeta, IGF-1, IGF-1R, OVX-E2, p-PI3K, pBad, SHAM, tBid, TNF-alpha
26  2018 DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells. DDIAS, DISC, HCC, NSCLC, TRAIL
27  2018 Detection of RIPK1 in the FADD-Containing Death Inducing Signaling Complex (DISC) During Necroptosis. DISC, TNFRSF
28  2018 Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway. Bax, Bcl-2, DR5, HIBD, Sham, TRAIL
29  2018 Escin induces apoptosis in human bladder cancer cells: An in vitro and in vivo study. DMSO, NF-kappaB, PBMC, ROS
30  2018 FADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke. MDCS
31  2018 FADD at the Crossroads between Cancer and Inflammation. DR
32  2018 Gender difference in the effect of progesterone on neonatal hypoxic/ischemic brain injury in mouse. F-JB, MRI, NHI, PROG, TNFR1, TRAF6, TRIF
33  2018 Hepatitis B Spliced Protein (HBSP) Suppresses Fas-Mediated Hepatocyte Apoptosis via Activation of PI3K/Akt Signaling. DISC, FLICE, FLIPL, HBSP, HBV, PHH, PI3K
34  2018 Improved age-related deficits in cognitive performance and affective-like behavior following acute, but not repeated, 8-OH-DPAT treatments in rats: regulation of hippocampal FADD. ---
35  2018 Interleukin-35 Inhibits TNF-alpha-Induced Osteoclastogenesis and Promotes Apoptosis via Shifting the Activation From TNF Receptor-Associated Death Domain (TRADD)-TRAF2 to TRADD-Fas-Associated Death Domain by JAK1/STAT1. IL-35, TRADD, TRAP
36  2018 Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. c-FLIP, DR5, Iri, NAC, ROS, TRAIL
37  2018 K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death. CHIP, DISC
38  2018 Molecular cloning and characterization of FADD from the orange-spotted grouper (Epinephelus coioides). bp, FHM, GS, IFN, ISRE, SGIV
39  2018 Palmitic Acid-Induced Podocyte Apoptosis via the Reactive Oxygen Species-Dependent Mitochondrial Pathway. Bcl-2, CKD, PA, ROS
40  2018 Repeated treatment with the alpha2-adrenoceptor agonist UK-14304 improves cognitive performance in middle-age rats: Role of hippocampal Fas-associated death domain. ---
41  2018 Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death. 3Cpro, ds, RIPK1, RIPK3, ROS, TLR3
42  2018 RIP3-deficience attenuates potassium oxonate-induced hyperuricemia and kidney injury. ABCG2, HU, IkappaBalpha, MDA, NF-kappaB, NLRP3, OAT1, OCT1, OCTN1, RIP3, SOD, TLR4
43  2018 SPOP promotes FADD degradation and inhibits NF-kappaB activity in non-small cell lung cancer. NSCLC, SPOP
44  2018 Stimulation of Fas/FasL-mediated apoptosis by luteolin through enhancement of histone H3 acetylation and c-Jun activation in HL-60 leukemia cells. ChIP, ERK, FasL, JNK
45  2018 The extracellular SEMA domain attenuates intracellular apoptotic signaling of semaphorin 6A in lung cancer cells. Sema6A
46  2018 The Protective Effects of Clams on Hypercholesterolemia in Late-Stage Triple-Transgenic Alzheimer's Diseased Mice Hearts. AD, GC
47  2018 Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells. ADAM17, Bcl-2, c-FLIP, CrmA, DISC, FAS, TIMP-3, VSMCs
48  2018 [Expression of c-FLIP in peripheral blood mononuclear cells of patients with rheumatoid arthritis and its relation with extrinsic apoptotic pathway]. PBMCs
49  2017 Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer. FOM
50  2017 Anti-apoptotic and Pro-survival Effects of Food Restriction on High-Fat Diet-Induced Obese Hearts. ---
51  2017 Bufadienolides from amphibians: A promising source of anticancer prototypes for radical innovation, apoptosis triggering and Na+/K+-ATPase inhibition. ---
52  2017 Complement C5a induces mesenchymal stem cell apoptosis during the progression of chronic diabetic complications. Bax, Bcl-2, C5aR, MSCs
53  2017 D4F alleviates macrophage-derived foam cell apoptosis by inhibiting the NF-kappaB-dependent Fas/FasL pathway. FasL, NF-kappaB, oxLDL
54  2017 Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample. DLPFC
55  2017 Distinct Roles of the Antiapoptotic Effectors NleB and NleF from Enteropathogenic Escherichia coli. EPEC, FasL, LEE, RIPK1
56  2017 Dynamic expression of death receptor adapter proteins tradd and fadd in Eimeria tenella-induced host cell apoptosis. TRADD
57  2017 Editor's Highlight: Periodic Exposure to Smartphone-Mimic Low-Luminance Blue Light Induces Retina Damage Through Bcl-2/BAX-Dependent Apoptosis. FasL, RPE
58  2017 Elucidation of Altered Pathways in Tumor-Initiating Cells of Triple-Negative Breast Cancer: A Useful Cell Model System for Drug Screening. BAD, CSCs, NF-kappaB
59  2017 Expression of Caspase Signaling Components in the Outer Membranes of Chronic Subdural Hematomas. CSDH, DFF45, PARP, RIP
60  2017 Infection-derived lipids elicit an immune deficiency circuit in arthropods. IMD, PODAG, POPG, XIAP
61  2017 Inhibitory effects of rosmarinic acid on pterygium epithelial cells through redox imbalance and induction of extrinsic and intrinsic apoptosis. CAT, HO-1, MTT, Nrf2, PECs, RA, ROS, SOD, TNF-alpha, UV
62  2017 Linarin sensitizes tumor necrosis factor-related apoptosis (TRAIL)-induced ligand-triggered apoptosis in human glioma cells and in xenograft nude mice. Bcl-2, DISC, FCI, JNK, LIN, MCL, ROS, TRAIL
63  2017 Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death. ALL, Fer-1, LOX, NDGA, ROS
64  2017 Liquiritin (LT) exhibits suppressive effects against the growth of human cervical cancer cells through activating Caspase-3 in vitro and xenograft mice in vivo. LT, PARP
65  2017 Long Noncoding RNA H19/miR-675 Axis Promotes Gastric Cancer via FADD/Caspase 8/Caspase 3 Signaling Pathway. lncRNA, qRT-PCR
66  2017 MiR-3202 - Promoted H5V Cell Apoptosis by Directly Targeting Fas Apoptotic Inhibitory Molecule 2 (FAIM2) in High Glucose Condition. ECs, FAIM2, miRNAs
67  2017 Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis. CHOP, ER, TNFRSF1A, TUDCA, UPR
68  2017 NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity. EHEC, EPEC
69  2017 Overexpression of FADD and Caspase-8 inhibits proliferation and promotes apoptosis of human glioblastoma cells. Caspase-8, GBM, NC
70  2017 Phosphorylated FADD is not prognostic for local control in T1-T2 supraglottic laryngeal carcinoma treated with radiotherapy. CI, HR, LSCC
71  2017 RIPK3/Fas-Associated Death Domain Axis Regulates Pulmonary Immunopathology to Cryptococcal Infection Independent of Necroptosis. RIPK3
72  2017 Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis. TNF
73  2017 Sodium fluoride causes oxidative stress and apoptosis in the mouse liver. AKP, AST, caspase-3, caspase-8, CAT, GSH-Px, GST, MDA, qRT-PCR, ROS, SOD, TNFR1, TRADD
74  2017 SUMO-Modified FADD Recruits Cytosolic Drp1 and Caspase-10 to Mitochondria for Regulated Necrosis. Drp1, Mff, SUMO2
75  2017 Targeting of miR-20a against CFLAR to potentiate TRAIL-induced apoptotic sensitivity in HepG2 cells. CASP8, HCC, miR-20a, TNF
76  2017 The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD). EPEC, RIPK1
77  2017 The role of FADD in pancreatic cancer cell proliferation and drug resistance. ---
78  2017 Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways. HNSCC, IAP, Smac
79  2017 Up-regulated Ectonucleotidases in Fas-Associated Death Domain Protein- and Receptor-Interacting Protein Kinase 1-Deficient Jurkat Leukemia Cells Counteract Extracellular ATP/AMP Accumulation via Pannexin-1 Channels during Chemotherapeutic Drug-Induced Apoptosis. Panx1, RIP1
80  2016 A20 targets caspase-8 and FADD to protect HTLV-I-infected cells. ATL, HTLV-I
81  2016 Apoptotic Cell Death Induced by ofLBP6A, Lipopolysaccharide Binding Protein Model Peptide, Derived from Paralichthy olivaceus on MKN-28 Cells. LBP
82  2016 Clinical Implications of FADD Gene Amplification and Protein Overexpression in Taiwanese Oral Cavity Squamous Cell Carcinomas. CI, CNVs, DFS, HR, OS, OSCCs
83  2016 Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer. PIDD, PIDD
84  2016 E1/E2 of Hepatitis C Virus Genotype4 and Apoptosis. Apaf-1, HCV GT4
85  2016 Effect of superoxide anion scavenger on rat hearts with chronic intermittent hypoxia. AIF, EndoG, TUNEL
86  2016 Effect of UVC radiation on mouse fibroblasts deficient for FAS-associated protein with death domain. UV
87  2016 Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration. ADs, ECS, FLIP-L, MAO, NET, p-PEA-15, SERT
88  2016 FADD regulates NF-kappaB activation and promotes ubiquitination of cFLIPL to induce apoptosis. cFLIPL, cIAP2, DISC
89  2016 Fas-associated protein with death domain (FADD) regulates autophagy through promoting the expression of Ras homolog enriched in brain (Rheb) in human breast adenocarcinoma cells. Rheb
90  2016 FasL expression in cardiomyocytes activates the ERK1/2 pathway, leading to dilated cardiomyopathy and advanced heart failure. CHF, DCM, FasL, LOS, NF-kappaB, PRED, RIP, TGF-beta1, WT
91  2016 Human islet cells are killed by BID-independent mechanisms in response to FAS ligand. ---
92  2016 Laryngeal squamous cell carcinoma progression is associated with the NFkappaB signaling pathway regulated by IkappaB kinase beta. IKKbeta, LSCC, TNFR1
93  2016 MiR-7a is an important mediator in Fas-associated protein with death domain (FADD)-regulated expression of focal adhesion kinase (FAK). FAK
94  2016 Mutagenesis and Functional Analysis of the Bacterial Arginine Glycosyltransferase Effector NleB1 from Enteropathogenic Escherichia coli. EPEC, FasL, GlcNAc
95  2016 NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-kappaB-Dependent and -Independent Functions. IBD, IECs, NF-kappaB, RIPK1
96  2016 PKC-theta is a negative regulator of TRAIL-induced and FADD-mediated apoptotic spectrin aggregation. PKCtheta, PS, TRAIL
97  2016 Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis. c-IAP, CypD, GPX4, LN, MLKL, PARP1, RIPK, RN, TNFR1
98  2016 Resveratrol analogue (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline induces apoptosis via Fas-mediated pathway in HL-60 human leukemia cells. 8-ADEQ, DISC, MMP, PARP, ROS
99  2016 Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95. DOX, FLIP, PCa
100  2016 SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2. HNSCC