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Abbreviation : FASN
Long Form : fatty acid synthase
No. Year Title Co-occurring Abbreviation
2019 1alpha,25(OH)2 D3 alleviates high glucose-induced lipid accumulation in rat renal tubular epithelial cells by inhibiting SREBPs. HMGCR, SREBP-1c
2019 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers. ACC, DGAT, PDHK
2019 A role for ATP Citrate Lyase in cell cycle regulation during myeloid differentiation. ACL
2019 Anoikis resistant mediated by FASN promoted growth and metastasis of osteosarcoma. AR, OS
2019 Celecoxib alleviates AKT/c-Met-triggered rapid hepatocarcinogenesis by suppressing a novel COX-2/AKT/FASN cascade. COX-2, HCC, PCNA
2019 Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans. dnSrebp2, FA, HCC, HMG-CoA, SREBP2
2019 Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues. AC, AF, AFS, AM, COX-2, IRS, TG
2019 Cooperative impact of thiazolidinedione and fatty acid synthase on human osteogenesis. BM-MSCs
2019 De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer. dhS1P, S1P, SphK, SPHK1 and 2
10  2019 Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN). ---
11  2019 Down-regulation of PKM2 decreases FASN expression in bladder cancer cells through AKT/mTOR/SREBP-1c axis. PKM2, SREBP-1c
12  2019 Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma. PDH, PDK4, SCD
13  2019 EGCG-Derivative G28 Shows High Efficacy Inhibiting the Mammosphere-Forming Capacity of Sensitive and Resistant TNBC Models. ALDH, BCSC, EGCG, EMT, TNBC
14  2019 Eicosapentaenoic Acid Improves Hepatic Metabolism and Reduces Inflammation Independent of Obesity in High-Fat-Fed Mice and in HepG2 Cells. CPT, EPA, HF, miRNA, mRNA, NAFLD, TNF-alpha
15  2019 Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish. DESI-MS, LPL
16  2019 FASN activity is important for the initial stages of the induction of senescence. IL-1 alpha
17  2019 Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma. CXPAs, PAs
18  2019 Fatty Acid Synthase Promotes the Palmitoylation of Chikungunya Virus nsP1. CHIKV, PA, ZDHHCs
19  2019 Fatty acid synthase, Her2/neu, and E2F1 as prognostic markers of progression in non-muscle invasive bladder cancer. BCG, MIBC, NMIBC, PFS, RFS
20  2019 Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase. ---
21  2019 Ferulic acid ameliorates nonalcoholic fatty liver disease and modulates the gut microbiota composition in high-fat diet fed ApoE-/- mice. AhR, FA, HFD, I3A, LDL-C, NAFLD, SREBP-1c, TC, TG
22  2019 Gut microbiota signatures and lipids metabolism profiles by exposure to polyene phosphatidylcholine. CD36, CPT1A, FATP5, FFA, L-FABP, LPS, PPC, TMAO
23  2019 High expression of cell death-inducing DFFA-like effector a (CIDEA) promotes milk fat content in dairy cows with clinical ketosis. CIDEA, NEFA, TAG, XDH
24  2019 Identification of metabolic pathways related to the bisphenol A-induced adipogenesis in differentiated murine adipocytes by using RNA-sequencing. DEGs, LPL, SREBF1
25  2019 Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs). ACC1, FFPE, PFS, PNETs
26  2019 Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer. AR, AR-V7, mCRPC
27  2019 KDM5B promotes breast cancer cell proliferation and migration via AMPK-mediated lipid metabolism reprogramming. ACLY, AMPK, EMT
28  2019 Laparoscopic sleeve gastrectomy induces molecular changes in peripheral white blood cells. FAS, FTO, GHRL, IRS-1, LEP, LSG, MC4R, PPARG, PWBC, TNF, VLCD
29  2019 PET Imaging of Hepatocellular Carcinomas: 18F-Fluoropropionic Acid as a Complementary Radiotracer for 18F-Fluorodeoxyglucose. 18F-FDG, 18F-FPA, GLUT1, MMP2, PET
30  2019 Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice. ACOX1, ADRP, ALD, CASP3, CCL2, CCL5, Ccr2, Ccr5, CVC, GSDMD, IL, MO, PARP, TNF
31  2019 Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPalpha-SIRT1 pathway. GD, GR, NAFLD, PCE, PW, SREBP-1c
32  2019 Roles of the HOXA10 gene during castrate-resistant prostate cancer progression. AR, HOXA10, PCa
33  2019 Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation. IL1B, NAFLD, OA, PA, PIH, PRKAA1, SCD, SIRT1, SREBF1, STS, TGFB1, TNF
34  2019 Speckle-type POZ protein suppresses lipid accumulation and prostate cancer growth by stabilizing fatty acid synthase. FA, PCa, SPOP
35  2019 Splicing factor ESRP1 controls ER-positive breast cancer by altering metabolic pathways. EMT, ESRP1 and ESRP2, PHGDH, SCD1
36  2019 The Cholesterol-Modulating Effect of Methanol Extract of Pigeon Pea (Cajanus cajan (L.) Millsp.) Leaves on Regulating LDLR and PCSK9 Expression in HepG2 Cells. HMGCR, HNF-1alpha, IDOL, LXRalpha, MECC, PCSK9, SREBP-2
37  2019 Thymoquinone Augments Cyclophosphamide-Mediated Inhibition of Cell Proliferation in Breast Cancer Cells TQ
38  2019 Treatment with myo-inositol attenuates binding of the carbohydrate-responsive element-binding protein to the ChREBP-beta and FASN genes in rat nonalcoholic fatty liver induced by high-fructose diet. ChoREs, ChREBP, mI, TG
39  2019 Yarrow supercritical extract exerts antitumoral properties by targeting lipid metabolism in pancreatic cancer. SCD
40  2018 (-)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer. EGCG, TNBC
41  2018 8u, a pro-apoptosis/cell cycle arrest compound, suppresses invasion and metastasis through HSP90alpha downregulating and PI3K/Akt inactivation in hepatocellular carcinoma cells. ---
42  2018 A comparative analysis of label-free liquid chromatography-mass spectrometry liver proteomic profiles highlights metabolic differences between pig breeds. CES3, HIST2H2BF, KHK, LC-MS, sPLS-DA
43  2018 A family with hypothyroidism caused by fatty acid synthase and apolipoprotein B receptor mutations. APOBR
44  2018 Activation of sterol regulatory element-binding protein 1 (SREBP1)-mediated lipogenesis by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma. EBV, LMP1, mTOR, NPC, siRNA, SREBP1
45  2018 Adipogenic/lipogenic gene expression and fatty acid composition in chuck, loin, and round muscles in response to grain feeding of Yanbian Yellow cattle. LPL, PPARgamma, SCD
46  2018 An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation. TLR
47  2018 Anti-hypercholesterolemic Effects and a Good Safety Profile of SCM-198 in Animals: From ApoE Knockout Mice to Rhesus Monkeys. ApoA1, AS, HDL, LDL, TC, TG
48  2018 Anti-proliferative activity of Origanum vulgare inhibited lipogenesis and induced mitochondrial mediated apoptosis in human stomach cancer cell lines. ACC, EO, HMGCR
49  2018 Association between FASN gene polymorphisms ultrasound carcass traits and intramuscular fat in Qinchuan cattle. SNPs
50  2018 Association of single nucleotide polymorphisms in fat metabolism candidate genes with fatty acid profiles of muscle and subcutaneous fat in heavy pigs. FAs, H-FABP, MTTP, SCD, SNPs
51  2018 Autophagy dysregulation caused by ApoM deficiency plays an important role in liver lipid metabolic disorder. ACACA, ApoM, SREBP1
52  2018 Beyond regulation of pol III: Role of MAF1 in growth, metabolism, aging and cancer. mTOR, TBP
53  2018 Breast cancer metabolic cross-talk: Fibroblasts are hubs and breast cancer cells are gatherers of lipids. ---
54  2018 De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination. FA, PPAR, SC
55  2018 Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy. LRS
56  2018 Development of an in vitro model to study hepatitis C virus effects on hepatocellular lipotoxicity and lipid metabolism. HCV, HMOX1
57  2018 Diazinon exposure activated transcriptional factors CCAAT-enhancer-binding proteins alpha (C/EBPalpha) and peroxisome proliferator-activated receptor gamma (PPARgamma) and induced adipogenesis in 3T3-L1 preadipocytes. ACC, AChE, FABP4, LPL, PPARgamma
58  2018 Dietary energy level affects adipose depot mass but does not impair in vitro subcutaneous adipose tissue response to short-term insulin and tumor necrosis factor-alpha challenge in nonlactating, nonpregnant Holstein cows. CON, DGAT2, IL-10, IL-6, INS, INSIG1, INSR, NFKB1, PPARG, SAT, SREBF1, SUMO2, SUMO3
59  2018 Dual Effects of Metformin on Adipogenic Differentiation of 3T3-L1 Preadipocyte in AMPK-Dependent and Independent Manners. AMP, ERK, JNK, mRNA
60  2018 Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet. CT, CYP7A1, GSH-Px, HF, HMGR, LCAT, LXRalpha, Se, TC
61  2018 Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state. Cav-1, Hsp90, P-gp
62  2018 Elucidating the novel BRCA1 function as a non-genomic metabolic restraint in ER-positive breast cancer cell lines. ---
63  2018 Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. CrAT, mmBCFAs
64  2018 Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells. CPT-1, DNL, EC, EGCG, MMP, ROS
65  2018 FASN-TGF-beta1-PD-L1 axis contributes to the development of resistance to NK cell cytotoxicity of cisplatin-resistant lung cancer cells. NK, NSCLC
66  2018 Fatty Acid Synthase and Acetyl-CoA Carboxylase Are Expressed in Nodal Metastatic Melanoma But Not in Benign Intracapsular Nodal Nevi. ACC, HMB-45
67  2018 Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma. OSCC, qRT-PCR
68  2018 Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL. DLBCL
69  2018 Fatty acid synthase is required for profibrotic TGF-beta signaling. ---
70  2018 Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer. EGFR, NSCLC, TKI
71  2018 Fish Oil Suppresses Body Fat Accumulation in Zebrafish. ---
72  2018 Genome-wide association study and prediction of genomic breeding values for fatty-acid composition in Korean Hanwoo cattle using a high-density single-nucleotide polymorphism array. CCDC57, FAC, GBLUP, GPs, GWAS, PBLUP, SNP
73  2018 Glycine enhances expression of adiponectin and IL-10 in 3T3-L1 adipocytes without affecting adipogenesis and lipolysis. ATGL, HSL, IL-10, PPARgamma
74  2018 High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy. AMPK, GBM, TMZ
75  2018 Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing's syndrome. ACC, ACTH, CS, DEX, GC, GR, GRE, HDACi, SREBP-1c, VPA
76  2018 Histone modifications in fatty acid synthase modulated by carbohydrate responsive element binding protein are associated with non‑alcoholic fatty liver disease. ChoRE, ChREBP, NAFLD
77  2018 In silico screening for identification of fatty acid synthase inhibitors and evaluation of their antiproliferative activity using human cancer cell lines. DNL, KS, MD
78  2018 In vivo evidence on the functional variation within fatty acid synthase gene associated with lipid metabolism in bovine longissimus dorsi muscle tissue. IMF, LM
79  2018 Inhibition of cellular fatty acid synthase impairs replication of budded virions of Autographa californica multiple nucleopolyhedrovirus in Spodoptera frugiperda cells. AcMNPV
80  2018 Inhibition of FASN and ERalpha signalling during hyperglycaemia-induced matrix-specific EMT promotes breast cancer cell invasion via a caveolin-1-dependent mechanism. EMT
81  2018 Inhibition of FASN expression enhances radiosensitivity in human non-small cell lung cancer. DSB, NSCLC
82  2018 Integrated analysis of the gene expression profile and DNA methylation profile of obese patients with type 2 diabetes. CCND1, DEGs, DMGs, GCK, miRNA, PPI, SCD, T2D, TAT
83  2018 Kahweol inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2-overexpressing cancer cells. AP-2, HER2, mTOR, PEA3, SREBP-1c
84  2018 Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment. ACC
85  2018 Metformin Targets Glucose Metabolism in Triple Negative Breast Cancer. BC, TNBC
86  2018 miR-15b negatively correlates with lipid metabolism in mammary epithelial cells. ---
87  2018 miR‑127 aggravates myocardial failure by promoting the TGF‑beta1/Smad3 signaling. miR, SCD1, UCP1
88  2018 Neonatal overfeeding induced glucocorticoid overexposure accelerates hepatic lipogenesis in male rats. DNL, GC, GR, HF, Mi, NAFLD, OA, SCD1, SREBP-1c, TG
89  2018 Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis. BAT, DNL, WAT
90  2018 Nicotine induces oral dysplastic keratinocyte migration via fatty acid synthase-dependent epidermal growth factor receptor activation. e-cigs, EGFR, OSCC
91  2018 NLRP3 Inflammasome Modulates Post-Burn Lipolysis and Hepatic Fat Infiltration via Fatty Acid Synthase. FFA, WT
92  2018 Novel treatment strategies for patients with HER2-positive breast cancer who do not benefit from current targeted therapy drugs. ADC, SH2
93  2018 Orlistat as a FASN inhibitor and multitargeted agent for cancer therapy. FA
94  2018 Ovarian Cancer-Intrinsic Fatty Acid Synthase Prevents Anti-tumor Immunity by Disrupting Tumor-Infiltrating Dendritic Cells. DCs, OVCA, TIDCs
95  2018 Overexpression of SREBF chaperone (SCAP) enhances nuclear SREBP1 translocation to upregulate fatty acid synthase (FASN) gene expression in bovine mammary epithelial cells. SCAP, SREBP1
96  2018 Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. CRC, PDXs
97  2018 Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism. ACC1, CPT1A, SFN, TRAMP
98  2018 Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. ACC1, ALT, AST, COX-2, CPT1, FXR, GCLC, GCLM, HMGB-1, HO-1, LPS, nuclear factor-kappa B, SCD1, TC, TFs
99  2018 Protective effect of atorvastatin meditated by HMGCR gene on diabetic rats with atherosclerosis: An in vivo and in vitro study. AVT, FBG, HDL-C, INS, LDL-C, LDLR, RT-qPCR, TC, TG, VLDL-C
100  2018 Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN. USP14