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Abbreviation : FDC
Long Form : fixed-dose combination
No. Year Title Co-occurring Abbreviation
2020 A phase IV randomised, open-label pilot study to evaluate switching from protease-inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide single tablet regimen in Integrase inhibitor-naive, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations (PIBIK study): study protocol for a randomised trial. bPI
2020 A Retrospective Analysis Comparing Persistence and Adherence to Treatment With Free- Versus Fixed-Dose Combination of an Alpha-Blocker and an Antimuscarinic Agent in Men With LUTS in Spain. AB, AM, HR, LUTS, MPR
2020 Aclidinium bromide and formoterol fumarate for the maintenance treatment of chronic obstructive pulmonary disease. RCTs
2020 Adding a Second Bronchodilator in COPD: A Meta-Analysis on the Risk of Specific Cardiovascular Serious Adverse Events of Tiotropium/Olodaterol Fixed-Dose Combination. RCTs, T/O
2020 Adherence to antihypertensive fixed-dose combination among Egyptian patients presenting with essential hypertension. ---
2020 Amlodipine/valsartan fixed-dose combination treatment in the management of hypertension: A double-blind, randomized trial. BP, DBP, SBP
2020 Analysis of the Authorized Target Populations for Fixed Dose Combination Products Between 2000 and 2017 Reveals Discrepancies Between EMA's and FDA's Views on Initial Dual-Therapy. EMA, FDA, HIV, T2DM
2020 Association of Low-Dose Triple Combination Therapy With Therapeutic Inertia and Prescribing Patterns in Patients With Hypertension: A Secondary Analysis of the TRIUMPH Trial. BP
2020 Asthma control and COPD symptom burden in patients using fixed-dose combination inhalers (SPRINT study). ACT, CAT, COPD, ICS, LABAs
10  2020 Asthma control factors in the Gulf Cooperation Council (GCC) countries and the effectiveness of ICS/LABA fixed dose combinations: a dual rapid literature review. CASP, GCC, ICS/LABA, RCTs, UAE
11  2020 Bioequivalence of Ertugliflozin/Metformin Fixed-Dose Combination Tablets and Coadministration of Respective Strengths of Individual Components. ---
12  2020 Bioequivalence of Macitentan and Tadalafil Given as Fixed-dose Combination or Single-component Tablets in Healthy Subjects. EU, PK, US
13  2020 Bioequivalence Study Comparing Fixed-Dose Combination of Clopidogrel and Aspirin with Coadministration of Individual Formulations in Chinese Subjects Under Fed Conditions: A Phase I, Open-Label, Randomized, Crossover Study. ASA, CI, DAPT, RSABE
14  2020 Comparative Safety Profile of the Fixed-Dose Combination Corticosteroid and Long-acting beta2-Agonist Fluticasone Propionate/Formoterol Fumarate: A 36-Month Longitudinal Cohort Study in UK Primary Care. CPRD, HRs, PY
15  2020 Comparison of Efficacies of Commonly Used Hypertension Treatment Modalities: A Retrospective Study of 1900 Participants in a Hypertension Clinic. FEC, HTN
16  2020 Comparison of Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan/Rosuvastatin with Concomitant Administration of Amlodipine/Losartan and Rosuvastatin in Healthy Volunteers. GMR, LC
17  2020 Comparison of the Pharmacokinetics of a Fixed-Dose Combination of Rosuvastatin/Metformin Sustained-Release (10/1000 mg) and Separate Tablets in Healthy Male Subjects. CI, GMR, PK
18  2020 Compatibility investigation for a new antituberculotic fixed dose combination with an adequate drug delivery. ---
19  2020 Demonstrating Contribution of Components of Fixed-Dose Drug Combinations Through Longitudinal Exposure-Response Analysis. E-R, FP, LER
20  2020 Design and optimization of a child-friendly dispersible tablet containing isoniazid, pyrazinamide, and rifampicin for treating tuberculosis in pediatrics. TB
21  2020 Development of a dissolution method for lumefantrine and artemether in immediate release fixed dose artemether/lumefantrine tablets. APIs, ART, LUM
22  2020 Dispensing Practices of Fixed Dose Combination Controller Therapy for Asthma in Australian Children and Adolescents. AUD, ICS
23  2020 Evaluating triple ICS/LABA/LAMA therapies for COPD patients: a network meta-analysis of ETHOS, KRONOS, IMPACT, and TRILOGY studies. SUCRA
24  2020 Fixed-dose combination of amlodipine and atorvastatin improves clinical outcomes in patients with concomitant hypertension and dyslipidemia. CI, FEC, MI
25  2020 Fixed-Dose Combination of Netarsudil and Latanoprost in Ocular Hypertension and Open-Angle Glaucoma: Pooled Efficacy/Safety Analysis of Phase3 MERCURY-1 and -2. IOP, OAG, OHT
26  2020 Formulation and Bioequivalence Testing of Fixed-Dose Combination Orally Disintegrating Tablets for the Treatment of Tuberculosis in the Paediatric Population. ODTs, PBPK, TB
27  2020 Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets. GLB, MET, ODTs, PEG, SLS
28  2020 Health technology assessment of fixed-dose combination regimen in treatment of newly diagnosed smear-positive pulmonary tuberculosis: A meta-analysis. CI, RCTs, RR, TB
29  2020 Lung function, pharmacokinetics, and tolerability of inhaled indacaterol maleate and acetate in asthma patients. ICS, OD, PEF, PK
30  2020 Management of benign prostate hyperplasia (BPH) by combinatorial approach using alpha-1-adrenergic antagonists and 5-alpha-reductase inhibitors. 5alphaRI, ARAs, BPH, IPSS, LUTS, PUF, QOL, RCTs
31  2020 NMR-Based Metabolomics for the Assessment of Inhaled Pharmacotherapy in Chronic Obstructive Pulmonary Disease Patients. COPD, EBC, ICS, NMR
32  2020 Non-statin lipid-lowering therapy over time in very-high-risk patients: effectiveness of fixed-dose statin/ezetimibe compared to separate pill combination on LDL-C. GPs, LLT
33  2020 Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge. ADR
34  2020 One Year of Netarsudil and Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure: Phase 3, Randomized MERCURY-1 Study. AE, IOP, OAG, OHT
35  2020 Oral cedazuridine/decitabine for MDS and CMML: a phase 2 pharmacokinetic/pharmacodynamic randomized crossover study. CMML, LINE-1, LSM, MDS
36  2020 Patient Characteristics and Healthcare Resource Utilization Among Patients with COPD New to LAMA/LABA Fixed-Dose Combination Treatment in US-Based Real-World Practice. HCRU, LABA, LAMA
37  2020 Pharmacokinetic and Safety Profiles of a Fixed-Dose Combination of Amlodipine, Valsartan, and Atorvastatin: A 3-Period Replicate Crossover Study. AUCt, BE, CIs, GMRs, TEAEs
38  2020 Pharmacokinetics and bioequivalence of fixed-dose combination of candesartan cilexetil/amlodipine besylate (16/10 mg) versus coadministration of individual formulations in healthy subjects. CIs, GMRs
39  2020 Pharmacokinetics and pharmacodynamics of a fixed-dose combination of gemigliptin/metformin sustained release 25/500 mg compared to the loose combination in healthy male subjects. DPP-4, PD, PK, SR, T2DM
40  2020 Phase I Pharmacokinetic Study of Fixed-Dose Combinations of Ibuprofen and Acetaminophen in Healthy Adult and Adolescent Populations. PK
41  2020 Physical Functioning in Patients with Chronic Obstructive Pulmonary Disease Treated with Tiotropium/Olodaterol Respimat in Routine Clinical Practice in Italy. COPD, GOLD, PGE
42  2020 Rapid and efficient chiral method development for lamivudine and tenofovir disoproxil fumarate fixed dose combination using ultra-high performance supercritical fluid chromatography: A design of experiment approach. AIDS, CCD, DoE, HIV, SFC, TDF
43  2020 Rosuvastatin/Ezetimibe: A Review in Hypercholesterolemia. LDL-C
44  2020 SD1000: High Sustained Viral Response Rate in 1361 Patients With Hepatitis C Genotypes 1, 2, 3, and 4 Using a Low-cost, Fixed-dose Combination Tablet of Generic Sofosbuvir and Daclatasvir: A Multicenter, Phase III Clinical Trial. ---
45  2020 The Clinical Implications of Triple Therapy in Fixed-Dose Combination in COPD: From the Trial to the Patient. ICS, LABAs
46  2020 The Effect of Moderate- and High-Fat Meals on the Bioavailability of Dolutegravir/Rilpivirine Fixed-Dose Combination Tablet. ---
47  2020 The Impact of Baseline Pain Intensity on the Analgesic Efficacy of Ibuprofen/Caffeine in Patients with Acute Postoperative Dental Pain: Post Hoc Subgroup Analysis of a Randomised Controlled Trial. PAR, PID, SPRID0-8h
48  2020 Tramadol/Diclofenac Fixed-Dose Combination: A Review of Its Use in Severe Acute Pain. ---
49  2020 Treatment persistence with a fixed-dose combination of tadalafil (5 mg) and tamsulosin (0.4 mg) and reasons for early discontinuation in patients with benign prostatic hyperplasia and erectile dysfunction. ---
50  2020 Trends in licence approvals for ophthalmic medicines in the United Kingdom. MA
51  2020 Triple fixed-dose combination empagliflozin, linagliptin, and metformin for patients with type 2 diabetes. AUC, CIs, T2D
52  2020 Tube Length Adjustment and Tube Trimming Technique in Refractory Glaucoma. BGI, IOP, NVG, PDR, SO
53  2019 "Development of Fixed Dose Combination Products" Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy. AAPS, BE, GI
54  2019 3D printed, controlled release, tritherapeutic tablet matrix for advanced anti-HIV-1 drug delivery. 3DP, EFV, HA-PQ10, TDF
55  2019 A budget impact analysis of budesonide/formoterol in patients with mild asthma in Egypt. HIO
56  2019 A Fixed-Dose Combination Of Gemigliptin And Rosuvastatin Exhibits Similar Pharmacokinetics, Pharmacodynamics, And Safety Compared To That Of A Loose Combination In Healthy Subjects. PD, PK
57  2019 A new strategy for taste masking on bitter drug by other combined drug in fixed-dose combination: bitterness of Amlodipine besylate could be masked efficiently by Valsartan. AML, TEL, VAL
58  2019 A Phase I Study to Show the Relative Bioavailability and Bioequivalence of Fixed-Dose Combinations of Ambrisentan and Tadalafil in Healthy Subjects. PAH, PK
59  2019 A PK/PD study comparing twice-daily to once-daily dosing regimens of ertugliflozin inhealthy subjects
. AUC24, GMR, PD, PK, UGE24
60  2019 A Retrospective Claims Analysis of Dual Bronchodilator Fixed-Dose Combination Versus Bronchodilator Monotherapy in Patients with Chronic Obstructive Pulmonary Disease. COPD, DT, LABA, LAMA, MT, PPPM, PSM
61  2019 Acceptability of a first-line anti-tuberculosis formulation for children: qualitative data from the SHINE trial. TB
62  2019 An integrated safety analysis of combined acetaminophen and ibuprofen (Maxigesic /Combogesic) in adults. AEs, IBP
63  2019 Analysis of the Authorized Target Populations for Fixed Dose Combination Products Between 2000 and 2017 Reveals Discrepancies Between EMA's and FDA's Views on Initial Dual-Therapy. EMA, FDA, HIV, T2DM
64  2019 Bioequivalence of Ertugliflozin/Sitagliptin Fixed-Dose Combination Tablets and Coadministration of Respective Strengths of Individual Components. ---
65  2019 Bioequivalence Study Of A Fixed-Dose Combination Tablet Containing Melitracen 10 mg And Flupentixol 0.5 mg In Healthy Chinese Volunteers Under Fasted And Fed Conditions. AEs, GMR
66  2019 Changes in ocular signs and symptoms in patients switching from bimatoprost-timolol to tafluprost-timolol eye drops: an open-label phase IV study. BAK, IOP, OAG, PF
67  2019 Clinical Benefits of Fixed Dose Combinations Translated to Improved Patient Compliance. T2DM
68  2019 Comparison of different combinations of maximum medical therapy for lowering intraocular pressure in primary open angle glaucoma: 12-month retrospective consecutive case series. ADRs, DMT, IOP, POAG, TMT
69  2019 Current research toward optimizing dosing of first-line antituberculosis treatment. ---
70  2019 Ease of Taking and Palatability of Fixed-Dose Orally Disintegrating Mitiglinide/Voglibose Tablets. APIs, ICs, ODTs, VAS, VRS
71  2019 Effect of Food on the Pharmacokinetics of Ertugliflozin and Its Fixed-Dose Combinations Ertugliflozin/Sitagliptin and Ertugliflozin/Metformin. ---
72  2019 Effectiveness and Impact on Adherence of a New Fixed-Dose Combination of Ivabradine and Metoprolol in a Wide Range of Stable Angina Patients in Real-Life Practice. CAD, CCS, HR, MI, SAN
73  2019 Efficacy and safety of fixed-dose combination therapy with gemigliptin (50 mg) and rosuvastatin compared with monotherapy in patients with type 2 diabetes and dyslipidaemia (BALANCE): A multicentre, randomized, double-blind, controlled, phase 3 trial. ---
74  2019 Efficacy of a fixed dose combination of irbesartan and atorvastatin (Rovelito) in Korean adults with hypertension and hypercholesterolemia. BP, CVD, HTN, LDL-C
75  2019 Evaluation of weight-based prescription of antiretroviral therapy in children. ART, IQR
76  2019 Fixed-dose combination antihypertensives and risk of medication errors. DDI, RR
77  2019 Fixed-dose combinations banned in India: is it the right decision? An eye-opening review. API, DTAB
78  2019 Improvement In Self-Reported Physical Functioning With Tiotropium/Olodaterol In Central And Eastern European COPD Patients. ---
79  2019 Investigation of bioequivalence, safety, and tolerability of a fixed-dose combination of nifedipine GITS and candesartan compared with the corresponding loose-dose combination under fed conditions
. AEs, CIs, GITS
80  2019 Low Antituberculosis Drug Concentrations in HIV-Tuberculosis-Coinfected Adults with Low Body Weight: Is It Time To Update Dosing Guidelines? IQR
81  2019 Metformin Hydrochloride and Sitagliptin Phosphate Fixed-Dose Combination Product Prepared Using Melt Granulation Continuous Processing Technology. MET, SIT
82  2019 Netarsudil/Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure:Three-Month Data from a Randomized Phase 3 Trial. IOP
83  2019 Netarsudil/latanoprost fixed-dose combination for the treatment of open-angle glaucoma or ocular hypertension. FDA, IOP, OAG, OHT, PGA
84  2019 Older HIV-infected adults. Complex patients (III): Polypharmacy. ART, ARVs, PLWH
85  2019 Once-Daily Netarsudil/Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure in the Randomized Phase 3 MERCURY-2 Study. AE, IOP
86  2019 Optimization of a paediatric fixed dose combination mini-tablet and dosing regimen for the first line treatment of tuberculosis. ---
87  2019 Patient-reported outcomes of dual bronchodilator fixed-dose combination versus bronchodilator monotherapy in individuals with COPD. CCQ, ICS, LABA, LAMA, LCADL, PROs, PSM, WPAI
88  2019 Pharmacokinetic and bioequivalence study ofa fixed-dose combination of amlodipine besylate and rosuvastatin calcium compared to co-administration of separate tablets in healthy Korean subjects
. AEs, CIs, ECGs
89  2019 Pharmacokinetic comparison between fixed-dose combination of fimasartan/amlodipine 60/10 mg and the corresponding loose combination through partial replicated crossover study in healthy subjects. CIs, GMRs, PKs
90  2019 Pharmacokinetic comparison of a fixed-dose combination versus concomitant administration of amlodipine, olmesartan, and rosuvastatin in healthy adult subjects. PK
91  2019 Pharmacokinetic comparison of gemigliptin 50mg and metformin 500 mg as a fixed-dose combination and loose combination
. DM, GMR
92  2019 Pharmacokinetic Drug Interactions Between Amlodipine, Valsartan, and Rosuvastatin in Healthy Volunteers. AEs
93  2019 Pharmacokinetic Properties of Ibuprofen (IBU) From the Fixed-Dose Combination IBU/Caffeine (400/100mg; FDC) in Comparison With 400mg IBU as Acid or Lysinate Under Fasted and Fed Conditions-Data From 2 Single-Center, Single-Dose, Randomized Crossover Studies in Healthy Volunteers. AUC, IBU, PK, Tmax
94  2019 Polypills for primary prevention of cardiovascular disease. BP, CVD
95  2019 Population pharmacokinetics and pharmacodynamics of the artesunate-mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children. ACT, ASMQ, AUC, DHA, PK, WHO
96  2019 Prescription pattern & adverse drug reactions of prokinetics. ADRs, AEs
97  2019 Proof-of-concept preparation and characterization of dual-drug amorphous nanoparticle complex as fixed-dose combination of poorly soluble drugs. CIP, ITZ
98  2019 Quality of fixed dose artemether/lumefantrine products in Jimma Zone, Ethiopia. ACT, APIs, ART, JuLaDQ, LUM, RPN
99  2019 Real-life effectiveness of indacaterol-glycopyrronium after switching from tiotropium or salmeterol/fluticasone therapy in patients with symptomatic COPD: the POWER study. CAT, ICS, IND/GLY, LABA, OD, RCTs, SFC, TDI
100  2019 Real-life effectiveness of inhaler device switch from dry powder inhalers to pressurized metred-dose inhalers in patients with asthma treated with ICS/LABA. DPI, OAC, pMDI, RDAC