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Abbreviation : FI
Long Form : factor I
No. Year Title Co-occurring Abbreviation
2018 Genotype-phenotype correlations of low-frequency variants in the complement system in renal disease and age-related macular degeneration. aHUS, AMD, C3G, CFH, CFI, FH, SCR20
2017 A cohort of French pediatric patients with primary immunodeficiencies: are patient preferences regarding replacement immunotherapy fulfilled in real-life conditions? CHQ-PF, IgRT, IVIG, LQI, PIDD, SCIG
2017 A teleost CD46 is involved in the regulation of complement activation and pathogen infection. PBL, rCsCD46
2017 Early Versus Late Diagnosis of Complement Factor I Deficiency: Clinical Consequences Illustrated in Two Families with Novel Homozygous CFI Mutations. ---
2017 Increased activity of the complement system in cerebrospinal fluid of the patients with Non-HIV Cryptococcal meningitis. C4BP, CM, CSF, Ctrl, ELISA, FB, FH, MBL
2017 Local complement activation in aqueous humor in patients with age-related macular degeneration. FH, nAMD
2017 Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses. FH, TED
2017 Systematic Functional Testing of Rare Variants: Contributions of CFI to Age-Related Macular Degeneration. CFI, GWAS
2017 The Functional Effect of Rare Variants in Complement Genes on C3b Degradation in Patients With Age-Related Macular Degeneration. AMD, CFH, CFI, FH
10  2016 Leptospira interrogans Lsa23 protein recruits plasminogen, factor H and C4BP from normal human serum and mediates C3b and C4b degradation. C4BP, FH, NHS, PLG
11  2016 Streptococcus pyogenes Employs Strain-dependent Mechanisms of C3b Inactivation to Inhibit Phagocytosis and Killing of Bacteria. FH, GAS, hPm, iC3b, PAM
12  2015 Interplay between fibrinolysis and complement: plasmin cleavage of iC3b modulates immune responses. TE
13  2015 Local expression of complement factor I in breast cancer cells correlates with poor survival and recurrence. ---
14  2015 Myocardial infarctions and other acute coronary syndromes in rare congenital bleeding disorders: a critical analysis of all reported cases. FII, FV, FVII, FX, FXI, FXIII
15  2015 Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels. AMD, CFI
16  2014 An ELISA assay with two monoclonal antibodies allows the estimation of free factor H and identifies patients with acquired deficiency of this complement regulator. aHUS, FH
17  2014 Molecular characterization and expression analysis of the complement factor I (CpFI) in the whitespotted bamboo shark (Chiloscyllium plagiosum). CpFI, FIMAC, LP
18  2014 Purification and functional characterization of factor I. ---
19  2014 Yersinia pestis Ail recruitment of C4b-binding protein leads to factor I-mediated inactivation of covalently and noncovalently bound C4b. C4BP, NHS
20  2014 Yersinia pestis Ail recruitment of C4b-binding protein leads to factor I-mediated inactivation of covalently and noncovalently bound C4b. C4BP, NHS
21  2013 Complete factor I deficiency due to dysfunctional factor I with recurrent aseptic meningo-encephalitis. ---
22  2013 Interaction of Leptospira elongation factor Tu with plasminogen and complement factor H: a metabolic leptospiral protein with moonlighting activities. EF-Tu, FH
23  2013 Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. AHLE, IL-1, MAC
24  2012 Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia. C4BP, FH
25  2012 Analysis of binding sites on complement factor I using artificial N-linked glycosylation. FIMAC, LDLr1, SP
26  2012 Factor H autoantibodies and deletion of Complement Factor H-Related protein-1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome. aHUS, C4BP, CFHR1, FH, RA, SLE
27  2012 Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr⁴⁰His polymorphism. AMD, CRP, FB, FD
28  2012 Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic. FH
29  2011 Complement factor I in health and disease. FIMAC, LDLR, SP
30  2011 Molecular characterization of two novel cases of complete complement inhibitor Factor I deficiency. FIMAC
31  2011 Structural basis for complement factor I control and its disease-associated sequence polymorphisms. ---
32  2010 Analysis of binding sites on complement factor I that are required for its activity. FIMAC, LDLr1
33  2010 Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation. AP, DAF, DDD, FH, MCP
34  2010 Mutations in complement factor I as found in atypical hemolytic uremic syndrome lead to either altered secretion or altered function of factor I. aHUS
35  2009 Genetic, molecular and functional analyses of complement factor I deficiency. ---
36  2009 Hypoxia increases susceptibility of non-small cell lung cancer cells to complement attack. FH, NSCLC
37  2008 Non-small cell lung cancer cells produce a functional set of complement factor I and its soluble cofactors. C4BP, MCP, NSCLC
38  2008 Preimplantation embryos cooperate with oviductal cells to produce embryotrophic inactivated complement-3b. Crry, iC3b, OE
39  2008 Separation of decay-accelerating and cofactor functional activities of Kaposi's sarcoma-associated herpesvirus complement control protein using monoclonal antibodies. CCP, CFA, DAA, KCP, KSHV
40  2007 A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation. aHUS, FH, MCP
41  2007 The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models. aHUS, AMD, AP, FH, MCP, MPGN, SCR
42  2006 Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides. ---
43  2006 Recombinant generation of two fragments of the rat complement inhibitory factor H [FH(SCR1-7) and FH(SCR1-4)] and their structural and functional characterization in comparison to FH isolated from rat serum. aa, FH, Mr, SCR
44  2005 The catalytically active serine protease domain of human complement factor I. FH
45  2004 Human complement factor I does not require cofactors for cleavage of synthetic substrates. FH
46  2003 CCP1-4 of the C4b-binding protein alpha-chain are required for factor I mediated cleavage of complement factor C3b. C4BP, CCP, FH
47  2003 Effects of zinc on factor I cofactor activity of C4b-binding protein and factor H. ---
48  2003 Functional activity of the complement regulator encoded by Kaposi's sarcoma-associated herpesvirus. KSHV
49  2003 Molecular characterization of homozygous hereditary factor I deficiency. ---
50  2003 Mutations in alpha-chain of C4BP that selectively affect its factor I cofactor function. C4BP, CCP
51  2003 Ontogeny of complement regulatory proteins - concentrations of factor h, factor I, c4b-binding protein, properdin and vitronectin in healthy children of different ages and in adults. C4BP, FH
52  2002 Constitutive expression and regulation of rat complement factor H in primary cultures of hepatocytes, Kupffer cells, and two hepatoma cell lines. FH, HC, KC, LPS
53  2001 Complement factor I is upregulated in rat hepatocytes by interleukin-6 but not by interferon-gamma, interleukin-1beta, or tumor necrosis factor-alpha. ---
54  2001 Enhancement of complement-mediated lysis by a peptide derived from SCR 13 of complement factor H. FH, NHS
55  2001 Expression and regulation of complement factors H and I in rat and human cells: some critical notes. HC, HUVEC, KC
56  2001 Inherited complete factor I deficiency associated with systemic lupus erythematosus, higher susceptibility to infection and low levels of factor H. SLE
57  1999 Rat complement factor I: molecular cloning, sequencing and expression in tissues and isolated cells. aa, bp, HC, HSC, HUVEC, KC, PCR, RT, SEC
58  1997 Complement-activating ability of leucocytes from patients with complement factor I deficiency. AP, CR2, PBL, PMN
59  1989 Production of interleukin 1 inhibitors by the murine macrophage cell line P388D1 which produces interleukin 1. FII, IL-1