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Abbreviation : GAA
Long Form : guanidinoacetate
No. Year Title Co-occurring Abbreviation
2019 Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans. AGAT, Arg, GAMT, Gly, hArg, Lys, NOS
2018 Astrocytic gamma-aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. BGT1, CHO, CRT, GABA, GATs, TAUT
2018 Effects of single and combined metformin and L-citrulline supplementation on L-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications. AGAT, BMD, GAMT, hArg, MDA, nNOS, NO, NOS
2018 Hydrophilic interaction chromatography coupled to tandem mass spectrometry as a method for simultaneous determination of guanidinoacetate and creatine. Cr, HILIC, MRM, RSM
2017 Creatine biosynthesis and transport by the term human placenta. AGAT, GAMT
2017 First reported Chinese case of guanidinoacetate methyltransferase deficiency in a 4-year-old child. Cr, EEG, GAMT
2017 Influence of Glycine and Arginine on Cylindrospermopsin Production and aoa Gene Expression in Aphanizomenon ovalisporum. Arg, CYN, Gly
2017 Metabolism and distribution of pharmacological homoarginine in plasma and main organs of the anesthetized rat. ADMA, Arg, hArg, MDA, NO, NOS, TTC
2017 Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity. CYN
10  2017 The role of L-arginine/L-homoarginine/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients. AD, ADMA, AGAT, aIMT, Arg, hArg, NO, PRMT, TIA
11  2016 Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency. ADMA, Arg1, eNOS, iNOS, NO, UCD
12  2016 Creatine metabolism: detection of creatine and guanidinoacetate in saliva of healthy subjects. Cr, GC
13  2016 Methionine metabolism in Yucatan miniature swine. DNA, IUGR, PC
14  2016 Simultaneous stable-isotope dilution GC-MS measurement of homoarginine, guanidinoacetate and their common precursor arginine in plasma and their interrelationships in healthy and diseased humans. AGAT, ECNICI, GATM, GC-MS, hArg
15  2015 Arginine:glycine amidinotransferase (AGAT) deficiency: Clinical features and long term outcomes in 16 patients diagnosed worldwide. AGAT, IDD
16  2015 Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free L-arginine in humans. ADMA, AGAT, Arg, GAMT, hArg, NO, PRMTs, SAM
17  2015 First evidence of accumulation in cyanobacteria of guanidinoacetate, a precursor of the toxin cylindrospermopsin. CYN
18  2015 Guanidinoacetate is more effective than creatine at enhancing tissue creatine stores while consequently limiting methionine availability in Yucatan miniature pigs. Cr, PC, SAM
19  2014 Alcohol consumption decreases rat hepatic creatine biosynthesis via altered guanidinoacetate methyltransferase activity. EtOH, GAMT, SAM
20  2014 Cerebral creatine deficiencies: a group of treatable intellectual developmental disorders. AGAT, GAMT
21  2014 Diagnosis and therapeutic monitoring of inborn errors of creatine metabolism and transport using liquid chromatography-tandem mass spectrometry in urine, plasma and CSF. CSF, CT, CTN
22  2014 Identification of metabolomic biomarkers for drug-induced acute kidney injury in rats. 3-IS, 3-MH
23  2014 Increased methylation demand exacerbates ethanol-induced liver injury. GAMT
24  2014 Synthesis of guanidinoacetate and creatine from amino acids by rat pancreas. AGAT, GAMT
25  2013 Biochemical, molecular, and clinical diagnoses of patients with cerebral creatine deficiency syndromes. CCDS
26  2013 Characterization of Aphanizomenon ovalisporum amidinotransferase involved in cylindrospermopsin synthesis. AMDT, CYN
27  2013 Effect of the MTHFR 677C/T polymorphism on homocysteinemia in response to creatine supplementation: a case study. Cr, Hcy, MTHFR, PC, SAM, THF
28  2013 Partitioning of [methyl-3H]methionine to methylated products and protein is altered during high methyl demand conditions in young Yucatan miniature pigs. IUGR, NW, PC
29  2013 [Simultaneous determination of guanidinoacetate, creatine and creatinine by liquid chromatography-tandem mass spectrometry: a diagnostic tool for creatine deficiency syndromes in body fluids and a perspective use on cultured fibroblasts]. CDS, Cr, Crn, LC/MSMS
30  2012 Guanidinoacetate methyltransferase (GAMT) deficiency in two Tunisian siblings: clinical and biochemical features. Cr, GAMT
31  2012 In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism. AGAT, Cr, D3Cr
32  2012 Screening for primary creatine deficiencies in French patients with unexplained neurological symptoms. PCD
33  2011 Simultaneous determination of creatine and guanidinoacetate in plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS). LOD, LOQ
34  2010 Creatine prevents the inhibition of energy metabolism and lipid peroxidation in rats subjected to GAA administration. GAMT, TBARS
35  2010 Is there a role for routinely screening children with autism spectrum disorder for creatine deficiency syndrome? ASD, CDS, Cr
36  2009 Simultaneous assay of isotopic enrichment and concentration of guanidinoacetate and creatine by gas chromatography-mass spectrometry. GC-MS
37  2009 The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats: involvement of creatine and taurine transporters. BBB, CRT
38  2009 The effect of L-arginine and creatine on vascular function and homocysteine metabolism. ---
39  2008 Activation of cerebellar granule cells GABA(A) receptors by guanidinoacetate. GAMT
40  2008 Effects in vitro of guanidinoacetate on adenine nucleotide hydrolysis and acetylcholinesterase activity in tissues from adult rats. GAMT
41  2008 Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant. BCSFB, CRT
42  2008 Guanidinoacetate administration increases acetylcholinesterase activity in striatum of rats and impairs retention of an inhibitory avoidance task. AChE, GAMT-deficiency
43  2008 Guanidinoacetate decreases antioxidant defenses and total protein sulfhydryl content in striatum of rats. GAMT, TRAP
44  2007 Creatine synthesis: production of guanidinoacetate by the rat and human kidney in vivo. AGAT, AV, GAMT
45  2007 Evidence that the inhibitory effects of guanidinoacetate on the activities of the respiratory chain, Na+,K+-ATPase and creatine kinase can be differentially prevented by taurine and vitamins E and C administration in rat striatum in vivo. CK, GAMT
46  2007 Guanidinoacetate inhibits glutamate uptake in rat striatum of rats at different ages. GAMT
47  2007 Successful treatment of a guanidinoacetate methyltransferase deficient patient: findings with relevance to treatment strategy and pathophysiology. Cr, GAMT
48  2007 Treatment monitoring of brain creatine deficiency syndromes: a 1H- and 31P-MR spectroscopy study. AGAT-d, ATP, Cr, GAMT-d, PCr, TCr
49  2006 Influence of hematocrit and localisation of punch in dried blood spots on levels of amino acids and acylcarnitines measured by tandem mass spectrometry. aa, AC
50  2006 Intrastriatal administration of guanidinoacetate inhibits Na+, K+-ATPase and creatine kinase activities in rat striatum. CK, GAMT-deficiency, TBARS
51  2006 Methods for the diagnosis of creatine deficiency syndromes: a comparative study. CDS, Cr, GC/MS
52  2006 Quantitative determination of guanidinoacetate and creatine in dried blood spot by flow injection analysis-electrospray tandem mass spectrometry. Cr, FIA
53  2006 Reaction mechanism of guanidinoacetate methyltransferase, concerted or step-wise. AdoMet, ZPE
54  2006 Theoretical study of the methyl transfer in guanidinoacetate methyltransferase. GAMT, SAH, SAM
55  2005 1H chemical shift imaging of the brain in guanidino methyltransferase deficiency, a creatine deficiency syndrome; guanidinoacetate accumulation in the gray matter. GAMT
56  2005 Guanidinoacetate methyltransferase deficiency identified in adults and a child with mental retardation. GAMT
57  2004 Catalytic mechanism of guanidinoacetate methyltransferase: crystal structures of guanidinoacetate methyltransferase ternary complexes. GAMT, GUN, SAH
58  2004 Creatine and guanidinoacetate: diagnostic markers for inborn errors in creatine biosynthesis and transport. Cr, CSF, GAMT
59  2004 Evaluation of the mechanism underlying the inhibitory effect of guanidinoacetate on brain Na+, K+-ATPase activity. GAMT-deficiency, L-NAME, NO, Tau
60  2004 L-arginine increases plasma homocysteine in apoE-/-/iNOS-/- double knockout mice. DKO, L-Arg, L-Met, SAH, SAM, tHcy
61  2004 Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency. GAMT
62  2003 Inhibition of Na+, K+-ATPase activity in rat striatum by guanidinoacetate. AA, AChE, GAMT, GC, Pi
63  2002 Activation of GABA(A) receptors by guanidinoacetate: a novel pathophysiological mechanism. GAMT
64  2002 Guanidinoacetate and creatine plus creatinine assessment in physiologic fluids: an effective diagnostic tool for the biochemical diagnosis of arginine:glycine amidinotransferase and guanidinoacetate methyltransferase deficiencies. AGAT, GAMT
65  2001 Analysis of guanidinoacetate and creatine by isotope dilution electrospray tandem mass spectrometry. GAMT, MRM
66  2001 Improving treatment of guanidinoacetate methyltransferase deficiency: reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation. GAMT