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Abbreviation : GGCT
Long Form : gamma-glutamyl cyclotransferase
No. Year Title Co-occurring Abbreviation
2020 Characterization of the mechanism of thioredoxin-dependent activation of gamma-glutamylcyclotransferase, RipAY, from Ralstonia solanacearum. AtTrx-h5, Trxs
2020 gamma-Glutamyl cyclotransferase contributes to endometrial carcinoma malignant progression and upregulation of PD-L1 expression during activation of epithelial-mesenchymal transition. EMT
2020 GGCT promotes colorectal cancer migration and invasion via epithelial-mesenchymal transition. CRC, EMT
2019 Blockade of gamma-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells. ---
2019 Depletion of gamma-glutamylcyclotransferase inhibits cancer cell growth by activating the AMPK-FOXO3a-p21 axis. AMPK
2019 Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating gamma-glutamyl cyclotransferase expression. IGF
2019 iTRAQ-Based Quantitative Proteomics Approach Identifies Novel Diagnostic Biomarkers That Were Essential for Glutamine Metabolism and Redox Homeostasis for Gastric Cancer. GLS1
2019 Pro-GA, a Novel Inhibitor of gamma-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth. MMC
2018 A Novel Prodrug of a gamma-Glutamylcyclotransferase Inhibitor Suppresses Cancer Cell Proliferation in vitro and Inhibits Tumor Growth in a Xenograft Mouse Model of Prostate Cancer. GA
10  2018 Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence. CDKIs
11  2018 gamma-Glutamyl cyclotransferase contributes to tumor progression in high grade serous ovarian cancer by regulating epithelial-mesenchymal transition via activating PI3K/AKT/mTOR pathway. EMT, HGSC
12  2018 Mechanisms of Tumor Growth Inhibition by Depletion of gamma-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy. ---
13  2018 Prohibitin-2 is a novel regulator of p21WAF1/CIP1 induced by depletion of gamma-glutamylcyclotransferase. PHB2
14  2018 The Ralstonia solanacearum type III effector RipAY targets plant redox regulators to suppress immune responses. ---
15  2016 Depletion of gamma-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation. C7orf24, SA-beta-gal
16  2016 Gamma-glutamylcyclotransferase promotes the growth of human glioma cells by activating Notch-Akt signaling. ---
17  2016 Knockdown of GGCT inhibits cell proliferation and induces late apoptosis in human gastric cancer. shRNA
18  2016 RipAY, a Plant Pathogen Effector Protein, Exhibits Robust gamma-Glutamyl Cyclotransferase Activity When Stimulated by Eukaryotic Thioredoxins. ---
19  2016 Role of gamma-glutamyl cyclotransferase as a therapeutic target for colorectal cancer based on the lentivirus-mediated system. CRC, PRAS40
20  2016 Synthesis and GGCT Inhibitory Activity of N-Glutaryl-L-alanine Analogues. ---
21  2015 A GGCT fluorogenic probe: design, synthesis and application to cancer-related cells. ---
22  2015 Defining the cytosolic pathway of glutathione degradation in Arabidopsis thaliana: role of the ChaC/GCG family of gamma-glutamyl cyclotransferases as glutathione-degrading enzymes and AtLAP1 as the Cys-Gly peptidase. LAPs
23  2015 gamma-Glutamylcyclotransferase Knockdown Inhibits Growth of Lung Cancer Cells Through G0/G1 Phase Arrest. ---
24  2015 Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment. ---
25  2015 Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis. DEPs, G6PD, GSTP1, IDH1, IDH2, nLC, PPI, TMT
26  2015 PEGylated hyaluronic acid-modified liposomal delivery system with anti-gamma-glutamylcyclotransferase siRNA for drug-resistant MCF-7 breast cancer therapy. PEG-HA-NP
27  2014 Botch is a gamma-glutamyl cyclotransferase that deglycinates and antagonizes Notch. ---
28  2014 gamma-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors. ESCC, HGIEN, IHC, LGIEN
29  2013 A fluorogenic probe for gamma-glutamyl cyclotransferase: application of an enzyme-triggered O-to-N acyl migration-type reaction. ---
30  2013 A gamma-glutamyl cyclotransferase protects Arabidopsis plants from heavy metal toxicity by recycling glutamate to maintain glutathione homeostasis. 5-OP
31  2012 A fluorescence-based microtiter plate assay for gamma-glutamylcyclotransferase. ---
32  2012 Widespread expression of gamma-glutamyl cyclotransferase suggests it is not a general tumor marker. ---
33  2010 Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism. GGACT
34  2009 Localization and characterization of gamma-glutamyl cyclotransferase in cancer cells. C7orf24
35  2008 The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle. ---