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Abbreviation : GUSB
Long Form : beta-glucuronidase
No. Year Title Co-occurring Abbreviation
2019 Beta-Glucuronidase Catalyzes Deconjugation and Activation of Curcumin-Glucuronide in Bone. ---
2019 First Report of a Patient with MPS Type VII, Due to Novel Mutations in GUSB, Who Underwent Enzyme Replacement and Then Hematopoietic Stem Cell Transplantation. ERT, HSCT, MPS
2018 Conjugated estrogens in the endometrium during the estrous cycle in pigs. MRP, OATPs, STS, SULT, UGT
2017 Activity-based probes for functional interrogation of retaining beta-glucuronidases. ABPs, HPSE
2017 C-Type Lectin Receptor Dectin-2 Binds to an Endogenous Protein beta-Glucuronidase on Dendritic Cells. BMDCs, CLRs
2017 Identification of stable housekeeping genes in response to ionizing radiation in cancer research. Cq, HKGs, IPO8, IR, TBP, TFRC, UBC
2017 Multiplex Tandem Mass Spectrometry Enzymatic Activity Assay for Newborn Screening of the Mucopolysaccharidoses and Type 2 Neuronal Ceroid Lipofuscinosis. DBS, I2S, IDUA, NAGLU, TPP1
2017 Prolonged Expression of Secreted Enzymes in Dogs After Liver-Directed Delivery of Sleeping Beauty Transposons: Implications for Non-Viral Gene Therapy of Systemic Disease. cFIX, cSEAP, IDUA, SB
2016 Identification of stable reference genes for quantitative PCR in cells derived from chicken lymphoid organs. ACTB, B2M, GAPDH, qPCR, r28S, TBP
10  2016 Selection and validation of reference house-keeping genes in the J774A1 macrophage cell line for quantitative real-time PCR. ECM, GAPDH, HKGs, PPIA, qPCR, RPL13A
11  2015 beta-Glucuronidase, a Regulator of Lyme Arthritis Severity, Modulates Lysosomal Trafficking and MMP-9 Secretion in Response to Inflammatory Stimuli. ---
12  2015 Bilateral single-site intracerebral injection of a nonpathogenic herpes simplex virus-1 vector decreases anxiogenic behavior in MPS VII mice. HSV-1, LAT
13  2015 Selection of suitable reference genes for normalization of genes of interest in canine soft tissue sarcomas using quantitative real-time polymerase chain reaction. PSMB6
14  2014 Combined effects of thermal stress and Cd on lysosomal biomarkers and transcription of genes encoding lysosomal enzymes and HSP70 in mussels, Mytilus galloprovincialis. ctsl, HEX, HSP70
15  2014 Lysosomal beta-glucuronidase regulates Lyme and rheumatoid arthritis severity. GAGs
16  2014 Reference genes for expression studies in hypoxia and hyperglycemia models in human umbilical vein endothelial cells. ACTB, GAPDH, HUVEC, qRT-PCR, RPLP0, TFRC
17  2014 Relationship between the expression of CES2, UGT1A1, and GUSB in colorectal cancer tissues and aberrant methylation. CES, UGT1A
18  2013 Human beta-glucuronidase: structure, function, and application in enzyme replacement therapy. MPS VII
19  2013 Pathogenesis of mitral valve disease in mucopolysaccharidosis VII dogs. CTSB, GAGs, MPS VII, MV
20  2013 Quality control methods for optimal BCR-ABL1 clinical testing in human whole blood samples. Abl, bcr, RT
21  2013 The effect of neonatal gene therapy on skeletal manifestations in mucopolysaccharidosis VII dogs after a decade. MPS
22  2013 The effect of neonatal gene therapy with a gamma retroviral vector on cardiac valve disease in mucopolysaccharidosis VII dogs after a decade. ERT, GAGs, MPS VII, RV
23  2013 Validation of internal reference genes for real-time quantitative polymerase chain reaction studies in the tick, Ixodes scapularis (Acari: Ixodidae). gpdh, qPCR, RPS4, SG, SYN, tbp
24  2012 A novel GUSB mutation in Brazilian terriers with severe skeletal abnormalities defines the disease as mucopolysaccharidosis VII. MPS VII
25  2012 Effect of neonatal gene therapy on lumbar spine disease in mucopolysaccharidosis VII dogs. ERT, MPS VII, RV
26  2012 Embryonic morphogen nodal promotes breast cancer growth and progression. hESC, MPS VII
27  2012 Pathogenesis of lumbar spine disease in mucopolysaccharidosis VII. GAGs, MPS VII, TLR4
28  2012 Selection of reference genes in different myocardial regions of an in vivo ischemia/reperfusion rat model for normalization of antioxidant gene expression. Actb, hmbs, I/R, IRR, papbn1, rpl13a, RR, RT-qPCR, RV, tbp
29  2012 Skeletal response to lentiviral mediated gene therapy in a mouse model of MPS VII. GAGs, MPS VII
30  2011 Expression of genes involved in lipogenesis is not increased in patients with HCV genotype 3 in human liver. apoB, HCV, HCVGT1, HCVGT3, MTTP, PPARA, PPARG, PRKAA1, SFRS4, SREBF1
31  2010 Analysis of mRNA from human heart tissue and putative applications in forensic molecular pathology. COL1A1, COL3A1, L-PMI, NOS3, S-PMIs
32  2010 Genetic engineering of IgG-glucuronidase fusion proteins. BBB, HIR, mAb
33  2009 Long-term AAV vector gene and protein expression in mouse brain from a small pan-cellular promoter is similar to neural cell promoters. AAV, LSE
34  2009 Quantitative TaqMan real-time PCR assays for gene expression normalisation in feline tissues. ABL, ACTB, B2M, GAPDH, gDNA, HMBS, HPRT, RPS7
35  2008 Effects of dimethyl sulfoxide and dexamethasone on mRNA expression of housekeeping genes in cultures of C2C12 myotubes. ACTB, DEX, DMSO, GAPDH, HPRT1, PGK1, PPIA, TFRC
36  2008 Instability of standard PCR reference genes in adipose-derived stem cells during propagation, differentiation and hypoxic exposure. ASCs, GAPDH, TBP
37  2008 Lysosomal enzyme replacement of the brain with intravenous non-viral gene transfer. BBB
38  2008 Neonatal intravenous injection of a gammaretroviral vector has a low incidence of tumor induction in mice. gamma-RVs, LTR
39  2008 Widespread nonhematopoietic tissue distribution by transplanted human progenitor cells with high aldehyde dehydrogenase activity. ALDH
40  2007 Clinical response to persistent, low-level beta-glucuronidase expression in the murine model of mucopolysaccharidosis type VII. MPS VII
41  2006 Attenuation of murine lysosomal storage disease by allogeneic neonatal bone marrow transplantation using costimulatory blockade and donor lymphocyte infusion without myeloablation. BMT, DLI, MPS VII
42  2006 Effects of prototypical drug-metabolizing enzyme inducers on mRNA expression of housekeeping genes in primary cultures of human and rat hepatocytes. ACTB, DEX, GAPDH, HPRT1, OME, PPIA, RIF, TBP, TFRC
43  2006 Encapsulation cell therapy for mucopolysaccharidosis type VII using genetically engineered immortalized human amniotic epithelial cells. BBB, CNS, GAGs, IHAE, MPS VII
44  2006 Expression in blood cells may contribute to biochemical and pathological improvements after neonatal intravenous gene therapy for mucopolysaccharidosis VII in dogs. MPS VII, RV
45  2006 Molecular monitoring of chronic myelogenous leukemia: identification of the most suitable internal control gene for real-time quantification of BCR-ABL transcripts. BCR-ABL, CML
46  2006 Widespread correction of lysosomal storage in the mucopolysaccharidosis type VII mouse brain with a herpes simplex virus type 1 vector expressing beta-glucuronidase. HSV-1, MPS
47  2005 Stable levels of long-term transgene expression driven by the latency-associated transcript promoter in a herpes simplex virus type 1 vector. HSV-1, LAT
48  2004 Brain transplantation of genetically modified bone marrow stromal cells corrects CNS pathology and cognitive function in MPS VII mice. BMS, GAGs, LSDs, MPS VII
49  2004 Electrocardiographic and other cardiac anomalies in beta-glucuronidase-null mice corrected by nonablative neonatal marrow transplantation. BM, LSD
50  2004 Gene therapy ameliorates cardiovascular disease in dogs with mucopolysaccharidosis VII. GAGs, MPS VII, RV
51  2004 Human CD34+ hematopoietic progenitor cell-directed lentiviral-mediated gene therapy in a xenotransplantation model of lysosomal storage disease. LSDs, MPS VII
52  2004 Neonatal retroviral vector-mediated hepatic gene therapy reduces bone, joint, and cartilage disease in mucopolysaccharidosis VII mice and dogs. GAGs, MPS VII, RV
53  2003 Adeno-associated virus vector-mediated transduction in the cat brain. AAV
54  2003 Biodistribution and efficacy of donor T lymphocytes in a murine model of lysosomal storage disease. LSDs, PTLs
55  2003 Donor cell expansion is delayed following nonablative in utero transplantation to treat murine mucopolysaccharidosis type VII. MPS VII, PB
56  2003 Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model of lysosomal storage disease. MPS VII, NOD/SCID
57  2003 Improvement of skeletal lesions in mice with mucopolysaccharidosis type VII by neonatal adenoviral gene transfer. AxCAhGUS, MPS VII
58  2003 Intravitreal gene therapy reduces lysosomal storage in specific areas of the CNS in mucopolysaccharidosis VII mice. MPSs
59  2003 Transgene produces massive overexpression of human beta -glucuronidase in mice, lysosomal storage of enzyme, and strain-dependent tumors. ---
60  2002 Abnormal osteoclast morphology and bone remodeling in a murine model of a lysosomal storage disease. IL-1, MPS VII
61  2002 Assignment of the beta-glucuronidase (GUSB) gene to porcine chromosome SSC3p16-->p14 by FISH and confirmation by hybrid panel analyses. ---
62  2002 Evaluation of pathological manifestations of disease in mucopolysaccharidosis VII mice after neonatal hepatic gene therapy. MPS VII
63  2002 Prolongation of transgene expression by coexpression of cytokine response modifier a in rodent liver after adenoviral gene transfer. CrmA
64  2001 Accumulation of abnormal amounts of glycosaminoglycans in murine mucopolysaccharidosis type VII neural progenitor cells does not alter the growth rate or efficiency of differentiation into neurons. GAGs, MPS VII, NPCs
65  2001 Adenoviral vector-mediated beta-glucuronidase cDNA transfer to treat MPS VII RPE in vitro. Ad-GUSB, GAG, MPS VII, RPE
66  2001 Adenovirus-mediated gene therapy for corneal clouding in mice with mucopolysaccharidosis type VII. AxCAhGUS
67  2001 Biodistribution, kinetics, and efficacy of highly phosphorylated and non-phosphorylated beta-glucuronidase in the murine model of mucopolysaccharidosis VII. ERT, RE
68  2001 Engraftment of genetically engineered amniotic epithelial cells corrects lysosomal storage in multiple areas of the brain in mucopolysaccharidosis type VII mice. AEC, CNS, MPS VII
69  2001 In utero fetal liver cell transplantation without toxic irradiation alleviates lysosomal storage in mice with mucopolysaccharidosis type VII. FLC, MPS VII
70  2001 In utero transplantation of fetal liver cells in the mucopolysaccharidosis type VII mouse results in low-level chimerism, but overexpression of beta-glucuronidase can delay onset of clinical signs. BMT, MPS
71  2001 Intracranial injection of recombinant adeno-associated virus improves cognitive function in a murine model of mucopolysaccharidosis type VII. GAGs, MPS VII
72  2001 Prevention of systemic clinical disease in MPS VII mice following AAV-mediated neonatal gene transfer. AAV, MPS VII
73  2001 Widespread distribution of adenovirus-transduced monkey amniotic epithelial cells after local intracerebral injection: implication for cell-mediated therapy for lysosome storage disorders. MAEC, MPS VII
74  2000 Adenovirus-mediated gene therapy for mucopolysaccharidosis VII: involvement of cross-correction in wide-spread distribution of the gene products and long-term effects of CTLA-4Ig coexpression. AxCAhGUS, MPS VII
75  2000 Phenotype correction in murine mucopolysaccharidosis type VII by transplantation of human amniotic epithelial cells after adenovirus-mediated gene transfer. HAE
76  2000 Significantly increased expression of beta-glucuronidase in the central nervous system of mucopolysaccharidosis type VII mice from the latency-associated transcript promoter in a nonpathogenic herpes simplex virus type 1 vector. CNS, HSV, LAT
77  1999 Biochemical basis of the beta-glucuronidase gene defect causing canine mucopolysaccharidosis VII. GAGs, MPS VII, RPE
78  1999 Neonatal gene transfer leads to widespread correction of pathology in a murine model of lysosomal storage disease. MPS VII
79  1999 Neonatal intramuscular injection with recombinant adeno-associated virus results in prolonged beta-glucuronidase expression in situ and correction of liver pathology in mucopolysaccharidosis type VII mice. AAV, MPS VII
80  1999 [Gene therapy for acute hepatitis using CrmA gene transduction]. CrmA, CTLs
81  1998 Cloning of the canine beta-glucuronidase cDNA, mutation identification in canine MPS VII, and retroviral vector-mediated correction of MPS VII cells. MPS VII
82  1997 Characterization of beta-glucuronidase in the retinal pigment epithelium. 4-MUG, GAGs, RPE
83  1997 Decreased lysosomal storage in the adult MPS VII mouse brain in the vicinity of grafts of retroviral vector-corrected fibroblasts secreting high levels of beta-glucuronidase. MPS
84  1996 Localization by fluorescence in situ hybridization of the human functional beta-glucuronidase gene (GUSB) to 7q11.21 --> q11.22 and two pseudogenes to 5p13 and 5q13. FISH
85  1995 High level expression and export of beta-glucuronidase from murine mucopolysaccharidosis VII cells corrected by a double-copy retrovirus vector. GLA, LTRs, MPS, TK
86  1994 Cross-correction of beta-glucuronidase deficiency by retroviral vector-mediated gene transfer. MPS
87  1992 Mucopolysaccharidosis type VII (beta-glucuronidase deficiency): a chronic variant with an oligosymptomatic severe skeletal dysplasia. ---
88  1991 Deletion mapping of plasminogen activator inhibitor, type I (PLANH1) and beta-glucuronidase (GUSB) in 7q21----q22. ---
89  1990 Gene dosage effect in acquired monosomy 7: distinct behaviour of beta-glucuronidase and phosphoserine phosphatase. PSP
90  1988 Chromosomal mapping of lysosomal enzyme structural genes in the domestic cat. FUCA, GLA, GLB1, HEX A, MANA
91  1983 Assignment of the human phosphoserine phosphatase gene (PSP) to the pter leads to q22 region of chromosome 7. PSP
92  1983 Complex chromosome homologies between the rhesus monkey (Macaca mulatta) and man. HEX A, ITPA, NAGA, NP, PGM3, PKM2
93  1983 Gene dosage effect for beta-glucuronidase (GUSB) in monosomy 7 cells of patients with myeloproliferative disorders. ARSA, GLB