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Abbreviation : HAase
Long Form : hyaluronidase
No. Year Title Co-occurring Abbreviation
2020 A dual-readout nanosensor based on biomass-based C-dots and chitosan@AuNPs with hyaluronic acid for determination of hyaluronidase. BC-dots, HA
2020 A high sensitivity background eliminated fluorescence sensing platform for hyaluronidase activity detection based on Si QDs/HA-delta-FeOOH nanoassembly. delta-FeOOH
2020 A hyaluronic acid fluorescent hydrogel based on fluorescence resonance energy transfer for sensitive detection of hyaluronidase. FRET, HA
2020 A novel surface-enhanced Raman scattering-based ratiometric approach for detection of hyaluronidase in urine. HA, SERS, TBN, TPA-AuAgNPs
2020 A tumor-targeted theranostic nanomedicine with strong absorption in the NIR-II biowindow for image-guided multi-gradient therapy. CDT, EPR, GOx, HA, LbL
2020 A versatile nanoplatform for synergistic chemo-photothermal therapy and multimodal imaging against breast cancer. FL, HA, MSNs, NIR
2020 Enzyme/pH-triggered anticancer drug delivery of chondroitin sulfate modified doxorubicin nanocrystal. CSOA, DOX, NC
2020 Exploitation of Filamentous and Picoplanktonic Cyanobacteria for Cosmetic Applications: Potential to Improve Skin Structure and Preserve Dermal Matrix Components. ---
2020 LDH-stabilized ultrasmall iron oxide nanoparticles as a platform for hyaluronidase-promoted MR imaging and chemotherapy of tumors. DOX, HA, LDH, MR
10  2020 Mechanism Investigation of Hyaluronidase-Combined Multistage Nanoparticles for Solid Tumor Penetration and Antitumor Effect. ECM, EPI, HA, IFP
11  2020 One-pot synthesis of hyaluronic acid-coated gold nanoparticles as SERS substrate for the determination of hyaluronidase activity. HA-AuNPs, SERS
12  2020 Oxyhemoglobin nano-recruiter preparation and its application in biomimetic red blood cells to relieve tumor hypoxia and enhance photodynamic therapy activity. BRBCs, HA, oxyHb, PDT
13  2020 Randomized, Double-Blind, Placebo-Controlled Trial on the Efficacy of Hyaluronidase in Preventing Perineal Trauma in Nulliparous Women. ---
14  2020 Stimuli-Responsive Polysaccharide Enveloped Liposome for Targeting and Penetrating Delivery of survivin-shRNA into Breast Tumor. CS, FRET, HA, HCLR, IAP
15  2020 Temperature-controlled molecular weight of hyaluronic acid produced by engineered Bacillus subtilis. HA
16  2020 Tumor microenvironment targeting with dual stimuli-responsive nanoparticles based on small heat shock proteins for antitumor drug delivery. CIA, Mj-sHSPs, NPs, PAHA, PTX, Tat, TME
17  2020 Tumor- and mitochondria-targeted nanoparticles eradicate drug resistant lung cancer through mitochondrial pathway of apoptosis. HA, MOMP, NP, PTX, TPH, TPP
18  2020 Tumor-specific nanomedicine via sequential catalytic reactions for accurate tumor therapy. GOD, TME
19  2019 A dual-targeted hyaluronic acid-gold nanorod platform with triple-stimuli responsiveness for photodynamic/photothermal therapy of breast cancer. ALA, GNRs, HA, NIR, PDT, PTT, ROS
20  2019 A Dynamic 3D Tumor Spheroid Chip Enables More Accurate Nanomedicine Uptake Evaluation. MTC-chip, NPs
21  2019 A self-delivery system based on an amphiphilic proapoptotic peptide for tumor targeting therapy. DOX, DSDSs, HA
22  2019 A Sequential Target-Responsive Nanocarrier with Enhanced Tumor Penetration and Neighboring Effect In Vivo. DOX, ECM, HA, NPs, ZDHD
23  2019 Biodegradable hybrid mesoporous silica nanoparticles for gene/chemo-synergetic therapy of breast cancer. HA, HMSN, PEI
24  2019 Co-delivery of TRAIL and siHSP70 using hierarchically modular assembly formulations achieves enhanced TRAIL-resistant cancer therapy. MMP2, TRAIL
25  2019 Efficient PD-L1 gene silence promoted by hyaluronidase for cancer immunotherapy. ECM, HA, NPs, PD-1, PD-L1, shPD-L1
26  2019 Halting hyaluronidase activity with hyaluronan-based nanohydrogels: development of versatile injectable formulations. HA, HA-CH NHs
27  2019 Hyaluronic acid-targeted and pH-responsive drug delivery system based on metal-organic frameworks for efficient antitumor therapy. alpha-TOS, DDSs, HA, TME, ZIF-8
28  2019 Mitochondrial targeting nanodrugs self-assembled from 9-O-octadecyl substituted berberine derivative for cancer treatment by inducing mitochondrial apoptosis pathways. BD, DSPE-PEG2000, HA
29  2019 Near-infrared boosted ROS responsive siRNA delivery and cancer therapy with sequentially peeled upconversion nano-onions. HA, RB, RNAi, siRNA, UCNOs, UCNPs
30  2019 Outer-Frame-Degradable Nanovehicles Featuring Near-Infrared Dual Luminescence for in Vivo Tracking of Protein Delivery in Cancer Therapy. DS, HA, NIR, UCL, UCNPs
31  2019 PEGylated hyaluronidase/NIR induced drug controlled release system for synergetic chemo-photothermal therapy of hepatocellular carcinoma. DOX, HA, HCC, NIR, PTT
32  2019 Sensitive Hyaluronidase Biosensor Based on Target-Responsive Hydrogel Using Electronic Balance as Readout. HA, NPs, PEI
33  2019 The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER. ECM, HA, KO, TMEM2
34  2018 A cellular/intranuclear dual-targeting nanoplatform based on gold nanostar for accurate tumor photothermal therapy. GNS, HA, NLS, PTT
35  2018 Bacterial adaptability of enzyme and pH dual-responsive surface for infection resistance. LbL, VAN
36  2018 Biological properties of butanol extracts from green pine cone of Pinus densiflora. GPCs
37  2018 Coadministration of iRGD with Multistage Responsive Nanoparticles Enhanced Tumor Targeting and Penetration Abilities for Breast Cancer Therapy. HN
38  2018 Double-Targeting Explosible Nanofirework for Tumor Ignition to Guide Tumor-Depth Photothermal Therapy. CuS-HA, NIR, PTT, UCNP
39  2018 Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy. DOX, ICG
40  2018 Evaluation of in vitro and in vivo antitumor effects of gambogic acid-loaded layer-by-layer self-assembled micelles. C6-M, GA, GA-M, HA, PRM
41  2018 Fine Tuning of Core-Shell Structure of Hyaluronic Acid/Cell-Penetrating Peptides/siRNA Nanoparticles for Enhanced Gene Delivery to Macrophages in Antiatherosclerotic Therapy. CPP, HA, MCP-1, NCs
42  2018 Glycocalyx degradation leads to blood-brain barrier dysfunction and brain edema after asphyxia cardiac arrest in rats. BBB, CA, CPR, HC
43  2018 HAase-sensitive dual-targeting irinotecan liposomes enhance the therapeutic efficacy of lung cancer in animals. EGFR
44  2018 Highly enhanced cancer immunotherapy by combining nanovaccine with hyaluronidase. CpG, DCs, ECM, HA, OVA, PEI
45  2018 Hyaluronidase Injection in the Vocal Folds for Vocal Hemorrhage, Reinke Edema, and Hyaluronic Acid Overinjection: A Novel Application in the Larynx. HA
46  2018 Intelligent MoS2 Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery To Overcome Cancer Chemotherapy Resistance Guided by PET Imaging. DOX, HA, NIR, P-gp, PEI, PET
47  2018 Preparation and evaluation of tumour microenvironment response multistage nanoparticles for epirubicin delivery and deep tumour penetration. EPI, HA
48  2018 Tailor-Making Fluorescent Hyaluronic Acid Microgels via Combining Microfluidics and Photoclick Chemistry for Sustained and Localized Delivery of Herceptin in Tumors. HMGs, s.c
49  2018 Tumor-Targeted Graphitic Carbon Nitride Nanoassembly for Activatable Two-Photon Fluorescence Imaging. g-CN, HA
50  2017 An enhanced chemotherapeutic effect facilitated by sonication of MSN. m-HA, MSN, SDT, US
51  2017 Bio-stimuli-responsive multi-scale hyaluronic acid nanoparticles for deepened tumor penetration and enhanced therapy. FITC, HA, MTX, PAMAM
52  2017 Cationic Carbon Dots for Modification-Free Detection of Hyaluronidase via an Electrostatic-Controlled Ratiometric Fluorescence Assay. C-CDs, CDs, FRET, HA, NR
53  2017 Hyaluronic Acid-Templated Ag Nanoparticles/Graphene Oxide Composites for Synergistic Therapy of Bacteria Infection. GO, HA
54  2017 Hyaluronidase and Chondroitinase. GAGs
55  2017 In vivo aggregation-induced transition between T1 and T2 relaxations of magnetic ultra-small iron oxide nanoparticles in tumor microenvironment. MRI
56  2017 Mesoporous silica-based versatile theranostic nanoplatform constructed by layer-by-layer assembly for excellent photodynamic/chemo therapy. LbL, MSNs, PDT, supraPSs, TPZ
57  2017 Mitochondria-targeting "Nanoheater" for enhanced photothermal/chemo-therapy. HA, NIR, PTT
58  2017 Optimal Fermentation Conditions of Hyaluronidase Inhibition Activity on Asparagus cochinchinensis Merrill by Weissella cibaria. AC
59  2017 Overcoming the Heat Endurance of Tumor Cells by Interfering with the Anaerobic Glycolysis Metabolism for Improved Photothermal Therapy. DC, GNRs, HA, HSP, PTT
60  2017 Plaque-hyaluronidase-responsive high-density-lipoprotein-mimetic nanoparticles for multistage intimal-macrophage-targeted drug delivery and enhanced anti-atherosclerotic therapy. apoA-I, HA, iMPhi, rHDL
61  2017 Turn-on theranostic fluorescent nanoprobe by electrostatic self-assembly of carbon dots with doxorubicin for targeted cancer cell imaging, in vivo hyaluronidase analysis, and targeted drug delivery. DOX, HA, PEI
62  2016 A Hyaluronidase-Responsive Nanoparticle-Based Drug Delivery System for Targeting Colon Cancer Cells. DOX, HA, MSN
63  2016 A ratiometric fluorescent probe for hyaluronidase detection via hyaluronan-induced formation of red-light emitting excimers. HA
64  2016 Antioxidant and hyaluronidase inhibitory activities of diverse phenolics in Phyllanthus emblica. ---
65  2016 Cloning, structural modelling and characterization of VesT2s, a wasp venom hyaluronidase (HAase) from Vespa tropica. ---
66  2016 Construction, Enzyme Response, and Substrate Capacity of a Hyaluronan-Cyclodextrin Supramolecular Assembly. 2,6-TNS, HA, ThT
67  2016 Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy. ECM, EPR, NM-Ce6, PDT, SLNs
68  2016 Light-Induced Hydrogel Based on Tumor-Targeting Mesoporous Silica Nanoparticles as a Theranostic Platform for Sustained Cancer Treatment. HA, MSNs, NIR
69  2016 One-Step Synthesis of Water-Soluble MoS2 Quantum Dots via a Hydrothermal Method as a Fluorescent Probe for Hyaluronidase Detection. HA
70  2016 Optimization of Hyaluronidase Inhibition Activity from Prunus davidiana (Carriere) Franch Fruit Extract Fermented by its Isolated Bacillus subtilis Strain SPF4211. CCD
71  2016 Reversing Cancer Multidrug Resistance in Xenograft Models via Orchestrating Multiple Actions of Functional Mesoporous Silica Nanoparticles. DDS, DOX, HA, MDR
72  2016 Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots. TNF
73  2015 Cationic Conjugated Polymer/Hyaluronan-Doxorubicin Complex for Sensitive Fluorescence Detection of Hyaluronidase and Tumor-Targeting Drug Delivery and Imaging. CCP, DOX, HA, PFEP
74  2015 Dual-stimuli responsive hyaluronic acid-conjugated mesoporous silica for targeted delivery to CD44-overexpressing cancer cells. CD44, CLSM, DOX, FACS, HA, MSN, PBS, SS
75  2015 Effects of enzymatic degradation after loading in temporomandibular joint. COX-2, IL-1beta, MMPs, OA, TMJ
76  2015 Enhanced DNA release from disulfide-containing layered nanocomplexes by heparin-electrostatic competition. Bmi-1, DPSHA-HP, HA, HP
77  2015 Enzymatic production of specifically distributed hyaluronan oligosaccharides. HA
78  2015 Molecular Interactions of Flavonoids to Hyaluronidase: Insights from Spectroscopic and Molecular Modeling Studies. ---
79  2015 Tamarind Seed (Tamarindus indica) Extract Ameliorates Adjuvant-Induced Arthritis via Regulating the Mediators of Cartilage/Bone Degeneration, Inflammation and Oxidative Stress. IL, MMPs, TRAP, TSE
80  2014 Direct detection of hyaluronidase in urine using cationic gold nanoparticles: a potential diagnostic test for bladder cancer. CTAB, HA
81  2014 Hyaluronidase for reducing perineal trauma. CI, ICTRP, RR
82  2014 Hyaluronidase-sensitive nanoparticle templates for triggered release of HIV/AIDS microbicide in vitro. HA-NPs
83  2014 One-step facile synthesis of hyaluronic acid functionalized fluorescent gold nanoprobes sensitive to hyaluronidase in urine specimen from bladder cancer patients. FITC-HA, FRET
84  2014 Sensitivity and specificity of urinary hyaluronic acid and hyaluronidase in detection of bladder transitional cell carcinoma. HA, TCC
85  2013 Active hyaluronidase 2 expression in the granulation tissue formed in the healing process of equine superficial digital flexor tendonitis. HA, HYAL2
86  2013 Hyaluronidase treatment of acute lymphedema in a mouse tail model. LYVE, TGF, TNF, VEGFR-3
87  2013 Reaction-complexation coupling between an enzyme and its polyelectrolytic substrate: determination of the dissociation constant of the hyaluronidase-hyaluronan complex from the hyaluronidase substrate-dependence. HA
88  2012 Dual-functional liposomes based on pH-responsive cell-penetrating peptide and hyaluronic acid for tumor-targeted anticancer drug delivery. CLSM, CPP, HA, HA-R6H4-L, NIRD15, R6H4-L
89  2012 Lifetime-based sensing of the hyaluronidase using fluorescein labeled hyaluronic acid. HA, HAs, LBS
90  2012 Phlorotannin extracts from fucales characterized by HPLC-DAD-ESI-MSn: approaches to hyaluronidase inhibitory capacity and antioxidant properties. ---
91  2011 A close relationship between type 1 diabetes and vitamin A-deficiency and matrix metalloproteinase and hyaluronidase activities in skin tissues. ECM, MMP, RA, STZ, VAD
92  2011 HYAL1 overexpression is correlated with the malignant behavior of human breast cancer. ECM, HA, HYAL1
93  2011 Identification, characterization, and molecular cloning of a novel hyaluronidase, a member of glycosyl hydrolase family 16, from Penicillium spp. ---
94  2011 Quantitative measurement of serum hyaluronic acid molecular weight in rheumatoid arthritis patients and the role of hyaluronidase. HA, MW, RA
95  2011 Targeting hyaluronidase for cancer therapy: antitumor activity of sulfated hyaluronic acid in prostate cancer cells. AR, HA, NF-kappaB, PI3K, sHA
96  2011 Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis. ECM, HA, HYAL1
97  2011 Use of hyaluronidase to prevent perineal trauma during spontaneous births: a randomized, placebo-controlled, double-blind, clinical trial. ---
98  2010 HYAL-1 hyaluronidase: a potential prognostic indicator for progression to muscle invasion and recurrence in bladder cancer. BCa, HA, HYAL-1
99  2010 Inhibition of hyaluronidase activity of human and rat spermatozoa in vitro and antispermatogenic activity in rats in vivo by Terminalia chebula, a flavonoid rich plant. T. chebula
100  2010 pH effects on the hyaluronan hydrolysis catalysed by hyaluronidase in the presence of proteins: Part I. Dual aspect of the pH-dependence. BSA, HA