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Abbreviation : HBP
Long Form : hexosamine biosynthetic pathway
No. Year Title Co-occurring Abbreviation
2019 Author's view: epithelial plasticity metabolically reprograms normal cells towards a neoplastic-prone state. ---
2019 Bittersweet tumor development and progression: Emerging roles of epithelial plasticity glycosylations. EMT, EP, MET, OIS, UDP-GlcNAc
2019 Blocked O-GlcNAc cycling disrupts mouse hematopoeitic stem cell maintenance and early T cell development. HSCs, OGA
2019 Cholinergic drugs ameliorate endothelial dysfunction by decreasing O-GlcNAcylation via M3 AChR-AMPK-ER stress signaling. ACh, AMPK, ER, HFD, HUVECs, O-GlcNAc
2019 Deficiency of AtGFAT1 activity impairs growth, pollen germination and tolerance to tunicamycin in Arabidopsis. GFAT1, GlcN, TM
2019 Elevation of O-GlcNAc and GFAT expression by nicotine exposure promotes epithelial-mesenchymal transition and invasion in breast cancer cells. CEBPB, CHOP, EMT, GFAT, NIC
2019 Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer. UDP-GlcNAc
2019 Hexosamine Biosynthetic Pathway and Glycosylation Regulate Cell Migration in Melanoma Cells. ---
2019 Inhibition of the hexosamine biosynthesis pathway potentiates cisplatin cytotoxicity by decreasing BiP expression in non-small-cell lung cancer cells. GFAT, NSCLC, UPR
10  2019 Metabolic Stress and Cardiovascular Disease in Diabetes Mellitus: The Role of Protein O-GlcNAc Modification. O-GlcNAcylation
11  2019 O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. LPS, O-GlcNAc, OGT
12  2019 O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors. DDR, DSB, GlcNAc
13  2019 O-GlcNAcylation, a sweet link to the pathology of diseases. O-GlcNAc, OGA, OGT, UDP-GlcNAc
14  2019 Roles of the hexosamine biosynthetic pathway and pentose phosphate pathway in bile acid-induced cancer development. ESCCs, G6PD, NF-kappaB, O-GlcNAc, OGT, PPP, TCA
15  2019 The impact of sugar-sweetened beverage intake on rat cardiac function. NOGPs, SSB, SSB
16  2019 Type II Epithelial-Mesenchymal Transition Upregulates Protein N-Glycosylation To Maintain Proteostasis and Extracellular Matrix Production. ECM, EMT, ERAD, TGF-beta, UPR
17  2018 "Nutrient-sensing" and self-renewal: O-GlcNAc in a new role. ESC/HSC, OGT
18  2018 2-Deoxy-d-glucose increases GFAT1 phosphorylation resulting in endoplasmic reticulum-related apoptosis via disruption of protein N-glycosylation in pancreatic cancer cells. 2DG, AMPK, CHOP, ER, GFAT1, GRP78, MET, UDP-GlcNAc
19  2018 A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway. HDAC4
20  2018 Azide- and Alkyne-Bearing Metabolic Chemical Reporters of Glycosylation Show Structure-Dependent Feedback Inhibition of the Hexosamine Biosynthetic Pathway. GFAT, MCRs, UDP-GlcNAc
21  2018 Cellular glycosylation senses metabolic changes and modulates cell plasticity during epithelial to mesenchymal transition. EMT
22  2018 Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity. AGEs, PKC
23  2018 Chronic O-GlcNAcylation and Diabetic Cardiomyopathy: The Bitterness of Glucose. AGE, DC, OGT, T2D
24  2018 Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression. DR, GFAT, HFD, NR4A1
25  2018 Cross regulation between mTOR signaling and O-GlcNAcylation. mTOR, O-GlcNAcylation, OGT, UDP-GlcNAc
26  2018 Cross-Dysregulation of O-GlcNAcylation and PI3K/AKT/mTOR Axis in Human Chronic Diseases. mTOR, O-GlcNAcylation, OGT, PI3K, Ser, T2D, Thr, UDP-GlcNAc
27  2018 Direct One-Step Fluorescent Labeling of O-GlcNAc-Modified Proteins in Live Cells Using Metabolic Intermediates. GlcN-NBD, O-GlcNAc, OGT, UDP-GlcNAc
28  2018 FGF23 Induction of O-Linked N-Acetylglucosamine Regulates IL-6 Secretion in Human Bronchial Epithelial Cells. CF, COPD, FGF, IL-6, NFAT, O-GlcNAc, OGT, PLCgamma
29  2018 GFPT2-Expressing Cancer-Associated Fibroblasts Mediate Metabolic Reprogramming in Human Lung Adenocarcinoma. CAF, GFAT2, GFPT2, NSCLC, SCC
30  2018 Glycolysis and the Hexosamine Biosynthetic Pathway as Novel Targets for Upper and Lower Airway Inflammation. ATP
31  2018 Hexosamine Biosynthetic Pathway Inhibition Leads to AML Cell Differentiation and Cell Death. AML, OGT
32  2018 Hexosamine pathway regulates StarD7 expression in JEG-3 cells. UPR
33  2018 High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase B O-GlcNAcylation. GSK3beta, HG, mTOR, PT
34  2018 Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis. TNBC, UPR
35  2018 mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation. GFAT1, mTOR, mTORC2
36  2018 O-GlcNAc elevation through activation of the hexosamine biosynthetic pathway enhances cancer cell chemoresistance. CPT, DOX, XBP1
37  2018 O-GlcNAc in cancer: An Oncometabolism-fueled vicious cycle. ---
38  2018 O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity. O-GlcNAc, VSVs
39  2018 O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. EMT, O-GlcNAcylation, OIS
40  2018 Parameter estimation of qualitative biological regulatory networks on high performance computing hardware. BRNs, HPC
41  2018 Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease. AD
42  2018 Real Talk: The Inter-play Between the mTOR, AMPK, and Hexosamine Biosynthetic Pathways in Cell Signaling. AMPK, mTOR, OGA, OGT
43  2018 Stem Cell Intrinsic Hexosamine Metabolism Regulates Intestinal Adaptation to Nutrient Content. ISCs
44  2018 TGF-beta1 Causes EMT by Regulating N-Acetyl Glucosaminyl Transferases via Downregulation of Non Muscle Myosin II-A through JNK/P38/PI3K Pathway in Lung Cancer. C2GnT-M, EMT, NM, NMII-A
45  2018 The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring. PTMs, UDP-GlcNAc
46  2018 Too sweet to resist: Control of immune cell function by O-GlcNAcylation. O-GlcNAcylation, OGA, OGT
47  2018 [At the heart of diabetic cardiomyopathy: Bscl2 knockout mice to investigate glucotoxicity]. HF, SGLT2, SKO, T2DM
48  2017 A Genetic Model to Study Increased Hexosamine Biosynthetic Flux. GlcNAc, hmn
49  2017 Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer. ---
50  2017 GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis. AICAR, AMPK, GFAT1, O-GlcNAc, VEGF, WT
51  2017 High expression of GFAT1 predicts unfavorable prognosis in patients with hepatocellular carcinoma. AFP, GFAT, HCC, OS, RFS
52  2017 Hyper-O-GlcNAcylation induces cisplatin resistance via regulation of p53 and c-Myc in human lung carcinoma. ---
53  2017 Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway. GFAT
54  2017 Impact of protein O-GlcNAcylation on neural tube malformation in diabetic embryopathy. NTDs, OGT, UDP-GlcNAc
55  2017 Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications. ---
56  2017 Metabolic Profiling in Association with Vascular Endothelial Cell Dysfunction Following Non-Toxic Cadmium Exposure. Cd, HUVECs, NO, TCA
57  2017 MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect. MPI
58  2017 Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation. OGT
59  2017 The sweet side of AMPK signaling: regulation of GFAT1. AMP, ATP, GFAT1
60  2016 Elevated glucose levels impair the WNT/beta-catenin pathway via the activation of the hexosamine biosynthesis pathway in endometrial cancer. EC
61  2016 Emerging tale of UPR and cancer: an essentiality for malignancy. UPR
62  2016 Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation. EMT
63  2016 Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression. OGT
64  2016 Glucosamine induces REDD1 to suppress insulin action in retinal Muller cells. GAM
65  2016 High expression of GFAT1 predicts poor prognosis in patients with pancreatic cancer. OS
66  2016 Hijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic Phenotypes. EMT, TFs
67  2016 Hyaluronan Production Regulates Metabolic and Cancer Stem-like Properties of Breast Cancer Cells via Hexosamine Biosynthetic Pathway-coupled HIF-1 Signaling. CSCs, GFAT1, HA
68  2016 Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders. AGEs, RAGEs, ROS
69  2016 Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer. AR, ChREBP, CRPC, GNPNAT1, PCa, Sp1, UDP-GlcNAc
70  2016 Linking Cancer Metabolism to DNA Repair and Accelerated Senescence. 2-HG, DSB, TCA
71  2016 Loss of GFAT1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer. EMT, GFAT1
72  2016 mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1. ---
73  2016 New insights: A role for O-GlcNAcylation in diabetic complications. UDP-GlcNAc
74  2016 Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway. ATF4
75  2016 O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling. ---
76  2016 Reciprocal regulation between O-GlcNAcylation and tribbles pseudokinase 2 (TRIB2) maintains transformative phenotypes in liver cancer cells. GUCY1A3, TRIB2
77  2016 Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions. CSCs
78  2016 Silencing the Nucleocytoplasmic O-GlcNAc Transferase Reduces Proliferation, Adhesion, and Migration of Cancer and Fetal Human Colon Cell Lines. O-GlcNAc, OGA, OGT
79  2016 Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma. DLBCL, ECG, NF-kappaB, NFATc1, O-GlcNAc, OGT
80  2015 ER stress and hexosamine pathway during tumourigenesis: A pas de deux? ER, ERS
81  2015 Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism. Glc, Tet
82  2015 Hexosamine biosynthetic pathway activity in leptin resistant sucrose-drinking rats. GFAT
83  2015 High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation. O-GlcNAc
84  2015 Hyperglycaemia and lipid differentially impair mouse oocyte developmental competence. ER, Gfpt2, OGT
85  2015 In vivo and in vitro evidence that chronic activation of the hexosamine biosynthetic pathway interferes with leptin-dependent STAT3 phosphorylation. GFAT, O-GlcNAc
86  2015 mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer. O-GlcNAc, OGT
87  2015 O-Linked N-acetylglucosaminylation of Sp1 interferes with Sp1 activation of glycolytic genes. GAPDH, O-GlcNAc, PFK, UDP-GlcNAc
88  2015 Regulated Hyaluronan Synthesis by Vascular Cells. HA, HAS2, UDP-GlcNAc, VSMCs
89  2015 Removal of O-GlcNAcylation is important for pig preimplantation development. Gfpt, OGA, OGT, Pol II
90  2015 Studying N-linked glycosylation of receptor tyrosine kinases. RTK
91  2015 UAP1 is overexpressed in prostate cancer and is protective against inhibitors of N-linked glycosylation. AR, ER, UAP1, UDP-GlcNAc
92  2014 Aberrant O-GlcNAcylated Proteins: New Perspectives in Breast and Colorectal Cancer. UDP-GlcNAc
93  2014 Differential hexosamine biosynthetic pathway gene expression with type 2 diabetes. GFPT, O-GlcNAc, OGT
94  2014 Disruption of O-GlcNAc Cycling in C. elegans Perturbs Nucleotide Sugar Pools and Complex Glycans. O-GlcNAc
95  2014 Effect of epidermal growth factor-like peptides on the metabolism of in vitro- matured mouse oocytes and cumulus cells. COCs, EGF, FAD, FSH, IVM, REDOX
96  2014 Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiology. O-GlcNAc, OGA, OGT
97  2014 Role of O-GlcNAcylation in nutritional sensing, insulin resistance and in mediating the benefits of exercise. O-GlcNAc
98  2014 Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway. O-GlcNAc, UDP-GlcNAc, UPR
99  2014 Sugarcoating ER Stress. ---
100  2014 The detrimental effects of acute hyperglycemia on myocardial glucose uptake. AGE, AGE, AHG, NOGP, PP, PPP, ROS