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Abbreviation : HDAC
Long Form : histone deacetylase
No. Year Title Co-occurring Abbreviation
2022 4-Phenylbutyric acid promotes plant regeneration as an auxin by being converted to phenylacetic acid via an IBR3-independent pathway. 4-PBA, ARF, PAA
2022 A "Double-Locked" and Enzyme/pH-Activated Theranostic Agent for Accurate Tumor Imaging and Therapy. NTR, ZBG
2022 A capped Tudor domain within a core subunit of the Sin3L/Rpd3L histone deacetylase complex binds to nucleic acid G-quadruplexes. ---
2022 A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway. AD, AMPA, APP, GluR2, GRIP1, HDACi, SYP
2022 A diverse English keyword search reveals the value of scriptaid treatment for porcine embryo development following somatic cell nuclear transfer. HDACi, SCNT
2022 A Histone Deacetylase (HDAC) Inhibitor with Pleiotropic In Vitro Anti-Toxoplasma and Anti-Plasmodium Activities Controls Acute and Chronic Toxoplasma Infection in Mice. ---
2022 A phase I/II study of ivaltinostat combined with gemcitabine and erlotinib in patients with untreated locally advanced or metastatic pancreatic adenocarcinoma. CI, DCR, MTD, ORR, OS, PDAC, PFS
2022 A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model. BW, COPD, MLI, PPE, SIRT1, SP-C, TAZ, YAP
2022 A switchable Cas12a enabling CRISPR-based direct histone deacetylase activity detection. ---
10  2022 Angiotensin II Mediates Cardiomyocyte Hypertrophy in Atrial Cardiomyopathy via Epigenetic Transcriptional Regulation. Ang II, MEF2
11  2022 Antidepressant-like Effects of Combined Fluoxetine and Zinc Treatment in Mice Exposed to Chronic Restraint Stress Are Related to Modulation of Histone Deacetylase. CRS, ELISA
12  2022 Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability. ---
13  2022 Balancing Histone Deacetylase (HDAC) Inhibition and Drug-likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors. ---
14  2022 Beneficial and Sexually Dimorphic Response to Combined HDAC Inhibitor Valproate and AMPK/SIRT1 Pathway Activator Resveratrol in the Treatment of ALS Mice. ALS, AMPK, Bcl-xL, BDNF
15  2022 Blocking autophagy overcomes resistance to dual histone deacetylase and proteasome inhibition in gynecologic cancer. PDO
16  2022 Bone tissue engineering using 3D silk scaffolds and human dental pulp stromal cells epigenetic reprogrammed with the selective histone deacetylase inhibitor MI192. ALP, hDPSCs, MSCs
17  2022 Butyrate oxidation attenuates the butyrate-induced improvement of insulin sensitivity in myotubes. IRS1, SCFA
18  2022 Butyrate Prevents Induction of CXCL10 and Non-Canonical IRF9 Expression by Activated Human Intestinal Epithelial Cells via HDAC Inhibition. SCFAs
19  2022 CBX4-dependent regulation of HDAC3 nuclear translocation reduces Bmp2-induced osteoblastic differentiation and calcification in adamantinomatous craniopharyngioma. ACP, ALP, BMP-2, CBX4, HAT, OCN, OPN
20  2022 Changes in uridine 5'-diphospho-glucuronosyltransferase 1A6 expression by histone deacetylase inhibitor valproic acid. AhR, ERK, JNK, MAPKs, Nrf2, UGT, VPA
21  2022 Changes to the Simian Immunodeficiency Virus (SIV) Reservoir and Enhanced SIV-Specific Responses in a Rhesus Macaque Model of Functional Cure after Serial Rounds of Romidepsin Administrations. ART, PBMC, PWH, RM, SIV
22  2022 Characterizing HDAC Pathway Copy Number Variation in Pan-Cancer. CNV, MHC-I
23  2022 Chemical Proteomics Reveals MBLAC2 as a Major Off-Target of HDAC Inhibitors. MBLAC2
24  2022 Chemoprotective Effect of Scutellarin against Gastric Cancer in Rats: An in vitro and in vivo Study. LDH, MNNG, SC
25  2022 Chidamide and mitomycin C exert synergistic cytotoxic effects against bladder cancer cells in vitro and suppress tumor growth in a rat bladder cancer model. BCG, MNU
26  2022 Chimeric HDAC and the cytoskeleton inhibitor broxbam as a novel therapeutic strategy for liver cancer. CAM
27  2022 Chronic stress increases DNA methylation of the GR promoter in the central nucleus of the amygdala of female rats. CeA, GR, IBS, TSA, WAS
28  2022 CKD-581 Downregulates Wnt/β-Catenin Pathway by DACT3 Induction in Hematologic Malignancy. DACT3, MM
29  2022 Classification models and SAR analysis on HDAC1 inhibitors using machine learning methods. DT
30  2022 Clinical and immune correlate results from a phase 1b study of the histone deacetylase inhibitor mocetinostat with ipilimumab and nivolumab in unresectable stage III/IV melanoma. CPIs
31  2022 Co-targeting leukemia-initiating cells and leukemia bulk leads to disease eradication. APL, ATRA, CR, LICs, SAHA, VPA
32  2022 Combination of Radiosensitivity Gene Signature and PD-L1 Status Predicts Clinical Outcome of Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma: A Study Based on The Cancer Genome Atlas Dataset. AUC, DEG, GEO, HNSCC, RR, RS
33  2022 Combinatorial epigenetic mechanisms of sulforaphane, genistein and sodium butyrate in breast cancer inhibition. DNMT, GE, SFN
34  2022 Comprehensive Genome-Wide Analysis of Histone Acetylation Genes in Roses and Expression Analyses in Response to Heat Stress. HAT
35  2022 Comprehensive Transcriptomic Analysis of Novel Class I HDAC Proteolysis Targeting Chimeras (PROTACs). IAP, PROTACs, VHL
36  2022 Correction to: Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis. ---
37  2022 Correlation Analysis of Protein Expression of 10 HDAC/Sirtuin Isoenzymes with Sensitivities of 23 Anticancer Drugs in 17 Cancer Cell Lines and Potentiation of Drug Activity by Co-Treatment with HDAC Inhibitors. NCI
38  2022 CREB1K292 and HINFPK330 as Putative Common Therapeutic Targets in Alzheimer's and Parkinson's Disease. AD, PD
39  2022 Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors. SmHDAC8
40  2022 CUDC907, a dual phosphoinositide-3 kinase/histone deacetylase inhibitor, promotes apoptosis of NF2 Schwannoma cells. MD-SC, NF2, PI3K, VS
41  2022 Cyclic Tetrapeptides with Synergistic Antifungal Activity from the Fungus Aspergillus westerdijkiae Using LC-MS/MS-Based Molecular Networking. CTPs, OSMAC
42  2022 Design, synthesis and antitumor activity study of PARP-1/HDAC dual targeting inhibitors. PARP-1
43  2022 Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. TP
44  2022 Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors. SAR, Top
45  2022 Diabetes impairs cardioprotective function of endothelial progenitor cell-derived extracellular vesicles via H3K9Ac inhibition. ChIP-seq, ECs, EPCs, EVs, I/R, LAD, MI, VPA
46  2022 Dietary fiber in the prevention of obesity and obesity-related chronic diseases: From epidemiological evidence to potential molecular mechanisms. CVD, GLP-1, GPRs, PYY, T2DM
47  2022 Discovery of DNA-Targeting HDAC Inhibitors with Potent Antitumor Efficacy In Vivo That Trigger Antitumor Immunity. ---
48  2022 Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors. ---
49  2022 Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety. ---
50  2022 E-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC Inhibitors. DGC, HDGC, LBC
51  2022 Effect of AR42 in Primary Vestibular Schwannoma Cells and a Xenograft Model of Vestibular Schwannoma. ABR, HL, pHDAC2, VS
52  2022 Effects of dexmedetomidine on cognitive dysfunction and neuroinflammation via the HDAC2/HIF-1α/PFKFB3 axis in a murine model of postoperative cognitive dysfunction. alpha2-AR, DEX, ELISA, LPS, POCD
53  2022 Effects of tubastatin A on adrenocorticotropic hormone synthesis and proliferation of AtT-20 corticotroph tumor cells. POMC, Pttg1
54  2022 Enhancement of cordycepin production from Cordyceps militaris culture by epigenetic modification. VPA
55  2022 Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis. CLP, DNMT, EE, SE
56  2022 Environmental Enrichment and Estrogen Upregulate Beta-Hydroxybutyrate Underlying Functional Improvement. BDNF, betaHB, EE
57  2022 Epicardial HDAC3 Promotes Myocardial Growth Through a Novel MicroRNA Pathway. IGF, KO, miR
58  2022 Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML. AML, HDACi, IFN, pDC
59  2022 Epigenetic modifiers during in vitro maturation as a strategy to increase oocyte competence in bovine. IVM, IVP, TSA
60  2022 Establishment and evaluation of a dual HDAC / BET inhibitor as a therapeutic option for germ cell tumors and other urological malignancies. BET, GCT
61  2022 Evidence that HDAC7 acts as an epigenetic "reader" of AR acetylation through NCoR-HDAC3 dissociation. AR
62  2022 Evodiamine-Inspired Topoisomerase-Histone Deacetylase Dual Inhibitors: Novel Orally Active Antitumor Agents for Leukemia Therapy. Top
63  2022 Ferulic acid mediates prebiotic responses of cereal-derived arabinoxylans on host health. GPR, Keap1-Nrf2, PPARgamma, ROS, SCFA
64  2022 Functions and Interactions of Mammalian KDM5 Demethylases. 2OG, Rb
65  2022 Generation of immunocompetent syngeneic allograft mouse models for pediatric diffuse midline glioma. DMG, H3WT, IUE
66  2022 Genetic and Molecular Characterization Revealed the Prognosis Efficiency of Histone Acetylation in Pan-Digestive Cancers. CNV, HAT
67  2022 Genome-wide investigation of histone acetyltransferase gene family and its responses to biotic and abiotic stress in foxtail millet (Setaria italica [L.] P. Beauv). HAT
68  2022 Harmine-based dual inhibitors targeting histone deacetylase (HDAC) and DNA as a promising strategy for cancer therapy. HDACIs, HDACs
69  2022 HDAC class I inhibitor domatinostat sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation. CI, CSC, FOXM1, PDAC
70  2022 HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression. BCL2, DLBCL, MYC
71  2022 HDAC inhibitors with potential to overcome drug resistance in castration-resistant prostate cancer. CRPC
72  2022 HDAC1 Promotes Myocardial Fibrosis in Diabetic Cardiomyopathy by Inhibiting BMP-7 Transcription Through Histone Deacetylation. alpha-SMA, BMP-7, CFs, DCM, HG, MF
73  2022 HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma. DNMT, HAT
74  2022 HDAC3 single-nucleotide polymorphism rs2530223 is associated with increased susceptibility and severity of primary immune thrombocytopenia. ITP, OR, PLT, SNP
75  2022 HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer. ICB, PDAC
76  2022 HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells. GBM, iTRAQ, lncRNAs, miRNA, RBPs
77  2022 HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation. IKK, LPS, NF-kappaB
78  2022 High Histone Deacetylase 2/3 Expression in Non-Functioning Pituitary Tumors. IHC, NFPAs, NP
79  2022 High-Throughput Identification of Epigenetic Compounds to Enhance Chicken Host Defense Peptide Gene Expression. HDPs
80  2022 Histone deacetylase (HDAC) 11 inhibits matrix metalloproteinase (MMP) 3 expression to suppress colorectal cancer metastasis. CAC, CRC, MMP
81  2022 Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis. ---
82  2022 Histone Deacetylase (HDAC) Inhibitors: A Promising Weapon to Tackle Therapy Resistance in Melanoma. HDACi
83  2022 Histone Deacetylase 1 Depletion Alleviates Coronary Heart Disease Via the MicroRNA-182-Mediated Transforming Growth Factor β/Smad Signaling Pathway. CHD, dUTP, TdT, TGF
84  2022 Histone deacetylase 2 inhibitor valproic acid attenuates bisphenol A-induced liver pathology in male mice. BPA, BW, SC, VC, VPA, VPA
85  2022 Histone Deacetylase 3 Inhibitor Alleviates Cerebellar Defects in Perinatal Hypothyroid Mice by Stimulating Histone Acetylation and Transcription at Thyroid Hormone-Responsive Gene Loci. ---
86  2022 Histone Deacetylase 3: A Potential Therapeutic Target for Atherosclerosis. ---
87  2022 Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms. ASF, SCFA
88  2022 Histone Deacetylase Inhibition Restores Behavioral and Synaptic Function in a Mouse Model of 16p11.2 Deletion. FS, PFC
89  2022 Histone Deacetylase Inhibitor Improves the Dysfunction of Hippocampal Gamma Oscillations and Fast Spiking Interneurons in Alzheimer's Disease Model Mice. AD, NR4a
90  2022 Histone deacetylase inhibitors attenuated interleukin-1β-induced chondrogenesis inhibition in synovium-derived mesenchymal stem cells of the temporomandibular joint. IL, MMP-13, SAHA, SMSCs, TMJ
91  2022 Histone Deacetylase Inhibitors Downregulate Calcium Pyrophosphate Crystal Formation in Human Articular Chondrocytes. ANKH, CPP, ENPP1, HC-a cells, pNPP, TGF, TNAP, TSA
92  2022 Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. ACAT1, PINK1, SAHA
93  2022 Histone Deacetylases as Modulators of the Crosstalk Between Skeletal Muscle and Other Organs. ---
94  2022 Histone Deacetylation Controls Xylem Vessel Cell Differentiation via Transcriptional Regulation of a Transcription Repressor Complex OFP1/4-MYB75-KNAT7-BLH6. BLH6, OFP1, TSA, VND
95  2022 Histone H2B Deacylation Selectivity: Exploring Chromatin's Dark Matter with an Engineered Sortase. ---
96  2022 Identification of NOXA as a pivotal regulator of resistance to CAR T-cell therapy in B-cell malignancies. BCL2, CAR
97  2022 IFI16-dependent STING signaling is a crucial regulator of anti-HER2 immune response in HER2+ breast cancer. BC, IFI16, IRG, mAb
98  2022 Immunolabelling of Acetylated Histones 3 and 4 and Histone Deacetylases 1, 2 and 6 in Canine Soft Tissue Sarcomas. STSs
99  2022 Impact of Berberine on Some Epigenetic, Transcription Regulation and Inflammatory Biomarkers in a Mice Model of Epilepsy. BDNF, HIF-1alpha, NRSF, SE, TGF-1beta
100  2022 In silico Repurposing of Drugs for pan-HDAC and pan-SIRT Inhibitors: Consensus Structure-based Virtual Screening and Pharmacophore Modeling Investigations. FDA, SIRTs