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Abbreviation : HETE
Long Form : 15-hydroxyeicosatetraenoic acid
No. Year Title Co-occurring Abbreviation
2021 Cytochrome P450 2A6 is associated with macrophage polarization and is a potential biomarker for hepatocellular carcinoma. CYP2A6, EET, HCC
2021 Ferroptosis is involved in the anti-tumor effect of lycorine in renal cell carcinoma cells. ACSL4, GPX4, RCC
2021 Inhibition of 20-hydroxyeicosatetraenoic acid biosynthesis by vitamin E analogs in human and bovine cytochrome P450 microsomes. CYP450, CYP4F2
2021 Metabolomics reveals a correlation between hydroxyeicosatetraenoic acids and allergic asthma: Evidence from three years' immunotherapy. SCIT
2021 Prostaglandin E2, 9S-, 13S-HODE and resolvin D1 are strongly associated with the post-stroke cognitive impairment. CVLT, MoCA
2021 Tailored Polymer-Based Selective Extraction of Lipid Mediators from Biological Samples. DiHETrEs, HDoHE, HETrE, LC-MS-MS, MIP, NIP, PGs, PUFA, SPE
2021 Unraveling the Role of 12- and 20- HETE in Cardiac Pathophysiology: G-Protein-Coupled Receptors, Pharmacological Inhibitors, and Transgenic Approaches. EET
2021 Untargeted UHPLC-ESI-QTOF-MS/MS analysis with targeted feature extraction at precursor and fragment level for profiling of the platelet lipidome with ex vivo thrombin-activation. DIA, EICs, HHT, HODE, SWATH, TXB2
2020 12-Lipoxygenase as a key pharmacological target in the pathogenesis of diabetic nephropathy. 12-LOX, CREB, p38MAP, TGF-beta
10  2020 A paracrine effect of 15 (S)-hydroxyeicosatetraenoic acid revealed in prostaglandin production by human follicular dendritic cell-like cells. FDC, PG, PPARgamma
11  2020 Analysis of serum polyunsaturated fatty acid metabolites in allergic bronchopulmonary aspergillosis. A. fumigatus sIgE, AA, ABPA, HEPE, HHTrE, HPETE, HPODE
12  2020 Association of Arachidonic Acid-derived Lipid Mediators with Subsequent Onset of Acute Myocardial Infarction in Patients with Coronary Artery Disease. AMI, CAD, EET, PUFAs
13  2020 Changes in bioactive lipid mediators in response to short-term exposure to ambient air particulate matter: A targeted lipidomic analysis of oxylipin signaling pathways. ARA, COX, DHET, EPA, HDHA, HEPE, IQR, LOX, LTB4, PM, PM2.5, PUFAs
14  2020 Changes in erythrocyte membrane epoxyeicosatrienoic, dihydroxyeicosatrienoic, and hydroxyeicosatetraenoic acids during pregnancy. AA, DHET, EET
15  2020 Dihydrotanshinone I inhibits human glioma cell proliferation via the activation of ferroptosis. ACSL4, DHI, GPX4, LDH, MDA, MMP
16  2020 Eicosanoids in Nonalcoholic Fatty Liver Disease (NAFLD) Progression. Do Serum Eicosanoids Profile Correspond with Liver Eicosanoids Content during NAFLD Development and Progression? HODE, NAFLD
17  2020 Enantioselective ultra-high performance liquid chromatography-tandem mass spectrometry method based on sub-2m particle polysaccharide column for chiral separation of oxylipins and its application for the analysis of autoxidized fatty acids and platelet releasates. DiHETE, HDoHE, HEPE, HETrE, HODE, HOTrE, PUFA, SRM
18  2020 Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers. AA, PEH
19  2020 Impact of a weight loss and fitness intervention on exercise-associated plasma oxylipin patterns in obese, insulin-resistant, sedentary women. eCB, LOX, OxL, PUFA
20  2020 Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin. COX, IPA, PG, TX
21  2020 Testosterone replacement therapy in insulin-sensitive hypogonadal men restores phosphatidylcholine levels by regulation of arachidonic acid metabolism. AA, LPC, LTB4, PC, SM, TRT
22  2020 The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process. AA, COX-2, EETs, FFA, GDM, HODE, IR, LA, PCOS, PE
23  2019 Arachidonic acid-derived hydroxyeicosatetraenoic acids are positively associated with colon polyps in adult males: a cross-sectional study. HETrE
24  2019 Cerebral Lipid Dynamics in Chronic Cerebral Hypoperfusion Model by DESI-MS Imaging. ARA, BCCAO, DESI-IMS, DHA, PLS-DA, VD
25  2019 Effects of epoxygenases on the nonadrenergic noncholinergic relaxant responses induced by electrical field stimulation in rabbit corpus cavernosum. EET, EFS, l-NAME, NANC, NO, ODYA
26  2019 Mediatory roles of leukotriene B4 receptors in LPS-induced endotoxic shock. LTB4, PF
27  2019 Synthesis of oxidized phospholipids by sn-1 acyltransferase using 2-15-HETE lysophospholipids. 2-AA-LPC, cPLA2alpha, PNPLA8
28  2019 The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair. C1P, KI, KO, pDFs
29  2019 The role of the 12(S)-HETE/GPR31/12-HETER axis in cancer and ischemia-reperfusion injury. GPCRs, IR
30  2019 UPLC-QTOF-MS-Based Plasma Lipidomic Profiling Reveals Biomarkers for Inflammatory Bowel Disease Diagnosis. AUC, DHA, IBD, ROC, UPLC-QTOF-MS
31  2018 A sensitive and improved throughput UPLC-MS/MS quantitation method of total cytochrome P450 mediated arachidonic acid metabolites that can separate regio-isomers and cis/trans-EETs from human plasma. AA, DHET, EET
32  2018 A short-term increase in dietary cholesterol and fat intake affects high-density lipoprotein composition in healthy subjects. HChF, HDL, HODE, LChF, PON-1, SAA
33  2018 Cerebrovascular beta-amyloid deposition and associated microhemorrhages in a Tg2576 Alzheimer mouse model are reduced with a DHA-enriched diet. AD, CAA, DHA, LOX
34  2018 Deactivation of 12(S)-HETE through (omega-1)-hydroxylation and beta-oxidation in alternatively activated macrophages. ---
35  2018 Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond). COX, PG, TX
36  2018 Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease. AA, CKD, CRIC, CYP450, ESKD, IQR, LOX
37  2018 Immune responsive resolvin D1 programs peritoneal macrophages and cardiac fibroblast phenotypes in diversified metabolic microenvironment. Arg-1, DHA, IL-6, LA, LOX, RvD1, TNF-alpha, WT
38  2018 Inhibition of Arachidonate 12/15-Lipoxygenase Improves alpha-Galactosidase Efficacy in iPSC-Derived Cardiomyocytes from Fabry Patients. FC, FC-iPSC-CMs, iPSC, IVS
39  2018 Resveratrol improves cardiac function and exercise performance in MI-induced heart failure through the inhibition of cardiotoxic HETE metabolites. CYP1B1, HF, MI
40  2018 Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy. ATF6, ER, HRECs, LO, p-PERK, p-VEGFR2, PDI, WT
41  2018 Seasonal changes in eicosanoid metabolism in the brown bear. EET, PUFAs
42  2018 Untargeted Profiling of Concordant/Discordant Phenotypes of High Insulin Resistance and Obesity To Predict the Risk of Developing Diabetes. DG, IR
43  2018 Utility of 15(S)-HETE as a Serological Marker for Eosinophilic Esophagitis. EoE
44  2017 A rapid UPLC-MS/MS assay for eicosanoids in human plasma: Application to evaluate niacin responsivity. DiHETrE, EET
45  2017 Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension. Cyp2c44, EETs, HSC
46  2017 Cytochrome P450-derived eicosanoids and heart function. CVD, EDP, EET, PUFA
47  2017 Differences in the Oxylipid Profiles of Bovine Milk and Plasma at Different Stages of Lactation. ---
48  2017 Effects of in Utero PFOS Exposure on Transcriptome, Lipidome, and Function of Mouse Testis. DHA
49  2017 High levels of oxidized fatty acids in HDL are associated with impaired HDL function in patients with active rheumatoid arthritis. HDL, HII, HODE, LDL, MPO, OA, PON1, RA, SF
50  2017 Hypertension-Induced Enhanced Myogenic Constriction of Cerebral Arteries Is Preserved after Traumatic Brain Injury. MCA, SHR, TBI
51  2017 Isomer distribution of hydroxyoctadecadienoates (HODE) and hydroxyeicosatetraenoates (HETE) produced in the plasma oxidation mediated by peroxyl radical, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen. HODE, pero
52  2017 Non-polar lipids accumulate during storage of transfusion products and do not contribute to the onset of transfusion-related acute lung injury. PLT, RBCs, TRALI
53  2017 Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE). ARA, BMI, HETEs, IL-6, LOX, PUFA, sEH, TNF-alpha, WC
54  2017 Periparturient lipolysis and oxylipid biosynthesis in bovine adipose tissues. AT, FFA, HODE, PP
55  2017 Quantitative Profiling of Hydroxy Lipid Metabolites in Mouse Organs Reveals Distinct Lipidomic Profiles and Modifications Due to Elevated n-3 Fatty Acid Levels. AA, DHA, EPA, HDHA, HEPE, PUFA
56  2017 Regulation of delta Opioid Receptor-Mediated Signaling and Antinociception in Peripheral Sensory Neurons by Arachidonic Acid-Dependent 12/15-Lipoxygenase Metabolites. AA, CHO, DOR, KOR, LOX, PGE2
57  2016 20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR. 20-HETE, Ang II, BP, CYP4A11
58  2016 Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1. ---
59  2016 Bioactive lipids accumulate in stored red blood cells despite leukoreduction: a targeted metabolomics study. AA, DHA, HDoHE, HODE, LA, LR, NLR, PUFAs, RBC, WBCs
60  2016 Decreased hepatic phosphorylated p38 mitogen-activated protein kinase contributes to attenuation of thioacetamide-induced hepatic necrosis in diet-induced obese mice. HEPE, hr, p38 MAPK, TA
61  2016 Enantioseparation of hydroxyeicosatetraenoic acids by hydroxypropyl-gamma-cyclodextrin-modified micellar electrokinetic chromatography. HP-gamma-CD
62  2016 Estradiol-17β increases 12- and 15-lipoxygenase (type2) expression and activity and reactive oxygen species in human umbilical vascular smooth muscle cells. LO, ROS, VSMC
63  2016 Food Polyphenol Apigenin Inhibits the Cytochrome P450 Monoxygenase Branch of the Arachidonic Acid Cascade. AA
64  2016 Influence of weight reduction on blood levels of C-reactive protein, tumor necrosis factor-alpha, interleukin-6, and oxylipins in obese subjects. AA, ALA, DGLA, DHA, EPA, hs-CRP, IL-6, LA, PUFA, TNF-alpha
65  2016 Interaction Between CYP4F2 rs2108622 and CPY4A11 rs9333025 Variants Is Significantly Correlated with Susceptibility to Ischemic Stroke and 20-Hydroxyeicosatetraenoic Acid Level. GMDR, IS
66  2016 Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE. 18beta-GA, AA, BIPAs, GJs, HPV, SMCs, SMMHC
67  2016 Plasma Vasoprotective Eicosanoid Concentrations in Healthy Greyhounds and Non-Greyhound Dogs. AA, DHET, SP
68  2015 Detection of 19 types of para-arachidonic acids in five types of plasma/serum by ultra performance liquid chromatography-tandem mass spectrometry. EDTA, EET, LTB4, PAAs, TXB2, UPLC-TMS
69  2015 Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease. htTKV
70  2015 Quantitative determination of 12-hydroxyeicosatetraenoic acids by chiral liquid chromatography tandem mass spectrometry in a murine atopic dermatitis model. AOO, DNCB
71  2015 Vascular hepoxilin and trioxilins mediate vasorelaxation through TP receptor inhibition in mouse arteries. 11,12,15-THETAs, 3mum, AA, HEETAs
72  2014 12/15-Lipoxygenase deficiency reduces densities of mesenchymal stem cells in the dermis of wounded and unwounded skin. dpw, LOX, MSCs, Sca, WT
73  2014 Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid. LOX
74  2014 Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. 12-LOX, LOXs
75  2014 [Isomeric specific analysis of hydroxyeicosatetraenoic acid in blood samples from obese patients with non-alcoholic and alcoholic steatohepatitis]. 5-HETE, REE
76  2013 12/15-Lipoxygenase-derived lipid metabolites induce retinal endothelial cell barrier dysfunction: contribution of NADPH oxidase. ECIS, REC, ROS, TER, ZO-1
77  2013 20-Hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity and vasoconstrictor response to angiotensin II in rat renal microvessels. Ang II, KCa, PLC, VSM
78  2013 A novel approach to oral apoA-I mimetic therapy. EV, LPA, PON, SAA, WD
79  2013 Biomarkers of lipid peroxidation in clinical material. HODE
80  2013 Cellular uptake and antiproliferative effects of 11-oxo-eicosatetraenoic acid. AA, COX, ECAPCI, ETE, HUVEC, MRP, oxo-ETE, SID, SRM
81  2013 Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts. AA, DHA, EPA, MSC, PUFA
82  2013 Eicosanoid post-mortem induction in kidney tissue is prevented by microwave irradiation. ---
83  2013 Enzymatic production of 15-hydroxyeicosatetraenoic acid from arachidonic acid by using soybean lipoxygenase. ---
84  2013 Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner. FABPs, LTA4, LTC4
85  2013 Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner. FABPs, LTA4, LTC4
86  2013 Predominant role of vasoconstrictors over dilatators derived from arachidonic acid in hypoxic pulmonary vasoconstriction. AA, EETs, HPV, IPAs, LOX, TX
87  2013 Proresolution lipid mediators in multiple sclerosis - differential, disease severity-dependent synthesis - a clinical pilot trial. MS, NPD1, PG, PUFA, RvD1
88  2013 Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice. MCA, SMC, TRP
89  2013 Role of arachidonic acid metabolites on the control of non-differentiated intestinal epithelial cell growth. AA, FBS, LTB4, PGE2
90  2012 Bay11-7082 inhibits the disintegration of the lymphendothelial barrier triggered by MCF-7 breast cancer spheroids; the role of ICAM-1 and adhesion. ALOX, CCID, ICAM-1, LEC
91  2012 Biosynthesis of eoxin C4 by porcine leukocytes. DiHETEs, EX, LO, MS, PMNL
92  2012 Dietary fish oil reduces glomerular injury and elevated renal hydroxyeicosatetraenoic acid levels in the JCR:LA-cp rat, a model of the metabolic syndrome. MetS, TXB2
93  2012 The protective effect of nordihydroguaiaretic acid on cerebral ischemia/reperfusion injury is mediated by the JNK pathway. I/R, JNK, LOX, MCAO, NDGA, OGD
94  2012 Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells. LOX
95  2011 Angiotensin II inhibits chemokine CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats. 12-LO, Ang II, ERK, MAP, SHR, VSMCs, WKY
96  2011 Effect of fish oil on levels of R- and S-enantiomers of 5-, 12-, and 15-hydroxyeicosatetraenoic acids in mouse colonic mucosa. LOX, S-HETEs
97  2011 NF-kappaB mediates the 12(S)-HETE-induced endothelial to mesenchymal transition of lymphendothelial cells during the intravasation of breast carcinoma cells. CCID, LEC
98  2011 The effects of estrogen receptors alpha- and beta-specific agonists and antagonists on cell proliferation and energy metabolism in human bone cell line. BA, CK, DPI, ER, LO, MPP, RAL, ROS
99  2011 The eicosanoid response to high dose UVR exposure of individuals prone and resistant to sunburn. COX, LOX, NOS, PG, SED
100  2011 Up-regulation of BLT2 is critical for the survival of bladder cancer cells. ROS