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Abbreviation : HHcy
Long Form : hyperhomocysteinemia
No. Year Title Co-occurring Abbreviation
2020 A prospective cohort study of MTHFR C677T gene polymorphism and its influence on the therapeutic effect of homocysteine in stroke patients with hyperhomocysteinemia. Hcy, MTHFR
2020 Ameliorative effect of Ozagrel, a thromboxane A2 synthase inhibitor, in hyperhomocysteinemia-induced experimental vascular cognitive impairment and dementia. MWM, TXA2, VCID
2020 An unusually high plasma concentration of homocysteine resulting from a combination of so-called "secondary" etiologies. ---
2020 Association between gene promoter methylation of the one-carbon metabolism pathway and serum folate among patients with hyperhomocysteinemia. BHMT, CBS, CVD, Hcy
2020 Association of genetic and epigenetic variants in one-carbon metabolism gene with folate treatment response in hyperhomocysteinaemia. SNPs
2020 Association of Hyperhomocysteinemia with Increased Coronary Microcirculatory Resistance and Poor Short-Term Prognosis of Patients with Acute Myocardial Infarction after Elective Percutaneous Coronary Intervention. AMI, IMR, IRV, LVEDD, LVEF, MACE, PCI
2020 Associations of homocysteine status and homocysteine metabolism enzyme polymorphisms with hypertension and dyslipidemia in a Chinese hypertensive population. CVD, HTN, TAG, TC
2020 Associations of MTRR A66G polymorphism and promoter methylation with ischemic stroke in patients with hyperhomocysteinemia. IS
2020 B cell-derived anti-beta 2 glycoprotein I antibody contributes to hyperhomocysteinaemia-aggravated abdominal aortic aneurysm. AAAs, anti-beta2GPI, Hcy, TLR4
10  2020 CBS gene polymorphism and promoter methylation-mediating effects on the efficacy of folate therapy in patients with hyperhomocysteinemia. ACME, CBS, CI
11  2020 Chronic mild hyperhomocysteinemia induces anxiety-like symptoms, aversive memory deficits and hippocampus atrophy in adult rats: New insights into physiopathological mechanisms. ---
12  2020 Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models. AD, NFTs, PP2A
13  2020 Effect of High Homocysteine Level on the Severity of Coronary Heart Disease and Prognosis After Stent Implantation. Hcy, MACCE
14  2020 Effect of Methionine Diet on Time-Related Metabolic and Histopathological Changes of Rat Hippocampus in the Model of Global Brain Ischemia. IRI, Met
15  2020 Elevated plasma homocysteine levels are associated with impaired peripheral microvascular vasomotor response. cRF, LHcy, PMED, RH-PAT
16  2020 Genes and genetics in hyperhomocysteinemia and the "1-carbon metabolism": implications for retinal structure and eye functions. Hcy
17  2020 H-Type Hypertension Is a Risk Factor for Cerebral Small-Vessel Disease. CMBs, CSVD, PVS, WMHs
18  2020 Hidradenitis Suppurativa and 1-Carbon Metabolism: Role of Gut Microbiome, Matrix Metalloproteinases, and Hyperhomocysteinemia. HFD, HS, TNF-alpha
19  2020 High-dose folic acid and its effect on early stage diabetic foot ulcer wound healing. ES-DFU, HDFA, NO, T2DM
20  2020 HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway. GSDMs, Hcy, HMGB1
21  2020 Homocysteine and Mitochondria in Cardiovascular and Cerebrovascular Systems. Hcy, ROS
22  2020 Homocysteine induces oxidative stress and ferroptosis of nucleus pulposus via enhancing methylation of GPX4. Hcy, IVDD
23  2020 Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1alpha-ERO1alpha-dependent oxidative stress manner. ER, FFAs, Hcy, HIF-1alpha, NAFL, TG
24  2020 Homocysteine, chronotype and clinical course in bipolar disorder patients. BD, Hcy, HDRS, MEQ, PSQI, YMRS
25  2020 Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling. CBS, CVD, Hcy, HM, SAH, SAM
26  2020 Hydrogen Sulfide Alleviates Anxiety, Motor, and Cognitive Dysfunctions in Rats with Maternal Hyperhomocysteinemia via Mitigation of Oxidative Stress. ---
27  2020 Hydrogen sulfide attenuates hyperhomocysteinemia-induced mitochondrial dysfunctions in brain. Hcy
28  2020 Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese. LVH, LVMH2.7, LVMI, MetS, OR
29  2020 Hyperhomocysteinemia and dyslipidemia in point mutation G307S of cystathionine beta-synthase-deficient rabbit generated using CRISPR/Cas9. CBS, CBS-KO, Hcy, LDL-C, TC, TG, WT
30  2020 Hyperhomocysteinemia Concurrent with Metabolic Syndrome Is Independently Associated with Chronic Kidney Disease among Community-Dwelling Adults in an Urban Korean Population. CKD, Hcy, MetS, OR
31  2020 Hyperhomocysteinemia in patients with acute porphyrias: A potentially dangerous metabolic crossroad? ALA, AP, CBS, CGL, Cys, Hcy, PBG
32  2020 Hyperhomocysteinemia Induced by Methionine Excess Is Effectively Suppressed by Betaine in Geese. Met
33  2020 Hyperhomocysteinemia is an independent risk factor for intracranial aneurysms: a case-control study in a Chinese Han population. CI, IAs, OR
34  2020 Hyperhomocysteinemia-Induced Oxidative Stress Exacerbates Cortical Traumatic Brain Injury Outcomes in Rats. Hcy, TBI
35  2020 Hyperhomocysteinemia: an instigating factor for periodontal disease. ---
36  2020 Hyperhomocysteinemia: Clinical Insights. Cys, Hcy, Met
37  2020 Identifying gene-environment interactions on the efficacy of folic acid therapy for hyperhomocysteinemia based on prediction model. CHD, tHcy, wGRS
38  2020 IL‑37 expression is decreased in patients with hyperhomocysteinemia and protects cells from inflammatory injury by homocysteine. Hcy, IL, PBMCs
39  2020 Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction. AD, AMD, BBB, BRB, CVD, DR, Hcy, NMDAR
40  2020 Low doses of folic acid can reduce hyperhomocysteinemia-induced glomerular injury in spontaneously hypertensive rats. FA, Hcy, HFA, SHRs
41  2020 Low-dose alcohol ameliorated homocysteine-induced anxiety-related behavior via attenuating oxidative stress in mice. EPM, Hcy, HO-1, IL-1beta, MDA, OF, SOD, SOD1
42  2020 Metabolic Consequences of Supplemented Methionine in a Clinical Context. Hcy, LOAEL, Met
43  2020 Metformin inhibited homocysteine-induced upregulation of endothelin receptors through the Sirt1/NF-kappaB signaling pathway in vascular smooth muscle cells. ETA, Hcy, MET, NIC, SIRT1, SMA, VSMCs
44  2020 Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer's disease. AD
45  2020 New insights into phenotypic switching of VSMCs induced by hyperhomocysteinemia: Role of endothelin-1 signaling. ET-1, VSMCs
46  2020 Nicorandil reversed homocysteine-induced coronary microvascular dysfunction via regulating PI3K/Akt/eNOS pathway. AMI, HCAECs, LVEF, LVFS, NOS, PI3K
47  2020 Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging. TFEB
48  2020 No Effect of Diet-Induced Mild Hyperhomocysteinemia on Vascular Methylating Capacity, Atherosclerosis Progression, and Specific Histone Methylation. HFLM, SAM, tHcy
49  2020 Nonlinear association between blood lead and hyperhomocysteinemia among adults in the United States. BLL, eGFR, LnBLL, NHANES, OR
50  2020 NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment. AAA, ATX, Hcy, NSun2
51  2020 Ocimum Sanctum Linn: A Potential Adjunct Therapy for Hyperhomocysteinemia-Induced Vascular Dementia. EEOS, MWM, VaD
52  2020 Protecting the aging eye with hydrogen sulfide. AMD, BRB, DR, ER, RGCs, ROS, RPE
53  2020 Relationship between total plasma homocysteine and the risk of aneurysms - a meta-analysis. Hcy
54  2020 Role of hyperhomocysteine, thyroid dysfunction and their interaction in ischemic stroke patients with non-valvular atrial fibrillation. AF, Hcy
55  2020 Serum homocysteine levels and their association with clinical characteristics of inflammatory arthritis. AS, HCs, Hcy, HUA, MTX, OA, RA
56  2020 Shikonin attenuates hyperhomocysteinemia-induced CD4+ T cell inflammatory activation and atherosclerosis in ApoE-/- mice by metabolic suppression. PKM2, SKN
57  2020 Synaptic remodeling and reduced expression of the transcription factors, HES1 and HES5, in the cortex neurons of cognitively impaired hyperhomocysteinemic mice. Hes
58  2020 Telomere length and mtDNA copy number in human cystathionine beta-synthase deficiency. CBS, Hcy, mtDNA, TL
59  2020 The Association between Hyperhomocysteinemia and Thoracoabdominal Aortic Aneurysms in Chinese Population. OR, TAAAs, tHcy
60  2020 The association of parental methylenetetrahydrofolate reductase polymorphisms (MTHFR 677C > T and 1298A > C) and fetal loss: a case-control study in South Australia. FL, LMH, WCH
61  2020 The interaction Between Arachidonic Acid Metabolism and Homocysteine. AA, CVD, EETs, Hcy, HETEs, PGs, TXA
62  2019 Aberrant MFN2 transcription facilitates homocysteine-induced VSMCs proliferation via the increased binding of c-Myc to DNMT1 in atherosclerosis. Hcy, Mfn2, VSMC
63  2019 Association between BHMT and CBS gene promoter methylation with the efficacy of folic acid therapy in patients with hyperhomocysteinemia. BHMT, CBS, Hcy
64  2019 Association between the BHMT gene rs3733890 polymorphism and the efficacy of oral folate therapy in patients with hyperhomocysteinemia. BHMT
65  2019 Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults at risk of cognitive decline (MAPT Study). GDS, IC, LGI, MAPT, SPPB, WHO
66  2019 Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-kappaB and GRP78/PERK Pathways in Human Aorta Endothelial Cells. HAECs, Hcy, ROS
67  2019 Central But Not General Obesity Is Positively Associated with the Risk of Hyperhomocysteinemia in Middle-Aged Women. CVD, Hcy, WC
68  2019 Cerebroprotective effects of hydrogen sulfide in homocysteine-induced neurovascular permeability: Involvement of oxidative stress, arginase, and matrix metalloproteinase-9. Hcy
69  2019 Chronic mild Hyperhomocysteinemia impairs energy metabolism, promotes DNA damage and induces a Nrf2 response to oxidative stress in rats brain. Hcy, Nrf2, SDH
71  2019 Culprit Lesion Characteristics in Young Patients with Hyperhomocysteinemia. MetS, OCT, TCFA
72  2019 Depression, isotretinoin, and folic acid: A practical review. ISO
73  2019 DNA methylation abnormalities in atherosclerosis. EC, LDLs, SMC
74  2019 Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia. Hcy
75  2019 E3 ubiquitin ligase siah‑1 nuclear accumulation is critical for homocysteine‑induced impairment of C6 astroglioma cells. Hcy
76  2019 Effect of Methionine Diet on Metabolic and Histopathological Changes of Rat Hippocampus. Met
77  2019 Effects of hyperhomocysteinaemia and metabolic syndrome on reproduction in women with polycystic ovary syndrome: a secondary analysis. Hcy, PCOS
78  2019 Endogenous hydrogen sulfide and ERK1/2-STAT3 signaling pathway may participate in the association between homocysteine and hypertension. ACE1, AGTR1, BP, Hcy, RAAS
79  2019 Excess homocysteine upregulates the NRF2-antioxidant pathway in retinal Muller glial cells. Hcy, RGC, ROS
80  2019 Expression Analysis of the Circular RNA Molecules in the Human Retinal Cells Treated with Homocysteine. circRNAs, Hcy, RPE
81  2019 Ganoderma triterpenes Protect Against Hyperhomocysteinemia Induced Endothelial-Mesenchymal Transition via TGF-beta Signaling Inhibition. BAECs, EndMT, GT
82  2019 Genetic and epigenetic regulation of BHMT is associated with folate therapy efficacy in hyperhomocysteinaemia. BHMT, SNPs
83  2019 Homocysteine and Hyperhomocysteinaemia. CbetaS, Hcy, MS, MTHFR
84  2019 Homocysteine and psoriasis. Hcy
85  2019 Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis. ER, Ero1alpha, GPx7
86  2019 Homocysteine Levels are Associated with Endothelial Function in Newly Diagnosed Type 2 Diabetes Mellitus Patients. Hcy, LDL-C, RHI, T2DM
87  2019 Human tissue kallikrein-1 protects against the development of erectile dysfunction in a rat model of hyperhomocysteinemia. ED, hKLK1, Met, SD, WTRs
88  2019 Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction. CBS, Hcy, SV
89  2019 Hydrogen sulfide attenuates homocysteine-induced osteoblast dysfunction by inhibiting mitochondrial toxicity. ATP, Hcy, ROS
90  2019 Hydrogen sulfide intervention in cystathionine-beta-synthase mutant mouse helps restore ocular homeostasis. BRB, BSA-FITC, CSE, ER, Hcy, HMD, IOP, LDBT, MTHFR, NORT, PBS, SAHH
91  2019 Hydrogen Sulfide Protects Hyperhomocysteinemia-Induced Renal Damage by Modulation of Caveolin and eNOS Interaction. CKD, ECM, eNOS, Hcy, SBP
92  2019 Hydrogen sulfide suppresses homocysteine-induced glial activation and inflammatory response. 3-NT, CBS, CSE, eNOS, GFAP, Iba-1, IL-6, iNOS, MCP-1, PECAM, TNF-alpha
93  2019 Hydrogen sulphide mitigates homocysteine-induced apoptosis and matrix remodelling in mesangial cells through Akt/FOXO1 signalling cascade. CKD, DeltaPsim, ECM, FOXO, Hcy
94  2019 Hyperhomocysteinemia induced endothelial progenitor cells dysfunction through hyper-methylation of CBS promoter. 5-aza, BM, CBS, DNMT1, EPCs, HMD
95  2019 Hypertension with Hyperhomocysteinemia Increases the Risk of Early Cognitive Impairment after First-Ever Ischemic Stroke. Hcy, PSCI
96  2019 Impaired autophagy mediates hyperhomocysteinemia-induced HA-VSMC phenotypic switching. HA, KLF4, VSMC
97  2019 Implication of homocysteine in protein quality control processes. Hcy, PQC, UPR, UPS
98  2019 Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing beta-oxidation of fatty acid in mice. EETs, PPAR-alpha, sEH
99  2019 Is hyperhomocysteinemia associated with the structural changes of the substantia nigra in Parkinson's disease? A two-year follow-up study. DKI, MK, PD, SN, SSLI
100  2019 Ly6C+ Inflammatory Monocyte Differentiation Partially Mediates Hyperhomocysteinemia-Induced Vascular Dysfunction in Type 2 Diabetic db/db Mice. T2DM