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Abbreviation : HMG-CoA
Long Form : 3-hydroxy-3-methylglutaryl coenzyme A
No. Year Title Co-occurring Abbreviation
2020 A double-blind, placebo-controlled, phase II, randomized study of lovastatin therapy in the treatment of mildly active rheumatoid arthritis. ---
2020 A Late-onset and Relatively Rapidly Progressive Case of Pure Spinal Form Cerebrotendinous Xanthomatosis with a Novel Mutation in the CYP27A1 Gene. ---
2020 African Walnuts (Tetracarpidium conophorum) Modulate Hepatic Lipid Accumulation in Obesity via Reciprocal Actions on HMG-CoA Reductase and Paraoxonase. ET, OC, RES, SC, T-Chol, TG
2020 Anti-tumor Activities of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors and Bisphosphonates in Pancreatic Cell Lines Which Show Poor Responses to Gemcitabine. HMG
2020 Association Between Genetically Proxied Inhibition of HMG-CoA Reductase and Epithelial Ovarian Cancer. GWAS, LDL, NPC1L1, OCAC, OR, PCSK9, SNPs
2020 Association of a novel homozygous mutation in the HMGCS2 gene with an HMGCSD in an Iranian patient. HMGCSD, PCR, WES
2020 Atorvastatin Targets the Islet Mevalonate Pathway to Dysregulate mTOR Signaling and Reduce beta-Cell Functional Mass. ATOR, GGPP, MafA, mTOR, sGP
2020 Bok-choy promotes growth performance, lipid metabolism and related gene expression in Syrian golden hamsters fed with a high-fat diet. CPT2, LPL, PPAR-alpha
2020 Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans. dnSrebp2, FA, FASN, HCC, SREBP2
10  2020 Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms. ACAT2, CVD, FC, LDL-C, NAFLD
11  2020 Cholesterol-Lowering Action of a Novel Nutraceutical Combination in Uremic Rats: Insights into the Molecular Mechanism in a Hepatoma Cell Line. CKD, LDLR
12  2020 Delineation of cell death mechanisms induced by synergistic effects of statins and erlotinib in non-small cell lung cancer cell (NSCLC) lines. EGFR, Fer1, MEV, Nec1, NSCLC, PI, TKI
13  2020 Dietary Cholesterol Exacerbates Statin-Induced Hepatic Toxicity in Syrian Golden Hamsters and in Patients in an Observational Cohort Study. ATV, HCD, RSV, WT
14  2020 Discrepancy Between Fasting Flow-Mediated Dilation and Parameter of Lipids in Blood: A Randomized Exploratory Study of the Effect of Omega-3 Fatty Acid Ethyl Esters on Vascular Endothelial Function in Patients With Hyperlipidemia. FMD, omega-3, TG
15  2020 E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation. SIRT2
16  2020 Effect of 3-Hydroxy-3-Methyl-Glutaryl-Coenzyme A Reductase Inhibitors on the Meibomian Gland Morphology in Patients with Dyslipidemia. MG, MGD
17  2020 Effect of Food Preparations on In Vitro Bioactivities and Chemical Components of Fucus vesiculosus. AChE, SEM
18  2020 Effect of thermosonication pre-treatment on mung bean (Vigna radiata) and white kidney bean (Phaseolus vulgaris) proteins: Enzymatic hydrolysis, cholesterol lowering activity and structural characterization. SE-HPLC
19  2020 Enhancement of gibberellic acid production from Fusarium fujikuroi by mutation breeding and glycerol addition. NTG
20  2020 Eryngium carlinae Ethanol Extract Corrects Lipid Abnormalities in Wistar Rats with Experimental Diabetes. C-HDL, CVD, LDLR
21  2020 High-fat diet induced alteration in lipid enzymes and inflammation in cardiac and brain tissues: Assessment of the effects of Atorvastatin-loaded nanoparticles. AC-NP, HFD, IL-1beta, LDLR
22  2020 In Vitro Blood-Brain Barrier Permeability and Cytotoxicity of an Atorvastatin-Loaded Nanoformulation Against Glioblastoma in 2D and 3D Models. ---
23  2020 Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRalpha/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-alpha-Induced Lung Inflammation. Akt, APO, ARE, ChIP, DPI, HO-1, HPAEpiCs, ICAM, MVS, NAC, NOX, PDFG-r, ROS, siRNA, TNF
24  2020 Investigation of HMG-CoA reductase inhibitory and antioxidant effects of various hydroxycoumarin derivatives. ---
25  2020 Kefir microbial composition is a deciding factor in the physiological impact of kefir in a mouse model of obesity. PPARgamma
26  2020 Mechanistic Effects of Vitamin D Supplementation on Metabolic Syndrome Components in Patients with or without Vitamin D Deficiency. MetS
27  2020 Metabolic engineering Saccharomyces cerevisiae for de novo production of the sesquiterpenoid (+)-nootkatone. HPO, MVA, SDR
28  2020 Pharmacological evidence for the involvement of the opioid system in the antidepressant-like effect of simvastatin in mice: Without tolerance and withdrawal syndrome. FST, OFT
29  2020 Plasma mevalonic acid exposure as a pharmacodynamic biomarker of fluvastatin/atorvastatin in healthy volunteers. MVA, MVL
30  2020 Pleiotropic effects of statins: A focus on cancer. ---
31  2020 Proteaphagy in Mammalian Cells Can Function Independent of ATG5/ATG7. ATG, BTZ, CMA, DHFR, UPS
32  2020 Protocol for systematic review and meta-analysis: impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases. hs-CRP, IL-1beta, sCD14, TNF-alpha
33  2020 Rosuvastatin enhanced functional recovery after sciatic nerve injury in the rat. ---
34  2020 Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis. CFU, CLP
35  2020 Statin Use Is Associated with Decreased Risk of Invasive Mechanical Ventilation in COVID-19 Patients: A Preliminary Study. aOR, CI, CVD, ICU, IMV
36  2020 Statins and Abnormal Liver Function Tests: Is There a Correlation? DILI, LFTs, NICVD, ULN
37  2020 Statins Stimulate New Myocyte Formation After Myocardial Infarction by Activating Growth and Differentiation of the Endogenous Cardiac Stem Cells. CSC, MI
38  2020 The Efficacy of Squalene in Cardiovascular Disease Risk-A Systematic Review. CVD, SQ
39  2020 The potential hepatoprotective effects of lovastatin combined with oral hypoglycemic agents in streptozotocin-induced diabetes in rats. ALP, ALT, AST, CRP, GST, LDH, NOx, SOD, STZ, TBARS, TNF-alpha
40  2020 Transporter-Mediated Delivery of Small Molecule Drugs to the Brain: A Critical Mechanism That Can Advance Therapeutic Development for Ischemic Stroke. BBB
41  2019 An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism. Mtb
42  2019 Anti-cancer effect of doxorubicin is mediated by downregulation of HMG-Co A reductase via inhibition of EGFR/Src pathway. ---
43  2019 Antihyperlipidemic and Antioxidative Potentials of Onion (Allium cepa L.) Extract Fermented with a Novel Lactobacillus casei HD-010. CETP, HDL, LDL, ORAC, TG
44  2019 Application of nanotechnology to improve the therapeutic benefits of statins. LDL-C
45  2019 Atorvastatin Decreases Renal Menaquinone-4 Formation in C57BL/6 Male Mice. ---
46  2019 Atorvastatin Exerts Antileukemia Activity via Inhibiting Mevalonate-YAP Axis in K562 and HL60 Cells. MMP, ROS
47  2019 Atorvastatin Improves Hepatic Lipid Metabolism and Protects Renal Damage in Adenine-Induced Chronic Kidney Disease in Sprague-Dawley Rats. ACAT2, CKD, LCAT, LPL, SR-B1
48  2019 Atorvastatin Inhibited ROS Generation and Increased IL-1beta And IL-6 Release by Mononuclear Cells from Diabetic Patients. ATV, iPKCbeta, PBMNC, T2DM
49  2019 beta-hydroxybutyrate protects hepatocytes against endoplasmic reticulum stress in a sirtuin 1-independent manner. BHB, ER, SIRT1
50  2019 Chenodeoxycholic Acid: An Update on Its Therapeutic Applications. CDCA, CTX, FXR, GLP-1, LCA, UDCA
51  2019 Computational study of conformational changes in human 3-hydroxy-3-methylglutaryl coenzyme reductase induced by substrate binding. hHMGR, HMGR, MD, PCA
52  2019 Consortia of bioactives in supercritical carbon dioxide extracts of mustard and small cardamom seeds lower serum cholesterol levels in rats: new leads for hypocholesterolaemic supplements from spices. BW, SC, scCO2, YM
53  2019 Effects of sanshoamides and capsaicinoids on plasma and liver lipid metabolism in hyperlipidemic rats. FXR
54  2019 Effects of Talinum triangulare leaf flavonoid extract on streptozotocin-induced hyperglycemia and associated complications in rats. STZ, TTFE
55  2019 Eugenol Reduces LDL Cholesterol and Hepatic Steatosis in Hypercholesterolemic Rats by Modulating TRPV1 Receptor. AI, ALP, CAT, FRED, HCFD, HDL, LDL, SOD, TC, TG
56  2019 Evaluation of the anti-atherogenic potential of Egyptian artichoke leaf extract in hypercholesterolemic rats. HCD
57  2019 Fluvastatin Inhibits HMG-CoA Reductase and Prevents Non-Small Cell Lung Carcinogenesis. NSCLC
58  2019 Fluvastatin Sodium Ameliorates Obesity through Brown Fat Activation. BAT, FDA, FS, HFD, sWAT, UCP1
59  2019 Fusarisolins A⁻E, Polyketides from the Marine-Derived Fungus Fusarium solani H918. MPA
60  2019 Heterozygous Disruption of Beclin 1 Alleviates Zinc Oxide Nanoparticles-Induced Disturbance of Cholesterol Biosynthesis in Mouse Liver. SREBP2, ZnO NPs
61  2019 Identification of cis-regulatory regions responsible for developmental and hormonal regulation of HbHMGS1 in transgenic Arabidopsis thaliana. GA, GUS, HMGR, MeJA, MVA
62  2019 Impact of statins on cellular respiration and de-differentiation of myofibroblasts in human failing hearts. alpha-SMA, CF, HF, hVFs, OCR, TGF-beta1
63  2019 In Vitro Activity of Statins against Naegleria fowleri. PAM
64  2019 Induction of a Toxin-Antitoxin Gene Cassette under High Hydrostatic Pressure Enables Markerless Gene Disruption in the Hyperthermophilic Archaeon Pyrococcus yayanosii. HHP, HHP-TAC, TA
65  2019 Kruppel-like factor 2 mediated anti-proliferative and anti-metastasis effects of simvastatin in p53 mutant colon cancer. KLF2, mutp53
66  2019 Lipid accumulation responses in the liver of Rana nigromaculata induced by perfluorooctanoic acid (PFOA). ACC, FAS, GPAT, PFOA, PPARgamma, qRT-PCR, SREBP2, T-CHO, TG
67  2019 Lunasin Improves the LDL-C Lowering Efficacy of Simvastatin via Inhibiting PCSK9 Expression in Hepatocytes and ApoE-/- Mice. HNF-1alpha, LDL-C, LDLR, PCSK9, TC
68  2019 Modulation of Coenzyme Q10 content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging. CoQ10, HDF
69  2019 Modulation of lipid metabolism and colonic microbial diversity of high-fat-diet C57BL/6 mice by inulin with different chain lengths. ABCA1, GSH-Px, LPPC, SREBP-1
70  2019 Musculoskeletal toxicities in patients receiving concomitant statin and daptomycin therapy. CPK
71  2019 Mutations in hmg1, Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus. ---
72  2019 n-3 Fatty Acids Abrogate Dyslipidemia-Induced Changes in Bile Acid Uptake, Synthesis, and Transport in Young and Aged Dyslipidemic Rats. ALA, ASBT, BA, BAT, BSEP, CYP7A1, DHA, EPA, FA, FXR, HF, HNF4A, LRH-1, mRNA, Ntcp, SHP
73  2019 New beta-Lactone with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus MCCC3A00957. ---
74  2019 Nifedipine Modulates Renal Lipogenesis via the AMPK-SREBP Transcriptional Pathway. CoA, FFA, KIM-1, ROS
75  2019 Novel HMGCS2 pathogenic variants in a Chinese family with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency. ---
76  2019 Policosanol Attenuates Cholesterol Synthesis via AMPK Activation in Hypercholesterolemic Rats. AMPK, LDL
77  2019 Prevention of Hepatocellular Carcinoma by Statins: Clinical Evidence and Plausible Mechanisms. HCC
78  2019 Short telomere subtelomeric hypomethylation is associated with telomere attrition in elderly diabetic patients 1. T2D
79  2019 Siamese neem flower extract suppresses cholesterol absorption by interfering NPC1L1 and micellar property in vitro and in intestinal Caco-2 cells. NPC1L1, PPARdelta
80  2019 Simvastatin Therapy and Bronchoalveolar Lavage Fluid Biomarkers in Chronic Obstructive Pulmonary Disease. BALF, COPD, SP-D
81  2019 Statin treatment prevents the development of pulmonary arterial hypertension in a nonhuman primate model of HIV-associated PAH. HIV, NHP, PAH, SIV
82  2019 Statin use and its potential therapeutic role in esophageal cancer: a systematic review and meta-analysis. DFS, OS
83  2019 Statins and the potential for higher diabetes mellitus risk. CVD, DM
84  2019 Structural and Functional Characterization of Dynamic Oligomerization in Burkholderia cenocepacia HMG-CoA Reductase. ---
85  2019 Synthesis, stability and insecticidal activity of 2-arylstilbenes. SAR
86  2019 Targeted delivery of atorvastatin via asialoglycoprotein receptor (ASGPR). ASGPR, AT
87  2019 The effect of HMG-CoA reductase inhibitors on thrombolysis-induced haemorrhagic transformation. tPA
88  2019 The Effects of Administration of Vitamin D, Infliximab, and Leflunomide on Testosterone Concentrations in Rats under Atorvastatin Therapy. ---
89  2019 The Impact of Statin Therapy on the Survival of Patients with Gastrointestinal Cancer. ---
90  2019 The specific molecular architecture of plant 3-hydroxy-3-methylglutaryl-CoA lyase. ---
91  2019 The stimulatory impact of d-delta-Tocotrienol on the differentiation of murine MC3T3-E1 preosteoblasts. ---
92  2019 Whole barley prevents obesity and dyslipidemia without the involvement of the gut microbiota in germ free C57BL/6J obese mice. CYP7A1, GF, HFA, HFD, SREBP-1c, WB
93  2018 A Multiperspective Approach to Solvent Regulation of Enzymatic Activity: HMG-CoA Reductase. ---
94  2018 A Renewed Focus on the Association Between Thyroid Hormones and Lipid Metabolism. ChREBP, LDL, PCSK9, SREBP-2
95  2018 Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review. HPLC, ROS, UV
96  2018 Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro. ACE, HAECs
97  2018 Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches. ---
98  2018 Association with Monoclonal Antibody Promotes Intracellular Delivery of Lycopene. DMSO, DMSO-L, L-6B9 mAb
99  2018 Atorvastatin Downregulates In Vitro Methyl Methanesulfonate and Cyclophosphamide Alkylation-Mediated Cellular and DNA Injuries. AAs, AVA, CPA, MMS
100  2018 Atorvastatin Prevents Early Oxidative Events and Modulates Inflammatory Mediators in the Striatum Following Intranasal 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Administration in Rats. CNS, i.n, MPTP, PD, RS