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Abbreviation : HNF4alpha
Long Form : hepatocyte nuclear factor 4alpha
No. Year Title Co-occurring Abbreviation
2022 A hierarchical regulatory network ensures stable albumin transcription under various pathophysiological conditions. ALB, FOXA2, LPCs, RAR
2022 Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α. ---
2022 Comparison of Different Hepatocyte Nuclear Factor 4α Clones for Invasive Mucinous Adenocarcinoma of the Lung. IMA, NMA
2022 Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet. GR, HET, HFHS, KO, SREBP-1
2022 Development of the nervous system in mouse liver. BECs, CK19, HA, IHBD, NFs, PGP 9.5, PT, SOX9
2022 Epigenetic regulation of Fructose-1,6-Bisphosphatase 1 by host transcription factor Speckled 110 kDa during Hepatitis B Virus infection. FBP1, HBV, HCC, SIRT2, Sp110
2022 Establishment and characterization of a new cell culture system for hepatitis B virus replication and infection. CP, HBV, hNTCP, pgRNA
2022 FACI Is a Novel CREB-H-Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity. cAMP, Cas9, CRISPR, FACI, PGC-1alpha, SREBP1
2022 HDAC6/FOXP3/HNF4α axis promotes bile acids induced gastric intestinal metaplasia. BA, DCA, FoxP3, HDAC6, IM
10  2022 Hepatocyte nuclear factor 4α in the pathogenesis of non-alcoholic fatty liver disease. NAFLD, NASH
11  2022 IRF2BP2 is a novel HNF4α co-repressor: Its role in gluconeogenic gene regulation via biochemically labile interaction. IRF2BP2, PGC-1alpha
12  2022 Lauric acid impairs insulin-induced Akt phosphorylation by upregulating SELENOP expression via HNF4α induction. ChIP, MCFAs, PUFAs
13  2022 Let-7 underlies metformin-induced inhibition of hepatic glucose production. ---
14  2022 Naringenin in Si-Ni-San formula inhibits chronic psychological stress-induced breast cancer growth and metastasis by modulating estrogen metabolism through FXR/EST pathway. EST, FXR, SNS
15  2022 Prenatal glucocorticoid administration accelerates the maturation of fetal rat hepatocytes. CDK1, DEX, GC, HGF, RT-PCR, Thy-1
16  2022 Progressive loss of hepatocyte nuclear factor 4 alpha activity in chronic liver diseases in humans. CLDs, LC
17  2022 PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α-GLUT2 pathway. PCN, PXR
18  2022 Royal jelly fatty acids downregulate ANGPTL8 expression through the decrease in HNF4α protein in human hepatoma HepG2 cells. ANGPTL8, RJ, RJ, SA
19  2022 Small Molecule-Induced Differentiation As a Potential Therapy for Liver Cancer. ATRA, SMC
20  2022 Therapeutic Potential of HNF4α in End-stage Liver Disease. ESLD, LETFs, NAFLD, OLT
21  2021 6-Gingerol Ameliorates Hepatic Steatosis via HNF4α/miR-467b-3p/GPAT1 Cascade. FFA, GPAT1, HFD, miRNA, NAFLD
22  2021 Disruption of Tumor Suppressors HNF4alpha/HNF1alpha Causes Tumorigenesis in Liver. HNF1alpha
23  2021 Efficient Generation of Functional Hepatocytes from Human Induced Pluripotent Stem Cells for Disease Modeling and Disease Gene Discovery. AFP, ALB, ESCs
24  2021 Establishment of a 3D hyperuricemia model based on cultured human liver organoids. ALB, E-Ca, HUA
25  2021 Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure. ALF, LPCs
26  2021 GATA binding protein 4 promotes the expression and transcription of hepatitis B virus by facilitating hepatocyte nuclear factor 4 alpha in vitro. GATA4, HBsAg, HBV, HBV-HCC, HCC
27  2021 Hepatocyte Nuclear Factor 4-α (HNF4α) controls the insulin resistance-induced pancreatic β-cell mass expansion. GSIS, KO, WT
28  2021 Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment. ---
29  2021 Hepatocytic Activating Transcription Factor 3 Protects Against Steatohepatitis via Hepatocyte Nuclear Factor 4α. ATF3
30  2021 Identification of promoter response elements that mediate propionate induction of bovine cytosolic phosphoenolpyruvate carboxykinase (PCK1) gene transcription. cAMP, CRE
32  2021 Immunohistochemical detection of hepatocyte nuclear factor-4α in vertebrates. ---
33  2021 Influence of HNF4α and HNF4α-AS1 gene variants on the risk of anti-tuberculosis drugs-induced hepatotoxicity. ATDH, HNF4alpha-AS1, PXR, TB, WHO
34  2021 Lipid overload impairs hepatic VLDL secretion via oxidative stress-mediated PKCdelta-HNF4alpha-MTP pathway in large yellow croaker (Larimichthys crocea). HFD, MTP, OA, PKCdelta, ROS, TG, VLDL
35  2021 LncRNA Lnc-APUE is Repressed by HNF4alpha and Promotes G1/S Phase Transition and Tumor Growth by Regulating MiR-20b/E2F1 Axis. HCC, lncRNAs, RFS
36  2021 Novel function of SART1 in HNF4α transcriptional regulation contributes to its antiviral role during HBV infection. AAV, cccDNA, ChIP, HBV, SART1
37  2021 PPARalpha/RXRalpha downregulates amino acid catabolism in the liver via interaction with HNF4alpha promoting its proteasomal degradation. AACE, PPARalpha, RXRalpha, SDS
38  2021 Regulation of long-chain polyunsaturated fatty acid biosynthesis in teleost fish. FADS, miRNA, Sp1, SREBP1
39  2021 Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases. AH, IL-1beta, IL-6, TGF-beta1, TNF-alpha
40  2021 Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4α. HFD, SIRT2
41  2021 Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage. ---
42  2021 Ssu72-HNF4α signaling axis classify the transition from steatohepatitis to hepatocellular carcinoma. HCC
43  2021 The N6-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression. ALKBH5, FTO, m6A, METTL3, UGTs, UTR
44  2020 18beta-Glycyrrhetinic acid acts through hepatocyte nuclear factor 4 alpha to modulate lipid and carbohydrate metabolism. apoB, G6PC, MTP, PLA2G12B, VLDL
45  2020 A negative reciprocal regulatory axis between cyclin D1 and HNF4alpha modulates cell cycle progression and metabolism in the liver. ChIP-seq, HCC
46  2020 A Novel Organoid Model of Damage and Repair Identifies HNF4alpha as a Critical Regulator of Intestinal Epithelial Regeneration. ---
47  2020 ABCA7 links sterol metabolism to the host defense system: Molecular background for potential management measure of Alzheimer's disease. ABC, apo, HDL, LXR, SREBP
48  2020 Andrographolide modulates HNF4alpha activity imparting on hepatic metabolism. AP, apoB, G6PC, MTP, PGC-1alpha, PLA2G12B, VLDL
49  2020 ATSC transplantation contributes to liver regeneration following paracetamol-induced acute liver injury through differentiation into hepatic-like cells. AFP, ALI, ATSCs, CYP1A2, DILI, FISH, HGF, LG, qRT-PCR
50  2020 Bioinformatic Analyses of miRNA-mRNA Signature during hiPSC Differentiation towards Insulin-Producing Cells upon HNF4alpha Mutation. hiPSC
51  2020 Cellular Location of HNF4alpha is Linked With Terminal Liver Failure in Humans. ---
52  2020 Chemical Starting Matter for HNF4alpha Ligand Discovery and Chemogenomics. MODY
53  2020 Chrysin ameliorates hepatic steatosis induced by a diet deficient in methionine and choline by inducing the secretion of hepatocyte nuclear factor 4alpha-dependent very low-density lipoprotein. CHR, NAFLD, PKC, VLDL
54  2020 Generation of uniform liver spheroids from human pluripotent stem cells for imaging-based drug toxicity analysis. HLC, hPSCs
55  2020 Hepatic Polarization Accelerated by Mechanical Compaction Involves HNF4alpha Activation. ---
56  2020 Hepatic stellate cell reprogramming via exosome-mediated CRISPR/dCas9-VP64 delivery. CRISPR, HSCs
57  2020 Hepatocyte Nuclear Factor 4α Prevents the Steatosis-to-NASH Progression by Regulating p53 and Bile Acid Signaling (in mice). HFCF
58  2020 HNF4alpha regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer. SAA
59  2020 Identification of miR-145 as a Key Regulator Involved in LC-PUFA Biosynthesis by Targeting hnf4alpha in the Marine Teleost Siganus canaliculatus. LC-PUFA, SCHL
60  2020 Introducing Point Mutations into Human Pluripotent Stem Cells using Seamless Genome Editing. CRISPR
61  2020 Inverse regulation of claudin-2 and -7 expression by p53 and hepatocyte nuclear factor 4α in colonic MCE301 cells. CLDN7, TEN
62  2020 LINC00511-dependent inhibition of IL-24 contributes to the oncogenic role of HNF4alpha in colorectal cancer. ChIP, CRC, LINC00511
63  2020 Long non-coding RNA SNHG16 regulates cell behaviors through miR-542-3p/HNF4alpha axis via RAS/RAF/MEK/ERK signaling pathway in pediatric neuroblastoma cells. EMT, lncRNA, NB, SNHG16
64  2020 Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model. CYP450, ECM, HC, HCs, LSECs, PDMS
65  2020 Polysaccharides of vinegar-baked radix bupleuri promote the hepatic targeting effect of oxymatrine by regulating the protein expression of HNF4alpha, Mrp2, and OCT1. HBV, Mrp2, OCT1, RTe, RUE, VBRB
66  2020 Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4. PDAC
67  2020 Regulation of Organic Anion Transporting Polypeptide 2B1 Expression by MicroRNA in the Human Liver. 3'UTR, miRNAs
68  2020 Rimonabant suppresses RNA transcription of hepatitis B virus by inhibiting hepatocyte nuclear factor 4alpha. GPCRs, HBV, mRNAs, PHH
69  2020 Ser100-Phosphorylated RORalpha Orchestrates CAR and HNF4alpha to Form Active Chromatin Complex in Response to Phenobarbital to Regulate Induction of CYP2B6. CAR, HPHs, IP, OARE, PB, PBREM, RORalpha
70  2020 Sex-determining region Y box 4 (SOX4) suppresses Hepatitis B virus replication by inhibiting hepatocyte nuclear factor 4alpha expression. HBV, SOX4
71  2020 SOX9 represses hepatitis B virus replication through binding to HBV EnhII/Cp and inhibiting the promoter activity. HBV, HMG, SOX9
72  2020 Suppression of Hepatocyte Nuclear Factor 4 alpha by Long-term Infection of Hepatitis B Virus Contributes to Tumor Cell Proliferation. HBV, HBx, HCC
73  2020 Synergistic regulation of hepatic Fsp27b expression by HNF4alpha and CREBH. FSP27
74  2020 Telomere Dysfunction Activates p53 and Represses HNF4alpha Expression Leading to Impaired Human Hepatocyte Development and Function. hESCs, TERT
75  2020 TGR5-HNF4alpha axis contributes to bile acid-induced gastric intestinal metaplasia markers expression. BAs, CDX2, DCA, IM, KLF4
76  2020 Vitamin D receptor targets hepatocyte nuclear factor 4alpha and mediates protective effects of vitamin D in nonalcoholic fatty liver disease. HFD, MCD, NAFLD, VDR
77  2019 A subpopulation of airway epithelial cells that express hepatocyte nuclear factor 4alpha - its implication in the development of non-terminal respiratory unit-type lung adenocarcinoma. LADCs, TRU
78  2019 An Unexpected Role of Cholesterol Sulfotransferase and its Regulation in Sensitizing Mice to Acetaminophen-Induced Liver Injury. ALF
79  2019 Atypical goblet cell hyperplasia occurs in CPAM 1, 2, and 3, and is a probable precursor lesion for childhood adenocarcinoma. AC, AGCH, CPAM, FGF10, FOXA1, MUC5AC, YY1
80  2019 Caffeine-free hawk tea lowers cholesterol by reducing free cholesterol uptake and the production of very-low-density lipoprotein. apoB, HTE, LDLR, MTP, NPC1L1, SREBP2
81  2019 Clonal expansion of hepatic progenitor cells and differentiation into hepatocyte-like cells. ALB, CK7, FGF9, HGF, HPCs, TGF-beta
82  2019 Deletion of the Mitochondrial Protein VWA8 Induces Oxidative Stress and an HNF4α Compensatory Response in Hepatocytes. ROS, VWA8
83  2019 Endothelial HNF4alpha potentiates angiogenic dysfunction via enhancement of vascular endothelial growth factor resistance in T2DM. VEGF
84  2019 Enhanced expression of HNF4alpha during intestinal epithelial differentiation is involved in the activation of ER stress. ATF6, IRE1, UPR
85  2019 Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity. 5-aza, EMT, PHH
86  2019 ERK1/2-HNF4alpha axis is involved in epigallocatechin-3-gallate inhibition of HBV replication. EGCG
87  2019 FoxO4 inhibits HBV core promoter activity through ERK-mediated downregulation of HNF4alpha. FoxO, HBV
88  2019 Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors. AAV, HOPX, Tbx15, TFCP2L1
89  2019 Generation of functional hepatocyte-like cells from human bone marrow mesenchymal stem cells by overexpression of transcription factor HNF4alpha and FOXA2. AAT, ALB, hiHep cells, ICG, MSCs
90  2019 Hepatocyte nuclear factor 4alpha (Hnf4alpha) is involved in transcriptional regulation of Delta6/Delta5 fatty acyl desaturase (Fad) gene expression in marine teleost Siganus canaliculatus. FAD, LCPUFAs, SCHL, siRNA, TF
91  2019 HNF4alpha and CDX2 Regulate Intestinal YAP1 Promoter Activity. CDX2, YAP1
92  2019 HNF4alpha Combinatorial Isoform Heterodimers Activate Distinct Gene Targets that Differ from Their Corresponding Homodimers. ---
93  2019 HNF4alpha pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer. GC, IDH1
94  2019 Liver Proliferation Is an Essential Driver of Fibrosis in Mouse Models of Nonalcoholic Fatty Liver Disease. CUGBP1, Gank, GLKO, HFD, NAFLD
95  2019 Long non-coding RNA LINC00858 exerts a tumor-promoting role in colon cancer via HNF4alpha and WNK2 regulation. EdU, lncRNAs
96  2019 MC4R and HNF4alpha promoter methylation at birth contribute to triglyceride levels in childhood: A prospective cohort study. MC4R, TG
97  2019 MiR-15/16 mediate crosstalk between the MAPK and Wnt/beta-catenin pathways during hepatocyte differentiation from amniotic epithelial cells. AECs, APC
98  2019 miR-34a inhibits proliferation, migration and invasion of paediatric neuroblastoma cells via targeting HNF4alpha. miR-34a, MMP-14, MMP-2
99  2019 Mitigative effects of the bioactive flavonol fisetin on high-fat/high-sucrose induced nonalcoholic fatty liver disease in rats. ELISA, HFHS, NAFLD, PARP-1, ROS, RT-PCR, TXNIP
100  2019 Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation. SUMO