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Abbreviation : HOTAIR
Long Form : HOX transcript antisense intergenic RNA
No. Year Title Co-occurring Abbreviation
2020 Association Analysis Between the rs1899663 Polymorphism of HOTAIR and Risk of Psychiatric Conditions in an Iranian Population. ADHD, BPD1, lncRNAs, MDD, SCZ
2020 Diagnostic roles of HOX transcript antisense intergenic RNA in cancer. CI
2020 Down-regulation of long non-coding RNA HOTAIR promotes angiogenesis via regulating miR-126/SCEL pathways in burn wound healing. HUVECs, lncRNA, SCEL
2020 HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 via miR-221-3p binding. MPTP, PD
2020 HOTAIR LncRNA: A novel oncogenic propellant in human cancer. lncRNAs
2020 HOTAIR regulates lipopolysaccharide-induced inflammatory response in hepatocytes. CCK-8, IL, lncRNA, LPS, TNF
2020 HOTAIR-induced apoptosis is mediated by sponging miR-130a-3p to repress chondrocyte autophagy in knee osteoarthritis. KOA, lncRNA
2020 Long Non-Coding RNA HOTAIR in Breast Cancer Therapy. BC, lncRNAs
2020 Long non-coding RNA HOTAIR promotes cell viability, migration and invasion in thyroid cancer cells by sponging miR-17-5p. lncRNAs
10  2020 Long-chain non-coding RNA HOTAIR promotes the progression of osteoarthritis via sponging miR-20b/PTEN axis. ECM, IL, lncRNA, MMP, OA, PTEN
11  2020 Prognostic Value of LncRNA HOTAIR in Colorectal Cancer: A Meta-analysis. CI, CRC, HR, lncRNAs
12  2020 Roles of HOTAIR in lung cancer susceptibility and prognosis. GEPIA, NSCLC, SNPs
13  2020 The rs4759314 SNP within Hotair lncRNA is associated with risk of multiple sclerosis. lncRNAs, MS, SNPs
14  2019 Association between expression of HOTAIR and invasiveness of gliomas, and its predictive value. MMP-7, MMP-9, qRT-PCR, ROC, VEGF
15  2019 Effects of lncRNA HOTAIR on proliferation and apoptosis of myeloma cells through NF-kappaB pathway. lncRNA, MTT, NF-kappaB, RT-PCR
16  2019 Epitranscriptomic Signatures in lncRNAs and Their Possible Roles in Cancer. lncRNAs, MALAT1, XIST
17  2019 HOTAIR/miR-214-3p/FLOT1 axis plays an essential role in the proliferation, migration, and invasion of hepatocellular carcinoma. HCC, lncRNA
18  2019 Knockdown of long noncoding RNA HOTAIR inhibits cell growth of human lymphoma cells by upregulation of miR-148b. 3'-UTR, ERK, MAPK, qRT-PCR
19  2019 lncRNA HOTAIR Protects Myocardial Infarction Rat by Sponging miR-519d-3p. LAD, MI
20  2019 Long non-coding RNA HOTAIR in circulatory exosomes is correlated with ErbB2/HER2 positivity in breast cancer. lncRNA, qRT-PCR, RTK
21  2019 Long non-coding RNA HOTAIR mediates the switching of histone H3 lysine 27 acetylation to methylation to promote epithelial-to-mesenchymal transition in gastric cancer. EMT, GC, PRC2
22  2019 Long Noncoding RNA HOTAIR Promotes Endometrial Carcinoma Cell Proliferation by Binding to PTEN via the Activating Phosphatidylinositol 3-Kinase/Akt Signaling Pathway. EC, lncRNAs, PI3K
23  2019 Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15. ---
24  2019 Paeonol reverses promoting effect of the HOTAIR/miR-124/Notch1 axis on renal interstitial fibrosis in a rat model. EMT, lncRNAs, miR-124, Pae, RIF, UUO
25  2019 Parathyroid Neoplasms: Immunohistochemical Characterization and Long Noncoding RNA (lncRNA) Expression. INSM1, Linc-ROR or ROR, lncRNA
26  2019 SNP-SNP and SNP-environment interactions of potentially functional HOTAIR SNPs modify the risk of hepatocellular carcinoma. CI, HCC, MDR, OR, SNPs
27  2019 The lncRNA HOTAIR transcription is controlled by HNF4alpha-induced chromatin topology modulation. HNF4alpha
28  2019 The prognostic potential of long noncoding RNA HOTAIR expression in human digestive system carcinomas: A meta-analysis. CI, HR, lncRNAs
29  2018 Association on polymorphisms in LncRNA HOTAIR and susceptibility to HNSCC in Chinese population. CI, HNSCC, lncRNA, OR
30  2018 Down-Regulated LncRNA-HOTAIR Suppressed Colorectal Cancer Cell Proliferation, Invasion, and Migration by Mediating p21. CRC
31  2018 Downregulation of Long Noncoding RNA HOTAIR and EZH2 Induces Apoptosis and Inhibits Proliferation, Invasion, and Migration of Human Breast Cancer Cells. EZH2
32  2018 Effect of HOTAIR rs12826786 and rs1899663 polymorphisms on lung cancer susceptibility and clinicopathological characteristics in a turkish population: a hospital-based case-control study. lncRNA, SNPs
33  2018 HOTAIR alleviates ox-LDL-induced inflammatory response in Raw264.7 cells via inhibiting NF-kappaB pathway. AS, CCK-8, ELISA, HDL-C, LDL-C, NF-kappaB, qRT-PCR, TC
34  2018 HOTAIR gene polymorphisms contribute to increased neuroblastoma susceptibility in Chinese children. ---
35  2018 Impact of HOTAIR Gene Polymorphism and Environmental Risk on Oral Cancer. OR, OSCC
36  2018 Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid Growth Factor Receptor (OGFr). DEGs, DEPs, HCC, OGFr, PRM
37  2018 JMJD6 induces HOTAIR, an oncogenic lincRNA, by physically interacting with its proximal promoter. JMJD6
38  2018 Long non-coding RNA HOTAIR acts as a competing endogenous RNA to promote glioma progression by sponging miR-126-5p. ceRNA, GLS
39  2018 Long non-coding RNA HOTAIR promotes tumorigenesis and forecasts a poor prognosis in cholangiocarcinoma. CCA, EMT, HIBEC, lncRNAs
40  2018 Long Non-coding RNA Linc-ROR Is Upregulated in Papillary Thyroid Carcinoma. EMT, ISH, Linc-ROR, ROR, lncRNAs, PVT1, TMAs
41  2018 Long noncoding RNA HOTAIR promotes renal cell carcinoma malignancy through alpha-2, 8-sialyltransferase 4 by sponging microRNA-124. lncRNA, miR-124, RCC, ST8SIA4
42  2018 Naked-eye and electrochemical detection of isothermally amplified HOTAIR long non-coding RNA. HRP, lncRNA, RT-RPA, TMB
43  2018 Plasma long non-coding RNA HOTAIR as a potential biomarker for gastric cancer. lncRNAs
44  2018 Polymorphisms of long non-coding RNA HOTAIR with breast cancer susceptibility and clinical outcomes for a southeast Chinese Han population. BC, CI, DFS, HR, lncRNA, OR, OS, SNPs
45  2018 Tagging SNPs in the HOTAIR gene are associated with bladder cancer risk in a Chinese population. BCa, CI, lncRNA, OR, tagSNPs
46  2018 The association between HOTAIR polymorphisms and cancer susceptibility: an updated systemic review and meta-analysis. ORs
47  2018 The effect of lncRNA HOTAIR on chemoresistance of ovarian cancer through regulation of HOXA7. lncRNAs, qRT-PCR
48  2018 The effect of long noncoding RNAs HOX transcript antisense intergenic RNA single-nucleotide polymorphisms on breast cancer, cervical cancer, and ovarian cancer susceptibility: A meta-analysis. BC, CC, CI, lncRNA, OC, OR, SNP
49  2017 Association of Functional Genetic Variants of HOTAIR with Hepatocellular Carcinoma (HCC) Susceptibility in a Chinese Population. HCC, lncRNA, RT-PCR, SNPs
50  2017 Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis. RFLP, SNPs
51  2017 Expression of the long non-coding RNA HOTAIR as a prognostic factor in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis. lncRNAs, SCCHN
52  2017 HOX transcript antisense intergenic RNA represses E-cadherin expression by binding to EZH2 in gastric cancer. AUC-ROC, GC, qPCR, TNM
53  2017 Long Non-coding RNA-mRNA Correlation Analysis Reveals the Potential Role of HOTAIR in Pathogenesis of Sporadic Thoracic Aortic Aneurysm. CABG, GO, lncRNA, S-TAA
54  2017 Long noncoding RNA HOTAIR promotes the proliferation and metastasis of osteosarcoma cells through the AKT/mTOR signaling pathway. lnc, MMP, OS
55  2017 The analysis of lncRNA HOTAIR rs12826786 C>T polymorphism and gastric cancer susceptibility in a Turkish population: lack of any association in a hospital-based case-control study. GC, lncRNA, PCR, SNP
56  2017 The long noncoding RNA HOTAIR promotes Parkinson's disease by upregulating LRRK2 expression. lncRNAs, PD
57  2017 The Role of HOTAIR/miR-148b-3p/USF1 on Regulating the Permeability of BTB. BTB, GECs, lncRNA, USF1
58  2016 A functional HOTAIR rs12826786 C>T polymorphism is associated with breast cancer susceptibility and poor clinicopathological characteristics in a Turkish population: a hospital-based case-control study. BC, CI, lncRNA, OR, PCR, SNP
59  2016 Analysis of the association of HOTAIR single nucleotide polymorphism (rs920778) and risk of cervical cancer. CI, OR, SNP
60  2016 Association of HOTAIR expression with PI3K/Akt pathway activation in adenocarcinoma of esophagogastric junction. AEJ
61  2016 Association of HOTAIR polymorphisms rs4759314 and rs920778 with cancer susceptibility on the basis of ethnicity and cancer type. CI, OR
62  2016 Association of well-characterized lung cancer lncRNA polymorphisms with lung cancer susceptibility and platinum-based chemotherapy response. CCAT2, HOTTIP, lncRNAs, MALAT1, MEG3
63  2016 Elevated RNA expression of long non‑coding HOTAIR promotes cell proliferation and predicts a poor prognosis in patients with diffuse large B cell lymphoma. DLBCL, lncRNAs
64  2016 Epigenetic silencing of p21 by long non-coding RNA HOTAIR is involved in the cell cycle disorder induced by cigarette smoke extract. CSE, EZH2, HBE, lncRNAs
65  2016 Expression level and clinical significance of HOX transcript antisense intergenic RNA in cervical cancer: a meta-analysis. ORs, SMDs
66  2016 Expression of long non-coding RNA-HOTAIR in oral squamous cell carcinoma Tca8113 cells and its associated biological behavior. DOX, OSCC
67  2016 HOTAIR overexpression correlated with worse survival in patients with solid tumors. HRs, OS
68  2016 HOTAIR, a long non-coding RNA driver of malignancy whose expression is activated by FOXC1, negatively regulates miRNA-1 in hepatocellular carcinoma. FOXC1, HCC, lncRNAs
69  2016 LncRNA HOTAIR controls the expression of Rab22a by sponging miR-373 in ovarian cancer. ceRNAs, miR
70  2016 Long Non-coding RNA HOTAIR Expression in Diffuse Large B-Cell Lymphoma: In Relation to Polycomb Repressive Complex Pathway Proteins and H3K27 Trimethylation. DLBCLs, PRC2
71  2016 Prognostic role of lncRNA HOTAIR in esophageal squamous cell carcinoma. CNKI, ESCC, HRs, LNM, OS
72  2016 Quantitative Assessment of the Polymorphisms in the HOTAIR lncRNA and Cancer Risk: A Meta-Analysis of 8 Case-Control Studies. lncRNA
73  2016 RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis. DDX5, EpCAM, HBV, HBx, HCC, Mex3b, PRC2, SUZ12
74  2016 The long non-coding RNA HOTAIR affects the radiosensitivity of pancreatic ductal adenocarcinoma by regulating the expression of Wnt inhibitory factor 1. CCK-8, HPDE, PDAC, qRT-PCR, WIF-1
75  2016 [Prognostic value of lncRNA HOTAIR expression in 
patients with cancer: A Meta-analysis]. lncRNA
76  2015 A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control study. GC, lncRNA, SNP
77  2015 Associations between polymorphisms of HOTAIR and risk of gastric cardia adenocarcinoma in a population of north China. GCA, htSNPs, PCR-RFLP, RT-PCR, SNP, TNM, UGIC
78  2015 Breast Cancer: Radiogenomic Biomarker Reveals Associations among Dynamic Contrast-enhanced MR Imaging, Long Noncoding RNA, and Metastasis. DCE, lncRNA, MFS, MR
79  2015 Circulating DNA of HOTAIR in serum is a novel biomarker for breast cancer. AUC, ROC
80  2015 Effect of HOTAIR rs920778 polymorphism on breast cancer susceptibility and clinicopathologic features in a Turkish population. BC, CI, lncRNA, OR, PCR, SNP, TNM
81  2015 Expression of long noncoding RNA-HOX transcript antisense intergenic RNA in oral squamous cell carcinoma and effect on cell growth. OSCC
82  2015 Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior. lncRNAs, MALAT1, MEG3, NFPAs, PCNA
83  2015 HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer. CI, DNAme
84  2015 HOTAIR is a potential target for the treatment of cisplatin‑resistant ovarian cancer. ---
85  2015 HOTAIR is upregulated in acute myeloid leukemia and that indicates a poor prognosis. AML, qRT-PCR, siRNA
86  2015 Long non-coding RNA HOTAIR is associated with human cervical cancer progression. EMT, lncRNAs
87  2015 Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner. LSD1, PRC2
88  2015 Long non-coding RNA HOTAIR: A novel oncogene (Review). lncRNAs
89  2015 Long noncoding RNA HOTAIR, a hypoxia-inducible factor-1alpha activated driver of malignancy, enhances hypoxic cancer cell proliferation, migration, and invasion in non-small cell lung cancer. ChIP, EMSA, HIF-1alpha, HREs, lncRNA, NSCLC, qRT-PCR
90  2015 Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia. AML, BM, OS
91  2015 Prognostic impact of HOTAIR expression is restricted to ER-negative breast cancers. lincRNA, RNA-ISH
92  2015 Prognostic role of HOTAIR in four estrogen-dependent malignant tumors: a meta-analysis. DFS, HRs, MFS, OS, RFS
93  2015 Prognostic value of long noncoding RNA HOTAIR in digestive system malignancies. CI, HR, HR, OS
94  2015 Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Noncoding RNA Hox Transcript Antisense Intergenic RNA (HOTAIR) in HeLa Cells. lncRNAs, VIM
95  2015 SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma. GBM, snoRNAs
96  2015 The association analysis of lncRNA HOTAIR genetic variants and gastric cancer risk in a Chinese population. CI, OR, SNP
97  2014 HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. CRC
98  2014 Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer. SCLC
99  2014 Long noncoding RNA HOX transcript antisense intergenic RNA (HOTAIR) as a foe and novel potential therapeutic target for endometrial carcinoma. ---
100  2014 Prognostic value of long non-coding RNA HOTAIR in various cancers. CI, DFS, HR, MFS, OS, RFS