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Abbreviation : HupA
Long Form : Huperzine A
No. Year Title Co-occurring Abbreviation
2019 Huperzine A ameliorates cognitive dysfunction and neuroinflammation in kainic acid-induced epileptic rats by antioxidant activity and NLRP3/caspase-1 pathway inhibition. AChE, MDA, MWM, NOR, SOD, TLE
2019 Selection of Reference Genes for Expression Analysis in Chinese Medicinal Herb Huperzia serrata. TCM
2018 Alterations in the Timing of Huperzine A Cerebral Pharmacodynamics in the Acute Traumatic Brain Injury Setting. FPI, GABA, ppTMS, TBI
2018 Genomic Characterization Provides New Insights Into the Biosynthesis of the Secondary Metabolite Huperzine a in the Endophyte Colletotrichum gloeosporioides Cg01. CAO, DEGs, GO, HAT, HDAC, HGT, HMT, LDC, PKS
2018 Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer's disease. AD, LF, NPs, PLGA, TMC
2018 Protective properties of Huperzine A through activation Nrf2/ARE-mediated transcriptional response in X-rays radiation-induced NIH3T3 cells. ---
2017 Administration of Huperzine A exerts antidepressant-like activity in a rat model of post-stroke depression. 5-HT, 5-HT1AR, BDNF, CREB, DA, NE, pCREB, PSD
2017 Effects of Huperzin-A on the Beta-amyloid accumulation in the brain and skeletal muscle cells of a rat model for Alzheimer's disease. AD, betaAP, CMAP
2017 Expression and functional analysis of the lysine decarboxylase and copper amine oxidase genes from the endophytic fungus Colletotrichum gloeosporioides ES026. AD, CAO, LDC
10  2017 Global transcriptome analysis of Huperzia serrata and identification of critical genes involved in the biosynthesis of huperzine A. H. serrata, LDC-like, TFs
11  2017 Huperzine A alleviates neuroinflammation, oxidative stress and improves cognitive function after repetitive traumatic brain injury. AChEI, AD, CHI, ROS, TBI
12  2017 Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer's disease. AChE, AD, AEDs
13  2017 Identification and characterization of L-lysine decarboxylase from Huperzia serrata and its role in the metabolic pathway of lycopodium alkaloid. LDCs, RACE
14  2017 Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake. AUC, SMEDDS, SPIP
15  2016 Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons. AChE, AD, ATP, DON, FAC, LIP, ROS
16  2016 Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis. CI, IQ, RCTs, WMD, WMD
17  2016 Evaluation of the invitro and invivo metabolic pathway and cytochrome P450 inhibition/induction profile of Huperzine A. DDI
18  2016 Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease. AChE, DON, Ese, HSA, TAC
19  2016 Huperzine A Alleviates Oxidative Glutamate Toxicity in Hippocampal HT22 Cells via Activating BDNF/TrkB-Dependent PI3K/Akt/mTOR Signaling Pathway. BDNF, NT-3, NT-4, p-Akt, p-mTOR, p-p70s6, p-TrkB, PI3K
20  2016 Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research. AChE
21  2016 Huperzine A for treatment of cognitive impairment in major depressive disorder: a systematic review of randomized controlled trials. AChE, MDD, RCTs
22  2016 Huperzine A protects sepsis associated encephalopathy by promoting the deficient cholinergic nervous function. SAE
23  2016 In vivo blockade of acetylcholinesterase increases intraovarian acetylcholine and enhances follicular development and fertility in the rat. ACh, AChE, GCs
24  2016 Molecular cloning, expression, and functional analysis of the copper amine oxidase gene in the endophytic fungus Shiraia sp. Slf14 from Huperzia serrata. CAO, GC-MS
25  2016 [Cholinergic anti-inflammatory pathway involves in the neuroprotective effect of huperzine A on sepsis-associated encephalopathy]. ChAT, CHRM1, ELISA, IL-1 beta, NeuN, RT-qPCR, SAE, TNF-alpha
26  2016 [Molecular cloning, expression and characterization of lysine decarboxylase gene of endophytic fungus Shiraia sp. Slf14 from Huperzia serrata]. LDC
27  2015 Huperzine A production by Paecilomyces tenuis YS-13, an endophytic fungus isolated from Huperzia serrata. ---
28  2015 Huperzine A prophylaxis against pentylenetetrazole-induced seizures in rats is associated with increased cortical inhibition. LICI, ppTMS, PTZ
29  2015 Huperzine A protects neural stem cells against Abeta-induced apoptosis in a neural stem cells and microglia co-culture system. BrdU, IFA, NSCs
30  2014 Efficient strategy for maintaining and enhancing the huperzine A production of Shiraia sp. Slf14 through inducer elicitation. HSE
31  2014 Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats. AChE, BDNF, CAT, ChAT, DACD, GSH-Px, MDA, SOD, STZ
32  2014 Huperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidant, anti-apoptotic and anti-inflammatory mechanisms. CK, cTnT, GSH-Px, IL-1beta, LDH, MDA, NF-kappaB, SOD, TNF-alpha
33  2014 Huperzine A attenuates hepatic ischemia reperfusion injury via anti-oxidative and anti-apoptotic pathways. AST, CAT, HI/R, MDA, SOD
34  2014 Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer's Disease? AChE, AD
35  2014 Indentification of huperzine A-producing endophytic fungi isolated from Huperzia serrata. AChE
36  2014 Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease. AD, ADAM10
37  2014 The protective effect of huperzine A against hepatic ischemia reperfusion injury in mice. AST, CAT, HI/R, IL-1beta, MDA, NF-kappaB, SOD
38  2013 A novel approach to medical countermeasures against organophosphorus compound toxicity. AChE, HSMs, MP, OPs
39  2013 Comparative in vitro and in vivo evaluation of lipid based nanocarriers of Huperzine A. GRAS, ME, NLCs, SLNs
40  2013 Controlled iontophoretic transport of huperzine A across skin in vitro and in vivo: effect of delivery conditions and comparison of pharmacokinetic models. ---
41  2013 Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors. AChE
42  2013 Ethanol and methanol can improve huperzine A production from endophytic Colletotrichum gloeosporioides ES026. ---
43  2013 Huperzine A inhibits CCL2 production in experimental autoimmune encephalomyelitis mice and in cultured astrocyte. CNS, EAE, LPS
44  2013 Huperzine a restores cortico-hippocampal functional connectivity after bilateral AMPA lesion of the nucleus basalis of meynert. AD, EEG, NBM
45  2013 Huperzine A, but not tacrine, stimulates S100B secretion in astrocyte cultures. AChE, ELISA
46  2013 Preparation and in vitro and in vivo evaluation of HupA PLGA microsphere. AChEIs, AD, PLGA
47  2013 Production of huperzine A and other Lycopodium alkaloids in Huperzia species grown under controlled conditions and in vitro. AD
48  2013 [Effect of Huperzine A on neural lesion of acute organophosphate poisoning in mice]. ---
49  2012 Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice. AChEI, AD, ADAM10, APP, BACE1, PS1
50  2012 Huperzine A ameliorates experimental autoimmune encephalomyelitis via the suppression of T cell-mediated neuronal inflammation in mice. EAE
51  2012 Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography. AD, HupB, Preparative HPLC, TFA
52  2012 Steady and fluctuant methods of inhibition of acetylcholinesterase differentially regulate neurotrophic factors in the hippocampus of juvenile mice. AChE, BDNF, NGF
53  2012 Validation of a microscale extraction and high-throughput UHPLC-QTOF-MS analysis method for huperzine A in Huperzia. ---
54  2011 Huperzine A activates Wnt/beta-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model. AChE, AD
55  2011 Isolation and characterization of endophytic huperzine A-producing fungi from Huperzia serrata. AChE, ChEI, RP-HPLC
56  2010 A novel endophytic Huperzine A-producing fungus, Shiraia sp. Slf14, isolated from Huperzia serrata. AChE, HPLC
57  2010 Analysis of expressed sequence tags from the Huperzia serrata leaf for gene discovery in the areas of secondary metabolite biosynthesis and development regulation. ESTs, LDC
58  2010 Huperzine alkaloids from Australasian and southeast Asian Huperzia. HupB
59  2010 Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats. i.t
60  2010 Modification and validation of a high-performance liquid chromatography method for quantification of Huperzine A in Huperzia crispata. ---
61  2009 Age-related expression of calcium/calmodulin-dependent protein kinase II A in the hippocampus and cerebral cortex of senescence accelerated mouse prone/8 mice is modulated by anti-Alzheimer's disease drugs. AD, BW, CaMKIIalpha, DSS, HL, LW, RT-PCR, SAM, SAMR1, TXF
62  2009 Development of a sensitive high-performance liquid chromatographic method with simple extraction for simultaneous determination of huperzine A and huperzine B in the species containing lycopodium alkaloids. HupB
63  2009 Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. AD, ADL, MMSE
64  2009 Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide. ATP
65  2008 Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats. MCAO, ROS
66  2008 In vitro production of huperzine A, a promising drug candidate for Alzheimer's disease. AD
67  2008 Pharmacokinetics of Huperzine A after transdermal and oral administration in beagle dogs. ---
68  2008 Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia. AChE, AD, APP, VaD
69  2007 Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors. AChE, AD
70  2007 Controlled release of huperzine A from biodegradable microspheres: In vitro and in vivo studies. AD
71  2007 Huperzine A from Huperzia species--an ethnopharmacolgical review. AD
72  2006 Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism. ROS
73  2006 In vitro and in vivo characterization of huperzine a loaded microspheres made from end-group uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co-glycolide acid). EE
74  2006 Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease. AChE, AD, NGF
75  2006 Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. AChE
76  2006 [Effect of HuperzineA on neurophathologic change of mouse exposed by isocarbophos and phoxim]. HE
77  2006 [Effect of yizhi jiannao granule on the behavior and neuron apoptosis in SAMP/8 mice]. FCM, YCF
78  2005 A cyanopropyl reversed phase chromatography enables resolution of huperzine A and B on analytical and preparative scales. CN, HupB
79  2005 Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells. LDH, NGF
80  2005 Ion-pair reverse-phase high performance liquid chromatography method for determination of Huperzine-A in beagle dog serum. AD, RP-HPLC
81  2005 Is there a better source of huperzine A than Huperzia serrata? Huperzine A content of Huperziaceae species in China. ---
82  2005 Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease. AD, VD
83  2004 Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells. APP, PKC
84  2004 The Lycopodium alkaloids. AChE, AD
85  2003 Effects of huperzine A on liver cytochrome P-450 in rats. 3-MC, CYP
86  2003 How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations. SMD, TcAChE
87  2003 Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons. ---
88  2003 The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease. AChE, AD, OP
89  2003 [Effect of tetramethylpyrazine on learning, memory and cholinergic system in D-galactose-lesioned mice]. AChE, TMP
90  2002 Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons. ---
91  2002 Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons. ---
92  2001 Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation. OGD
93  2001 Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells. AChE
94  2001 Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation. OGD
95  2001 The NMDA receptor ion channel: a site for binding of Huperzine A. AChE, BChE, NMDA, OP
96  2000 Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury. AChE, AD, CAT, GSH-Px, MDA, SOD
97  2000 Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells. CAT, GSH-Px, MDA, SOD
98  2000 [Effects of bushen yizhi recipe on somatostatin-like immunopositive and somatostatin messenger ribonucleic acid expressed-positive neurons in Alzheimer's disease model rats]. AD, IBO, SS-like
99  1999 Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury. MDA
100  1999 Molecular dynamics of mouse acetylcholinesterase complexed with huperzine A. ---