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Abbreviation : IAP
Long Form : inhibitor of apoptosis
No. Year Title Co-occurring Abbreviation
2020 A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2. Bcl-2, cIAP1, TNF-alpha, UPS
2020 Anticancer agents based on vulnerable components in a signalling pathway. Chk1, MDM2, MELK, ROS1, SK2, WEE1
2020 BIRC5 Expression is Regulated in Uterine Epithelium During the Estrous Cycle. BIRC5
2020 Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression. H-PCL, IL, NPs
2020 Codelivery of STAT3 siRNA and BV6 by carboxymethyl dextran trimethyl chitosan nanoparticles suppresses cancer cell progression. NPs, STAT3
2020 Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo. HBsAg, HBV, MDR1
2020 Development of RNAi methods to control the harlequin bug, Murgantia histrionica. dsRNA, GPCR, HB, PP1, RNAi
2020 Double-stranded RNAs targeting inhibitor of apoptosis gene show no significant cross-species activity. dsRNA, RNAi
2020 Enhancing RNAi Efficiency to Decipher the Functional Response of Potential Genes in Bemisia tabaci AsiaII-1 (Gennadius) Through dsRNA Feeding Assays. AQP, CAL, CQD, CYCP, RNAi
10  2020 Evaluation of inhibitor of apoptosis genes as targets for RNAi-mediated control of insect pests. RNAi, TcA
11  2020 Evolutionary and functional analyses of the interaction between the Bombyx mori inhibitor of apoptosis (IAP) and nucleopolyhedrovirus IAPs. BmNPV
12  2020 Future Therapeutic Directions for Smac-Mimetics. SMs
13  2020 Orally delivered dsRNA induces knockdown of target genes and mortality in the Asian long-horned beetle, Anoplophora glabripennis. ALB, dsRNA, RNAi, ssk
14  2020 SMAC mimetic plus triple combination bispecific HIVxCD3 DART molecules in SHIV.C.CH505-infected, ART-suppressed rhesus macaques. ADA, ART, Env
15  2020 Stimuli-Responsive Polysaccharide Enveloped Liposome for Targeting and Penetrating Delivery of survivin-shRNA into Breast Tumor. CS, FRET, HA, HAase, HCLR
16  2020 Targeting triple-negative breast cancers with the Smac-mimetic birinapant. PDX, TNBC
17  2020 Transcriptional Alteration of Gene Biomarkers in Hemocytes of Wild Ostrea edulis with Molecular Evidence of Infections with Bonamia spp. and/or Marteilia refringens Parasites. EC-SOD, FAS, Gal, GST, HSP, MT, SOD
18  2019 Alternative isoforms of BmYki have different transcriptional co-activator activity in the silkworm, Bombyx mori. Bmpr, BmYki3, crb, dpp, ex, fj, serr, STAT, Yki
19  2019 Antibiotic Tetrocarcin-A Down-regulates JAM-A, IAPs and Induces Apoptosis in Triple-negative Breast Cancer Models. JAM-A, TNBC
20  2019 CCAR2/DBC1 and Hsp60 Positively Regulate Expression of Survivin in Neuroblastoma Cells. ---
21  2019 Genome Analysis of a Novel Clade II.b Alphabaculovirus Obtained from Artaxa digramma. ArdiNPV, bros, Dbp, dsDNA, hrs, ORFs
22  2019 Identification of Smac mimetics as novel substrates for p-glycoprotein. DOXO, ETO, MDR, VCR
23  2019 Inhibition of NF-kappaB transcriptional activity enhances fucoxanthinol-induced apoptosis in colorectal cancer cells. CRC, FX, FXOH, NF-kappaB
24  2019 Manipulation of the Alternative NF-kappaB Pathway in Mice Has Sexually Dimorphic Effects on Bone. NIK, OC
25  2019 NOD Signaling and Cell Death. ---
26  2019 Overexpression of apoptosis-related protein, survivin, in fibroblasts from patients with systemic sclerosis. dcSSc, SSc
27  2019 Regulation of the expression of nine antimicrobial peptide genes by TmIMD confers resistance against Gram-negative bacteria. AMP, IMD
28  2019 Resveratrol enhances chemosensitivity of renal cell carcinoma to paclitaxel. PTX, RCC, RES
29  2019 Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress. CHOP, cIAP, ER, GRP78, NF-kappaB, PERK, Smac, TG, TM, UPR, XBP1
30  2019 Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment. BIR, cIAP1, SMs, XIAP
31  2018 A Systematic Study of RNAi Effects and dsRNA Stability in Tribolium castaneum and Acyrthosiphon pisum, Following Injection and Ingestion of Analogous dsRNAs. RNAi, VTE
32  2018 APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells. ---
33  2018 Butein induces apoptotic cell death of human cervical cancer cells. ---
34  2018 cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells. EGFR, MAPK
35  2018 cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-kappaB Activation in Human Macrophages. cIAPs, JNK, SMM, TRAF2
36  2018 Epigenetic mechanism of survivin dysregulation in human cancer. ---
37  2018 Exosomal survivin facilitates vesicle internalization. TME
38  2018 High BIRC7 Expression Might Be an Independent Prognostic Indicator of Poor Recurrence-Free Survival in Patients With Prostate Cancer. ---
39  2018 Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization. ---
40  2018 Interplay between Endoplasmic Reticular Stress and Survivin in Colonic Epithelial Cells. 4-PBA, ERS, IF, IHC, PARP, UPR
41  2018 Overexpression of protocadherin 7 inhibits neuronal survival by downregulating BIRC5 in vitro. ---
42  2018 Regulation of innate and adaptive antitumor immunity by IAP antagonists. ---
43  2018 Selection of the sex-linked inhibitor of apoptosis in mountain pine beetle (Dendroctonus ponderosae) driven by enhanced expression during early overwintering. ---
44  2018 Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation. GLMN
45  2018 The anti-apoptotic ubiquitin conjugating enzyme BIRC6/BRUCE regulates autophagosome-lysosome fusion. BIRC6
46  2018 The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1beta Activation. ---
47  2018 The SMAC mimetic LCL-161 displays antitumor activity in preclinical models of rituximab-resistant B-cell lymphoma. RGV, RRCLs, Smac
48  2017 Analysis of the inhibitors of apoptosis identifies BIRC3 as a facilitator of malignant progression in glioma. HGG, LGG, MT
49  2017 Anticancer Effects of Salvia miltiorrhiza Alcohol Extract on Oral Squamous Carcinoma Cells. OSCC
50  2017 Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-kappaB signaling by degrading TRAF2-associated cIAP1 in cancer cells. BIR3, cIAP1, TNF
51  2017 c-Myc-InducedSurvivinIsEssentialforPromoting theNotch-DependentTCellDifferentiationfrom HematopoieticStemCells. DN
52  2017 Cellular inhibitor of apoptosis protein 2 promotes the epithelial-mesenchymal transition in triple-negative breast cancer cells through activation of the AKT signaling pathway. EMT, MET, TNBC
53  2017 Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells. ---
54  2017 Correlation between E-cadherin interactions, survivin expression, and apoptosis in MDCK and ts-Src MDCK cell culture models. NAC, PL, ROS
55  2017 Dietary myo-inositol deficiency decreased the growth performances and impaired intestinal physical barrier function partly relating to nrf2, jnk, e2f4 and mlck signaling in young grass carp (Ctenopharyngodon idella). APAF-1, bax, Bcl-2, E2F4, fasL, GST, jnk, Keap1, Mcl-1, MDA, MLCK, nrf2, PC, PI, PWG, ROS, ZO
56  2017 Diverse ubiquitin linkages regulate RIP kinases-mediated inflammatory and cell death signaling. ---
57  2017 Hyperosmotic stress enhances cytotoxicity of SMAC mimetics. SM, Smac, TNF
58  2017 Identification of mTOR as a primary resistance factor of the IAP antagonist AT406 in hepatocellular carcinoma cells. HCC
59  2017 Inhibitors of apoptosis: clinical implications in cancer. ---
60  2017 Knockdown of PARP6 or survivin promotes cell apoptosis and inhibits cell invasion of colorectal adenocarcinoma cells. PARPs
61  2017 Molecular Alliance of Lymantria dispar Multiple Nucleopolyhedrovirus and a Short Unmodified Antisense Oligonucleotide of Its Anti-Apoptotic IAP-3 Gene: A Novel Approach for Gypsy Moth Control. LdMNPV, RING
62  2017 Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model. IFN-gamma, RMS, SMCs, TWEAK
63  2017 Racial differences in the expression of inhibitors of apoptosis (IAP) proteins in extracellular vesicles (EV) from prostate cancer patients. EV, EV, IAPs
64  2017 RNA interference in the Asian Longhorned Beetle:Identification of Key RNAi Genes and Reference Genes for RT-qPCR. ALB, dsRBP, dsRNA, RNAi
65  2017 Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma. SMCs
66  2017 Smac Mimetics to Therapeutically Target IAP Proteins in Cancer. ---
67  2017 Subcellular Localization of Survivin Determines Its Function in Cardiomyocytes. SVV
68  2017 Survivin and gynaecological tumours. ---
69  2017 Targeting survivin suppresses proliferation and invasion of retinoblastoma cells in vitro and in vivo. Rb
70  2017 The HtrA2 Drosophila model of Parkinson's disease is suppressed by the pro-survival Bcl-2 Buffy. HtrA2, PD
71  2017 The Smac Mimetic BV6 Improves NK Cell-Mediated Killing of Rhabdomyosarcoma Cells by Simultaneously Targeting Tumor and Effector Cells. NK, RMS, SM, TRAIL
72  2017 Therapeutic targeting of necroptosis by Smac mimetic bypasses apoptosis resistance in acute myeloid leukemia cells. AML, TNF-alpha, TNFR1
73  2017 Thioredoxin-1 attenuates sepsis-induced cardiomyopathy after cecal ligation and puncture in mice. HO-1, Trx-1, TXNIP, WTCLP, WTS
74  2017 Transfection with Livin and Survivin shRNA inhibits the growth and proliferation of non‑small cell lung cancer cells. sh
75  2017 Un-methylation of the survivin gene has no effect on immunohistochemical expression of survivin protein in lung cancer patients with squamous cell carcinoma. ---
76  2016 A novel Smac mimetic APG-1387 demonstrates potent antitumor activity in nasopharyngeal carcinoma cells by inducing apoptosis. NPC
77  2016 A Phase I Dose-Escalation Study Evaluating the Safety Tolerability and Pharmacokinetics of CUDC-427, a Potent, Oral, Monovalent IAP Antagonist, in Patients with Refractory Solid Tumors. AE, DLT, MCP-1, PBMC
78  2016 Association Between a Polymorphism (rs2071214) in Baculoviral IAP Repeat Containing 5 Gene (BIRC5) and Ischemic Stroke in Korean Population. BIRC5, CIs, ORs, SNPs
79  2016 Baculovirus Inhibitor-of-Apoptosis Op-IAP3 Blocks Apoptosis by Interaction with and Stabilization of a Host Insect Cellular IAP. BIR
80  2016 Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing. ---
81  2016 Characterization and functional analysis of two inhibitor of apoptosis genes in Zhikong scallop Chlamys farreri. ---
82  2016 Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis. BIR, FP, LTalpha, SAR, Smac, TNF
83  2016 Cotreatment with Smac mimetics and demethylating agents induces both apoptotic and necroptotic cell death pathways in acute lymphoblastic leukemia cells. 5-AC, ALL, cIAP, DAC, MLKL, RIP, TNF, XIAP
84  2016 Curcumin Induces Pancreatic Adenocarcinoma Cell Death Via Reduction of the Inhibitors of Apoptosis. ---
85  2016 Electrophilic Oxidation and [1,2]-Rearrangement of the Biindole Core of Birinapant. HBV
86  2016 IAPs: Mediators of Oncogenesis and Targets for Anticancer Therapy. NF-kappaB, NO
87  2016 Inhibitor of apoptosis proteins as intracellular signaling intermediates. cIAP
88  2016 Pellino-1 confers chemoresistance in lung cancer cells by upregulating cIAP2 through Lys63-mediated polyubiquitination. ---
89  2016 Sensitization of acute lymphoblastic leukemia cells for LCL161-induced cell death by targeting redox homeostasis. ALL, BSO, ROS
90  2016 Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers. AML
91  2016 Smac mimetic triggers necroptosis in pancreatic carcinoma cells when caspase activation is blocked. MLKL, PC, RIP, RIPK3, Smac, TNF, TNFR1
92  2016 Survivin inhibition via EZN-3042 in canine lymphoma and osteosarcoma. OS
93  2016 Survivin is a guardian of the intestinal stem cell niche and its expression is regulated by TGF-beta. ---
94  2016 Survivin: a unique target for tumor therapy. ---
95  2016 Targeting cell death signalling in cancer: minimising 'Collateral damage'. ---
96  2016 Targeting Cell Survival Proteins for Cancer Cell Death. HSP
97  2016 Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics. SM, TNF
98  2015 A Phase I Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma. MTD, PK/PD, Smac
99  2015 Analysis of pro-apoptotic protein trafficking to and from mitochondria. AIF, EndoG
100  2015 Butein Shows Cytotoxic Effects and Induces Apoptosis in Human Ovarian Cancer Cells. MTP