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Abbreviation : IGF-IR
Long Form : IGF-I receptor
No. Year Title Co-occurring Abbreviation
2022 Assessment of androgen receptor, IGF-IR and insulin receptor expression in male patients with severe peripheral artery disease. AR, IR, PAD
2022 Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice. ECoG, IGF-I, LH
2022 It Takes Two to Tango: IGF-I and TSH Receptors in Thyroid Eye Disease. TED, TSHR
2022 Teprotumumab Divergently Alters Fibrocyte Gene Expression: Implications for Thyroid-associated Ophthalmopathy. HA, TAO
2020 Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans. BMMSCs, CGIs, DCN
2020 IGFBP-3/IGFBP-3 Receptor System as an Anti-Tumor and Anti-Metastatic Signaling in Cancer. IGFBP-3, TMEM219
2020 Mechanisms of putative IGF-I receptor resistance in active acromegaly. GH, IGF-I, S-Klotho
2020 New Insights from IGF-IR Stimulating Activity Analyses: Pathological Considerations. GPCR, IGF-I, IGF-II, RTKs
2020 Pregnancy-associated plasma proteins and Stanniocalcin-2 - Novel players controlling IGF-I physiology. IGFBPs, PAPP-A, STC2
10  2020 Targeting the IGF-Axis for Cancer Therapy: Development and Validation of an IGF-Trap as a Potential Drug. IGF, IR, KIRA
11  2019 Carthamus tinctorius L. extract activates insulin-like growth factor-I receptor signaling to inhibit FAS-death receptor pathway and suppress lipopolysaccharides-induced H9c2 cardiomyoblast cell apoptosis. IGF-I, LPS, TNF-alpha
12  2019 Involvement and expression of growth hormone/insulin-like growth factor member mRNAs in the ovarian development of turbot (Scophthalmus maximus). Atre, Evtg, GH, ghr, GSI, HSI, IGF, Mig-nucl, VTG
13  2019 Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice. IGF-I
14  2019 Regulation of IGF-I by IGFBP3 and IGFBP5 during odontoblast differentiation in mice. IGF-I, IGFBP, iOB, mOB, preOB
15  2019 Splenic serum from portal hypertensive patients enhances liver stem cell proliferation and self-renewal via the IGF-II/ERK signaling pathway. FLSCs, IGF, LSCs, PH
16  2018 Induction of uterine hyperplasia after cafeteria diet exposure. ERalpha, IGF-I
17  2018 Insulin-like Growth Factor I Receptor: A Novel Target for Hepatocellular Carcinoma Gene Therapy. HCC, IGF
18  2018 Insulin-like growth factor-I induces chemoresistence to docetaxel by inhibiting miR-143 in human prostate cancer. IGF-I, IRS-1, VEGF
19  2018 IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line. IGFs, IRSs, siRNA, USP9X
20  2018 Serum from Chronic Hepatitis B Patients Promotes Growth and Proliferation via the IGF-II/IGF-IR/MEK/ERK Signaling Pathway in Hepatocellular Carcinoma Cells. HBV, HCC, HDs, HRP-2, IGF, NUPR1, siRNA
21  2017 A network of insulin peptides regulate glucose uptake by astrocytes: Potential new druggable targets for brain hypometabolism. GluT1, IGF-I
22  2017 Effects of Prednisolone on Serum and Tissue Fluid IGF-I Receptor Activation and Post-Receptor Signaling in Humans. IGF-I, IGFBPs, PAPP-A, SBF, STC2
23  2017 IGF-I regulates HT1080 fibrosarcoma cell migration through a syndecan-2/Erk/ezrin signaling axis. HS, SDC2
24  2017 Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor. GIP, IRs
25  2016 Inflammation Promotes Expression of Stemness-Related Properties in HBV-Related Hepatocellular Carcinoma. GFP, HBV-HCC, HCC, IGF-I, inflamed-CM, MCP-1, OCT4, PPP, SP
26  2016 PAPP-A, IGFBP-4 and IGF-II are secreted by human adipose tissue cultures in a depot-specific manner. IGFBP-4, PAPP-A
27  2016 Potency of Full-Length MGF to Induce Maximal Activation of the IGF-I R Is Similar to Recombinant Human IGF-I at High Equimolar Concentrations. full-length MGF, HI, IGF-I, IRB, KIRA, MGF
28  2016 Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells. GPER, IGF-I
29  2016 The IGF-Axis and Diabetic Retinopathy Before and After Gastric Bypass Surgery. DR, IGF-I, IGFBP, LGB, T2D
30  2016 The insulin-like growth factor system in multiple myeloma: diagnostic and therapeutic potential. BM, IGF, IGFBPs, MM
31  2015 Cross-Talk between Adiponectin and IGF-IR in Breast Cancer. IGF-I
32  2015 Effect of insulin-like growth factor-I during the early postnatal period in intrauterine growth-restricted rats. IGF-I, IGFBP, IUGR, PND, PSS, rh
33  2015 IGF-I Signaling in Osterix-Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development. CCs, IPCs, OBs, Osx, PHCs, SOC, VEGF
34  2015 IGF-IR Targeted Therapy: Past, Present and Future. IGF-II, IR-A
35  2015 Influence of the toxicity of cryoprotective agents on the involvement of insulin-like growth factor-I receptor in surf clam (Spisula sachalinensis) larvae. CPAs, IGF-I
36  2015 Myostatin and IGF-I signaling in end-stage human heart failure: a qRT-PCR study. ActRIIB, ICM, IGF-I, Mstn
37  2015 PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma. IGF, IGFBP, PAPP-A
38  2015 The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins. IGFs, IR, IRSs
40  2015 Transforming growth factor-beta, insulin-like growth factor I/insulin-like growth factor I receptor and vascular endothelial growth factor-A: prognostic and predictive markers in triple-negative and non-triple-negative breast cancer. IGF-I, TGF-beta1, VEGFA
41  2014 Branched chain amino acid suppressed insulin-initiated proliferation of human cancer cells through induction of autophagy. BCAA, BECN1, IGF, qRT-PCR
42  2014 Decorin differentially modulates the activity of insulin receptor isoform A ligands. IR-A
43  2014 Decreased insulin-like growth factor-I and its receptor expression in the hippocampus and somatosensory cortex of the aged mouse. IGF-I
44  2014 Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders. ASDs, IGF-I, mTOR, PI3K, TSC1
45  2014 IGF-I and IGF-I receptor polymorphisms among elite swimmers. ---
46  2014 Immunolocalization of insulin-like growth factor-I (IGF-I) and its receptors (IGF-IR) in the equine epididymis. IGF-I, IHC
47  2014 Insulin and IGF-I actions on IGF-I receptor in seminiferous tubules from immature rats. ---
48  2014 Insulin-like growth factor I regulates the expression of isoforms of Wilms' tumor 1 gene in breast cancer. IGF-I, WT1
49  2014 Insulin-like growth factor-I regulates LH release by modulation of kisspeptin and NMDA-mediated neurotransmission in young and middle-aged female rats. NMDA
50  2014 Kaempferol Downregulates Insulin-like Growth Factor-I Receptor and ErbB3 Signaling in HT-29 Human Colon Cancer Cells. ERK, HRG, IGF, PI3K
51  2014 Lactoferrin inhibits apoptosis through insulin-like growth factor I in primary rat osteoblasts. bLF, IGF-I
52  2014 MEDI-573, alone or in combination with mammalian target of rapamycin inhibitors, targets the insulin-like growth factor pathway in sarcomas. IGF, IRA, mTORi
53  2014 Metformin inhibits androgen-induced IGF-IR up-regulation in prostate cancer cells by disrupting membrane-initiated androgen signaling. AR, CREB, CRTC2
54  2014 Surface-expressed insulin receptors as well as IGF-I receptors both contribute to the mitogenic effects of human insulin and its analogues. IR
55  2014 Thyroid hormone inhibition in L6 myoblasts of IGF-I-mediated glucose uptake and proliferation: new roles for integrin alphavbeta3. IGF-I
56  2013 Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development. IGF-I
57  2013 Caveolin-1 and polymerase I and transcript release factor: new players in insulin-like growth factor-I receptor signaling. Cav-1, PTRF
58  2013 Circulating IgGs may modulate IGF-I receptor stimulating activity in a subset of patients with Graves' ophthalmopathy. GO, TBIIs
59  2013 Concentrations of insulin glargine and its metabolites during long-term insulin therapy in type 2 diabetic patients and comparison of effects of insulin glargine, its metabolites, IGF-I, and human insulin on insulin and igf-I receptor signaling. GLA, IR
60  2013 Conditional VHL gene deletion causes hypoglycemic death associated with disproportionately increased glucose uptake by hepatocytes through an upregulated IGF-I receptor. GLUT, IGF-I, RACK, VHL-KO
61  2013 Dichotomy of decorin activity on the insulin-like growth factor-I system. IGF
62  2013 Effect of whole-body vibration and insulin-like growth factor-I on muscle paralysis-induced bone degeneration after botulinum toxin injection in mice. Akt, BTX, IGF-I, WBV
63  2013 Effects of insulin, insulin-like growth factor-I and -II on proliferation and intracellular signaling in endometrial carcinoma cells with different expression levels of insulin receptor isoform A. ERK, IGF, IR-A
64  2013 Functional collaboration of insulin-like growth factor-1 receptor (IGF-1R), but not insulin receptor (IR), with acute GH signaling in mouse calvarial cells. CR, GHR, IGF-1R, IR, JAK2, STAT5
65  2013 Growth hormone potentiates 17beta-estradiol-dependent breast cancer cell proliferation independently of IGF-I receptor signaling. ---
66  2013 IGF-I in human growth: lessons from defects in the GH-IGF-I axis. IUGR
67  2013 IGF-I signaling is essential for FSH stimulation of AKT and steroidogenic genes in granulosa cells. GCs, PKB
68  2013 Implication of insulin receptor A isoform and IRA/IGF-IR hybrid receptors in the aortic vascular smooth muscle cell proliferation: role of TNF-alpha and IGF-II. IR, IRA, IRB, TNFR1, VSMCs
69  2013 Insulin receptor phosphorylation by endogenous insulin or the insulin analog AspB10 promotes mammary tumor growth independent of the IGF-I receptor. IR
70  2013 Insulin-like growth factor binding protein-4 and -5 modulate ligand-dependent estrogen receptor-alpha activation in breast cancer cells in an IGF-independent manner. ERalpha, IGFBPs, IGFs
71  2013 Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. an interplay with E-cadherin. IR
72  2013 Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners. IGFs, USC
73  2013 MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors. EGFR, IGF
74  2013 New Modulators for IGF-I Activity within IGF-I Processing Products. IGF-I
75  2013 Pharmacodynamic and antineoplastic activity of BI 836845, a fully human IGF ligand-neutralizing antibody, and mechanistic rationale for combination with rapamycin. IGF
76  2013 Silencing the mannose 6-phosphate/IGF-II receptor differentially affects tumorigenic properties of normal breast epithelial cells. ---
77  2013 Sustained production of a soluble IGF-I receptor by gutless adenovirus-transduced host cells protects from tumor growth in the liver. sIGFIR
78  2013 Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro. IGF-I, mTOR, RCC
79  2013 The pro-forms of insulin-like growth factor I (IGF-I) are predominant in skeletal muscle and alter IGF-I receptor activation. IGF-I
80  2012 A stimulatory thyrotropin receptor antibody enhances hyaluronic acid synthesis in graves' orbital fibroblasts: inhibition by an IGF-I receptor blocking antibody. bTSH, GO, HA, TRAb
81  2012 Aflatoxin B1 up-regulates insulin receptor substrate 2 and stimulates hepatoma cell migration. AFB1, IRS
82  2012 Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats. DM-EX, IGF I, PI3K, STZ
83  2012 Exogenous GLP-2 and IGF-I induce a differential intestinal response in IGF binding protein-3 and -5 double knockout mice. GLP-2, IGFBP, KO, WT
84  2012 Growth cartilage expression of growth hormone/insulin-like growth factor I axis in spontaneous and growth hormone induced catch-up growth. GH, GHR, GP, IGFBP5
85  2012 Identification of common and distinctive mechanisms of resistance to different anti-IGF-IR agents in Ewing's sarcoma. ---
86  2012 IGF-IR signaling attenuates the age-related decline of diastolic cardiac function. IGF-I
87  2012 Insulin-like growth factor-I regulates the neonatal immune response in infection and maturation by suppression of IFN-gamma. CBMC, IGF-I
88  2012 Interstitial fluid contains higher in vitro IGF bioactivity than serum: a study utilizing the suction blister technique. IGFBP, IGFs, SBF, WIB, WLB
89  2012 Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation. IRS
90  2012 Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation. IGF-I, IGFs, IRS, PI3K
91  2012 Proinsulin binds with high affinity the insulin receptor isoform A and predominantly activates the mitogenic pathway. IR
92  2012 Targeting the insulin-like growth factor axis for the development of novel therapeutics in oncology. IGF, IR-A, IR-B
93  2011 Differential effects of IGF-I, IGF-II and insulin in human preadipocytes and adipocytes--role of insulin and IGF-I receptors. HR, IR
94  2011 Effects of the phytoestrogen genistein on the porcine anterior pituitary insulin-like growth factor system. AP, IGF, IGFBP, IM, LH
95  2011 Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner. INSR
96  2011 Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation. SMCC
97  2011 Expression of insulin-like growth factor (IGF) family members in porcine pregnancy. gd, IGF
98  2011 Expression of insulin-like growth factor I receptors at mRNA and protein levels during metamorphosis of Japanese flounder (Paralichthys olivaceus). IGF-I
99  2011 IGF-I stimulates cooperative interaction between the IGF-I receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells. CTK, SHPS-1
100  2011 Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation. ALP, BMP-2, DKK1, Dlx5, DPD, GSK-3beta, IDDM, IGF-I, Sost, STZ, TRAP