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Abbreviation : IMCD
Long Form : inner medullary collecting duct
No. Year Title Co-occurring Abbreviation
2020 Aldosterone Decreases Vasopressin-Stimulated Water Reabsorption in Rat Inner Medullary Collecting Ducts. AQP2
2020 Berberine ameliorates lipopolysaccharide‑induced inflammatory responses in mouse inner medullary collecting duct‑3 cells by downregulation of NF‑kappaB pathway. BBR, IL, LPS, NF
2020 Bilateral ureteral obstruction is rapidly accompanied by ER stress and activation of autophagic degradation of IMCD proteins, including AQP2. AQP2, BUO
2020 Nanoscale Mapping Reveals Functional Differences in Ion Channels Populating the Membrane of Primary Cilia. SICM
2020 Prostaglandin E2 receptor EP1 (PGE2/EP1) deletion promotes glomerular podocyte and endothelial cell injury in hypertensive TTRhRen mice. HKD, Htn, TAL, WT
2019 Atg7-dependent canonical autophagy regulates the degradation of aquaporin 2 in prolonged hypokalemia. AQP2
2019 Claudin 19 Is Regulated by Extracellular Osmolality in Rat Kidney Inner Medullary Collecting Duct Cells. ---
2019 Hydrogen sulfide upregulates renal AQP-2 protein expression and promotes urine concentration. AOAA, AQP, CBS, CSE, NDI, PPG, V2R
2019 Identification of matrix physicochemical properties required for renal epithelial cell tubulogenesis by using synthetic hydrogels. ECM
10  2019 Identification of NFAT5 as a transcriptional regulator of the EDN1 gene in collecting duct. ET-1
11  2019 Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC. ENaC, NO, UTs, WT
12  2019 Modulation of reninangiotensin system components by high glucose levels in the culture of collecting duct cells. ACE, Ang II, DN, HG, RAS
13  2019 Oxalate induces type II epithelial to mesenchymal transition (EMT) in inner medullary collecting duct cells (IMCD) in vitro and stimulate the expression of osteogenic and fibrotic markers in kidney medulla in vivo. EMT, HPL, Ox
14  2019 Role of PKC and AMPK in hypertonicity-stimulated water reabsorption in rat inner medullary collecting ducts. AMPK, AQP2, PDBu, PKC
15  2019 Site-1 protease-derived soluble (pro)renin receptor targets vasopressin receptor 2 to enhance urine concentrating capability. AQP2, AVP, CD, pro, S1P-derived
16  2019 Vasopressin Increases Urinary Acidification via V1a Receptors in Collecting Duct Intercalated Cells. V1aR
17  2019 Vasopressin-Independent Regulation of Aquaporin-2 by Tamoxifen in Kidney Collecting Ducts. AQP2, AVP, NDI, TAM, UUO, V2R
18  2018 An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells. AQP2, GEFs
19  2018 Bile Acid G Protein-Coupled Membrane Receptor TGR5 Modulates Aquaporin 2-Mediated Water Homeostasis. AQP2, FXR, LCA, NDI
20  2018 Chronic lithium treatment induces novel patterns of pendrin localization and expression. ICs, PCs
21  2018 Identification of UT-A1- and AQP2-interacting proteins in rat inner medullary collecting duct. AQP2
22  2018 PGE2 EP1 receptor inhibits vasopressin-dependent water reabsorption and sodium transport in mouse collecting duct. Htn, WT
23  2018 Proteomic determination of the lysine acetylome and phosphoproteome in the rat native inner medullary collecting duct. ---
24  2018 Sequence-based searching of custom proteome and transcriptome databases. cdbBLAST
25  2018 Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/beta-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection. LPS, TLR4
26  2017 Ecstasy induces reactive oxygen species, kidney water absorption and rhabdomyolysis in normal rats. Effect of N-acetylcysteine and Allopurinol in oxidative stress and muscle fiber damage. ALLO, AQP2, Ec, HN, Li, NAC, OS, ROS, SIADH
27  2017 Hypercalcemia induces targeted autophagic degradation of aquaporin-2 at the onset of nephrogenic diabetes insipidus. NDI
28  2017 Identification of beta-catenin-interacting proteins in nuclear fractions of native rat collecting duct cells. ChIP-MS, TF
29  2017 Impaired AQP2 trafficking in Fxyd1 knockout mice: A role for FXYD1 in regulated vesicular transport. AQP2
30  2017 MiR-21 Regulates TNF-alpha-Induced CD40 Expression via the SIRT1-NF-kappaB Pathway in Renal Inner Medullary Collecting Duct Cells. Ac-p65, miR-21, siRNA, SIRT1
31  2017 Periostin-binding DNA aptamer treatment attenuates renal fibrosis under diabetic conditions. PA, TGF-beta1
32  2017 Roflumilast and aquaporin-2 regulation in rat renal inner medullary collecting duct. AQP2, NDI, RNO
33  2017 Role for reactive oxygen species in flow-stimulated inner medullary collecting duct endothelin-1 production. ET-1, NO, NOX, ROS
34  2017 SIRT1 regulates lipopolysaccharide-induced CD40 expression in renal medullary collecting duct cells by suppressing the TLR4-NF-kappaB signaling pathway. LPS, p-NF-kappaB p65, PDTC, siRNA, SIRT1, TLR4
35  2017 Sustained hyperosmolarity increses TGF-ss1 and Egr-1 expression in the rat renal medulla. ---
36  2016 4-PBA improves lithium-induced nephrogenic diabetes insipidus by attenuating ER stress. 4-PBA, AQP2, BiP, ER, NDI
37  2016 Depletion of vacuolar protein sorting-associated protein 35 is associated with increased lysosomal degradation of aquaporin-2. AQP2, DDAVP, LAMP1, VPS35
38  2016 High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression. CDET-1KO, ET-1, ETB, NO, NOS1, VEETKO
39  2016 Low-dose paclitaxel ameliorates renal fibrosis by suppressing transforming growth factor-beta1-induced plasminogen activator inhibitor-1 signaling. alpha-SMA, JNK, PAI-1, TGF-beta1, UUO
40  2016 Modulation of kidney urea transporter UT-A3 activity by alpha2,6-sialylation. Con A, GlcNAc, GNL, Man, PKC, polyLacNAc
41  2016 Proteomic profiling of nuclear fractions from native renal inner medullary collecting duct cells. NE, NP
42  2016 Sirtuin1 (SIRT1) Regulates Tumor Necrosis Factor-alpha (TNF-alpha-Induced) Aquaporin-2 (AQP2) Expression in Renal Medullary Collecting Duct Cells Through Inhibiting the NF-kappaB Pathway. AQP2, PDTC, siRNA, SIRT1, TNF-alpha
43  2016 Transgenic Restoration of Urea Transporter A1 Confers Maximal Urinary Concentration in the Absence of Urea Transporter A3. UT-A1, UT-A3
44  2015 Activation of protein kinase Calpha increases phosphorylation of the UT-A1 urea transporter at serine 494 in the inner medullary collecting duct. PDBu
45  2015 Autophagic degradation of aquaporin-2 is an early event in hypokalemia-induced nephrogenic diabetes insipidus. NDI
46  2015 Biopsy proven medullary sponge kidney: clinical findings, histopathology, and role of osteogenesis in stone and plaque formation. MSK
47  2015 Cyclophosphamide-induced vasopressin-independent activation of aquaporin-2 in the rat kidney. 4-HC, AQP2, NKCC2, NSIAD, V2R
48  2015 Dexamethasone increases aquaporin-2 protein expression in ex vivo inner medullary collecting duct suspensions. AQP2
49  2015 Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts. AQP2, PGE2
50  2015 Extracellular pH affects phosphorylation and intracellular trafficking of AQP2 in inner medullary collecting duct cells. AQP2
51  2015 Insulin regulates nitric oxide production in the kidney collecting duct cells. BP, DAF-FM, eNOS, IGF-1R, mIMCD
52  2015 Regulation of calcium reabsorption along the rat nephron: a modeling study. MTAL, TRPV5
53  2015 Vasopressin regulation of multisite phosphorylation of UT-A1 in the inner medullary collecting duct. UT
54  2014 Angiotensin II increases the expression of (pro)renin receptor during low-salt conditions. Ang II, LS, NS
55  2014 Biochemical properties of urea transporters. Epac, PKA, UT
56  2014 Early targets of lithium in rat kidney inner medullary collecting duct include p38 and ERK1/2. ---
57  2014 Epoxyeicosatrienoic acids attenuating hypotonic-induced apoptosis of IMCD cells via gamma-ENaC inhibition. EETs
58  2014 Renal medullary cyclooxygenase-2 and (pro)renin receptor expression during angiotensin II-dependent hypertension. BP, COX-2, GFR, MABP, RBF
59  2014 Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters. UT
60  2013 Activation of liver X receptors reduces CFTR-mediated Cl(-) transport in kidney collecting duct cells. LXRs, MDCK
61  2013 Culturing primary rat inner medullary collecting duct cells. AQP2, AVP, V2R
62  2013 Distinct regulation of inner medullary collecting duct nitric oxide production from mice and rats. NO
63  2013 New advances in urea transporter UT-A1 membrane trafficking. ---
64  2013 Sex differences in ET-1 receptor expression and Ca2+ signaling in the IMCD. ET-1
65  2013 Urine concentration in the diabetic mouse requires both urea and water transporters. AQP2, STZ, WT
66  2013 [Nle3,d-Phe6 ]-gamma2 -melanocyte-stimulating hormone possesses the renal excretory but not the cardiovascular actions of the native gamma2 -melanocyte-stimulating hormone in anaesthetized rats. GFR, MAP
67  2012 3D spheroid defects in NPHP knockdown cells are rescued by the somatostatin receptor agonist octreotide. NPHP
68  2012 CD98 increases renal epithelial cell proliferation by activating MAPKs. CD98hc, HATs, Lats
69  2012 Extracellular signal-regulated kinases 1/2 signaling pathways are not involved in endothelin regulation of mouse inner medullary collecting duct nitric oxide production. ET-1, mIMCD-3, NO
70  2012 Molecular mechanisms of urea transport in health and disease. ---
71  2012 Patterns of gene and metabolite define the effects of extracellular osmolality on kidney collecting duct. BCAA
72  2012 Protein kinase C-alpha mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct. PKC
73  2012 Renal involvement in leptospirosis: the effect of glycolipoprotein on renal water absorption. GLPc, VP
74  2012 Toll-like receptor 4 activates NF-kappaB and MAP kinase pathways to regulate expression of proinflammatory COX-2 in renal medullary collecting duct cells. COX, EGFR, TLR4
75  2012 Vasopressin V2R-targeting peptide carrier mediates siRNA delivery into collecting duct cells. V2R
76  2011 Bilateral ureteral obstruction induces early downregulation and redistribution of AQP2 and phosphorylated AQP2. AQP2, AQP2pS256, BUO
77  2011 Developmental immunolocalization of heat shock protein 70 (HSP70) in epithelial cell of rat kidney. HSP70
78  2011 Distinct distribution of GLUT4 and insulin regulated aminopeptidase in the mouse kidney. AQP2
79  2011 Dynamin activates NO production in rat renal inner medullary collecting ducts via protein-protein interaction with NOS1. DNM, NOS
80  2011 Enhanced expression of epithelial sodium channels in the renal medulla of Dahl S rats. ENaC
81  2011 Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells. AQP2, FSS
82  2011 Glucocorticoids improve renal responsiveness to atrial natriuretic peptide by up-regulating natriuretic peptide receptor-A expression in the renal inner medullary collecting duct in decompensated heart failure. ANP, DEX, GR, NPR-A
83  2011 Mechanisms of vasopressin-induced intracellular Ca2+ oscillations in rat inner medullary collecting duct. AVP, cADPR, RyRs
84  2011 N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct. AQP2, NMDARs, sh
85  2011 Novel regulation of endothelin-1 promoter activity by protein kinase C. ET-1, PKC, PMA
86  2011 Regulation of renal urea transport by vasopressin. UT-A1
87  2011 Role of NH3 and NH4+ transporters in renal acid-base transport. Rhbg, Rhcg
88  2010 A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. PDMS
89  2010 Carbamazepine can induce kidney water absorption by increasing aquaporin 2 expression. DI, Li
90  2010 Constructing kidney-like tissues from cells based on programs for organ development: toward a method of in vitro tissue engineering of the kidney. MM, UB, WD
91  2010 Cyclosporin-A induced toxicity in rat renal collecting duct cells: interference with enhanced hypertonicity induced apoptosis. CsA, TonEBP
92  2010 Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11beta-HSD activity. ALDO, CTGF, IRPTC, MR
93  2010 Identification of two nuclear factor of activated T-cells (NFAT)-response elements in the 5'-upstream regulatory region of the ET-1 promoter. NFAT
94  2010 Phosphoproteomic profiling reveals vasopressin-regulated phosphorylation sites in collecting duct. PKA
95  2010 Protein kinase C regulates urea permeability in the rat inner medullary collecting duct. PDBu, PKC
96  2010 Quantitative analysis of aquaporin-2 phosphorylation. APM, AQP2
97  2010 Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase. AQP2, AVP, HEK, p38 MAPK, PKA, V2R
98  2010 The N-terminal 81-aa fragment is critical for UT-A1 urea transporter bioactivity. ENaC
99  2010 Vasopressin increases phosphorylation of Ser84 and Ser486 in Slc14a2 collecting duct urea transporters. DDAVP
100  2009 A test of the hypothesis that the collecting duct calcium-sensing receptor limits rise of urine calcium molarity in hypercalciuric calcium kidney stone formers. CaSR