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Abbreviation : IbTX
Long Form : iberiotoxin
No. Year Title Co-occurring Abbreviation
2022 Inhibition of BKCa channels protects neonatal hearts against myocardial ischemia and reperfusion injury. IR, NCM
2021 Activation of TRPV4 channels leads to a consistent tocolytic effect on human myometrial tissues. AUC
2021 Estrogen-dependent KCa1.1 modulation is essential for retaining neuroexcitation of female-specific subpopulation of myelinated Ah-type baroreceptor neurons in rats. AP, BRNs, OVI
2021 Large-Conductance Calcium-Activated Potassium Channels and Voltage-Dependent Sodium Channels in Human Cementoblasts. HCEM, TEA
2020 Activation of BK Channel Contributes to PL-Induced Mesenchymal Stem Cell Migration. MSCs, PL, rMSCs
2020 Glucose fluctuations promote vascular BK channels dysfunction via PKCalpha/NF-kappaB/MuRF1 signaling. C-DM, MuRF1, NAC, NF, PKC, ROS, U-DM
2020 Hydrogen Sulfide Relaxes Human Uterine Artery via Activating Smooth Muscle BKCa Channels. hUASMC, SM, UA
2020 Macrovascular Protecting Effects of Berberine through Anti-inflammation and Intervention of BKCa in Type 2 Diabetes Mellitus Rats. CRP, IL-6, PE, SNP, T2DM, TGF-beta1, TNF-alpha, VSMCs
2019 Activation of the Large-Conductance, Voltage, and Ca2+- Activated K+ (BK) Channel in Acute Spinal Cord Injury in the Wistar Rat Is Neuroprotective. ISO, SCI
10  2019 BKCa compensates impaired coronary vasoreactivity through RhoA/ROCK pathway in hind-limb unweighted rats. HU, MLC, RCA, RhoA
11  2019 Endothelium-independent vasodilator effects of nobiletin in rat aorta. KATP, PE
12  2019 Glucose-mediated inhibition of calcium-activated potassium channels limits alpha-cell calcium influx and glucagon secretion. AP, GCG
13  2019 Naringin and Naringenin Relax Rat Tracheal Smooth by Regulating BKCa Activation. CCh, CVA
14  2019 Participation of PKG and PKA-related pathways in the IFN-gamma induced modulation of the BKCa channel activity in human cardiac fibroblasts. IFN, PKA, PKG
15  2019 The Cannabinoid-Like Compound, VSN16R, Acts on Large Conductance, Ca2+-Activated K+ Channels to Modulate Hippocampal CA1 Pyramidal Neuron Firing. 7-Pra-MarTx, AP, fAHP, ISI
16  2019 Zileuton, a 5-Lipoxygenase Inhibitor, Exerts Anti-Angiogenic Effect by Inducing Apoptosis of HUVEC via BK Channel Activation. 5-LO, Erg, HUVECs, NO, VEGF
17  2018 Cell Cycle Regulation by Ca2+-Activated K⁺ (BK) Channels Modulators in SH-SY5Y Neuroblastoma Cells. PAX, RESV
18  2018 Contribution of BKCa channels to vascular tone regulation by PDE3 and PDE4 is lost in heart failure. cAMP, CIL, HF, ISO
19  2018 Existence of nicotinic receptors in a subset of type I vestibular hair cells of guinea pigs. ACh, alpha-BTX, dTC, MEC, nAChRs, VHCs
20  2018 Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis. FLSs, RA
21  2018 The large-conductance voltage- and Ca2+ -activated K+ channel and its γ1-subunit modulate mouse uterine artery function during pregnancy. UA, WT
22  2018 [Downregulation of large conductance calcium-activated potassium channels in paraventricular nucleus contributes to sympathoexcitation in rats with chronic heart failure]. CHF, NE, NT-proBNP, PVN, RSNA
23  2017 Chronic glucocorticoid exposure activates BK-NLRP1 signal involving in hippocampal neuron damage. AD, DEX, GC, ISE, MAP2, NOD, PD
24  2017 Electrophysiological properties of strial pericytes and the effect of aspirin on pericyte K+ channels. Kv
25  2017 Large conductance voltage and Ca2+-activated K+ channels affect the physiological characteristics of human urine-derived stem cells. hUSCs
26  2017 Urothelial MaxiK-activity regulates mucosal and detrusor metabolism. ---
27  2016 Calycosin and Formononetin Induce Endothelium-Dependent Vasodilation by the Activation of Large-Conductance Ca2+-Activated K+ Channels (BKCa). ChTX, eNOS, HUVECs, nNOS, NO, NOS, TEACl
28  2016 Effectors of large-conductance calcium-activated potassium channel modulate glutamate excitotoxicity in organotypic hippocampal slice cultures. ---
29  2016 Properties and physiological function of Ca2+-dependent K+ currents in uniglomerular olfactory projection neurons. Ca, CTX, uPNs
30  2016 [Effects 'of beta3 adrenoceptors on the contractility of rat thoracic aorta smooth muscle and the mechanism]. PRA, PSS
31  2015 Caveolar disruption causes contraction of rat femoral arteries via reduced basal NO release and subsequent closure of BKCa channels. MbetaCD, SMC
32  2015 Insulin increases glomerular filtration barrier permeability through PKGIalpha-dependent mobilization of BKCa channels in cultured rat podocytes. PKGI
33  2015 KCa1.1 is potential marker for distinguishing Ah-type baroreceptor neurons in NTS and contributes to sex-specific presynaptic neurotransmission in baroreflex afferent pathway. EPSCs
34  2014 BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway. ---
35  2014 Cellular mechanism underlying hydrogen sulfide induced mouse tracheal smooth muscle relaxation: role of BKCa. l-Cys, OVA, TSM
36  2014 Emerging role of the calcium-activated, small conductance, SK3 K+ channel in distal tubule function: regulation by TRPV4. CCD, CNT, ICs, PCs
37  2014 Enhanced large conductance K+ channel activity contributes to the impaired myogenic response in the cerebral vasculature of Fawn Hooded Hypertensive rats. FHH, MCAs, MR, RNO1, VSMCs
38  2014 The large conductance Ca(2+) -activated K(+) (BKCa) channel regulates cell proliferation in SH-SY5Y neuroblastoma cells by activating the staurosporine-sensitive protein kinases. MPE, TEA
39  2013 Characteristics of single large-conductance Ca2+-activated K+ channels and their regulation of action potentials and excitability in parasympathetic cardiac motoneurons in the nucleus ambiguus. AP, fAHP, NA, PCMNs, SFA
40  2013 Emerging role of calcium-activated potassium channel in the regulation of cell viability following potassium ions challenge in HEK293 cells and pharmacological modulation. ACTZ, BFT, ChTX, DCP, ETX, HCT, MTZ, QUERC, RESV, TEA
41  2013 Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. KCa
42  2013 Involvement of large-conductance Ca(2+) -activated K(+) channels in both nitric oxide and endothelium-derived hyperpolarization-type relaxation in human penile small arteries. EDH, NO
43  2013 Molecular interaction and functional coupling between type 3 inositol 1,4,5-trisphosphate receptor and BKCa channel stimulate breast cancer cell proliferation. ATP, BAPTA, CDK4, IP3R3, MTT, PLC, siRNAs, TEA
44  2013 Positions of beta2 and beta3 subunits in the large-conductance calcium- and voltage-activated BK potassium channel. Cys, mbeta3, TM
45  2013 [Impact of BKCa channel in prostate smooth muscle cells on the membrane potential in rats with chronic abacterial prostatitis]. CAP, PSMCs
46  2012 Dietary obesity increases NO and inhibits BKCa-mediated, endothelium-dependent dilation in rat cremaster muscle artery: association with caveolins and caveolae. ACh, Ca, L-NAME, NO, SNP
47  2012 Involvement of large conductance Ca(2+)-activated K (+) channel in laminar shear stress-induced inhibition of vascular smooth muscle cell proliferation. Ca, PCNA, SS, VSMC
48  2012 Oxytocin hyperpolarizes cultured duodenum myenteric intrinsic primary afferent neurons by opening BK(Ca) channels through IP₃ pathway. IPANs, LMMP, OT, OTR
49  2012 Role of the BK channel (KCa1.1) during activation of electrogenic K+ secretion in guinea pig distal colon. ---
50  2012 Suppression of human detrusor smooth muscle excitability and contractility via pharmacological activation of large conductance Ca2+-activated K+ channels. DSM
51  2012 The Ca2+-activated, large conductance K+-channel (BKCa) is a player in the LH/hCG signaling cascade in testicular Leydig cells. PhTx-2, StAR
52  2012 Unoprostone isopropyl and metabolite M1 activate BK channels and prevent ET-1-induced [Ca⁺]i increases in human trabecular meshwork and smooth muscle. cAMP, cAMP, ET-1, PASMC, PG
53  2012 Upregulation of endothelium-derived hyperpolarizing factor compensates for the loss of nitric oxide in mesenteric arteries of Dahl salt-sensitive hypertensive rats. ACh, BKCa, DS, EDHF, NO
54  2011 Bladder contractility is mediated by different K+ channels in the urothelium and detrusor smooth muscle. 4-AP, CCh, ChTX, DSM, Glib, UE
55  2011 Bladder Contractility Is Mediated by Different K+ Channels in the Urothelium and Detrusor Smooth Muscle. 4-AP, CCh, ChTX, DSM, Glib, UE
56  2011 KCa1.1 channel contributes to cell excitability in unmyelinated but not myelinated rat vagal afferents. ChTX, IB4
57  2011 Mechanisms involved in the nitric oxide-induced vasorelaxation in porcine prostatic small arteries. ACh, Ca, EFS, NANC, NO, ODQ
58  2011 Molecular and electrophysiological evidence for the expression of BK channels in oligodendroglial precursor cells. OPCs
59  2011 Reduction of large-conductance Ca(+) -activated K(+) channel with compensatory increase of nitric oxide in insulin resistant rats. ---
60  2011 Role of caveolin-1 in endothelial BKCa channel regulation of vasoreactivity. Ca, Cav-1, CH, EC, MBCD
61  2011 Unique properties of muscularis mucosae smooth muscle in guinea pig urinary bladder. SPCs
62  2011 Vascular ATP-sensitive potassium channels are over-expressed and partially regulated by nitric oxide in experimental septic shock. iNOS, NF-kappaB
63  2010 Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity. ACh, Ca, Cav-1, EDHF
64  2010 Different expression of large-conductance calcium-activated K+ channels in human internal mammary and radial arteries. 4-AP, IMA, RA, SMCs, TEA
65  2010 Differential involvement of potassium channel subtypes in early and late sepsis-induced hyporesponsiveness to vasoconstrictors. 4-AP, APA, CLP, GLB, TEA
66  2010 Effects of bladder outlet obstruction on properties of Ca2+-activated K+ channels in rat bladder. BOO, CTX
67  2010 Electro-pharmacological profile of a mitochondrial inner membrane big-potassium channel from rat brain. ChTX
68  2010 Endothelium-derived nitric oxide inhibits the relaxation of the porcine coronary artery to natriuretic peptides by desensitizing big conductance calcium-activated potassium channels of vascular smooth muscle. 8-bromo-cGMP, ANP, CNP, SNP
69  2010 Nitric oxide activation of a potassium channel (BK(Ca)) in feline lower esophageal sphincter. Ca, LES, NO, SNP, TTX
70  2010 Novel role of endothelial BKCa channels in altered vasoreactivity following hypoxia. Ca, CH, EC, VSM
71  2009 Activation of the BK(Ca) channel increases outflow facility and decreases trabecular meshwork cell volume. TM
72  2009 Ca2+-activated K+ current in freshly isolated c-Kit positive cells in guinea-pig stomach. ICC-MY, ICCs, STOCs, TEA
73  2009 Comparative roles of ATP-sensitive K+ channels and Ca2+-activated BK+ channels in posthypoxic hyperexcitability and rapid hypoxic preconditioning in hippocampal CA1 pyramidal neurons in vitro. GC, PS
74  2009 Heterogeneity in function of small artery smooth muscle BKCa: involvement of the beta1-subunit. SMCs, STOCs, VSM
75  2009 Inhibition of intestinal motility by the putative BK(Ca) channel opener LDD175. ACh, EFS
76  2009 NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels, enhances erectile responses in rats. ED, HUVECs, SMCs
77  2009 Role of KCNMA1 gene in breast cancer invasion and metastasis to brain. ---
78  2008 Aldosterone increases KCa1.1 (BK) channel-mediated colonic K+ secretion. ---
79  2008 Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel. beta-ARs, BK-KO, UBSM, WT
80  2008 Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries. 2-AG, CYP, DAG, GEETs, PE, PvN
81  2008 Iberiotoxin-sensitive large conductance Ca2+ -dependent K+ (BK) channels regulate the spike configuration in the burst firing of cerebellar Purkinje neurons. 4-AP, PCs
82  2008 Kaempferol stimulates large conductance Ca2+ -activated K+ (BKCa) channels in human umbilical vein endothelial cells via a cAMP/PKA-dependent pathway. ChTX, HUVECs, Kv
83  2008 NFATc3 regulates BK channel function in murine urinary bladder smooth muscle. NFAT, UBSM
84  2008 Potentiation of large conductance, Ca2+-activated K+ (BK) channels by alpha5beta1 integrin activation in arteriolar smooth muscle. ECM, FN
85  2008 Relaxing effects of 17(18)-EpETE on arterial and airway smooth muscles in human lung. EPA, Glyb, HPA, PUFA
86  2008 The relaxant effect of nifedipine in human uterine smooth muscle and the BK(Ca) channel. ANOVA, Ca, TEA
87  2008 [Electrophysiological properties of outward voltage-gated potassium channels of neural stem cells from adult rat hippocampus]. GFAP, NSCs, TEA
88  2007 BK potassium channels facilitate high-frequency firing and cause early spike frequency adaptation in rat CA1 hippocampal pyramidal cells. fAHP
89  2007 Cellular and molecular effects of unoprostone as a BK channel activator. ---
90  2007 Characterization of voltage-and Ca2+-activated K+ channels in rat dorsal root ganglion neurons. ChTX, CNS, DRG
91  2007 Functional effects of 20-HETE on human bronchi: hyperpolarization and relaxation due to BKCa channel activation. 20-HETE, AA, ASM, CYP-450
92  2007 Heat shock proteins and p53 play a critical role in K+ channel-mediated tumor cell proliferation and apoptosis. 4-AP, GLI, HSP, TEA, Tet
93  2007 Prostaglandin E2 enhances acetylcholine-induced, Ca2+-dependent ionic currents in swine tracheal mucous gland cells. ACh, PKA, PKI, Rp, SC, SMGC
94  2007 Relaxing effects of 5-oxo-ETE on human bronchi involve BK Ca channel activation. 5-oxo-ETE, AA, ASM, MCh
95  2007 [Feature of ACh-sensitive potassium current in outer hair cells of guinea pig cochlea]. GABA
96  2006 Heterogeneous Kv1 function and expression in coronary myocytes from right and left ventricles in rats. 4-AP, LCA, RCA
97  2006 High dietary salt reduces the contribution of 20-HETE to arteriolar oxygen responsiveness in skeletal muscle. 17-ODYA, DDMS, TEA
98  2006 Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet. CCT, TAL
99  2006 Membrane potassium currents in human radial artery and their regulation by nitric oxide donor. 4-AP, ATP, TEA
100  2006 Synthesis of a biotin derivative of iberiotoxin: binding interactions with streptavidin and the BK Ca2+-activated K+ channel expressed in a human cell line. StrAv