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Abbreviation : KGA
Long Form : kidney-type glutaminase
No. Year Title Co-occurring Abbreviation
2022 A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase. ---
2022 Biodegradable self-assembly micelles significantly enhanced the solubility, biological stability and in vivo antitumor efficacy of Hexylselen. GDH, SOL
2022 Discovery of novel Glutaminase allosteric inhibitors through drug repurposing and comparative MMGB/PBSA and molecular dynamics simulation. GAC, MD
2022 Self-Assembled Micellar Glutaminase Allosteric Inhibitor for Effective Therapeutic Intervention. PVCap-PVA-PEG, SOL
2021 A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer. AR, GAC, GLS1, PCa
2021 Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders. GLS1
2019 Design and synthesis of novel tellurodibenzoic acid compounds as kidney-type glutaminase (KGA) inhibitors. DPAA
2019 Kidney-Type Glutaminase Inhibitor Hexylselen Selectively Kills Cancer Cells via a Three-Pronged Mechanism. GDH, TrxR
2019 Physapubescin I from husk tomato suppresses SW1990 cancer cell growth by targeting kidney-type glutaminase. CETSA, MST
10  2019 TNFalpha increases STAT3-mediated expression of glutaminase isoform KGA in cultured rat astrocytes. STAT3, TNF-alpha
11  2018 A natural inhibitor of kidney-type glutaminase: a withanolide from Physalis pubescens with potent anti-tumor activity. ---
12  2018 Caudatan A, an undescribed human kidney-type glutaminase inhibitor with tetracyclic flavan from Ohwia caudata. BPTES
13  2018 N-terminal phosphorylation of glutaminase C decreases its enzymatic activity and cancer cell migration. GAC, GAC
14  2018 Odor preference and olfactory memory are impaired in Olfaxin-deficient mice. DRG, KO, M/T, OB
15  2017 Ebselen: Mechanisms of Glutamate Dehydrogenase and Glutaminase Enzyme Inhibition. GDH, TrxR
16  2017 Glutaminase C overexpression in the brain induces learning deficits, synaptic dysfunctions, and neuroinflammation in mice. GAC
17  2017 Physapubescin, a natural withanolide as a kidney-type glutaminase (KGA) inhibitor. ---
18  2017 The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats. ANK, GAC
19  2016 T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions. GAC
20  2014 Cocaine-induced behavioral sensitization is associated with changes in the expression of endocannabinoid and glutamatergic signaling systems in the mouse prefrontal cortex. CB1, FAAH, MAGL, PFC
21  2014 Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA). cKGA, DON
22  2013 IL-1beta and TNF-alpha induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase. IL-1beta, NMDA, TNF-alpha
23  2012 Bmcc1s interacts with the phosphate-activated glutaminase in the brain. ---
24  2012 Diphenylarsinic acid promotes degradation of glutaminase C by mitochondrial Lon protease. DPAA, GAC
25  2012 Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. ---
26  2009 Glutamine in neoplastic cells: focus on the expression and roles of glutaminases. Glu, LGA
27  2009 Structure-effect relationship in the down-regulation of glutaminase in cultured human cells by phenylarsenic compounds. GAC, PAG
28  2006 Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. ---
29  2005 Lack of expression of the liver-type glutaminase (LGA) mRNA in human malignant gliomas. CNS, LGA
30  2003 Bacterial expression, purification, and characterization of rat kidney-type mitochondrial glutaminase. ---
31  2002 Complexity and species variation of the kidney-type glutaminase gene. pHRE