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Abbreviation : Kr
Long Form : K(+) current, I
No. Year Title Co-occurring Abbreviation
2020 The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine. ---
2014 Seasonal acclimatization of the cardiac action potential in the Arctic navaga cod (Eleginus navaga, Gadidae). AP
2012 Identification and characterization of a compound that protects cardiac tissue from human Ether-a-go-go-related gene (hERG)-related drug-induced arrhythmias. hERG
2012 Lipopolysaccharide prolongs action potential duration in HL-1 mouse cardiomyocytes. LPS, mERG
2012 RNA interference targeting E637K mutation rescues hERG channel currents and restores its kinetic properties. LQTS, siRNA, WT
2012 Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome. PI3K
2010 Electrophysiological effects of the anti-cancer drug lapatinib on cardiac repolarization. APD, Na
2010 Molecular determinants of human ether-a-go-go-related gene 1 (hERG1) K+ channel activation by NS1643. hERG1
2009 The evolutionarily conserved residue A653 plays a key role in HERG channel closing. hERG, WT
10  2008 Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome. LQTS, TdP
11  2007 Cardioversion of persistent atrial fibrillation by a combination of atrial specific and non-specific class III drugs in the goat. AF, AFCL
12  2006 [Identification of E-4031-sensitive potassium current component in murine P19 embryonic carcinoma cell line differentiated in cardiomyocytes]. ---
13  2005 Intracellular calcium cycling, early afterdepolarizations, and reentry in simulated long QT syndrome. EADs, LQT, SR
14  2005 Rapid stimulation causes electrical remodeling in cultured atrial myocytes. AF, APD, Ca,L, Ca,L
15  2005 Ventricular rate determines early bradycardic electrical remodeling. ---
16  2004 Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine. hERG, LQTS, WT
17  2004 In silico study of action potential and QT interval shortening due to loss of inactivation of the cardiac rapid delayed rectifier potassium current. APs, SQTS
18  2003 A new oral therapy for long QT syndrome: long-term oral potassium improves repolarization in patients with HERG mutations. LQT2, LQTS
19  2003 Effects of lomefloxacin and norfloxacin on pancreatic beta-cell ATP-sensitive K(+) channels. ATP, hERG
20  2003 Structural determinants and biophysical properties of HERG and KCNQ1 channel gating. ---
21  2002 Defective human Ether-a-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus. ER, hERG
22  2002 The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia. LQTS2, SNP
23  2001 Density and kinetics of I(Kr) and I(Ks) in guinea pig and rabbit ventricular myocytes explain different efficacy of I(Ks) blockade at high heart rate in guinea pig and rabbit: implications for arrhythmogenesis in humans. APD, Ks
24  2000 Electrophysiological effects of ibutilide on the delayed rectifier K(+) current in rabbit sinoatrial and atrioventricular node cells. AV, SA
25  1999 Bepridil differentially inhibits two delayed rectifier K(+) currents, I(Kr) and I(Ks), in guinea-pig ventricular myocytes. APD
26  1999 Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole. hERG
27  1999 Effects of low temperature on the chronotropic and inotropic responses to zatebradine, E-4031 and verapamil in isolated perfused dog atria. ---
28  1996 Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides. ---
29  1996 High affinity open channel block by dofetilide of HERG expressed in a human cell line. ---
30  1996 K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. ---