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Abbreviation : LA
Long Form : alpha-lipoic acid
No. Year Title Co-occurring Abbreviation
2020 A Randomized Controlled Trial of Long-Term (R)-alpha-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations. HMOX1
2020 alpha-Lipoic acid blocks the GMCSF induced protease/protease inhibitor spectrum associated with fetal membrane weakening in-vitro. FM
2020 Alpha-lipoic acid effectively attenuates ionizing radiation-mediated testicular dysfunction in rats: Crosstalk of NF-B, TGF-beta, and PPAR-ϒ pathways. IL, NF-B, TGF
2020 Alpha-lipoic acid inhibits lung cancer growth via mTOR-mediated autophagy inhibition. mTOR
2020 Alpha-lipoic acid inhibits proliferation and migration of human vascular endothelial cells through downregulating HSPA12B/VEGF signaling axis. HSPA12B, HUVECs
2020 alpha-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1alpha Signaling Pathway in P301S Mice. AD, BDNF, GLUT3, HIF-1alpha, HK, HO-1, PGC-1alpha, TrkB, VEGF
2020 Anti-allergic rhinitis activity of alpha-lipoic acid via balancing Th17/Treg expression and enhancing Nrf2/HO-1 pathway signaling. AR, OVA
2020 Antioxidant Effect of Alpha-Lipoic Acid in 6-Hydroxydopamine Unilateral Intrastriatal Injected Rats. DA, GPx, OS, PD, TBARS
2020 Development of Novel Silica-based Formulation of alpha-Lipoic Acid: Evaluation of Photo and Thermal Stability of the Encapsulated Drug. ---
10  2020 Granulocyte macrophage colony stimulating factor (GM-CSF), the critical intermediate of inflammation-induced fetal membrane weakening, primarily exerts its weakening effect on the choriodecidua rather than the amnion. AM, CD, FM, GM-CSF, MMPs, TIMPs, TNF
11  2020 Neuroprotective Mechanisms of Three Natural Antioxidants on a Rat Model of Parkinson's Disease: A Comparative Study. AOs, CAT, DA, EA, LPO, Myrt, PD, SO
12  2020 New insights into immunomodulation via overexpressing lipoic acid synthase as a therapeutic potential to reduce atherosclerosis. LIAS
13  2020 PEG Grafted Polymethacrylates Bearing Antioxidants as a New Class of Polymer Conjugates for Application in Cosmetology. AlHEMA, ATRP, EiBBr, FA, PBS
14  2020 Protective effect of alpha-lipoic acid and omega-3 fatty acids against cyclophosphamide-induced ovarian toxicity in rats. FSH, TNF
15  2020 Protective effect of alpha-lipoic acid on di-(2-ethylhexyl) phthalate-induced testicular toxicity in mice. CAT, DEHP, FSH, GPx, IL-1beta, LH, MDA, NO, SOD, TNF-alpha
16  2020 R-alpha-Lipoic Acid and 4-Phenylbutyric Acid Have Distinct Hypolipidemic Mechanisms in Hepatic Cells. LDLR, mTORC1, PBA, PCSK9
17  2020 Thermodynamic, Spatial and Methodological Considerations for the Manufacturing of Therapeutic Polymer Nanoparticles. MF, PEG-PLA, PFD, PLGA
18  2019 alpha-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway. ROS
19  2019 An alpha-lipoic acid-decursinol hybrid compound attenuates lipopolysaccharide-mediated inflammation in BV2 and RAW264.7 cells. COX-2, Dec, iNOS, LPS, NO
20  2019 Beneficial Effects of Alpha-Lipoic Acid on Hypertension, Visceral Obesity, UCP-1 Expression and Oxidative Stress in Zucker Diabetic Fatty Rats. UCP1, ZDF
21  2019 Effects of alpha-lipoic acid on LPS-induced neuroinflammation and NLRP3 inflammasome activation through the regulation of BV-2 microglial cells activation. IL, LPS, NLRP3
22  2019 Effects of lipoic acid and omega-3 long-chain polyunsaturated fatty acids on the kidney in the ovariectomized rat model of menopause. DHA, EPA
23  2019 N-acetylcysteine and alpha-lipoic acid improve antioxidant defenses and decrease oxidative stress, inflammation and serum lipid levels in ovariectomized rats via estrogen-independent mechanisms. CAT, GPx, GR, NAC, SOD
24  2019 Suggested pathology of systemic exertion intolerance disease: Impairment of the E3 subunit or crossover of swinging arms of the E2 subunit of the pyruvate dehydrogenase complex decreases regeneration of cofactor dihydrolipoic acid of the E2 subunit. CFS, DHLA, ME, PDC, SEID
25  2019 Systemic administration of alpha-lipoic acid suppresses excitability of nociceptive wide-dynamic range neurons in rat spinal trigeminal nucleus caudalis. WDR
26  2019 The antioxidant alpha-lipoic acid attenuates intermittent hypoxia-related renal injury in a mouse model of sleep apnea. IA, IH, OSA
27  2019 The comparisons in protective mechanisms and efficiencies among dietary alpha-lipoic acid, beta-glucan and l-carnitine on Nile tilapia infected by Aeromonas hydrophila. GLUC, L-CA
28  2019 The effect of alpha-and delta-tocopherol-lipoic acid ester co-drugs on the response of the rabbit bladder to in vitro ischemia/reperfusion. I/R, NZW, OBD
29  2019 The effect of n-3 long-chain polyunsaturated fatty acids and lipoic acid on the heart in the ovariectomized rat model of menopause. DHA, EPA
30  2018 alpha-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis. ALS, CNS
31  2018 alpha-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice. AD, NFTs
32  2018 alpha-Lipoic acid inhibits testicular and epididymal oxidative damage and improves fertility efficacy in arsenic-intoxicated rats. ---
33  2018 alpha-Lipoic Acid Potentiates the Anti-Inflammatory Activity of Avocado/Soybean Unsaponifiables in Chondrocyte Cultures. ASU, IL-1beta, LPS, NF-kappaB, OA, PGE2
34  2018 Autoimmune hypoglycaemia caused by alpha-lipoic acid: a rare condition in Caucasian patients. IAS
35  2018 Do Anti-Oxidants Vitamin D3, Melatonin, and Alpha-Lipoic Acid Have Synergistic Effects with Temozolomide on Cultured Glioblastoma Cells? TMZ
36  2018 Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model. EAE-ON, MS, OCT, OKR, ON
37  2018 Effects of lipoic acid and n-3 long-chain polyunsaturated fatty acid on the liver ovariectomized rat model of menopause. DHA, EPA
38  2018 In an in-vitro model using human fetal membranes, alpha-lipoic acid inhibits inflammation induced fetal membrane weakening. FM, GM-CSF, TNF
39  2018 Neuroprotective effects of alpha-lipoic acid on long-term experimental autoimmune encephalomyelitis. betaAPP, EAE, ELISA, HE, MBP, MDA, MS, SOD, TGF-beta, TNF-alpha
40  2018 Optimal alpha-lipoic acid strengthen immunity of young grass carp (Ctenopharyngodon idella) by enhancing immune function of head kidney, spleen and skin. ACP, IFN, Ig, IL, LEAP, LZ, NF-kappaB, PWG, TGF, TNF, TOR
41  2018 Potential role of alpha-lipoic acid and Ginkgo biloba against silver nanoparticles-induced neuronal apoptosis and blood-brain barrier impairments in rats. GB
42  2018 The protein-sparing effect of alpha-lipoic acid in juvenile grass carp, Ctenopharyngodon idellus: effects on lipolysis, fatty acid beta-oxidation and protein synthesis. AMPKalpha, mTOR
43  2017 alpha-lipoic acid ameliorates n-3 highly-unsaturated fatty acids induced lipid peroxidation via regulating antioxidant defenses in grass carp (Ctenopharyngodon idellus). CAT, GST, HSI, HUFAs, Keap1, KI, MDA, Nrf2, SOD
44  2017 alpha-Lipoic acid ameliorates oral mucositis and oxidative stress induced by methotrexate in rats. Histological and immunohistochemical study. MTX, nDNA
45  2017 Alpha-lipoic acid reduces methylmercury-induced neuronal injury in rat cerebral cortex via antioxidation pathways. gamma-GCSh, GSH-Px, HO-1, Nrf2, SOD
46  2017 Amelioration of panadol-induced nephrotoxicity via down-regulation of Bax/Bcl2 ratio with some antioxidants. CUR, IL-1beta, SOD, THQ, TNF-alpha
47  2017 An injectable collagen/poly(gamma-glutamic acid) hydrogel as a scaffold of stem cells and alpha-lipoic acid for enhanced protection against renal dysfunction. mMSCs, MSCs
48  2017 Effect of alpha-lipoic acid on relieving ammonia stress and hepatic proteomic analyses of broilers. AM, CTRL, GST, HMGB
49  2017 Effects of alpha-lipoic acid supplementation on growth performance, antioxidant capacity and biochemical parameters for ammonia-exposed broilers. AM
50  2017 Elucidation of the biosynthetic pathway of cis-jasmone in Lasiodiplodia theobromae. CJ, iso-OPDA, JA
51  2017 Investigation of the role of alpha-lipoic acid on fatty acids profile, some minerals (zinc, copper, iron) and antioxidant activity against aluminum-induced oxidative stress in the liver of male rats. FA
52  2017 Overproduction of alpha-Lipoic Acid by Gene Manipulated Escherichia coli. OA
53  2017 Protective effects of lipoic acid against acrylamide-induced neurotoxicity: involvement of mitochondrial energy metabolism and autophagy. ACR
54  2017 Protective role of alpha-lipoic acid in hyperuricemia-induced endothelial dysfunction. eNOS, NO, UA
55  2017 Suppression of a cancer stem-like phenotype mediated by alpha-lipoic acid in human lung cancer cells through down-regulation of beta-catenin and Oct-4. CSCs
56  2017 The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways. GIOP
57  2017 Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells. R-LA, S-LA
58  2017 Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms. CNS, MZD
59  2016 alpha-Lipoic acid sensitizes lung cancer cells to chemotherapeutic agents and anoikis via integrin beta1/beta3 downregulation. ROS
60  2016 alpha-Lipoic Acid Treatment Improves Vision-Related Quality of Life in Patients with Dry Age-Related Macular Degeneration. AMD, BCVA, CLVQOL, SOD
61  2016 Ameliorative effects of alpha-lipoic acid on high-fat diet-induced oxidative stress and glucose uptake impairment of T cells. HFD, ROS
62  2016 Biotinylated vanadium and chromium sulfide nanoparticles as probes for colocalization of membrane proteins. NPs
63  2016 CMX-2043 Efficacy in a Rat Model of Cardiac Ischemia-Reperfusion Injury. AR, IRI, MI
64  2016 Development of Sensitive Analytical Approach for the Quantification of alpha-Lipoic Acid Using Boron Doped Diamond Electrode. BDD
65  2016 Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-alpha-lipoic acid, in human hepatocellular carcinoma cells. mTORC1, PBA, TG
66  2016 Investigation of Enantioselective Membrane Permeability of alpha-Lipoic Acid in Caco-2 and MDCKII Cell. RLA, SLA
67  2016 Lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease. AD, HFD
68  2016 Novel NSAID-Derived Drugs for the Potential Treatment of Alzheimer's Disease. AD, GI, NSAIDs, PMA
69  2016 Role of Cyt-C/caspases-9,3, Bax/Bcl-2 and the FAS death receptor pathway in apoptosis induced by zinc oxide nanoparticles in human aortic endothelial cells and the protective effect by alpha-lipoic acid. HAECs, ZnO NPs
70  2016 The disulfide compound alpha-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondria. ---
71  2016 Type 1 5'-deiodinase activity is inhibited by oxidative stress and restored by alpha-lipoic acid in HepG2 cells. ---
72  2016 Well-defined reducible cationic nanogels based on functionalized low-molecular-weight PGMA for effective pDNA and siRNA delivery. ED, pDNA, PGMA, siRNA
73  2015 Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-alpha-lipoic acid. CREBH, SREBPs, TG, VLDL, ZDF
74  2015 Alpha-lipoic acid affects the oxidative stress in various brain structures in mice with methionine and choline deficiency. i.p, MCD
75  2015 alpha-Lipoic acid as a triglyceride-lowering nutraceutical. ---
76  2015 Alpha-lipoic acid attenuates lipopolysaccharide-induced kidney injury. LPS
77  2015 alpha-Lipoic acid attenuates LPS-induced liver injury by improving mitochondrial function in association with GR mitochondrial DNA occupancy. ALT, AST, GR, LPS, mtDNA
78  2015 Alpha-lipoic acid protects against cadmium-induced hepatotoxicity via calcium signalling and gap junctional intercellular communication in rat hepatocytes. CBX, Cd, GJIC
79  2015 Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes. DHLA, eNOS, RNS, ROS
80  2015 Analysis of Reaction between alpha-Lipoic Acid and 2-Chloro-1-methylquinolinium Tetrafluoroborate Used as a Precolumn Derivatization Technique in Chromatographic Determination of alpha-Lipoic Acid. CMQT
81  2015 Chronic pelvic pain, quality of life and sexual health of women treated with palmitoylethanolamide and alpha-lipoic acid. FSDS, FSFI, PEA, QOL, SF-36, VAS
82  2015 Determination of lipoic acid in biological samples. ---
83  2015 Dihydrolipoic but not alpha-lipoic acid affects susceptibility of eukaryotic cells to bacterial invasion. DHLA, NAC
84  2015 Enantioselective Pharmacokinetics of alpha-Lipoic Acid in Rats. RLA, SLA
85  2015 Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes. PA
86  2015 Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to alpha-lipoic acid. DN, HKC, OS, p-Akt, p38 MAPK, STZ, TCM, TGF, TNF
87  2015 Interaction of alpha-Lipoic Acid with the Human Na+/Multivitamin Transporter (hSMVT). hSMVT
88  2015 Lipoamide Acts as an Indirect Antioxidant by Simultaneously Stimulating Mitochondrial Biogenesis and Phase II Antioxidant Enzyme Systems in ARPE-19 Cells. LM, Nrf2, RPE
89  2015 Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death. ---
90  2015 Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil. 5-FU, CRC
91  2015 Neuroprotective effect of alpha-lipoic acid and methylprednisolone on the spinal cord ischemia/reperfusion injury in rabbits. CSF, I/R, MP
92  2015 Regioselective chemical and rapid enzymatic synthesis of a novel redox – Antiproliferative molecular hybrid. CALB, GEM
93  2015 Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-alpha-Lipoic Acid. 3-MST, DHLA, i.p
94  2015 Selective capture of glycoproteins using lectin-modified nanoporous gold monolith. BSA, Con A, np-Au, OVA, SAMs, TGA
95  2015 Supplementation with alpha-Lipoic Acid Alone or in Combination with Eicosapentaenoic Acid Modulates the Inflammatory Status of Healthy Overweight or Obese Women Consuming an Energy-Restricted Diet. ADGRE1, CRP, EPA, IL-10, IL-6
96  2015 The effect of lipoic acid on acrylamide-induced neuropathy in rats with reference to biochemical, hematological, and behavioral alterations. AChE, ACR, GPx, GR, GST, LPO
97  2015 The effects of alpha-lipoic acid on immature rats with traumatic brain injury. GPx, MDA, SOD, TBI, TUNEL
98  2015 The Neuroprotection of Lysosomotropic Agents in Experimental Subarachnoid Hemorrhage Probably Involving the Apoptosis Pathway Triggering by Cathepsins via Chelating Intralysosomal Iron. EBI, HO-1, LAMP1, LAP, SAH
99  2015 Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging. CR, HAT, HDAC
100  2014 Alpha-lipoic acid effects on brain glial functions accompanying double-stranded RNA antiviral and inflammatory signaling. dsRNA, PKR, TLR3