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Abbreviation : LA
Long Form : alpha-lipoic acid
No. Year Title Co-occurring Abbreviation
2020 Neuroprotective Mechanisms of Three Natural Antioxidants on a Rat Model of Parkinson's Disease: A Comparative Study. AOs, CAT, DA, EA, LPO, Myrt, PD, SO
2019 alpha-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway. ROS
2019 An alpha-lipoic acid-decursinol hybrid compound attenuates lipopolysaccharide-mediated inflammation in BV2 and RAW264.7 cells. COX-2, Dec, iNOS, LPS, NO
2019 Beneficial Effects of Alpha-Lipoic Acid on Hypertension, Visceral Obesity, UCP-1 Expression and Oxidative Stress in Zucker Diabetic Fatty Rats. UCP-1, ZDF
2019 Effects of alpha-lipoic acid on LPS-induced neuroinflammation and NLRP3 inflammasome activation through the regulation of BV-2 microglial cells activation. IL, LPS, NLRP3
2019 Effects of lipoic acid and omega-3 long-chain polyunsaturated fatty acids on the kidney in the ovariectomized rat model of menopause. DHA, EPA
2019 Granulocyte macrophage colony stimulating factor (GM-CSF), the critical intermediate of inflammation-induced fetal membrane weakening, primarily exerts its weakening effect on the choriodecidua rather than the amnion. AM, CD, FM, GM-CSF, MMPs, TIMPs, TNF
2019 N-acetylcysteine and alpha-lipoic acid improve antioxidant defenses and decrease oxidative stress, inflammation and serum lipid levels in ovariectomized rats via estrogen-independent mechanisms. CAT, GPx, GR, NAC, SOD
2019 Suggested pathology of systemic exertion intolerance disease: Impairment of the E3 subunit or crossover of swinging arms of the E2 subunit of the pyruvate dehydrogenase complex decreases regeneration of cofactor dihydrolipoic acid of the E2 subunit. CFS, DHLA, ME, PDC, SEID
10  2019 Systemic administration of alpha-lipoic acid suppresses excitability of nociceptive wide-dynamic range neurons in rat spinal trigeminal nucleus caudalis. WDR
11  2019 The antioxidant alpha-lipoic acid attenuates intermittent hypoxia-related renal injury in a mouse model of sleep apnea. IA, IH, OSA
12  2019 The comparisons in protective mechanisms and efficiencies among dietary alpha-lipoic acid, beta-glucan and l-carnitine on Nile tilapia infected by Aeromonas hydrophila. GLUC, L-CA
13  2019 The effect of n-3 long-chain polyunsaturated fatty acids and lipoic acid on the heart in the ovariectomized rat model of menopause. DHA, EPA
14  2018 alpha-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis. ALS, CNS
15  2018 alpha-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice. AD, NFTs
16  2018 alpha-Lipoic acid inhibits testicular and epididymal oxidative damage and improves fertility efficacy in arsenic-intoxicated rats. ---
17  2018 alpha-Lipoic Acid Potentiates the Anti-Inflammatory Activity of Avocado/Soybean Unsaponifiables in Chondrocyte Cultures. ASU, IL-1beta, LPS, NF-kappaB, OA, PGE2
18  2018 Autoimmune hypoglycaemia caused by alpha-lipoic acid: a rare condition in Caucasian patients. IAS
19  2018 Do Anti-Oxidants Vitamin D3, Melatonin, and Alpha-Lipoic Acid Have Synergistic Effects with Temozolomide on Cultured Glioblastoma Cells? TMZ
20  2018 Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model. EAE-ON, MS, OCT, OKR, ON
21  2018 Effects of lipoic acid and n-3 long-chain polyunsaturated fatty acid on the liver ovariectomized rat model of menopause. DHA, EPA
22  2018 In an in-vitro model using human fetal membranes, alpha-lipoic acid inhibits inflammation induced fetal membrane weakening. FM, GM-CSF, TNF
23  2018 Neuroprotective effects of alpha-lipoic acid on long-term experimental autoimmune encephalomyelitis. betaAPP, EAE, ELISA, HE, MBP, MDA, MS, SOD, TGF-beta, TNF-alpha
24  2018 Optimal alpha-lipoic acid strengthen immunity of young grass carp (Ctenopharyngodon idella) by enhancing immune function of head kidney, spleen and skin. ACP, IFN, Ig, IL, LEAP, LZ, NF-kappaB, PWG, TGF, TNF, TOR
25  2018 Potential role of alpha-lipoic acid and Ginkgo biloba against silver nanoparticles-induced neuronal apoptosis and blood-brain barrier impairments in rats. GB
26  2018 The effect of alpha-and delta-tocopherol-lipoic acid ester co-drugs on the response of the rabbit bladder to in vitro ischemia/reperfusion. I/R, NZW, OBD
27  2018 The protein-sparing effect of alpha-lipoic acid in juvenile grass carp, Ctenopharyngodon idellus: effects on lipolysis, fatty acid beta-oxidation and protein synthesis. AMPKalpha, mTOR
28  2017 alpha-lipoic acid ameliorates n-3 highly-unsaturated fatty acids induced lipid peroxidation via regulating antioxidant defenses in grass carp (Ctenopharyngodon idellus). CAT, GST, HSI, HUFAs, Keap1, KI, MDA, Nrf2, SOD
29  2017 alpha-Lipoic acid ameliorates oral mucositis and oxidative stress induced by methotrexate in rats. Histological and immunohistochemical study. MTX, nDNA
30  2017 Alpha-lipoic acid reduces methylmercury-induced neuronal injury in rat cerebral cortex via antioxidation pathways. gamma-GCSh, GSH-Px, HO-1, Nrf2, SOD
31  2017 Amelioration of panadol-induced nephrotoxicity via down-regulation of Bax/Bcl2 ratio with some antioxidants. CUR, IL-1beta, SOD, THQ, TNF-alpha
32  2017 An injectable collagen/poly(gamma-glutamic acid) hydrogel as a scaffold of stem cells and alpha-lipoic acid for enhanced protection against renal dysfunction. mMSCs, MSCs
33  2017 Effect of alpha-lipoic acid on relieving ammonia stress and hepatic proteomic analyses of broilers. AM, CTRL, GST, HMGB
34  2017 Effects of alpha-lipoic acid supplementation on growth performance, antioxidant capacity and biochemical parameters for ammonia-exposed broilers. AM
35  2017 Elucidation of the biosynthetic pathway of cis-jasmone in Lasiodiplodia theobromae. CJ, iso-OPDA, JA
36  2017 Investigation of the role of alpha-lipoic acid on fatty acids profile, some minerals (zinc, copper, iron) and antioxidant activity against aluminum-induced oxidative stress in the liver of male rats. FA
37  2017 Overproduction of alpha-Lipoic Acid by Gene Manipulated Escherichia coli. OA
38  2017 Protective effects of lipoic acid against acrylamide-induced neurotoxicity: involvement of mitochondrial energy metabolism and autophagy. ACR
39  2017 Protective role of alpha-lipoic acid in hyperuricemia-induced endothelial dysfunction. eNOS, NO, UA
40  2017 Suppression of a cancer stem-like phenotype mediated by alpha-lipoic acid in human lung cancer cells through down-regulation of beta-catenin and Oct-4. CSCs
41  2017 The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways. GIOP
42  2017 Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells. R-LA, S-LA
43  2017 Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms. CNS, MZD
44  2016 alpha-Lipoic acid sensitizes lung cancer cells to chemotherapeutic agents and anoikis via integrin beta1/beta3 downregulation. ROS
45  2016 alpha-Lipoic Acid Treatment Improves Vision-Related Quality of Life in Patients with Dry Age-Related Macular Degeneration. AMD, BCVA, CLVQOL, SOD
46  2016 Ameliorative effects of alpha-lipoic acid on high-fat diet-induced oxidative stress and glucose uptake impairment of T cells. HFD, ROS
47  2016 Biotinylated vanadium and chromium sulfide nanoparticles as probes for colocalization of membrane proteins. NPs
48  2016 CMX-2043 Efficacy in a Rat Model of Cardiac Ischemia-Reperfusion Injury. AR, IRI, MI
49  2016 Development of Sensitive Analytical Approach for the Quantification of alpha-Lipoic Acid Using Boron Doped Diamond Electrode. BDD
50  2016 Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-alpha-lipoic acid, in human hepatocellular carcinoma cells. mTORC1, PBA, TG
51  2016 Investigation of Enantioselective Membrane Permeability of alpha-Lipoic Acid in Caco-2 and MDCKII Cell. RLA, SLA
52  2016 Lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease. AD, HFD
53  2016 Novel NSAID-Derived Drugs for the Potential Treatment of Alzheimer's Disease. AD, GI, NSAIDs, PMA
54  2016 Role of Cyt-C/caspases-9,3, Bax/Bcl-2 and the FAS death receptor pathway in apoptosis induced by zinc oxide nanoparticles in human aortic endothelial cells and the protective effect by alpha-lipoic acid. HAECs, ZnO NPs
55  2016 The disulfide compound alpha-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondria. ---
56  2016 Type 1 5'-deiodinase activity is inhibited by oxidative stress and restored by alpha-lipoic acid in HepG2 cells. ---
57  2016 Well-defined reducible cationic nanogels based on functionalized low-molecular-weight PGMA for effective pDNA and siRNA delivery. ED, pDNA, PGMA, siRNA
58  2015 Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-alpha-lipoic acid. CREBH, SREBPs, TG, VLDL, ZDF
59  2015 Alpha-lipoic acid affects the oxidative stress in various brain structures in mice with methionine and choline deficiency. i.p, MCD
60  2015 alpha-Lipoic acid as a triglyceride-lowering nutraceutical. ---
61  2015 Alpha-lipoic acid attenuates lipopolysaccharide-induced kidney injury. LPS
62  2015 alpha-Lipoic acid attenuates LPS-induced liver injury by improving mitochondrial function in association with GR mitochondrial DNA occupancy. ALT, AST, GR, LPS, mtDNA
63  2015 Alpha-lipoic acid protects against cadmium-induced hepatotoxicity via calcium signalling and gap junctional intercellular communication in rat hepatocytes. CBX, Cd, GJIC
64  2015 Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes. DHLA, eNOS, RNS, ROS
65  2015 Analysis of Reaction between alpha-Lipoic Acid and 2-Chloro-1-methylquinolinium Tetrafluoroborate Used as a Precolumn Derivatization Technique in Chromatographic Determination of alpha-Lipoic Acid. CMQT
66  2015 Chronic pelvic pain, quality of life and sexual health of women treated with palmitoylethanolamide and alpha-lipoic acid. FSDS, FSFI, PEA, QOL, SF-36, VAS
67  2015 Determination of lipoic acid in biological samples. ---
68  2015 Dihydrolipoic but not alpha-lipoic acid affects susceptibility of eukaryotic cells to bacterial invasion. DHLA, NAC
69  2015 Enantioselective Pharmacokinetics of alpha-Lipoic Acid in Rats. RLA, SLA
70  2015 Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes. PA
71  2015 Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to alpha-lipoic acid. DN, HKC, OS, p-Akt, p38 MAPK, STZ, TCM, TGF, TNF
72  2015 Interaction of alpha-Lipoic Acid with the Human Na+/Multivitamin Transporter (hSMVT). hSMVT
73  2015 Lipoamide Acts as an Indirect Antioxidant by Simultaneously Stimulating Mitochondrial Biogenesis and Phase II Antioxidant Enzyme Systems in ARPE-19 Cells. LM, Nrf2, RPE
74  2015 Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death. ---
75  2015 Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil. 5-FU, CRC
76  2015 Neuroprotective effect of alpha-lipoic acid and methylprednisolone on the spinal cord ischemia/reperfusion injury in rabbits. CSF, I/R, MP
77  2015 Regioselective chemical and rapid enzymatic synthesis of a novel redox – Antiproliferative molecular hybrid. CALB, GEM
78  2015 Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-alpha-Lipoic Acid. 3-MST, DHLA, i.p
79  2015 Selective capture of glycoproteins using lectin-modified nanoporous gold monolith. BSA, Con A, np-Au, OVA, SAMs, TGA
80  2015 Supplementation with alpha-Lipoic Acid Alone or in Combination with Eicosapentaenoic Acid Modulates the Inflammatory Status of Healthy Overweight or Obese Women Consuming an Energy-Restricted Diet. ADGRE1, CRP, EPA, IL-10, IL-6
81  2015 The effect of lipoic acid on acrylamide-induced neuropathy in rats with reference to biochemical, hematological, and behavioral alterations. AChE, ACR, GPx, GR, GST, LPO
82  2015 The effects of alpha-lipoic acid on immature rats with traumatic brain injury. GPx, MDA, SOD, TBI, TUNEL
83  2015 The Neuroprotection of Lysosomotropic Agents in Experimental Subarachnoid Hemorrhage Probably Involving the Apoptosis Pathway Triggering by Cathepsins via Chelating Intralysosomal Iron. EBI, HO-1, LAMP1, LAP, SAH
84  2015 Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging. CR, HAT, HDAC
85  2014 Alpha-lipoic acid effects on brain glial functions accompanying double-stranded RNA antiviral and inflammatory signaling. dsRNA, PKR, TLR3
86  2014 alpha-Lipoic acid protected cardiomyoblasts from the injury induced by sodium nitroprusside through ROS-mediated Akt/Gsk-3beta activation. NO, SNP
87  2014 alpha-Lipoic acid protects kidney from oxidative stress and mitochondrial dysfunction associated to inflammatory conditions. LPS
88  2014 alpha-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice. LPS, NO
89  2014 Alpha-lipoic acid protects oxidative stress, changes in cholinergic system and tissue histopathology during co-exposure to arsenic-dichlorvos in rats. ---
90  2014 alpha-Lipoic acid suppresses migration and invasion via downregulation of cell surface beta1-integrin expression in bladder cancer cells. ERK
91  2014 Arsenic trioxide induces unfolded protein response in vascular endothelial cells. eIF2alpha, ER, TRB3, UPR
92  2014 Comparison of the protective effects of antioxidant compounds in the liver and kidney of Cd- and Cr-exposed common carp. Cd, Cr, CUR, NAC, Tau
93  2014 Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia. AOPP, SOD, TAS, TBARS
94  2014 Effect of palladium alpha-lipoic acid complex on energy in the brain mitochondria of aged rats. AD, ATP, CAT, LDH, Pd-LA, ROS, SOD
95  2014 Effects of alpha-lipoic acid supplementation in different stages on growth performance, antioxidant capacity and meat quality in broiler chickens. CAT, XO
96  2014 Effects of Dietary Alpha-lipoic Acid and Acetyl-L-carnitine on Growth Performance and Meat Quality in Arbor Acres Broilers. ADG, AFI, ALC, FCR
97  2014 Effects of dietary alpha-lipoic acid, acetyl-l-carnitine, and sex on antioxidative ability, energy, and lipid metabolism in broilers. ALC, GLU, GSH-Px, INS, SOD, TG
98  2014 Neuroprotective effects of the andrographolide analogue AL-1 in the MPP⁺/MPTP-induced Parkinson's disease model in vitro and in mice. MPTP, PD, TH
99  2014 Reduction in central H2O2 levels prevents voluntary ethanol intake in mice: a role for the brain catalase-H2O2 system in alcohol binge drinking. CNS, EtOH
100  2014 Role of alpha-lipoic acid in LPS/d-GalN induced fulminant hepatic failure in mice: studies on oxidative stress, inflammation and apoptosis. d-GalN, LPS