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Abbreviation : LANA
Long Form : latency-associated nuclear antigen
No. Year Title Co-occurring Abbreviation
2020 Biophysical Screens Identify Fragments That Bind to the Viral DNA-Binding Proteins EBNA1 and LANA. EBNA1, EBV, KSHV, SPR, STD
2020 Discovery of Novel Latency-Associated Nuclear Antigen Inhibitors as Antiviral Agents Against Kaposi's Sarcoma-Associated Herpesvirus. FP, KSHV, SPR
2020 Epigenetic factor siRNA screen during primary KSHV infection identifies novel host restriction factors for the lytic cycle of KSHV. KSHV, NuRD, RTA
2020 Hit-to-lead optimization of a latency-associated nuclear antigen inhibitor against Kaposi's sarcoma-associated herpesvirus infections. EMSA, FP, KSHV
2020 Kaposi's Sarcoma-Associated Herpesvirus LANA Modulates the Stability of the E3 Ubiquitin Ligase RLIM. KSHV
2020 KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence. KS
2020 LANA and hnRNP A1 Regulate the Translation of LANA mRNA through G-Quadruplexes. hnRNP A1, KSHV, MHC
2019 Fragment-Based Discovery of a Qualified Hit Targeting the Latency-Associated Nuclear Antigen of the Oncogenic Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8. ---
2019 Kaposi's Sarcoma-Associated Herpesvirus LANA-Adjacent Regions with Distinct Functions in Episome Segregation or Maintenance. GFP, KSHV, TR
10  2019 Latency-associated nuclear antigen inhibits lytic replication of Kaposi's sarcoma-associated herpesvirus by regulating let-7a/RBPJ signaling. KSHV, NICD, RBPJ
11  2019 Low prevalence of human gammaherpesvirus 8 (HHV-8) infection among HIV-infected pregnant women in Rio De Janeiro, Brazil. HHV-8, HIV
12  2019 Minichromosome Maintenance Proteins Cooperate with LANA during the G1/S Phase of the Cell Cycle To Support Viral DNA Replication. aa, CBD, iPOND, iPOND, KSHV, MCM, TR
13  2019 NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA. KSHV, NDRG1, PCNA, TR
14  2019 Reduction of Kaposi's Sarcoma-Associated Herpesvirus Latency Using CRISPR-Cas9 To Edit the Latency-Associated Nuclear Antigen Gene. Ad-CC9-LANA, EBV, KS, KSHV
15  2018 Epstein-Barr virus enhances genome maintenance of Kaposi sarcoma-associated herpesvirus. EBNA1, EBV, KSHV, PEL
16  2018 Functional Imaging of Viral Transcription Factories Using 3D Fluorescence Microscopy. KSHV, RNAPII
17  2018 KSHV Genome Replication and Maintenance in Latency. HHV-8, KSHV, PEL
18  2018 No detectable human herpesvirus-8 oral shedding in seronegative-healthy, immunocompetent individuals from non-endemic regions for Kaposi's sarcoma: A pilot study. HHV-8, IFA, KS, PCR
19  2018 Superresolution microscopy reveals structural mechanisms driving the nanoarchitecture of a viral chromatin tether. dSTORM, KSHV, TRs
20  2017 Diagnosis and Treatment of Kaposi Sarcoma. KS, KSHV
21  2017 Effects of the NEDD8-Activating Enzyme Inhibitor MLN4924 on Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. KSHV, ORF50p, PEL, SB, TPA
22  2017 Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues. KS, KSHV, MCD, PEL, RTA, TR
23  2017 Full-Length Isoforms of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Accumulate in the Cytoplasm of Cells Undergoing the Lytic Cycle of Replication. KSHV, ORF50, RTA
24  2017 Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency. KS, KSHV, MCD, PEL
25  2017 Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence. KSHV
26  2017 Macavirus latency-associated protein evades immune detection through regulation of protein synthesis in cis depending upon its glycin/glutamate-rich domain. AlHV-1, gammaHV, GE, MCF
27  2017 Murine Gammaherpesvirus 68 Expressing Kaposi Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen (LANA) Reveals both Functional Conservation and Divergence in LANA Homologs. DBDs, kLANA, KLKI, KSHV, MHV-68, WT
28  2017 ORF73 LANA homologs of RRV and MneRV2 contain an extended RGG/RG-rich nuclear and nucleolar localization signal that interacts directly with importin beta1 for non-classical nuclear import. NLS
29  2017 Structural basis for spumavirus GAG tethering to chromatin. CBS, PFV
30  2017 Synthetic Posttranslational Modifications: Chemical Catalyst-Driven Regioselective Histone Acylation of Native Chromatin. DSH, PTMs
31  2017 The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/Sentrin-Specific Peptidase 6 To Facilitate Establishment of Latency. ChIP-seq, KSHV, SENP6
32  2016 3-D Microwell Array System for Culturing Virus Infected Tumor Cells. KSHV
33  2016 Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA. KSHV
34  2016 Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. cGAS, KSHV
35  2016 Expression pattern of the CXCL12/CXCR4-CXCR7 trio in Kaposi sarcoma skin lesions. KS, VEGF
36  2016 G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV. KSHV, QGRS, TR
37  2016 Genipin Enhances Kaposi's Sarcoma-Associated Herpesvirus Genome Maintenance. AIDS, CTCF, KSHV, RTA, SMC3
38  2016 Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication. GST, Hsc70, KSHV, MHV-68, shRNA, WT
39  2016 Kaposi's Sarcoma Herpesvirus Genome Persistence. KSHV
40  2016 KSHV encoded LANA recruits Nucleosome Assembly Protein NAP1L1 for regulating viral DNA replication and transcription. KSHV, NAP1L1, TR
41  2016 KSHV Genome Replication and Maintenance. HHV-8, KSHV, LBS, TR
42  2016 KSHV-Mediated Regulation of Par3 and SNAIL Contributes to B-Cell Proliferation. EMT, KSHV
43  2016 LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection. KSHV
44  2016 Localization of latency-associated nuclear antigen (LANA) on mitotic chromosomes. FM-EM, KSHV
45  2016 New insights into the expression and functions of the Kaposi's sarcoma-associated herpesvirus long noncoding PAN RNA. KSHV, PAN
46  2015 Bub1 in Complex with LANA Recruits PCNA To Regulate Kaposi's Sarcoma-Associated Herpesvirus Latent Replication and DNA Translesion Synthesis. KSHV, PCNA, TR
47  2015 Identification of Caspase Cleavage Sites in KSHV Latency-Associated Nuclear Antigen and Their Effects on Caspase-Related Host Defense Responses. IL-1beta, KSHV, PEL
48  2015 Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Inhibits Major Histocompatibility Complex Class II Expression by Disrupting Enhanceosome Assembly through Binding with the Regulatory Factor X Complex. CIITA, CREB, KSHV, MHC-II, NF-Y, RFX, RFXANK, RFXAP
49  2015 Kaposi's sarcoma-associated herpesvirus-encoded LANA associates with glucocorticoid receptor and enhances its transcriptional activities. GR, KSHV
50  2015 KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA. LBS, TR
51  2015 KSHV Down-regulates Tropoelastin in Both an in-vitro and in-vivo Kaposi's Sarcoma Model. ECM, KS, KSHV
52  2015 Proteomic profiling identifies the SIM-associated complex of KSHV-encoded LANA. KSHV, SIM, SIM, SIM, SUMO
53  2015 The 3D structure of Kaposi sarcoma herpesvirus LANA C-terminal domain bound to DNA. DBD, EBNA1, KSHV, LBS1
54  2015 The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence. KSHV
55  2015 Trends in Kaposi's sarcoma-associated Herpesvirus antibodies prior to the development of HIV-associated Kaposi's sarcoma: a nested case-control study. KS, KSHV
56  2014 A lytic viral long noncoding RNA modulates the function of a latent protein. KSHV, lncRNA, PAN RNA
57  2014 Assay Development and High-Throughput Screening for Inhibitors of Kaposi's Sarcoma-Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes. FP, HTS, KSHV, N-LANA
58  2014 Crystallization, room-temperature X-ray diffraction and preliminary analysis of Kaposi's sarcoma herpesvirus LANA bound to DNA. CTD
59  2014 Human cytomegalovirus major immediate early 1 protein targets host chromosomes by docking to the acidic pocket on the nucleosome surface. CTD, HCMV, IE1
60  2014 Inhibition of KAP1 enhances hypoxia-induced Kaposi's sarcoma-associated herpesvirus reactivation through RBP-Jkappa. HIF-1alpha, KS, KSHV, PEL, RTA, TPA
61  2014 Kaposi sarcoma herpes virus latency associated nuclear antigen protein release the G2/M cell cycle blocks by modulating ATM/ATR mediated checkpoint pathway. ---
62  2014 Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence. KSHV, PCNA, RFC
63  2014 Kaposi's sarcoma-associated herpesvirus-encoded LANA can induce chromosomal instability through targeted degradation of the mitotic checkpoint kinase Bub1. KS, KSHV, MCD, PEL
64  2014 Kaposi's sarcoma-associated herpesvirus-encoded LANA interacts with host KAP1 to facilitate establishment of viral latency. ChIP-seq, KAP1, KSHV
65  2014 KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation. EBV, KSHV, LMP1, PEL, UCH-L1
66  2014 KSHV LANA--the master regulator of KSHV latency. KSHV, SMARD
67  2014 LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complex. KSHV
68  2014 Long non-coding RNA and epigenetic gene regulation of KSHV. BCBL, KS, lncRNAs, PAN RNA
69  2014 Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesis. KMM, KS, KSHV, MM
70  2014 Site-specific association with host and viral chromatin by Kaposi's sarcoma-associated herpesvirus LANA and its reversal during lytic reactivation. ChIP-seq, KSHV, LBS1, TSSs
71  2013 Analysis of Kaposi's sarcoma-associated herpesvirus latent replication using a real-time polymerase chain reaction technique. KSHV, TR
72  2013 Comprehensive analysis of LANA interacting proteins essential for viral genome tethering and persistence. FRET, HMGs, KS, MCD, PEL
73  2013 Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency. ---
74  2013 CTCF regulates Kaposi's sarcoma-associated herpesvirus latency transcription by nucleosome displacement and RNA polymerase programming. CTCF, KSHV, RNAPII, v-cyclin
75  2013 H2AX phosphorylation is important for LANA-mediated Kaposi's sarcoma-associated herpesvirus episome persistence. ChIP, DDR, KSHV, LUR, MHV-68, PBMCs, TRs
76  2013 Identification of Kaposi's sarcoma-associated herpesvirus LANA regions important for episome segregation, replication, and persistence. EMSA, GFP, KSHV, TR
77  2013 Recruitment of the tumour suppressor protein p73 by Kaposi's Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells. KS, KSHV, MCD, PEL
78  2013 Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag. Gag, MuLV
79  2012 Carboxyl-terminal amino acids 1052 to 1082 of the latency-associated nuclear antigen (LANA) interact with RBP-Jkappa and are responsible for LANA-mediated RTA repression. KSHV, RAM, RTA
80  2012 Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins. Hsp90, KS, KSHV
81  2012 Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation. KSHV, SOCS
82  2012 Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors. ChIP, EMSA, HIFs, HRE, KSHV, LTc, PEL, RTA
83  2012 Kaposi's sarcoma-associated herpesvirus-encoded LANA recruits topoisomerase IIbeta for latent DNA replication of the terminal repeats. KSHV, TopoIIbeta, TR
84  2012 Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistence. KSHV, MHV-68, TR
85  2012 Phosphorylation of the chromatin binding domain of KSHV LANA. KSHV
86  2012 Post-Translational Modifications of Kaposi's Sarcoma-Associated Herpesvirus Regulatory Proteins - SUMO and KSHV. SUMO
87  2012 Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen. KSHV
88  2012 Quantitative analysis of the bidirectional viral G-protein-coupled receptor and lytic latency-associated nuclear antigen promoter of Kaposi's sarcoma-associated herpesvirus. ICN, KSHV, RRE, vGPCR
89  2012 Unbiased mutagenesis of MHV68 LANA reveals a DNA-binding domain required for LANA function in vitro and in vivo. KSHV, MHV-68, TR
90  2011 Conservation of complex nuclear localization signals utilizing classical and non-classical nuclear import pathways in LANA homologs of KSHV and RFHV. KSHV, NLS, RFHV
91  2011 Differences in Kaposi sarcoma-associated herpesvirus-specific and herpesvirus-non-specific immune responses in classic Kaposi sarcoma cases and matched controls in Sicily. CI, DTH, EBV, KS, KSHV, OR
92  2011 Kaposi's sarcoma-associated herpesvirus-encoded LANA down-regulates IL-22R1 expression through a cis-acting element within the promoter region. KS, KSHV, LBS
93  2011 KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation. KSHV, MCD, MIFC, PEL
94  2011 KSHV regulation of fibulin-2 in Kaposi's sarcoma: implications for tumorigenesis. DMVEC, ECM, KSHV, VEGF
95  2011 Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latency-associated nuclear antigen. MHV-68, v-cyclin
96  2011 Pathology of Kaposi's Sarcoma-Associated Herpesvirus Infection. KS, KSHV, MCD, PEL
97  2011 Rapid and quantitative assessment of KSHV LANA-mediated DNA replication. KSHV, qPCR, TR
98  2011 Regulation of Nm23-H1 and cell invasiveness by Kaposi's sarcoma-associated herpesvirus. KS, KSHV
99  2011 Ribosomal protein S6 interacts with the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. KSHV, MS/MS, PEL, rpS6, SRP72
100  2011 Single molecule analysis of replicated DNA reveals the usage of multiple KSHV genome regions for latent replication. KSHV, SMARD, TR