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Abbreviation : LBD
Long Form : ligand-binding domain
No. Year Title Co-occurring Abbreviation
2019 A New Tool for Inducible Gene Expression in Caenorhabditis elegans. ---
2019 A revisited version of the apo structure of the ligand-binding domain of the human nuclear receptor retinoic X receptor alpha. NRs, RXR
2019 Agonism activities of lyso-phosphatidylcholines (LPC) Ligands binding to peroxisome proliferator-activated receptor gamma (PPARgamma). LPC, MD, PPAR, PPARgamma
2019 Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand-independent functions. ASO, DBD, NR, SSO, VDR
2019 Assembly and Trafficking of Homomeric and Heteromeric Kainate Receptors with Impaired Ligand Binding Sites. ER, HEK293, iGluRs, KARs
2019 Bag-1L: a promising therapeutic target for androgen receptor-dependent prostate cancer. AR, CRPC
2019 Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output. IP3R
2019 Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1. LBP, NR
2019 Dimerization defective MODY mutations of hepatocyte nuclear factor 4alpha. NR
10  2019 Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORgamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. CRPC
11  2019 Discovery of deshydroxy bicalutamide derivatives as androgen receptor antagonists. ---
12  2019 Echo dephasing and heat capacity from constrained and unconstrained dynamics of triiodothyronine nuclear receptor protein. THRbeta
13  2019 Engineering Nanomolar Peptide LigandsThat Differentially Modulate EphA2 Receptor Signaling. EPHA2
14  2019 Glycogen Synthase Kinase-3alpha Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. FAs, GSK-3alpha
15  2019 Hsp70 Binds to the Androgen Receptor N-terminal Domain and Modulates the Receptor Function in Prostate Cancer Cells. AR, CRPC, NTD, PSA
16  2019 Identification of BR101549 as a lead candidate of non-TZD PPARgamma agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR. ---
17  2019 In vivo assembly and trafficking of olfactory Ionotropic Receptors. CREL, iGluRs, IRs
18  2019 Intradomain Interactions in an NMDA Receptor Fragment Mediate N-Glycan Processing and Conformational Sampling. NMR
19  2019 Ligand binding domain interface: A tipping point for pharmacological agents binding with GluN1/2A subunit containing NMDA receptors. NMDA
20  2019 Ligand-binding Domain-activating Mutations of ESR1 Rewire Cellular Metabolism of Breast Cancer Cells. ER, wtER
21  2019 Modulation of nuclear receptor function: Targeting the protein-DNA interface. DBD, NRs
22  2019 Molecular characterization and homology modeling of liver X receptor in Asian seabass, Lates calcarifer: predicted functions in reproduction and lipid metabolism. AF-1, AF-2, DBD, LXR
23  2019 Molecules targeting the androgen receptor (AR) signaling axis beyond the AR-Ligand binding domain. AR, DBD, PCa, TAD
24  2019 Natural helix 9 mutants of PPARgamma differently affect its transcriptional activity. FPDL3
25  2019 Quinoxalinedione deprotonation is important for glutamate receptor binding. AMPA, iGluRs
26  2019 Sertad1 promotes prostate cancer progression through binding androgen receptor ligand binding domain. AR, GST, IP, PCa, Sertad1
27  2019 Structural insight into the antagonistic action of diarylheptanoid on human estrogen receptor alpha. 4-OHT, DAH, ERalpha, FUL, RMSF
28  2019 The first identification of complete Eph-ephrin signalling in ctenophores and sponges reveals a role for neofunctionalization in the emergence of signalling domains. Ephs, RBD, RTKs
29  2019 The Molecular Mechanism of Nitrate Chemotaxis via Direct Ligand Binding to the PilJ Domain of McpN. ---
30  2019 The prevalence of estrogen receptor-1 mutation in advanced breast cancer: The estrogen receptor one study (EROS1). AI, cfDNA, ddPCR, ERalpha, ESR1, TAM
31  2019 Understanding the interaction of single-walled carbon nanotube (SWCNT) on estrogen receptor: A combined molecular dynamics and experimental study. ER, SWCNT
32  2018 21-Hydroxy-6,19-epoxyprogesterone: A Promising Therapeutic Agent and a Molecular Tool for Deciphering Glucocorticoid Action. GR
33  2018 25 S-Adamantyl-23-yne-26,27-dinor-1alpha,25-dihydroxyvitamin D3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex. VDR
34  2018 A bile acid derivative with PPARgamma-mediated anti-inflammatory activity. ---
35  2018 A current structural perspective on PXR and CAR in drug metabolism. B factors, CAR, DBD, HDX-MS, PXR
36  2018 A novel DMAPP-responding genetic circuit sensor for high-throughput screening and evolving isoprene synthase. DMAPP, E. coli, EGFP, FCM, IspS
37  2018 Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations. ER
38  2018 Alternative dimerization interfaces in the glucocorticoid receptor-alpha ligand binding domain. DBD, ERalpha, GRalpha, NRs
39  2018 Backbone 1H, 13C, and 15N resonance assignments of the ligand binding domain of the human wildtype glucocorticoid receptor and the F602S mutant variant. GR
40  2018 Bisphenol A (BPA) binding on full-length architectures of estrogen receptor. BPA, DBD, ER
41  2018 Castration-Resistant Prostate Cancer Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents: Opportunities and Challenges. AR, ARAT, CRPC
42  2018 Comparative In Vitro and In Silico Analysis of the Selectivity of Indirubin as a Human Ah Receptor Agonist. AhR, hAhR, IR, mAhR, TCDD
43  2018 Computer-Aided Discovery of Small Molecule Inhibitors of Transcriptional Activity of TLX (NR2E1) Nuclear Receptor. NSC
44  2018 Crystal structure of the ligand-binding domain of a LysR-type transcriptional regulator: transcriptional activation via a rotary switch. DBD, LTTRs
45  2018 Defining a conformational ensemble that directs activation of PPARgamma. AF-2, NMR, PPARgamma
46  2018 Design of PPAR-gamma agonist based on algal metabolites and the endogenous ligand 15-deoxy-Delta12, 14-prostaglandin J2. ---
47  2018 Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay. DBD, ERalpha, GAL4RE, VP16 AD
48  2018 Development of a highly sensitive in vitro system to detect and discriminate between vitamin D receptor agonists and antagonists based on split-luciferase technique. E. coli, SLDB, VDR
49  2018 Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays. AR, MD, PCA, VS
50  2018 Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds. BTD
51  2018 Exploring the binding properties of agonists interacting with glucocorticoid receptor: an in silico approach. GR, MD
52  2018 Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets. GPIbalpha, ITP, IVIG, MSD
53  2018 From RORgammat Agonist to Two Types of RORgammat Inverse Agonists. ---
54  2018 Genome-wide identification, characterization and classification of ionotropic glutamate receptor genes (iGluRs) in the malaria vector Anopheles sinensis (Diptera: Culicidae). ATD, iGluRs, IRs
55  2018 Glutamate and Glycine Binding to the NMDA Receptor. iGluRs, NMDA
56  2018 GR Utilizes a Co-Chaperone Cytoplasmic CAR Retention Protein to Form an N/C Interaction. GR, NTD
57  2018 HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. AMPA, BDNF, OXP1
58  2018 High-Throughput Screening to Identify Chemoreceptor Ligands. ---
59  2018 Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles. PXR
60  2018 Identification of the Histidine Residue in Vitamin D Receptor That Covalently Binds to Electrophilic Ligands. VDR
61  2018 Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival. Ad-E1A12, AR, E1A, NTD, PCa
62  2018 Interaction of azadirachtin with the lipid-binding domain: Suppression of lipid transportation in the silkworm, Bombyx mori. ---
63  2018 Interaction of the phosphorylated DNA-binding domain in nuclear receptor CAR with its ligand-binding domain regulates CAR activation. DBD, RXRalpha
64  2018 Molecular Characterization and Expression of Vitellogenin and Vitellogenin Receptor of Thitarodes pui (Lepidoptera: Hepialidae), an Insect on the Tibetan Plateau. EGF, LDLR, ORF, TM, Vg, VgR, VWD
65  2018 Molecular Dynamics Simulations Revealed the Regulation of Ligands to the Interactions between Androgen Receptor and Its Coactivator. AR, MD, PCa
66  2018 Molecular Insights into Function and Competitive Inhibition of Pseudomonas aeruginosa Multiple Virulence Factor Regulator. BB, MDR, WT
67  2018 Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains. DBD, hERalpha, NR
68  2018 Novel biosensor using split-luciferase for detecting vitamin D receptor ligands based on the interaction between vitamin D receptor and coactivator. VDR
69  2018 Novel split luciferase-based biosensors for evaluation of vitamin D receptor ligands and their application to estimate CYP27B1 activity in living cells. DRIP205, SRC-1, TIF2, VDR
70  2018 O-GlcNAc site-mapping of liver X receptor-alpha and O-GlcNAc transferase. LXRalpha, ncOGT, NTD, O-GlcNAc, OGT, TPR
71  2018 PPARbeta in yellow catfish Pelteobagrus fulvidraco: molecular characterization, tissue expression and transcriptional regulation by dietary Cu and Zn. DBD, ORF, PPARbeta, UTR
72  2018 Proteomic profiling identifies key coactivators utilized by mutant ERalpha proteins as potential new therapeutic targets. ERalpha
73  2018 Recent advances in peptidomimetics antagonists targeting estrogen receptor alpha-coactivator interaction in cancer therapy. ERalpha
74  2018 Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer. ER-positive, REs
75  2018 Selective PPARdelta Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD). DMD
76  2018 Selectively targeting the dimerization interface of human androgen receptor with small-molecules to treat castration-resistant prostate cancer. AR, CRPC, DBD, PCa
77  2018 Structural Basis for Polyamine Binding at the dCACHE Domain of the McpU Chemoreceptor from Pseudomonas putida. ---
78  2018 Structural insights into ligand-binding pocket formation in Nurr1 by molecular dynamics simulations. DHA, LBP, MD
79  2018 Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer. AR, ARv, CRPC
80  2018 Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling. CAR, EGF, GR, LEF, PXR, TER
81  2018 Ternary crystal structure of human RORgamma ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction. CoR, IL-17, RORgamma
82  2018 The activity of the C4-dicarboxylic acid chemoreceptor of Pseudomonas aeruginosa is controlled by chemoattractants and antagonists. ---
83  2018 The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. BZA, ERalpha, SERD
84  2018 The Transcriptional Factor PPARalphab Positively Regulates Elovl5 Elongase in Golden Pompano Trachinotus ovatus (Linnaeus 1758). DBD, ORF, PPARs, PUFA, TOCF, ToPPARalphab
85  2018 Thyroid Disruption by Bisphenol S Analogues via Thyroid Hormone Receptor beta: in Vitro, in Vivo, and Molecular Dynamics Simulation Study. BPA, BPSs, MD, TBBPA, TBBPS, TR
86  2018 Unique oestrogen receptor ligand-binding domain sequence of native parrots: a possible link between phytoestrogens and breeding success. AR, ESR1, ESR2, NZ, PR
87  2017 21-hydroxy-6,19-epoxyprogesterone: a Promising Therapeutic Agent and a Molecular Tool for Deciphering Glucocorticoid Action. GR
88  2017 4-Hydroxyalkenal-activated PPARdelta mediates hormetic interactions in diabetes. 4-HDDE, 4-HNE, PPARdelta, PUFA, RXR
89  2017 A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARgamma partial agonist with anti-proliferative ability. PPARgamma, SPR
90  2017 A de novo substructure generation algorithm for identifying the privileged chemical fragments of liver X receptorbeta agonists. LXRbeta, RLR, SVM
91  2017 A Molecular Modeling Study of the Hydroxyflutamide Resistance Mechanism Induced by Androgen Receptor Mutations. AR, HF, MD, MM-GBSA, WT
92  2017 A novel nonsense mutation in androgen receptor confers resistance to CYP17 inhibitor treatment in prostate cancer. ADT, AR, CRPC, PCa
93  2017 Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptorgamma. NTD, RA, RARs
94  2017 An alternative conformation of ERbeta bound to estradiol reveals H12 in a stable antagonist position. ERs
95  2017 Androgen receptor mutations in patients with castration-resistant prostate cancer treated with apalutamide. AAP, AR, CRPC, mCRPC, nmCRPC
96  2017 AR mutations in 28 patients with androgen insensitivity syndrome (Prader grade 0-3). AIS, AR, CAIS, PAIS
97  2017 Bypassing Drug Resistance Mechanisms of Prostate Cancer with Small Molecules that Target Androgen Receptor-Chromatin Interactions. AR, CRPC, DBD
98  2017 Changes in bone metabolic parameters following oral calcium supplementation in an adult patient with vitamin D-dependent rickets type 2A. DBD, VDDR2A, VDR
99  2017 Cloning and characterization of an Echinococcus granulosus ecdysteroid hormone nuclear receptor HR3-like gene. DBD, EgHR3, ORF
100  2017 Configurational Preference of the Glutamate Receptor Ligand Binding Domain Dimers. ---