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Abbreviation : LBS
Long Form : lysine binding site
No. Year Title Co-occurring Abbreviation
2019 Small size apolipoprotein(a) isoforms enhance inflammatory and proteolytic potential of collagen-primed monocytes. CPB, IV-2, MMP-9, ROS
2015 Lipoprotein(A) with An Intact Lysine Binding Site Protects the Retina From an Age-Related Macular Degeneration Phenotype in Mice (An American Ophthalmological Society Thesis). AMD, apoB, OxPL
2014 Expression of a novel chimeric-truncated tPA in Pichia pastoris with improved biochemical properties. CT tPA, EGF, PAI-1, PAs, tPA
2013 Apolipoprotein(a) stimulates nuclear translocation of beta-catenin: a novel pathogenic mechanism for lipoprotein(a). COX-2
2013 Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a). OxPLs, PC
2012 Accelerated fibrinolysis and its propagation on vascular endothelial cells by secreted and retained tPA. TIRF, tPA, VECs
2012 Crystal structure of the native plasminogen reveals an activation-resistant compact conformation. NTP, SP
2010 Human plasminogen kringle 3: solution structure, functional insights, phylogenetic landscape. hPgn K3, HSQC
2010 Residues essential for plasminogen binding by the cation-independent mannose 6-phosphate receptor. CI-MPR, Man-6-P, SPR
10  2010 Solution structure of the complex of VEK-30 and plasminogen kringle 2. Pg
11  2009 Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and kringle 5 of the substrate. BPg, Pg, Pm, SK
12  2009 Solution structure and functional characterization of human plasminogen kringle 5. OA
13  2008 Apolipoprotein(a), through its strong lysine-binding site in KIV(10'), mediates increased endothelial cell contraction and permeability via a Rho/Rho kinase/MYPT1-dependent pathway. MLC
14  2008 Dipeptidyl peptidase IV (DPP IV/CD26) is a cell-surface plasminogen receptor. ADA, Pg, Pm
15  2008 The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain. GAS, hPm, Pg
16  2007 Effect of staphylokinase-derived nonadecapeptide on the activation of plasminogen. PA, SAK
17  2007 Nuclear magnetic resonance (NMR) solution structure, dynamics, and binding properties of the kringle IV type 8 module of apolipoprotein(a). apoB-100, epsilon-ACA, LDL, NMR
18  2007 Plasmin decreases the BH3-only protein BimEL via the ERK1/2 signaling pathway in hepatocytes. EACA, Plg-KO, WT
19  2006 Binding of the COOH-terminal lysine residue of streptokinase to plasmin(ogen) kringles enhances formation of the streptokinase.plasmin(ogen) catalytic complexes. Pg, Pm, SK
20  2005 Baboon lipoprotein(a) binds very weakly to lysine-agarose and fibrin despite the presence of a strong lysine-binding site in apolipoprotein(a) kringle IV type 10. KV
21  2005 Role of the streptokinase alpha-domain in the interactions of streptokinase with plasminogen and plasmin. Pg, Pm, SK
22  2003 Structural/functional characterization of the alpha 2-plasmin inhibitor C-terminal peptide. A2PI, r-K1
23  2002 Bivalency of plasminogen monoclonal antibodies is required for plasminogen bridging to fibrin and enhanced plasmin formation. ---
24  2002 Comparative analyses of the lysine binding site properties of apolipoprotein(a) kringle IV types 7 and 10. KIV
25  2001 High-resolution crystal structure of apolipoprotein(a) kringle IV type 7: insights into ligand binding. ---
26  2001 Impact of apolipoprotein(a) isoform size heterogeneity on the lysine binding function of lipoprotein(a) in early onset coronary artery disease. ---
27  2001 Inhibition of fibrinolysis by lipoprotein(a). ---
28  2001 Polymorphisms in human apolipoprotein(a) kringle IV-10 and coronary artery disease: relationship to allele size, plasma lipoprotein(a) concentration, and lysine binding site activity. ---
29  1999 Comparison of the effects of Apo(a) kringle IV-10 and plasminogen kringles on the interactions of lipoprotein(a) with regulatory molecules. K5-PD
30  1999 Expression, isolation and characterization of a mutated human plasminogen kringle 3 with a functional lysine binding site. HPg
31  1999 Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance. EACA
32  1998 Enzymatic and chemical modifications of lipoprotein(a) selectively alter its lysine-binding functions. AAPH, NAC, PLA2
33  1998 Lysine-50 is a likely site for anchoring the plasminogen N-terminal peptide to lysine-binding kringles. NTP, Pgn, rK1
34  1998 Molecular cloning of the cDNA encoding the carboxy-terminal domain of chimpanzee apolipoprotein(a): an Asp57 --> Asn mutation in kringle IV-10 is associated with poor fibrin binding. ---
35  1998 Structural/functional properties of the Glu1-HSer57 N-terminal fragment of human plasminogen: conformational characterization and interaction with kringle domains. NTP, Pgn, SA/EM
36  1998 Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen. K5HPg, WT
37  1997 Lipoprotein(a) vascular accumulation in mice. In vivo analysis of the role of lysine binding sites using recombinant adenovirus. ---
38  1997 Oxidation of apolipoprotein(a) inhibits kringle-associated lysine binding: the loss of intrinsic protein fluorescence suggests a role for tryptophan residues in the lysine binding site. AAPH
39  1997 The solution phase interaction between apolipoprotein(a) and plasminogen inhibits the binding of plasminogen to a plasmin-modified fibrinogen surface. ---
40  1996 A quantitative immunoassay for the lysine-binding function of lipoprotein(a). Application to recombinant apo(a) and lipoprotein(a) in plasma. ---
41  1996 Evidence that the fibrinogen binding domain of Apo(a) is outside the lysine binding site of kringle IV-10: a study involving naturally occurring lysine binding defective lipoprotein(a) phenotypes. PM
42  1995 Determinants of lipoprotein(a) assembly: a study of wild-type and mutant apolipoprotein(a) phenotypes isolated from human and rhesus monkey lipoprotein(a) under mild reductive conditions. DTE, EACA, LDL, VLDL
43  1995 Effect of fucoidan during activation of human plasminogen. 6-AH, CNBr-Fbg, Glu-Plg, Lys-Plg, tPA
44  1993 Mycoplasma cells stimulate in vitro activation of plasminogen by purified tissue-type plasminogen activator. EACA, tPA
45  1991 Ligand specificity of human plasminogen kringle 4. ---
46  1991 Role of active center and lysine binding sites of plasmin in plasmin-induced platelet activation and disaggregation. EACA
47  1991 Stimulation of plasmin activity by aspirin. AHA
48  1988 Degradation of Glu- and Lys-plasminogen by elastase in the presence or absence of tranexamic acid. Glu-plg
49  1986 A monoclonal antibody directed against the high-affinity lysine-binding site (LBS) of human plasminogen. Role of LBS in the regulation of fibrinolysis. ---
50  1985 Effects of tranexamic acid on the conversion of Glu-plasminogen I and II to its Lys-forms. Glu-plg
51  1984 Fluorescence polarization and spectropolarimetric studies on the conformational changes induced by omega-aminoacids in two isozymes of Glu-plasminogen (I and II). 6-AHA, CD, t-x
52  1984 The binding of antifibrinolytic amino acids to kringle-4-containing fragments of plasminogen. ---