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Abbreviation : LCA
Long Form : lithocholic acid
No. Year Title Co-occurring Abbreviation
2019 Characterization of conjugated and unconjugated bile acid transport via human organic solute transporter alpha/beta. CA, CDCA, DCA, GCDCA, GDCA, GLCA, Ost, TCDCA, TLCA, UDCA
2019 Differential View on the Bile Acid Stress Response of Clostridioides difficile. CA, CDCA, DCA, LT
2019 Inhibition of Human SULT2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogues and Metabolites. DHEA, GLCA, SULT2A1, TLCA
2019 Intestinal Bile Acids Induce a Morphotype Switch in Vancomycin-Resistant Enterococcus that Facilitates Intestinal Colonization. VRE
2019 Liquid crystals-based sensor for the detection of lithocholic acid coupled with competitive host-guest inclusion. beta-CD, LCs, POM, SDS
2019 Metformin inhibits lithocholic acid-induced interleukin 8 upregulation in colorectal cancer cells by suppressing ROS production and NF-kB activity. CM, CRC, IL-8, ROS
2019 Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids. HFD, LPD, Pd, UDCA
2019 Potential biomarkers to predict outcome of faecal microbiota transfer for recurrent Clostridioides difficile infection. baiCD, FMT, rCDI
2019 Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential. BAs
10  2019 Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer. BAs, DCA, SCFAs
11  2019 TGR5 activation ameliorates hyperglycemia-induced cardiac hypertrophy in H9c2 cells. PKA, PLN
12  2019 Undernutrition Shapes the Gut Microbiota and Bile Acid Profile in Association with Altered Gut-Liver FXR Signaling in Weaning Pigs. DCA, FGF19, FXR
13  2019 Zebrafish olfactory receptors ORAs differentially detect bile acids and bile salts. ---
14  2018 Anti-Inflammatory Effects of Vardenafil Against Cholestatic Liver Damage in Mice: a Mechanistic Study. ALP, LDH, NF-kappaB, Nrf2
15  2018 Barley beta-glucan increases fecal bile acid excretion and short chain fatty acid levels in mildly hypercholesterolemic individuals. BA, HMW, LMW, MW, NS, SCFA
16  2018 Bile Acid G Protein-Coupled Membrane Receptor TGR5 Modulates Aquaporin 2-Mediated Water Homeostasis. AQP2, FXR, IMCD, NDI
17  2018 Bile acid oxidation by Eggerthella lenta strains C592 and DSM 2243T. HSDH, TLC
18  2018 Bile Acid Synthesis: From Nature to the Chemical Modification and Synthesis and Their Applications as Drugs and Nutrients. BAs, CA, CAR, CDCA, DCA, FDA, FXRs, PBC, PXR, UDCA, VDR
19  2018 Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. BAs, CA, GIP, GLP-1, PYY, TGR5
20  2018 Comprehensive bile acid profiling in hereditary intrahepatic cholestasis: Genetic and clinical correlations. ---
21  2018 Effect of lithocholic acid on biologically active alpha,beta-unsaturated aldehydes induced by H2O2 in glioma mitochondria for use in glioma treatment. MDA
22  2018 Lithocholic Acid Improves the Survival of Drosophila Melanogaster. PGC1alpha, srl
23  2018 Lithocholic Acid Is a Vitamin D Receptor Ligand That Acts Preferentially in the Ileum. VDR
24  2018 Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness. ---
25  2018 Lithocholic Acid-Based Peptide Delivery System for an Enhanced Pharmacological and Pharmacokinetic Profile of Xenopus GLP-1 Analogs. ---
26  2018 Lithocholic bile acid inhibits lipogenesis and induces apoptosis in breast cancer cells. ---
27  2018 Metabolomic analysis of cholestatic liver damage in mice. ANIT, DDC, PBC, PSC, UPLC-ESI-QTOFMS
28  2018 Nanotherapeutics Containing Lithocholic Acid-Based Amphiphilic Scorpion-Like Macromolecules Reduce In Vitro Inflammation in Macrophages: Implications for Atherosclerosis. AScM, NPs, oxLDL, SRs
29  2018 Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two-step hyperglycemic clamp. BAs, NGT, T2DM, TCA, UDCA
30  2018 Preventive effect of artemisinin extract against cholestasis induced via lithocholic acid exposure. ---
31  2018 Programmed 'triple-mode' anti-tumor therapy: Improving peritoneal retention, tumor penetration and activatable drug release properties for effective inhibition of peritoneal carcinomatosis. IPCh, PC, PTX
32  2018 Protective effects of yangonin from an edible botanical Kava against lithocholic acid-induced cholestasis and hepatotoxicity. FXR
33  2018 Reduction in hepatic secondary bile acids caused by short-term antibiotic-induced dysbiosis decreases mouse serum glucose and triglyceride levels. DCA
34  2018 Secondary bile acids inhibit Candida albicans growth and morphogenesis. DCA, GI
35  2018 Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor. GCDCA, hNoV, MNoV
36  2018 Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis. NEC, PXR, TLR4
37  2018 The Apoptosis Effect on Liver Cancer Cells of Gold Nanoparticles Modified with Lithocholic Acid. MMP, PEG, ROS
38  2018 Vitamin D receptor-targeted treatment to prevent pathological dedifferentiation of pancreatic beta cells under hyperglycaemic stress. T2D, VD3, VDR
39  2017 Chronic microaspiration of bile acids induces lung fibrosis through multiple mechanisms in rats. AECs, alpha-SMA, bFGF, CDCA, CTGF, DCA, EMT, FXR, GER, TGF-beta1, VEGF
40  2017 Deciphering the role of hydrophobic and hydrophilic bile acids in angiogenesis using in vitro and in vivo model systems. CA, CDCA, DCA, HUVECs, SIVs, VE-cadherin
41  2017 Decoding the vasoregulatory activities of bile acid-activated receptors in systemic and portal circulation: role of gaseous mediators. CSE, eNOS, FXR, LSECs
42  2017 Epigallocatechin gallate induces a hepatospecific decrease in the CYP3A expression level by altering intestinal flora. CYP3A, EGCG, GP, PXR
43  2017 Formation of Spherulitic J-Aggregates from the Coassembly of Lithocholic Acid and Cyanine Dye. ---
44  2017 Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor. T-bet, VDR
45  2017 Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a. LCAHA
46  2017 Lithocholic Acid Stimulates IL-8 Expression in Human Colorectal Cancer Cells Via Activation of Erk1/2 MAPK and Suppression of STAT3 Activity. CRC, IL-8
47  2017 Molecular Self-Assembly of Bile Acid-Phospholipids Controls the Delivery of Doxorubicin and Mice Survivability. CA, DCA
48  2017 Quantitative profiling of 19 bile acids in rat plasma, liver, bile and different intestinal section contents to investigate bile acid homeostasis and the application of temporal variation of endogenous bile acids. BAs, beta-MCA, CA, GCA, TCA
49  2017 Schisandrol B protects against cholestatic liver injury through pregnane X receptors. PXR, SolB
50  2017 The synthesis and antitumor activity of lithocholic acid and its derivatives. ---
51  2017 The Yin and Yang of bile acid action on tight junctions in a model colonic epithelium. CDCA, ROS, TJ
52  2017 Transgenic Overexpression of Steroid Sulfatase Alleviates Cholestasis. LXR, STS, SULT
53  2017 Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism. CDCA, DCA, UPR
54  2017 Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon. 6-MUDCA, DSS, UDCA
55  2016 An ultra-high performance liquid chromatography-tandem mass spectrometric assay for quantifying 3-ketocholanoic acid: Application to the human liver microsomal CYP3A-dependent lithocholic acid 3-oxidation assay. 3-KCA, CYP3A, MRM
56  2016 Bile acid: a potential inducer of colon cancer stem cells. CSCs, DCA, HCoEpiC, M3R, TCF/LEF
57  2016 Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease. BA, CA, CDCA, HC, IM, NAFLD
58  2016 Bile acids induce activation of alveolar epithelial cells and lung fibroblasts through farnesoid X receptor-dependent and independent pathways. AECs, CDCA, DCA, EMT, FXR, IPF, ROS
59  2016 Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis. ---
60  2016 Catalytic activity and thermal stability of horseradish peroxidase encapsulated in self-assembled organic nanotubes. HRP, MD
61  2016 Crystal Structure of the Vitamin D Receptor Ligand-Binding Domain with Lithocholic Acids. LBP, VDR
62  2016 Decreased C-reactive protein induces abnormal vascular structure in a rat model of liver dysfunction induced by bile duct ligation. BDL, CRP, HUVECs
63  2016 Deregulated methionine adenosyltransferase alpha1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans(‡). BDL, CCA, MATalpha1, SAMe
64  2016 Design, Synthesis and Biological Evaluation of Stilbene Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B. PTP1B
65  2016 Fast and sensitive quantification of human liver cytosolic lithocholic acid sulfation using ultra-high performance liquid chromatography-tandem mass spectrometry. LCA-S, MRM, PAPS
66  2016 Functional Intestinal Bile Acid 7alpha-Dehydroxylation by Clostridium scindens Associated with Protection from Clostridium difficile Infection in a Gnotobiotic Mouse Model. CDI, DCA
67  2016 Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid-Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration. PXR, UGT, WZ
68  2016 Hydrophobic bile acids relax rat detrusor contraction via inhibiting the opening of the Na⁺/Ca⁺ exchanger. BAs, DCB, FXR, SMCs
69  2016 Lithocholic acid attenuates cAMP-dependent Cl- secretion in human colonic epithelial T84 cells. BAs, CDCA, Isc
70  2016 Lithocholic acid induces endoplasmic reticulum stress, autophagy and mitochondrial dysfunction in human prostate cancer cells. CHOP, ER, p-eIF2alpha, ROS
71  2016 Oxidative stress markers, secondary bile acids and sulfated bile acids classify the clinical liver injury type: Promising diagnostic biomarkers for cholestasis. AUC, DCA, HA, ROC, ROS, SSBA, UDCA
72  2016 Profiling of bile acids in bovine follicular fluid by fused-core-LC-MS/MS. BAs, CA, CDCA, DCA, FF
73  2016 Reverse of Acute and Chronic Morphine Tolerance by Lithocholic Acid via Down-Regulating UGT2B7. CaMKIIalpha, M3G, M6G, MOR, mPFCs, SPE, UGT2B7
74  2016 Structure and functional characterization of a bile acid 7alpha dehydratase BaiE in secondary bile acid synthesis. CA, CDCA, DCA, NTF2
75  2016 Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. GLUC, VDR
76  2016 Synthesis of B- and C-ring-modified lithocholic acid analogues as potential sialyltransferase inhibitors. ST
77  2015 Activation of a novel c-Myc-miR27-prohibitin 1 circuitry in cholestatic liver injury inhibits glutathione synthesis in mice. ARE, BDL, Nrf2, PHB1
78  2015 Bile acids regulate nuclear receptor (Nur77) expression and intracellular location to control proliferation and apoptosis. BA, GI
79  2015 Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior. BBB, DCA, FXR, GCA, HDCA
80  2015 Galactosylated poly(ethyleneglycol)-lithocholic Acid selectively kills hepatoma cells, while sparing normal liver cells. LBA, PEG, PL
81  2015 Hepatoprotective effect of vitamin C on lithocholic acid-induced cholestatic liver injury in Gulo(-/-) mice. ---
82  2015 Impact of confinement on proteins concentrated in lithocholic acid based organic nanotubes. EGFP, FRAP, FRET
83  2015 Individual bile acids have differential effects on bile acid signaling in mice. BAs, Bsep, CA, CDCA, DCA, FXR-SHP, Ntcp, UDCA
84  2015 New method for the determination of bile acids in human plasma by liquid-phase microextraction using liquid chromatography-ion-trap-time-of-flight mass spectrometry. BAs, BAs, CA, CDCA, DCA, HF-LPME, UDCA
85  2015 Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism. BDL, OA
86  2015 Secondary bile acids effects in colon pathology. Experimental mice study. DOC
87  2015 The impact of ligands on the structure and flexibility of sulfotransferases: a molecular dynamics simulation study. PAPS
88  2014 Bioreducible carboxymethyl dextran nanoparticles for tumor-targeted drug delivery. CMD, DOX
89  2014 Effects of bile acids and the bile acid receptor FXR agonist on the respiratory rhythm in the in vitro brainstem medulla slice of neonatal Sprague-Dawley rats. CA, CDCA, DCA, DMSO, FXR, IA, RC, RRDA, TE, TI, UDCA
90  2014 Gastrectomy increases the expression of hepatic cytochrome P450 3A by increasing lithocholic acid-producing enteric bacteria in mice. PXR, TLCA
91  2014 HEK-293 cells expressing the cystic fibrosis transmembrane conductance regulator (CFTR): a model for studying regulation of Cl- transport. CFTR, HEK-CFTR, HEK293
92  2014 Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice. CYP3A4, VDR
93  2014 Lipidomics investigation of reversal effect of glycyrrhizin (GL) towards lithocholic acid (LCA)-induced alteration of phospholipid profiles. ALT, GL, i.p
94  2014 Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice. ICAM-1
95  2014 Lithocholic acid-induced placental tumor necrosis factor-alpha upregulation and syncytiotrophoblast cell apoptosis in intrahepatic cholestasis of pregnancy. ICP, TNF
96  2014 Low dose of oleanolic acid protects against lithocholic acid-induced cholestasis in mice: potential involvement of nuclear factor-E2-related factor 2-mediated upregulation of multidrug resistance-associated proteins. FXR, Luc, MRP2, Nrf2, OA, PXR, Sult2a1, Ugt1a1
97  2014 Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid-Mediated DILI. BA, BSEP, CDCA, DILI, FXR
98  2014 Morphology and shape control of porous silica nanostructures with dual-templating approaches. CATB, TEOS
99  2014 New highly toxic bile acids derived from deoxycholic acid, chenodeoxycholic acid and lithocholic acid. CDCA
100  2014 Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. ABC, ABCG5, BAs, CA, CDCA, DCA, FGF19, FXR, MRP2, OATP1B3, SHP, UDCA