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Abbreviation : LGS
Long Form : Lennox-Gastaut syndrome
No. Year Title Co-occurring Abbreviation
2019 A missense mutation in SLC6A1 associated with Lennox-Gastaut syndrome impairs GABA transporter 1 protein trafficking and function. GABA, GAT-1, MAE, YFP
2019 An evaluation of clobazam tablets and film (AQST-120) for the treatment of Lennox-Gastaut syndrome. ASD, CLB, COSF, EEG, FDA
2019 Cannabidiol as adjunctive treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome. CBD, DS
2019 Cannabidiol in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study. AEs, CBD, GWPCARE5, OLE
2019 Cannabidiol: A New Hope for Patients With Dravet or Lennox-Gastaut Syndromes. CBD, DS
2019 Development of a classifier to identify patients with probable Lennox-Gastaut syndrome in health insurance claims databases via random forest methodology. ---
2019 Evaluation of long-term safety, tolerability, and behavioral outcomes with adjunctive rufinamide in pediatric patients (≥1 to <4 years old) with Lennox-Gastaut syndrome: Final results from randomized study 303. AED, CBCL, TEAEs
2019 Evaluation of WO2014121383 A1: a process for preparation of rufinamide and intermediates. ---
2019 Factors affecting epilepsy prognosis in patients with tuberous sclerosis. EEG, MRI, TSC
10  2019 In trans variant calling reveals enrichment for compound heterozygous variants in genes involved in neuronal development and growth. IS, MAF
11  2019 Interstitial Stereotactic Laser Anterior Corpus Callosotomy: A Report of 2 Cases with Operative Technique and Effectiveness. LITT
12  2019 Lennox-Gastaut Syndrome in Mitochondrial Disease. ---
13  2019 Long-term safety and efficacy of cannabidiol in children and adults with treatment resistant Lennox-Gastaut syndrome or Dravet syndrome: Expanded access program results. AEDs, AEs, CBD, DS, EAP, SAS, TREs
14  2019 Novel seizure outcomes in patients with Lennox-Gastaut syndrome: Post hoc analysis of seizure-free days in rufinamide Study 303. ASD, QOL
15  2019 Pharmacological and Therapeutic Properties of Cannabidiol for Epilepsy. CBD, DS, GPR55, THC, TRPV1
16  2019 Spectrum and time course of epilepsy and the associated cognitive decline in MECP2 duplication syndrome. ---
17  2019 The direct cost of seizure events in severe childhood-onset epilepsies: A retrospective claims-based analysis. AED, DS, PPPY, TSC
18  2019 The epileptic network of Lennox-Gastaut syndrome: Cortically driven and reproducible across age. DCM, GPFA
19  2019 The refractory epilepsy screening tool for Lennox-Gastaut syndrome (REST-LGS). CRF, REST-LGS, REST-LGS
20  2019 Therapeutic approach to Lennox-Gastaut syndrome: a systematic review. ---
21  2018 A pilot, open-label study of the effectiveness and tolerability of low-dose ZX008 (fenfluramine HCl) in Lennox-Gastaut syndrome. CS
22  2018 Burden of illness in patients with possible Lennox-Gastaut syndrome: A retrospective claims-based study. AEDs, EEG, PPPY
23  2018 Cannabis Therapeutics and the Future of Neurology. AD, CBD, CBDA, CTE, MS, PD, TBI, THC, THCA
24  2018 Changes in functional brain network topology after successful and unsuccessful corpus callosotomy for Lennox-Gastaut Syndrome. CC
25  2018 Diagnosis switching and outcomes in a cohort of patients with potential epilepsy with myoclonic-atonic seizures. EMAS
26  2018 Efficacy and Safety of Adjunctive Cannabidiol in Patients with Lennox-Gastaut Syndrome: A Systematic Review and Meta-Analysis. AEDs, AEs, CBD, CIs, RRs
27  2018 Efficacy and Safety of Cannabidiol in Epilepsy: A Systematic Review and Meta-Analysis. AEs, CBD, CI, df, DS, RR
28  2018 Efficacy of rufinamide in childhood refractory epilepsy. ---
29  2018 Evolution and course of early life developmental encephalopathic epilepsies: Focus on Lennox-Gastaut syndrome. DEEs, WS/IS
30  2018 Few individuals with Lennox-Gastaut syndrome have autism spectrum disorder: a comparison with Dravet syndrome. ASD, DS, ID
31  2018 Late-onset Lennox-Gastaut syndrome: Diagnostic evaluation and outcome. CSF, SUDEP
32  2018 Lennox-Gastaut syndrome: a comprehensive review. ---
33  2018 Long-term Outcome of Resective Epilepsy Surgery in Patients With Lennox-Gastaut Syndrome. ---
34  2018 Optimizing clobazam treatment in patients with Lennox-Gastaut syndrome. AED, OLE
35  2018 Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the American Epilepsy Society and the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. AAN, AEDs, GTC, TR, TRAFE, TRCFE
36  2018 Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society. AEDs, FDA, GTC, TR, TRAFE, TRCFE
37  2018 Rufinamide efficacy and safety in children aged 1-4 years with Lennox-Gastaut syndrome. AEs
38  2018 Sulthiame add-on therapy in children with Lennox-Gastaut syndrome: A study of 44 patients. EEG
39  2018 The pharmacological management of Lennox-Gastaut syndrome and critical literature review. AEDs
40  2017 Application of rare variant transmission disequilibrium tests to epileptic encephalopathy trio sequence data. IS, TDT
41  2017 Assessment of treatment patterns and healthcare costs associated with probable Lennox-Gastaut syndrome. ---
42  2017 Cannabinoids in treatment-resistant epilepsy: A review. CBD, DS, MMJ, THC, TRE
43  2017 Cognitive network reorganization following surgical control of seizures in Lennox-Gastaut syndrome. EEG, fMRI
44  2017 Dosing considerations for rufinamide in patients with Lennox-Gastaut syndrome: Phase III trial results and real-world clinical data. AEs, OLE
45  2017 Early Diagnosis and Treatment of Lennox-Gastaut Syndrome. ---
46  2017 Electroencephalography Network Effects of Corpus Callosotomy in Patients with Lennox-Gastaut Syndrome. CC
47  2017 Expert Opinion on the Management of Lennox-Gastaut Syndrome: Treatment Algorithms and Practical Considerations. AED, VPA
48  2017 Influence of perfluorocarbons on Carbamazepine and Benzodiazepine for a neuro-lung protective strategy. AEDs, BDZ, CBZ, EDS, SEM, TEM
49  2017 Lennox-Gastaut syndrome in adulthood: Long-term clinical follow-up of 38 patients and analysis of their recorded seizures. ---
50  2017 Lennox-Gastaut Syndrome: A State of the Art Review. ---
51  2017 Ophthalmologic Features of Lennox-Gastaut Syndrome. ---
52  2017 Real-world data on rufinamide treatment in patients with Lennox-Gastaut syndrome: Results from a European noninterventional registry study. AEDs, TEAEs
53  2017 Report from a Survey of Parents Regarding the Use of Cannabidiol (Medicinal cannabis) in Mexican Children with Refractory Epilepsy. DS, OS, URE, WS
54  2017 Rufinamide in children and adults in routine clinical practice. ---
55  2017 Spectral characteristics of intracranial electroencephalographic activity in patients with Lennox-Gastaut syndrome. iEEG
56  2017 Thalamocortical functional connectivity in Lennox-Gastaut syndrome is abnormally enhanced in executive-control and default-mode networks. MRI
57  2017 Understanding Lennox-Gastaut syndrome: insights from focal epilepsy patients with Lennox-Gastaut features. GPFA
58  2017 Use and cost comparison of clobazam to other antiepileptic drugs for treatment of Lennox-Gastaut syndrome. AEDs
59  2017 Use of perampanel in children and adolescents with Lennox-Gastaut Syndrome. AEs
60  2016 Abnormal cognitive network interactions in Lennox-Gastaut syndrome: A potential mechanism of epileptic encephalopathy. EEG-fMRI, ICA, SD
61  2016 Adjunctive use of electroconvulsive therapy in patients with Lennox-Gastaut syndrome and drug-resistant epilepsy: A pilot study. ECT
62  2016 An integrative population pharmacokinetics approach to the characterization of the effect of hepatic impairment on clobazam pharmacokinetics. N-CLB, PPK
63  2016 Automatic Identification of Interictal Epileptiform Discharges in Secondary Generalized Epilepsy. EDs, EEG, iEEG, SSWs
64  2016 Brainstem dysfunction in patients with late-onset Lennox-Gastaut syndrome: Voxel-based morphometry and tract-based spatial statistics study. EEG, TBSS, VBM
65  2016 Challenges in identifying Lennox-Gastaut syndrome in adults: A case series illustrating its changing nature. ---
66  2016 Clobazam-treated patients with Lennox-Gastaut syndrome experienced fewer seizure-related injuries than placebo patients during trial OV-1012. AE, MedDRA
67  2016 Combined surgical intervention with vagus nerve stimulation following corpus callosotomy in patients with Lennox-Gastaut syndrome. CC, DAs, VNS
68  2016 Drug-metabolism mechanism: Knowledge-based population pharmacokinetic approach for characterizing clobazam drug-drug interactions. AEDs, DDIs, N-CLB, PK, PPK
69  2016 Epileptic encephalopathy de novo GABRB mutations impair gamma-aminobutyric acid type A receptor function. EEs, GABAA, IS
70  2016 Long-term safety and seizure outcome in Japanese patients with Lennox-Gastaut syndrome receiving adjunctive rufinamide therapy: An open-label study following a randomized clinical trial. AEs
71  2016 Nocturnal interictal epileptic discharges in adult Lennox-Gastaut syndrome: the effect of sleep stage and time of night. IEDs
72  2016 Pontine and cerebral atrophy in Lennox-Gastaut syndrome. VBM
73  2016 Predictive role of brain connectivity for resective surgery in Lennox-Gastaut syndrome. dDTF, EEG, PDC
74  2016 Resective surgery combined with corpus callosotomy for children with non-focal lesional Lennox-Gastaut syndrome. CCT
75  2016 Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study. AEDs, PK, TEAEs
76  2016 Short-term efficacy and safety of rufinamide for Lennox-Gastaut syndrome. RFN, RR
77  2016 Therapeutic effects of the ketogenic diet in children with Lennox-Gastaut syndrome. EEG, IEDs, KD
78  2016 Transcranial Direct Current Stimulation for Treatment of Childhood Pharmacoresistant Lennox-Gastaut Syndrome: A Pilot Study. tDCS
79  2016 Treatment of Adults with Lennox-Gastaut Syndrome: Further Analysis of Efficacy and Safety/Tolerability of Rufinamide. AEs
80  2016 [Effectiveness and safety of rufinamide at treatment of epilepsy with complications and drug-resistant epilepsy (according to meta-analysis data)]. ---
81  2015 A granulocytosis associated with rufinamide: A case report. AED
82  2015 Asymmetrical generalized paroxysmal fast activities in children with intractable localization-related epilepsy. GPFA, IVEEG, MEG, VEEG
83  2015 Clobazam is equally safe and efficacious for seizures associated with Lennox-Gastaut syndrome across different age groups: Post hoc analyses of short- and long-term clinical trial results. ---
84  2015 Comprehensive overview: efficacy, tolerability, and cost-effectiveness of clobazam in Lennox-Gastaut syndrome. FDA
85  2015 Copy number variant analysis from exome data in 349 patients with epileptic encephalopathy. CNVs, IS
86  2015 Diffuse alveolar hemorrhage due to valproic acid: Case report and review of the literature. VPA
87  2015 Endoscopic epilepsy surgery: Emergence of a new procedure. CCWC, EH, HH
88  2015 Lennox-Gastaut syndrome. Management update. ---
89  2015 Localization of epileptogenic zones in Lennox-Gastaut syndrome (LGS) using graph theoretical analysis of ictal intracranial EEG: a preliminary investigation. BC, iEEG, PLV
90  2015 Long-term prognosis of patients with Lennox--Gastaut syndrome in recent decades. ES, KD
91  2015 Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy. AEs, OCEs
92  2015 Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome. CBD, IS
93  2015 Relationship of Lennox-Gastaut syndrome with perinatal event: A cross-sectional study. MRI
94  2015 Retention rates of rufinamide in pediatric epilepsy patients with and without Lennox-Gastaut Syndrome. RFM
95  2015 The causal epileptic network identifies the primary epileptogenic zone in Lennox-Gastaut syndrome. dDTF, EEG, GSW
96  2015 [Hypokalemia in Lennox-Gastaut syndrome]. ---
97  2014 A case of Lennox-Gastaut syndrome in a patient with FOXG1-related disorder. FOXG1
98  2014 Anterior corpus callosotomy in school-aged children with Lennox-Gastaut syndrome: a prospective study. AEDs, CCT, IQ, QOL
99  2014 Budget impact analysis of antiepileptic drugs for Lennox-Gastaut syndrome. AED, PMPM
100  2014 CHD2 mutations in Lennox-Gastaut syndrome. ---