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Abbreviation : LORR
Long Form : loss of righting reflex
No. Year Title Co-occurring Abbreviation
2022 Altered Behavioral Responses Show GABA Sensitivity in Muscleblind-Like 2-Deficient Mice: Implications for CNS Symptoms in Myotonic Dystrophy. DM1, GABAAR, KO, MBNL2, WT
2022 Chronic knockdown of the tetraspanin gene CD81 in the mouse nucleus accumbens modulates anxiety and ethanol-related behaviors. EPM, LV, NAcc, OF, TBC
2022 E161111 is an ultra-short-acting etomidate analogue with stable haemodynamics that elicits only slight adrenocortical suppression in rats. MAP, RASS
2022 High-Dose Benzodiazepines Positively Modulate GABAA Receptors via a Flumazenil-Insensitive Mechanism. BZDs, GABAARs
2022 Hypoxia-triggered O-GlcNAcylation in the brain drives the glutamate-glutamine cycle and reduces sensitivity to sevoflurane in mice. EC50, LTWR, O-GlcNAc
2022 Intrahepatic Injection of Sodium Pentobarbital as an Alternative to Intraperitoneal Injection for the Euthanasia of Rats (Rattus norvegicus). CHB, PB
2022 Pre-treatment with Tandospirone attenuates fentanyl-induced respiratory depression without affecting the analgesic effects of fentanyl in rodents. i.v, TS
2022 The preclinical pharmacological study of a novel intravenous anesthetic, ET-26 hydrochloride, in aged rats. ET-26HCl
2021 A Pharmacokinetic-Pharmacodynamic Study of Intravenous Midazolam and Flumazenil in Adult New Zealand White-Californian Rabbits (Oryctolagus cuniculus). FLU, FLU/SAL, PD, PK, SAL
10  2021 Adolescent intermittent ethanol (AIE) produces sex specific alterations in adult neuroimmune gene expression and ethanol sensitivity that are independent of ethanol metabolism. AIE
11  2021 Contribution of GlyR α3 Subunits to the Sensitivity and Effect of Ethanol in the Nucleus Accumbens. DID, GlyR, NAc, WT
12  2021 Desformylflustrabromine (dFBr), a positive allosteric modulator of the alpha4beta2 nicotinic receptor modulates the hypnotic response to ethanol. AUD, dFBr, DHbetaE, nAChRs, PAM, TEVC
13  2021 Design, synthesis, and evaluation of phenylpiperazine-phenylacetate derivatives as rapid recovery hypnotic agents. ---
14  2021 Dopaminergic Projections From the Ventral Tegmental Area to the Nucleus Accumbens Modulate Sevoflurane Anesthesia in Mice. DA, EEG, NAc, RORR, VTA
15  2021 Ethanol-Related Behaviors in Mouse Lines Selectively Bred for Drinking to Intoxication. AUD, BALs, DID, DIL, FR3, HDID, PR
16  2021 Gabra6100Q allele Sprague-Dawley rats have a higher sensitivity to hypnosis induced by isoflurane and ethanol than the wild type rats. SD, WT
17  2021 High-Loading Self-Assembling Peptide Nanoparticles as a Lipid-Free Carrier for Hydrophobic General Anesthetics. ANS, DLS, GAs, HAAs, PROP-GQY, SAPs, TEM, ThT
18  2021 Self-Assembled Micelles Improve the Oral Bioavailability of Dihydromyricetin and Anti-Acute Alcoholism Activity. DMY
19  2021 Volatile anesthetics maintain tidal volume and minute ventilation to a greater degree than propofol under spontaneous respiration. fR, MAC, MV, TE, TI, TV, WBP
20  2020 A possible neuroprotective property of ethanol and/or NeuroAiD on the modulation of cognitive function. i.p
21  2020 Deficiency of Mitochondrial Functions and Peroxidation of Frontoparietal Cortex Enhance Isoflurane Sensitivity in Aging Mice. M group, MDA, TBARS
22  2020 GABAA receptors in the basal forebrain mediates emergence from propofol anaesthesia in rats. BF, EEG, RORR
23  2020 GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats. PAM, PNF
24  2020 KLF4 Exerts Sedative Effects in Pentobarbital-Treated Mice. LH, TMN, VLPO
25  2020 Lentiviral-mediated up-regulation of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor. D3R, GHT, let-7, LV, miRNA, NAcc, TBC
26  2020 Muscone reduced the hypnotic and analgesic effect of ketamine in mice. GABA, NR
27  2020 Normal Ethanol Sensitivity and Rapid Tolerance Require the G Protein Receptor Kinase 2 in Ellipsoid Body Neurons in Drosophila. EtOH, FlyGrAM, Gprk2
28  2020 Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats. CG, EEG, FC, GABAA, NB, RORR
29  2020 The indirect gamma-aminobutyric acid (GABA) receptor agonist gabaculine-induced loss of the righting reflex may inhibit the descending analgesic pathway. DRG, GABA, SP
30  2020 The preclinical pharmacological study on HX0969W, a novel water-soluble pro-drug of propofol, in rats. ---
31  2020 Toxicological effects of propofol abuse on the dopaminergic neurons in ventral tegmental area and corpus striatum and its potential mechanisms. DAT, RORR, Th
32  2019 Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats. ---
33  2019 Effects of Xingnaojing Injection on Adenosinergic Transmission and Orexin Signaling in Lateral Hypothalamus of Ethanol-Induced Coma Rats. A1R, AD, EIC, ENT1, LHA, OX1R, XNJI
34  2019 Optogenetic/Chemogenetic Activation of GABAergic Neurons in the Ventral Tegmental Area Facilitates General Anesthesia via Projections to the Lateral Hypothalamus in Mice. BSR, EEG, LH, RORR, VTA
35  2019 Phytochemical analysis of Ficus carica L. active compounds possessing anticonvulsant activity. Fc, i.c.v, STR
36  2019 The sesquiterpene beta-caryophyllene oxide attenuates ethanol drinking and place conditioning in mice. BCP, CB2, CPP
37  2018 Altered Function and Expression of ABC Transporters at the Blood-Brain Barrier and Increased Brain Distribution of Phenobarbital in Acute Liver Failure Mice. ALF, BBB, BCRP, CNS, MRP2, P-gp
38  2018 Apremilast Alters Behavioral Responses to Ethanol in Mice: II. Increased Sedation, Intoxication, and Reduced Acute Functional Tolerance. AFT, CPA, CPP, CTA, EtOH, LiCl
39  2018 Aquaporin-4 knockout mice exhibit increased hypnotic susceptibility to ketamine. GABA, KO, WT
40  2018 Automated Assessment of Loss of Consciousness Using Whisker And Paw Movements During Anesthetic Dosing in Head-Fixed Rodents. LOC, LOM
41  2018 Behavioral Characterization of beta-Arrestin 1 Knockout Mice in Anxiety-Like and Alcohol Behaviors. HET, KO, WT
42  2018 Chicken breast muscle hydrolysates ameliorate acute alcohol-induced liver injury in mice through alcohol dehydrogenase (ADH) activation and oxidative stress reduction. ADH, ALDH, ALT, AST, BAC, CBMHs, MDA, SOD, TG
43  2018 Dexmedetomidine and propofol sedation requirements in an autistic rat model. EEG, GABAA, NMDA, RORR
44  2018 HCN channels contribute to the sensitivity of intravenous anesthetics in developmental mice. HCN
45  2018 Influence of lipopolysaccharide on diazepam-modified loss of righting reflex duration by pentobarbital treatment in mice. GABA, LPS
46  2018 Late aging alters behavioral sensitivity to ethanol in a sex-specific manner in Fischer 344 rats. BECs, EtOH
47  2018 Ligustrazine Enhances the Hypnotic and Analgesic Effect of Ketamine in Mice. CI
48  2018 miRNA-regulated transcription associated with mouse strains predisposed to hypnotic effects of ethanol. ---
49  2018 The influence of central interleukin-6 on behavioral changes associated with acute alcohol intoxication in adult male rats. CTA, i.c.v, i.p, IL-6
50  2017 alpha6beta2 nicotinic acetylcholine receptors influence locomotor activity and ethanol consumption. bPiDI, DID, nAChRs
51  2017 Attenuation of high-frequency (30-200 Hz) thalamocortical EEG rhythms as correlate of anaesthetic action: evidence from dexmedetomidine. ---
52  2017 Chronic Ethanol During Adolescence Impacts Corticolimbic Dendritic Spines and Behavior. AUDs, BLA, CIE, FR, IL, PL
53  2017 Design, Synthesis, and Evaluation of a Series of Novel Benzocyclobutene Derivatives as General Anesthetics. HBA
54  2017 Establishment of a BALB/c Mouse Model for Assessing the Degree of Inebriation Induced by Luzhou-Flavor Liquors. DUR
55  2017 General anesthetic actions on GABAA receptors in vivo are reduced in phospholipase C-related catalytically inactive protein knockout mice. PRIP
56  2017 Increased ethanol drinking in "humanized" mice expressing the mu opioid receptor A118G polymorphism are mediated through sex-specific mechanisms. CPP, DID, SNP
57  2017 Propofol Anesthesia Is Reduced in Phospholipase C-Related Inactive Protein Type-1 Knockout Mice. GABAAR, LTWR, OA, PRIP-1, PRIP-1 KO
58  2017 Refinement of intraperitoneal injection of sodium pentobarbital for euthanasia in laboratory rats (Rattus norvegicus). CHB, CV, i.p, LH, LL
59  2017 Regional knockdown of NDUFS4 implicates a thalamocortical circuit mediating anesthetic sensitivity. KD, TC
60  2017 Sedative and Motor Incoordination Effects of Ethanol in Mice Lacking CD14, TLR2, TLR4, or MyD88. EtOH, TLR4
61  2017 Strain-specific programming of prenatal ethanol exposure across generations. PAE
62  2016 Assessment of Carbon Dioxide, Carbon Dioxide/Oxygen, Isoflurane and Pentobarbital Killing Methods in Adult Female Sprague-Dawley Rats. ---
63  2016 Atp1a2 contributes modestly to alcohol-related behaviors. AFT, DID, EPM, HIC, OFA
64  2016 Bumetanide, an Inhibitor of NKCC1 (Na-K-2Cl Cotransporter Isoform 1), Enhances Propofol-Induced Loss of Righting Reflex but Not Its Immobilizing Actions in Neonatal Rats. GABA, NKCC1, pCREB
65  2016 Effect of Lipid Composition in Propofol Formulations: Decisive Component in Reducing the Free Propofol Content and Improving Pharmacodynamic Profiles. LCT, MCG
66  2016 Effects of propofol on the dopamine, metabolites and GABAA receptors in media prefrontal cortex in freely moving rats. DA, DOPAC, HVA, LOC, mPFC, RORR
67  2016 Inhibitors of Calcium-Activated Anion Channels Modulate Hypnotic Ethanol Responses in Adult Sprague Dawley Rats. Best1, CAACs, i.p
68  2016 Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse. DID, EtOH, nAChR
69  2016 Sex differences in the behavioral sequelae of chronic ethanol exposure. AUDs, CIE
70  2016 Single-syringe ketamine-propofol for induction of anaesthesia in rabbits. ---
71  2016 The PI3K-AKT-mTOR pathway activates recovery from general anesthesia. EL
72  2016 Transgenerational Transmission of the Effect of Gestational Ethanol Exposure on Ethanol Use-Related Behavior. BEC, EtOH, PAE, PND
73  2016 Transient loss of consciousness during hypercapnia and hypoxia: Involvement of pathways associated with general anesthesia. MPTA, TLOC
74  2015 Determination of the Hypnotic Potency in Rats of the Novel Ketamine Ester Analogue SN 35210. ---
75  2015 Genetic and pharmacological manipulation of glyoxalase 1 regulates voluntary ethanol consumption in mice. DID, EtOH, FVB, GLO1
76  2015 Genetic inactivation and prolonged pharmacologic inhibition of monoacylglycerol lipase have opposite effects on anesthetic sensitivity to propofol. 2-AG, MGL
77  2015 Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists. LC
78  2015 Role of Steroids in Hyperexcitatory Adverse and Anesthetic Effects of Sevoflurane in Neonatal Rats. GABAAR
79  2015 The effects of acute alcohol on motor impairments in adolescent, adult, and aged rats. ARR, BEC, i.p, RR
80  2015 [Anesthetic effects of repeated dosing with propofol and vitamin C in mice]. ---
81  2014 2-deoxy-D-glucose enhances anesthetic effects in mice. 2-DG, ATP
82  2014 Adolescent and adult rat cortical protein kinase A display divergent responses to acute ethanol exposure. cAMP, PKA
83  2014 Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling. MOR, TLR
84  2014 Altered sedative effects of ethanol in mice with alpha1 glycine receptor subunits that are insensitive to Gbetagamma modulation. GlyR, KI, SCNs
85  2014 Chaos analysis of EEG during isoflurane-induced loss of righting in rats. EEG, FFT
86  2014 GABAA receptors containing rho1 subunits contribute to in vivo effects of ethanol in mice. ---
87  2014 Genetic relationship between predisposition for binge alcohol consumption and blunted sensitivity to adverse effects of alcohol in mice. AFT, BECs, DID, EtOH, HAP
88  2014 Increased behavioral responses to ethanol in Lmo3 knockout mice. Acb, DID, LMO3
89  2014 Nalmefene reverses carfentanil-induced loss of righting reflex and respiratory depression in rats. ---
90  2014 Selective blockade of N-methyl-D-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility. CAergic, DA, NMDA
91  2014 The cannabinoid receptor 2 agonist, beta-caryophyllene, reduced voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice. BCP, EtOH, EtOH-CPP
92  2014 The FlyBar: administering alcohol to flies. ANOVA
93  2014 Tolerance to ethanol intoxication after chronic ethanol: role of GluN2A and PSD-95. CIE
94  2013 Acetate as an active metabolite of ethanol: studies of locomotion, loss of righting reflex, and anxiety in rodents. ---
95  2013 Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice. ---
96  2013 Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention. ---
97  2013 Chronic voluntary alcohol consumption results in tolerance to sedative/hypnotic and hypothermic effects of alcohol in hybrid mice. ---
98  2013 Effect of aquaporin-4 deficiency on intravenous anaesthetic induced hypnotic effects in mice. AQP4, KO
99  2013 Fyn-dependent gene networks in acute ethanol sensitivity. NAc, PFC, RI, VMB
100  2013 Medial septal cholinergic neurons modulate isoflurane anesthesia. ---