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Abbreviation : LOX
Long Form : lysyl oxidase
No. Year Title Co-occurring Abbreviation
2020 2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth. AMTs, AMTz, ECM
2020 ATDC5 cells as a model of cartilage extracellular matrix neosynthesis, maturation and assembly. ECM, PGs, PTMs
2020 Boosting collagen deposition with a lysyl oxidase/bone morphogenetic protein-1 cocktail. BMP-1, HEK
2020 Cancer Associated Fibroblasts and Senescent Thyroid Cells in the Invasive Front of Thyroid Carcinoma. CAFs, GEO, TC
2020 Carvacrol Downregulates Lysyl Oxidase Expression and Ameliorates Oxidative Stress in the Liver of Rats with Carbon Tetrachloride-Induced Liver Fibrosis. Loxl2
2020 Characteristics of penile growth in pubertal rats and a non-invasive method to lengthen the penis. ---
2020 Comprehensive analysis on the expression levels and prognostic values of LOX family genes in kidney renal clear cell carcinoma. KIRC, LOXL2, OS, RCC
2020 Corneal Stiffness and Collagen Cross-Linking Proteins in Glaucoma: Potential for Novel Therapeutic Strategy. CH, ECM, LC, LOXL1, mRNA, TM
2020 Downregulation of lysyl oxidase in venous malformations: Association with vascular destabilization and sclerotherapy. alpha-SMA, ECM, HUVEC, TGF-beta, VM
10  2020 Effects of Adiponectin on Diastolic Function in Mice Underwent Transverse Aorta Constriction. APN, Cpc, TAC
11  2020 Elevated intracellular copper contributes a unique role to kidney fibrosis by lysyl oxidase mediated matrix crosslinking. CTR1, TGF-beta, TM
12  2020 Esophageal Cancer Development: Crucial Clues Arising from the Extracellular Matrix. EC, ECM, MMPs
13  2020 Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation. AAA, prostaglandin E receptor 4, VSMCs
14  2020 Expressions of extracellular matrix-remodeling factors in lymph nodes from oral cancer patients. ECMs, LN, MSH, OSCC
15  2020 Extracellular vesicles influence the pulmonary arterial extracellular matrix in congenital diaphragmatic hernia. CDH, ECM, MSC-EVs, PA, PH
16  2020 High Glucose Increases Binding of Lysyl Oxidase to Extracellular Matrix Proteins: Implications for Diabetic Retinopathy. Coll IV, ECM, FN, HG, WB
17  2020 Identification and characterization of the promoter of cancer-related gene LOXL2. ChIP, ECM
18  2020 Inhibition of lysyl oxidase ameliorates renal injury by inhibiting CD44-mediated pericyte detachment and loss of peritubular capillaries. ECM, PTCs, UUO
19  2020 Intermittent Hypoxia Alleviates beta-Aminopropionitrile Monofumarate Induced Thoracic Aortic Dissection in C57BL/6 Mice. BAPN, CatS, ECM, HUASMCs, IH, IL, MMP-9, RT-PCR, TAD
20  2020 Intracellular Role for the Matrix-Modifying Enzyme Lox in Regulating Transcription Factor Subcellular Localization and Activity in Muscle Regeneration. ECM, TEF, TF, vgll3
21  2020 Ionizing radiation attracts tumor targeting and apoptosis by radiotropic lysyl oxidase traceable nanoparticles. LOXab, LOXab-NPs
22  2020 Low oxygen enhances trophoblast column growth by potentiating differentiation of the extravillous lineage and promoting LOX activity. EVT
23  2020 LOX family and ZFPM2 as novel diagnostic biomarkers for malignant pleural mesothelioma. CCLE, CDH11, GEO, MPM, MSLN, SULF1, THBS2, ZFPM2
24  2020 LOX gene polymorphisms are associated with osteoporotic vertebral compression fracture in postmenopausal Chinese women. BMD, OVCF, SNPs
25  2020 LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2. BAG2
26  2020 LOXL2 in cancer: regulation, downstream effectors and novel roles. ECM, EMT, LOXL2, LTQ
27  2020 Lysyl Oxidase (LOX) Family Members: Rationale and Their Potential as Therapeutic Targets for Liver Fibrosis. ECM, LOXL1, LOXL2, LOXL3, LOXL4
28  2020 Lysyl Oxidase (LOX): Functional Contributions to Signaling Pathways. ECM
29  2020 Lysyl Oxidase Directly Contributes to Extracellular Matrix Production and Fibrosis in Systemic Sclerosis. ECM, IPF, SSc
30  2020 Lysyl oxidase expression is associated with inferior outcome and Extramedullary disease of acute myeloid leukemia. AML, EFS, OS
31  2020 Lysyl oxidase inhibits TNF-alpha induced rat nucleus pulposus cell apoptosis via regulating Fas/FasL pathway and the p53 pathways. CCK-8, ECM, IVDD, NP, RT-qPCR
32  2020 Lysyl oxidase suppresses the inflammatory response in anterior cruciate ligament fibroblasts and promotes tissue regeneration by targeting myotrophin via the nuclear factor-kappa B pathway. ACL, ACLfs, DEGs, MMPs, MTPN, NF-kappaB, TNF-alpha
33  2020 Lysyl oxidase-like 2 promotes esophageal squamous cell carcinoma cell migration independent of catalytic activity. ESCC, LOXL2, LOXL2, SRCR
34  2020 Mechanical injury and IL-1beta regulated LOXs and MMP-1, 2, 3 expression in ACL fibroblasts co-cultured with synoviocytes. ACL, ACLfs, IL, MMP, SCs
35  2020 Recognition of lysyl oxidase as a potential predictive biomarker for oral squamous cell carcinoma: an immunohistochemical study. OSCC
36  2020 Secreted Phospholipase A2-IIA Modulates Transdifferentiation of Cardiac Fibroblast through EGFR Transactivation: An Inflammation-Fibrosis Link. BMP, CFs, DCM, HB-EGF, ROS, sPLA2-IIA
37  2020 Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration. Atox1
38  2020 Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer. TNBC
39  2020 Th17/Treg imbalance modulates rat myocardial fibrosis and heart failure by regulating LOX expression. Ang II, HCFs, HF, Th, Treg
40  2020 Tocotrienol-rich fraction from annatto ameliorates expression of lysyl oxidase in human osteoblastic MG-63 cells. DNMTs, TRF
41  2019 A Three-Dimensional Model of Human Lysyl Oxidase, a Cross-Linking Enzyme. ---
42  2019 Aberrant Collagen Cross-linking in Human Oral Squamous Cell Carcinoma. ECM, LH2, LOXL2, OSCC, RLNM
43  2019 Alterations in phenotype and gene expression of adult human aneurysmal smooth muscle cells by exogenous nitric oxide. AAA, NO, SMC
44  2019 Analysis of lysyl oxidase as a marker for diagnosis of canine mammary tumors. CMTs
45  2019 Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships. AMT, SAR
46  2019 Astrocytes are direct cellular targets of lithium treatment: novel roles for lysyl oxidase and peroxisome-proliferator activated receptor-gamma as astroglial targets of lithium. AD, BD, ECM, PPARgamma
47  2019 ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis. LOXL
48  2019 Bilaterally Asymmetric Corneal Ectasia Following SMILE With Asymmetrically Reduced Stromal Molecular Markers. BMP-7, COLIA1, IL-6, MMP9, SMILE, TGF-beta, TIMP1
49  2019 Bone morphogenetic protein 2 increases lysyl oxidase activity via up-regulation of snail in human granulosa-lutein cells. BMP2, ECM, hGL
50  2019 Co-administration of resveratrol and beta-aminopropionitrile attenuates liver fibrosis development via targeting lysyl oxidase in CCl4-induced liver fibrosis in rats. BAPN, RES
51  2019 Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis. HGSOC
52  2019 Comparative Evaluation of role of Lysyl oxidase gene (LOXG473A) expression in pathogenesis and malignant transformation of Oral Submucous Fibrosis. ---
53  2019 Decreased lysyl oxidase level protects against development of retinal vascular lesions in diabetic retinopathy. AC, BM, PL, RTDs, STZ, WB, WT
54  2019 Defining the Clinical, Molecular and Ultrastructural Characteristics in Occipital Horn Syndrome: Two New Cases and Review of the Literature. OHS
55  2019 Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain. BMP-1
56  2019 Downregulation of lysyl oxidase and lysyl oxidase-like protein 2 suppressed the migration and invasion of trophoblasts by activating the TGF-beta/collagen pathway in preeclampsia. LOXL2
57  2019 Exogenous Lysyl Oxidase-Like 2 and Perfusion Culture Induce Collagen Crosslink Formation in Osteogenic Grafts. ECM, LOXL2, MSCs, PYD
58  2019 Fibrostenotic eosinophilic esophagitis might reflect epithelial lysyl oxidase induction by fibroblast-derived TNF-alpha. EoE
59  2019 Forkhead box C1 promotes metastasis and invasion of non-small cell lung cancer by binding directly to the lysyl oxidase promoter. FOXC1, NSCLC
60  2019 HIF2A-LOX Pathway Promotes Fibrotic Tissue Remodeling in Thyroid-Associated Orbitopathy. ECM, HIF, OFs, TAO
61  2019 Hypercapnia downregulates hypoxia-induced lysyl oxidase expression in pulmonary artery smooth muscle cells via inhibiting transforming growth factor beta1 signalling. mPAP, TGF-beta1
62  2019 Hypoxia and collagen crosslinking in the healthy and affected sites of periodontitis patients. CALs, GI, HIF, LH, PH, PI, VEGF
63  2019 Identification of Key Genes and Signaling Pathways Associated with the Progression of Gastric Cancer. APOE, BGN, COL1A1, DEGs, GO, GSEA, KEGG, MMP3, NPY, PPI, SPP1, SST
64  2019 Identification of potential biomarkers of lung adenocarcinoma brain metastases via microarray analysis of cDNA expression profiles. DEGs, LAD, LAD-BM, MMP-2, PPI
65  2019 Impaired Gastric Hormone Regulation of Osteoblasts and Lysyl Oxidase Drives Bone Disease in Diabetes Mellitus. BMD, GIP
66  2019 Induction of LOX by TGF-beta1/Smad/AP-1 signaling aggravates rat myocardial fibrosis and heart failure. BAPN, CHF, RAAS, RCFs
67  2019 Inhibition of Rho-associated kinases suppresses cardiac myofibroblast function in engineered connective and heart muscle tissues. ECT
68  2019 Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families. ECM
69  2019 Interplay Between LOX Enzymes and Integrins in the Tumor Microenvironment. ECM, IACs
70  2019 Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress. ---
71  2019 Involvement of miR-30b in kynurenine-mediated lysyl oxidase expression. ECM, KYN
72  2019 Lowered Decorin With Aberrant Extracellular Matrix Remodeling in Aqueous Humor and Tenon's Tissue From Primary Glaucoma Patients. AGMs, AH, alpha-SMA, COL1A1, CTGF, DCN, ECM, ELN, GFS, LOXL2, MCP-1, PACG, POAG, SPARC
73  2019 LOX inhibition downregulates MMP-2 and MMP-9 in gastric cancer tissues and cells. BAPN, MMP-2, PDGFR
74  2019 LOX/LOXL in pulmonary fibrosis: potential therapeutic targets. ECM, IPF, LOXL
75  2019 Lysyl oxidase and hypoxia-inducible factor 1alpha: biomarkers of gastric cancer. GC, HIF-1alpha, qRT-PCR
76  2019 Lysyl oxidase assists tumor‑initiating cells to enhance angiogenesis in hepatocellular carcinoma. ECM, TICs, VEGF
77  2019 Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer. ESCC
78  2019 Lysyl oxidase induces epithelial-mesenchymal transition and predicts intrahepatic metastasis of hepatocellular carcinoma. EMT, HCC, HIF-1alpha, IHC
79  2019 Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness. ---
80  2019 Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts. BAPN, CAFs, CT, GC, IHC, PDX, TME
81  2019 Lysyl oxidase-a possible role in systemic sclerosis-associated pulmonary hypertension: a multicentre study. IPAH, PRP, VEDOSS
82  2019 Lysyl oxidases: from enzyme activity to extracellular matrix cross-links. ECM
83  2019 Markers of the pre-metastatic niche "knock on the door" of metastasis-free cervical lymph nodes in patients with oral cancer. cap, FN, LNs, MMP, MS, PMN, SCS, VEGFR
84  2019 Non-contact co-culture with human vascular endothelial cells promotes epithelial-to-mesenchymal transition of cervical cancer SiHa cells by activating the NOTCH1/LOX/SNAIL pathway. ---
85  2019 Novel lysyl oxidase inhibitors attenuate hallmarks of primary myelofibrosis in mice. MPN, PMF
86  2019 Past, Present and Future Anti-Obesity Effects of Flavin-Containing and/or Copper-Containing Amine Oxidase Inhibitors. LSD, MAO
87  2019 Properties of a cryptic lysyl oxidase from haloarchaeon Haloterrigena turkmenica. HTU-LOX
88  2019 Role of the lysyl oxidase enzyme family in cardiac function and disease. ECM, LOXL
89  2019 Striae reconstructed, a full thickness skin model that recapitulates the pathology behind stretch marks. ECM, HDF, SD
90  2019 Substrate Strain Mitigates Effects of beta-Aminopropionitrile-Induced Reduction in Enzymatic Crosslinking. BAPN
91  2019 Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. GBM
92  2019 The effects of losartan on cytomegalovirus infection in human trabecular meshwork cells. CMV, CTGF, ELISA, SMA, TGF, TM
93  2019 The non-steroidal mineralocorticoid receptor antagonist finerenone prevents cardiac fibrotic remodeling. CTGF, LV, MR, TGF-ss
94  2019 The Role of Lysyl Oxidase Enzymes in Cardiac Function and Remodeling. ECM
95  2019 Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29. ECM, TSP-2
96  2019 Time-dependent variation in expression patterns of Lysyl Oxidase, Type I Collagen and tropoelastin mRNA in response to orthodontic force application. ANOVA, mRNA
97  2019 TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro. ECM, LOPP, MSC
98  2019 Upregulated LOX and increased collagen content associated with aggressive clinicopathological features and unfavorable outcome in oral squamous cell carcinoma. ECM, OSCC
99  2019 Upregulation of Lysyl Oxidase Expression in Vitreous of Diabetic Subjects: Implications for Diabetic Retinopathy. DR, PDR
100  2018 3D hydrogel breast cancer models for studying the effects of hypoxia on epithelial to mesenchymal transition. EMT, LMC