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Abbreviation : LRP1
Long Form : LDL receptor-related protein 1
No. Year Title Co-occurring Abbreviation
2020 Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome. PAI-1
2020 PAI-1 overexpression promotes invasion and migration of esophageal squamous carcinoma cells. Co-IP, ELISA, ESCC, PAI-1
2019 ApoC-III Glycoforms Are Differentially Cleared by Hepatic TRL (Triglyceride-Rich Lipoprotein) Receptors. LDLR, TRL
2019 APOE4-mediated amyloid-beta pathology depends on its neuronal receptor LRP1. AD, APO3-TR
2019 Apolipoprotein E/Amyloid-beta Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4. AD, APOE, LDLR, PSD-95
2019 CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy. LAMP1
2019 DNA methylation at LRP1 gene locus mediates the association between maternal total cholesterol changes in pregnancy and cord blood leptin levels. CpGs, DNAm, LDLR, SCARB1
2019 FactorVIII with a 237 amino acid B-domain has an extended half-life in F8-knockout mice. aa, FVIII-21, KO, SPR
2019 LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing. LPS, PNL, PNS, SDH
10  2019 PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles. GLUT4, PID1
11  2019 The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response. SOD3
12  2018 Advanced Whole-Genome Sequencing and Analysis of Fetal Genomes from Amniotic Fluid. cfDNA, CHD8
13  2018 Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1-mediated endocytosis. IFT88
14  2018 Clearance of plasmin-PN-1 complexes by vascular smooth muscle cells in human aneurysm of the ascending aorta. PN-1, VSMC
15  2018 Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B. CSPG4, HIOs, MEFs, PVRL3
16  2018 Intracellular lipid metabolism impairs beta cell compensation during diet-induced obesity. ---
17  2018 Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor. LDL, LPS, LTA, PCSK9
18  2018 Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature. ---
19  2018 Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury. SCs
20  2018 The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins. ICD, LDL, PID1, TRL
21  2018 The Expression of Lipoprotein Receptors Is Increased in the Infarcted Area After Myocardial Infarction Induced in Rats With Cardiac Dysfunction. INT, LDE, LDL, LDLR, LV, MI, SEN, sham, SR-BI
22  2017 APP, APLP2 and LRP1 interact with PCSK9 but are not required for PCSK9-mediated degradation of the LDLR in vivo. APLP2, APP, LDLRs, PCSK9, WT
23  2017 LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: towards pre-clinical simulation of symptomatic ICH. BBB, HT, MCAO, RAP, sICH
24  2017 News on the molecular regulation and function of hepatic low-density lipoprotein receptor and LDLR-related protein 1. LDLR
25  2017 Plasminogen activator inhibitor-1 regulates the vascular expression of vitronectin. PAI, PAI-1, SMCs, VG, VN, WT
26  2017 Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP). RAP
27  2017 Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation. RAP, sLRP1
28  2017 The LDL Receptor-Related Protein 1: At the Crossroads of Lipoprotein Metabolism and Insulin Signaling. ---
29  2016 ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. ApoC-III, ASOs, HSPG, LDLRs, LPL, TGs
30  2016 Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90alpha) to Survive a Hostile Hypoxic Environment. HSP90alpha
31  2016 Correction: LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages. ---
32  2016 Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE. FVIII, LDL
33  2016 Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells. PNS, SCs, tPA
34  2016 High Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation: CRITICAL ROLES OF LYSINES 60 AND 191. RAP
35  2016 LDL receptor-related protein 1 contributes to the clearance of the activated factor VII-antithrombin complex. FVIIa, macLRP1
36  2016 LDL receptor-related protein-1 regulates NFkappaB and microRNA-155 in macrophages to control the inflammatory response. LF, LPS, miR-155, RAP
37  2016 LRP1 Protein Deficiency Exacerbates Palmitate-induced Steatosis and Toxicity in Hepatocytes. ER
38  2016 Modulation of the Isoprenoid/Cholesterol Biosynthetic Pathway During Neuronal Differentiation In Vitro. HMGR, LDLR, MVA, SRB-1
39  2016 The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains. ---
40  2016 Uptake of Plasmin-PN-1 Complexes in Early Human Atheroma. PN-1, VSMCs
41  2015 High Preformed Vitamin A Intake during Pregnancy Prevents Embryonic Accumulation of Intact beta-Carotene from the Maternal Circulation in Mice. BC, BCO1, Cyp26A1, dpc, WT
42  2015 Hsp90alpha and Hsp90beta together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing. Hsp90
43  2015 Immunohistochemical analysis of transporters related to clearance of amyloid-beta peptides through blood-cerebrospinal fluid barrier in human brain. ABC, FPRL1, IDE, LDLR
44  2015 LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages. LDLR
45  2015 The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. NMDARs, PNS
46  2015 Tissue-type plasminogen activator (tPA) promotes M1 macrophage survival through p90 ribosomal S6 kinase (RSK) and p38 mitogen-activated protein kinase (MAPK) pathway. IL-4, MAPK, tPA
47  2014 An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. ACs, RANBP9
48  2014 Apolipoprotein E isoform-specific effects on lipoprotein receptor processing. APOE, BBB, LDLR
49  2014 Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties. An2, BBB, NT
50  2014 High density lipoprotein metabolism in low density lipoprotein receptor-deficient mice. CD36, CE, LDLR, SR-BI
51  2014 LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins. CROP, RBD
52  2014 Mechanisms of U87 astrocytoma cell uptake and trafficking of monomeric versus protofibril Alzheimer's disease amyloid-beta proteins. ---
53  2014 Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status. Fe, Hb, Hx
54  2013 Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice. HSPG, LDLR
55  2013 Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype. MTTP, PDIA2, PON1, SGA
56  2013 LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein. EI-tPA, p75NTR, tPA
57  2013 Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. ---
58  2013 Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice. ---
59  2013 The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events. PDGFRbeta
60  2013 The regulation of ApoB metabolism by insulin. apoB, HSPGs, LDLR, T2D
61  2012 Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis. cath-D, RIP
62  2012 Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer. LDL
63  2012 Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice. ---
64  2012 Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E. APOE, HDL, LDL, TRL
65  2012 LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis. ---
66  2012 Preliminary evidence for an association between LRP-1 genotype and body mass index in humans. APOE, BMI, GOLDN, SNPs, TGRL
67  2012 Role of CD47 and Signal Regulatory Protein Alpha (SIRPalpha) in Regulating the Clearance of Viable or Aged Blood Cells. SIRPalpha
68  2012 Upregulation of hepatic LRP1 by rosiglitazone: a possible novel mechanism of the beneficial effect of thiazolidinediones on atherogenic dyslipidemia. LETO, OLETF
69  2011 Adipose tissue gene expression of factors related to lipid processing in obesity. ASP, BMI, FABP4, IR, LPL, SAT, T2DM, VLDLR
70  2011 Inhibition of macrophage inflammatory cytokine secretion by chylomicron remnants is dependent on their uptake by the low density lipoprotein receptor. CMR, CRLPs, IL, LDLR, MCP-1, oxCRLPs, TNF-alpha
71  2011 Macrophage LRP1 suppresses neo-intima formation during vascular remodeling by modulating the TGF-beta signaling pathway. LDLR
72  2011 Molecular basis for the interaction of low density lipoprotein receptor-related protein 1 (LRP1) with integrin alphaMbeta2: identification of binding sites within alphaMbeta2 for LRP1. sLRP1
73  2011 Premature ligand-receptor interaction during biosynthesis limits the production of growth factor midkine and its receptor LDL receptor-related protein 1. ER, RAP
74  2011 Regulation of cytokine expression by Schwann cells in response to alpha2-macroglobulin binding to LRP1. TNF-alpha
75  2011 Regulation of the urokinase receptor (uPAR) by LDL receptor-related protein-1 (LRP1). uPAR
76  2011 Serpin-Enzyme Receptors LDL Receptor-Related Protein 1. ---
77  2011 The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury. CHOP, ER, PI3K, SCs, TNF-alpha, UPR
78  2011 The urokinase receptor system as strategic therapeutic target: challenges for the 21st century. uPAR
79  2010 LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome. Plxdc1, Sema4D
80  2010 Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking. Abeta42, AD
81  2010 The expression of LDL receptor in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model. BBB, LDLR, RAGE, SHRSP, WKY
82  2009 Alpha-tocopherol transport in the lung is affected by the apoE genotype--studies in transgenic apoE3 and apoE4 mice. APOE, LDLrec, SR-B1
83  2009 Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance. CR
84  2009 Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90alpha autocrine signaling to promote keratinocyte migration. HK, HSP90alpha
85  2009 RAGE, LDL receptor, and LRP1 expression in the brains of SAMP8. APP, LDLR, RAGE, RT-PCR
86  2009 Smooth muscle LDL receptor-related protein-1 inactivation reduces vascular reactivity and promotes injury-induced neointima formation. PRGFR
87  2008 A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents. CCI, P-p38, PNS
88  2008 apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. AD, BBB, VLDLR
89  2008 Mutational analysis of the FXNPXY motif within LDL receptor-related protein 1 (LRP1) reveals the functional importance of the tyrosine residues in cell growth regulation and signal transduction. FAK, LDL
90  2008 Novel actions of tissue-type plasminogen activator in chronic kidney disease. tPA
91  2008 tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis. tPA
92  2008 Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing. HSP90alpha, TGF alpha
93  2007 Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. TGRL
94  2007 Apolipoprotein E interrupts interleukin-1beta signaling in vascular smooth muscle cells. AP-1, APOE, IL-1beta, PKA, VSMCs
95  2007 Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells. MK, PDGF
96  2007 The acute phase protein alpha2-macroglobulin induces rat ventricular cardiomyocyte hypertrophy via ERK1,2 and PI3-kinase/Akt pathways. alpha 2M, ANF, beta-MHC, BNP, ERK1,2, MLC-2, mTOR, PI 3-kinase, RAP, SERCA2a
97  2007 The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein. LDL
98  2007 Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling. ILK, tPA
99  2005 LDL receptor-related protein and the vascular wall: implications for atherothrombosis. VSMCs
100  2004 Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier. BBB, LDL, RAP