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Abbreviation : LRP1
Long Form : lipoprotein receptor-related protein 1
No. Year Title Co-occurring Abbreviation
2020 A multimolecular signaling complex including PrPC and LRP1 is strictly dependent on lipid rafts and is essential for the function of tissue plasminogen activator. tPA
2020 A soluble derivative of PrPC activates cell-signaling and regulates cell physiology through LRP1 and the NMDA receptor. ADAM, NMDAR
2020 Alzheimer's amyloid-beta and tau protein accumulation is associated with decreased expression of the LDL receptor-associated protein in human brain tissue. AD, RAP
2020 Association of Low-Density Lipoprotein Receptor-Related Protein 1 and Its rs1799986 Polymorphism With Mild Cognitive Impairment in Chinese Patients With Type 2 Diabetes. AVLT, MCI, MoCA, OR, sLRP1, T2DM
2020 CRELD2 Is a Novel LRP1 Chaperone That Regulates Noncanonical WNT Signaling in Skeletal Development. EGF, ER
2020 Development of a Novel Dual-Order Protein-Based Nanodelivery Carrier That Rapidly Targets Low-Grade Gliomas with Microscopic Metastasis in Vivo. BBB, Fn-Rev-Ang, MRI, TfR1
2020 Effect of Zhenxin Xingshui Yizhi Fang on Abeta25-35 induced expression of related transporters in HBMEC cell model. AD, HBMEC, XSF
2020 Efficient LRP1-mediated uptake and low cytotoxicity of peptide L57 in vitro shows its promise as CNS drug delivery vector. CNS
2020 Gastrodin relieves inflammation injury induced by lipopolysaccharides in MRC-5 cells by up-regulation of miR-103. COPD
10  2020 Gout inheritance in an extended Chinese family analyzed by whole-exome sequencing: A case-report. OIT3, UC
11  2020 High-Affinity Binding of LDL Receptor-Related Protein 1 to Matrix Metalloprotease 1 Requires Protease:Inhibitor Complex Formation. ECM, MMP, TIMPs
12  2020 Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5). BBB, BCEC, hiPSC, SLC's, TEER, TfR
13  2020 Investigating the clearance of VWF A-domains using site-directed PEGylation and novel N-linked glycosylation. PEG, vWF
14  2020 Involvement of chronic unpredictable mild stress-induced hippocampal LRP1 up-regulation in microtubule instability and depressive-like behavior in a depressive-like adult male rat model. CUMS
15  2020 Involvement of the lipoprotein receptor LRP1 in AMP-IBP5-mediated migration and proliferation of human keratinocytes and fibroblasts. AMP-IBP5
16  2020 Knockdown of Lrp1 in RAW264cells inhibits osteoclast differentiation and osteoclast-osteoblast interactions invitro. ---
17  2020 Lactotransferrin Downregulation Drives the Metastatic Progression in Clear Cell Renal Cell Carcinoma. ccRCC, EMT
18  2020 Low density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional receptor in heart. ---
19  2020 Low density lipoprotein receptor-related protein 1 regulates cardiac hypertrophy induced by pressure overload. Ang II, NE, PE, TAC
20  2020 Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity. FA, FAO, HFD, NPR-A, pro-ANP
21  2020 LRP1 is a master regulator of tau uptake and spread. ---
22  2020 LRP1 knockdown aggravates Abeta1-42-stimulated microglial and astrocytic neuroinflammatory responses by modulating TLR4/NF-kappaB/MAPKs signaling pathways. AD, IL-1beta, IL-6, MAPKs, MyD88, NF-kappaB, TLR4, TNF-alpha, TRAF6
23  2020 LRP1-Mediated AggLDL Endocytosis Promotes Cholesteryl Ester Accumulation and Impairs Insulin Response in HL-1 Cells. aggLDL, CE, CVD, GLUT4, IR
24  2020 Lychee seed polyphenol inhibits Abeta-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction. AD, LSP
25  2020 Midkine promotes articular chondrocyte proliferation through the MK-LRP1-nucleolin signaling pathway. IP, OA, rhMK
26  2020 Mini Review: Opposing Pathologies in Cancer and Alzheimer's Disease: Does the PI3K/Akt Pathway Provide Clues? AD, IGFs, IRS-1, mTORC1, Pin1
27  2020 MiR-640 inhibition alleviates acute liver injury via regulating WNT signaling pathway and LRP1. ALI, KCs, LPS
28  2020 Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer's disease. AD, COX2, ICAM-1, MCP-1, MDP, PSD-95
29  2020 Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening. CHD, CNC, OFT
30  2020 Ovotransferrin Exhibits Osteogenic Activity Partially via Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Activation in MC3T3-E1 Cells. ---
31  2020 PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer. EECs, PAI-1, TGF-beta
32  2020 RNA Sequencing Reveals Cancer-Associated Changes in Laryngeal Cells Exposed to Non-Acid Pepsin. LPR
33  2020 Silencing of LRP1 Exacerbates Inflammatory Response Via TLR4/NF-kappaB/MAPKs Signaling Pathways in APP/PS1 Transgenic Mice. AD, MAPK, NF-kappaB, TLR4
34  2020 Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery. EHD1, SNX, SNX17
35  2020 The active contribution of OPCs to neuroinflammation is mediated by LRP1. OPCs
36  2020 The low density receptor-related protein 1 plays a significant role in ricin-mediated intoxication of lung cells. ---
37  2020 The Neuroprotective Effects of Danggui-Shaoyao San on Vascular Cognitive Impairment: Involvement of the Role of the Low-Density Lipoprotein Receptor-Related Protein. CCH, DSS, IKK, NF-kappaB, VCI
38  2020 Therapeutic Potential of Direct Clearance of the Amyloid-beta in Alzheimer's Disease. AD, CSF, RAGE
39  2020 Two weeks of western diet disrupts liver molecular markers of cholesterol metabolism in rats. ACAT-2, ACC, ChREBP, HMGCoAR, LDLR, SD, SREBP2, TG
40  2019 Activated alpha2-Macroglobulin Regulates LRP1 Levels at the Plasma Membrane through the Activation of a Rab10-dependent Exocytic Pathway in Retinal Muller Glial Cells. MGCs, PM
41  2019 alpha-2-Macroglobulin induces the shedding of microvesicles from cutaneous wound myofibroblasts. A2M, MVs
42  2019 Altered fibrinolytic system in rat models of depression and patients with first-episode depression. BDI, CUMS, LPS, PAI-1, PBMCs, tPA
43  2019 Analysis of Comparative Proteomic and Potent Targets of Peniciketal A in Human Acute Monocytic Leukemia. CALR, G6PD, KEGG, Pe-A
44  2019 Chronic cerebral hypoperfusion alters amyloid-beta transport related proteins in the cortical blood vessels of Alzheimer's disease model mouse. 4-HNE, AD, CAA, CCH, EDA, GLUT1, HIF-1alpha, HO-1, Mfsd2a, RAGE, WT
45  2019 Conditional Deletion of LRP1 Leads to Progressive Loss of Recombined NG2-Expressing Oligodendrocyte Precursor Cells in a Novel Mouse Model. CNS, EAE, KO, OPCs
46  2019 Copper-Induced Upregulation of MicroRNAs Directs the Suppression of Endothelial LRP1 in Alzheimer's Disease Model. AD, MVECs
47  2019 Developing LRP1 Agonists into a Therapeutic Strategy in Acute Myocardial Infarction. AAT, AMI, RISK
48  2019 Dual-targeting and microenvironment-responsive micelles as a gene delivery system to improve the sensitivity of glioma to radiotherapy. BBB, BCECs, CMC, MMP-2, RT
49  2019 Enhanced blood-brain-barrier penetrability and tumor-targeting efficiency by peptide-functionalized poly(amidoamine) dendrimer for the therapy of gliomas. Ang2, BBB, CNS, EGFR, OBOC
50  2019 Extracellular Hsp90alpha and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1. EMT
51  2019 Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA. ICD, NMDA, TGN
52  2019 Gender difference and genetic variance in lipoprotein receptor-related protein 1 is associated with mortality. SNPs
53  2019 Hemin induces autophagy in a leukemic erythroblast cell line through the LRP1 receptor. LC3, qRT-PCR, WB
54  2019 Identification of hepatokines involved in pathology of type 2 diabetes and obesity. AMPK, LECT2, ROS, SeP
55  2019 Letter by Hoekstra et al Regarding Article, "Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages". CCR7
56  2019 Letter by Potere et al Regarding Article, "Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages". CCR7
57  2019 Long-term consumption of alcohol exacerbates neural lesions by destroying the functional integrity of the blood-brain barrier. AQP4, BBB, Mfsd2a, RAGE
58  2019 Low Density Lipoprotein Receptor-Related Protein-1 in Cardiac Inflammation and Infarct Healing. AAT, AMI, HF
59  2019 Low Density Receptor-Related Protein 1 Interactions With the Extracellular Matrix: More Than Meets the Eye. ECM
60  2019 Low-density lipoprotein receptor-related protein 1 regulates muscle fiber development in cooperation with related genes to affect meat quality. ---
61  2019 Low-dose pioglitazone can ameliorate learning and memory impairment in a mouse model of dementia by increasing LRP1 expression in the hippocampus. AD, PPARgamma, SAMP8
62  2019 LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats. APOE, SAH, WMI
63  2019 LRP1 Has a Predominant Role in Production over Clearance of Abeta in a Mouse Model of Alzheimer's Disease. AD, APP, BBB, CSF, ISF, sAPP-alpha
64  2019 LRP1 promotes synthetic phenotype of pulmonary artery smooth muscle cells in pulmonary hypertension. IPAH, PASMC, PDGF, PH, SMC
65  2019 LRP1-upregulated nanoparticles for efficiently conquering the blood-brain barrier and targetedly suppressing multifocal and infiltrative brain metastases. BBB, BMECs
66  2019 Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis. EAM, MK, NETs, PMNs
67  2019 Molecular basis for the protective effects of low-density lipoprotein receptor-related protein 1 (LRP1)-derived peptides against LDL aggregation. GFC, GGE, HPTLC, PLA2, TEM
68  2019 Overexpression of PID1 reduces high density lipoprotein level and functionality in swine. apoA-I, HDL-C, PID1, PTB
69  2019 Paricalcitol accelerates BACE1 lysosomal degradation and inhibits calpain-1 dependent neuronal loss in APP/PS1 transgenic mice. BACE1, BER, PAL, SREBP2
70  2019 Recombinant expressing angiopep-2 fused anti-VEGF single chain Fab (scFab) could cross blood-brain barrier and target glioma. ANG, scFab, scFab
71  2019 Response by Mueller et al to Letter Regarding Article, "Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages". CCR7
72  2018 A Novel Delivery System of Cyclovirobuxine D for Brain Targeting: Angiopep-Conjugated Polysorbate 80-Coated Liposomes via Intranasal Administration. ANG, BBB, LPs, TEM
73  2018 A novel peptide ligand RAP12 of LRP1 for glioma targeted drug delivery. BBB, BBTB, RAP, VM
74  2018 Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation. APOE
75  2018 Beneficial Role of Rosuvastatin in Blood-Brain Barrier Damage Following Experimental Ischemic Stroke. BBB, MAPK, MCAO, MMPs, p-ERK, p-JNK, PDGFRalpha, rt-PA, TIMPs
76  2018 Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-beta42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. APOE, BBB
77  2018 Bovine lactoferrin promotes energy expenditure via the cAMP-PKA signaling pathway in human reprogrammed brown adipocytes. bLF, cAMP, CREB, LF, PGC1alpha, RAP, UCP1
78  2018 Cerebrovascular Angiogenic Reprogramming upon LRP1 Repression: Impact on Sphingosine-1-Phosphate-Mediated Signaling in Brain Endothelial Cell Chemotactism. S1P
79  2018 Chronic Arsenic Exposure Increases Abeta(1-42) Production and Receptor for Advanced Glycation End Products Expression in Rat Brain. RAGE
80  2018 Cognitive benefits of lithium chloride in APP/PS1 mice are associated with enhanced brain clearance of beta-amyloid. AD, CSF, i.c.v, LiCl, WT
81  2018 Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages. CCR7
82  2018 Design of multifunctional peptide collaborated and docetaxel loaded lipid nanoparticles for antiglioma therapy. GBM, SLN
83  2018 Effects of increased accumulation of doxorubicin due to emodin on efflux transporter and LRP1 expression in lung adenocarcinoma and colorectal carcinoma cells. DOX
84  2018 Liver-enriched transcription factor expression relates to chronic hepatic failure in humans. CDH1, CEBP, CYP3A4, FOXA2, HNF, LETFs, OTC, pMLC
85  2018 Low-density lipoprotein receptor-related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression. HFHC
86  2018 LRP1: A chameleon receptor of lung inflammation and repair. ---
87  2018 Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice. ---
88  2018 Macrophage LRP1 Promotes Diet-Induced Hepatic Inflammation and Metabolic Dysfunction by Modulating Wnt Signaling. ---
89  2018 Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation. AML, mP3, PMN
90  2018 Overexpression of low density lipoprotein receptor-related protein 1 (LRP1) is associated with worsened prognosis and decreased cancer immunity in clear-cell renal cell carcinoma. ccRCC, MVD, TIL
91  2018 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. ---
92  2018 Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-beta pathology in amyloid model mice. AD
93  2018 PID1 in adipocytes modulates whole-body glucose homeostasis. aP2-PID1tg, IR, PID1, WAT
94  2018 Regulatory effects of simvastatin and apoJ on APP processing and amyloid-beta clearance in blood-brain barrier endothelial cells. AD, APP, BBB, BCEC, CAA
95  2018 Synergistic role of HSP90alpha and HSP90beta to promote myofibroblast persistence in lung fibrosis. ECM, HSP, IPF
96  2018 The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM. AD, BBB
97  2018 TLR Crosstalk Activates LRP1 to Recruit Rab8a and PI3Kgamma for Suppression of Inflammatory Responses. GTPase, PI3K, TLRs
98  2018 Vitamin K2 improves proliferation and migration of bovine skeletal muscle cells in vitro. LDH, LDLR
99  2018 Voltage-gated calcium channel alpha 2delta subunits: an assessment of proposed novel roles. NMDA
100  2018 ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells. EMT, FN1, ITGB1, miRNAs, VM, ZEB1