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Abbreviation : LRP
Long Form : lipoprotein receptor-related protein
No. Year Title Co-occurring Abbreviation
2020 Angiopep-2 conjugated nanoparticles loaded with doxorubicin for the treatment of primary central nervous system lymphoma. ANG, BBB, BCECs, DOX, PCNSL, PEG-b-PCL
2020 CDDO-Me Elicits Anti-Breast Cancer Activity by Targeting LRP6 and FZD7 Receptor Complex. CDDO-Me, CSC, Dvl, FZD, MMTV
2020 Dual-targeting and excretable ultrasmall SPIONs for T1-weighted positive MR imaging of intracranial glioblastoma cells by targeting the lipoprotein receptor-related protein. BBB, MR, USPIONs
2020 Endosomal Wnt signaling proteins control microtubule nucleation in dendrites. dsh, fz, GFP
2020 Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-beta1 from ECM stores. ECM, HLF, SMA, TGF
2020 LRP10 Mutations May Correlate with Sporadic Parkinson's Disease in China. ---
2020 Metabolic Health in Obese Subjects-Is There a Link to Lactoferrin and Lactoferrin Receptor-Related Gene Polymorphisms? LTF, MHO, MUHO, WC
2020 Monitoring Neuroinflammation with an HOCl-Activatable and Blood-Brain Barrier Permeable Upconversion Nanoprobe. BBB, NI, UC, UCNPs
2020 The protective effect of polyethylene glycol-conjugated urokinase nanogels in rat models of ischemic stroke when administrated outside the usual time window. COX-2, EB, IL-1beta, NF-kappaB, NMDARs, PDGF-C, PEG-UK, pMCAO, TNF-alpha, UK
10  2019 Activation of WNT/Beta-Catenin Signaling and Regulation of the Farnesoid X Receptor/Beta-Catenin Complex After Murine Bile Duct Ligation. BAs, BDL, FXR, S45D, Tg, WT
11  2019 Hypothesis II: The majority of VLDL-apoB48 remnants in postprandial plasma are derived from the liver, not from the intestine. RLP
12  2019 Lipoprotein Receptor Signaling in Atherosclerosis. ApoER2, CD36, LDLR, LOX-1, SR-BI, VLDLR
13  2019 The fibrinolytic factor tPA drives LRP1-mediated melanoma growth and metastasis. MMP, tPA
14  2019 The role of anthrax toxin protein receptor 1 as a new mechanosensor molecule and its mechanotransduction in BMSCs under hydrostatic pressure. ANTXR, BMSCs, GSK
15  2019 The synthesized transporter K16APoE enabled the therapeutic HAYED peptide to cross the blood-brain barrier and remove excess iron and radicals in the brain, thus easing Alzheimer's disease. AD
16  2019 Time Course of the Effects of Buxin Yishen Decoction in Promoting Heart Function and Inhibiting the Progression of Renal Fibrosis in Myocardial Infarction Caused Type 2 Cardiorenal Syndrome Rats. alpha-SMA, Ang II, BNP, BUN, BXYS, cGMP, CHF, CRP, CRS, ECM, SCr, sCTGF
17  2018 ApoE and Neurodegenerative Diseases in Aging. AD, APOE, CSF, LDL, PD
18  2018 Lactoferrin promotes murine C2C12 myoblast proliferation and differentiation and myotube hypertrophy. ERK, LF, MyHC
19  2018 Long-term electroacupuncture stimulation prevents osteoporosis in ovariectomised osteopaenic rats through multiple signalling pathways. BMD, EA, JNK, OC, OPG, PMOP, RANKL, TRACP-5b
20  2018 Low density lipoprotein receptor-related protein 1 couples beta1 integrin activation to degradation. ---
21  2018 Magnesium Reduces Blood-Brain Barrier Permeability and Regulates Amyloid-beta Transcytosis. AD, BBB, MagT1, RAGE, TRPM7, VEGF
22  2018 Rapamycin protects against paraquat-induced pulmonary epithelial-mesenchymal transition via the Wnt/beta-catenin signaling pathway. EMT, PQ
23  2018 SGLT2 inhibition reduces atherosclerosis by enhancing lipoprotein clearance in Ldlr-/- type 1 diabetic mice. HSPG, LDLR, STZ, TG
24  2017 Coupling to a cancer-selective heparan-sulfate-targeted branched peptide can by-pass breast cancer cell resistance to methotrexate. ---
25  2017 Cyclized Oligopeptide Targeting LRP5/6-DKK1 Interaction Reduces the Growth of Tumor Burden in a Multiple Myeloma Mouse Model. DKK1
26  2017 Differences in Genetic Background Contribute to Pseudomonas Exotoxin A-Induced Hepatotoxicity in Rats. LE, PEA
27  2017 Identification and functional characterization of a novel member of low-density lipoprotein receptor-related protein (LRP)-like family in amphioxus. LPS, LTA, PGN
28  2017 Isoflurane Postconditioning Inhibits tPA-Induced Matrix Metalloproteinases Activation After Hypoxic Injury via Low-Density Lipoprotein Receptor-Related Protein and Extracellular Signal-Regulated Kinase Pathway. ERK, MMPs, tPA
29  2017 Rational design of DKK3 structure-based small peptides as antagonists of Wnt signaling pathway and in silico evaluation of their efficiency. CRD2, DKKs, HM, MD
30  2017 Wnt signaling in cardiovascular disease: opportunities and challenges. VSM
31  2016 Effects and relationship of intermittent hypoxia on serum lipid levels, hepatic low-density lipoprotein receptor-related protein 1, and hypoxia-inducible factor 1alpha. HIF, IH
32  2016 Glucagon-like peptide-1(GLP-1) receptor agonists: potential to reduce fracture risk in diabetic patients? BMSCs, GLP-1, GLP-1RA, OPG, RANK, RANKL, SOST
33  2016 miR-577 inhibits glioblastoma tumor growth via the Wnt signaling pathway. GBM, miRNAs
34  2016 Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review. APOE, LDL
35  2016 Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4. LPS, MIP-2, PAI-1, TLR4, TNF-alpha, VN, WT
36  2016 Prodigiosin inhibits Wnt/beta-catenin signaling and exerts anticancer activity in breast cancer cells. Dvl, GSK3beta
37  2016 SOX9 drives WNT pathway activation in prostate cancer. FZD, PCa
38  2016 The low density lipoprotein receptor-related protein (LRP) 1 and its function in lung diseases. ---
39  2016 Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways. AKAPs, BMM, cAMP, CTSK, PKA
40  2016 [The effect and mechanism of microRNA-21 on cis-dichlorodiamineplatinum resistance in lung cancer cell strain]. EGFR, MDR, MRP1, NSCLC, qRT-PCR
41  2015 Association of PS1 1/2, ACE I/D, and LRP C/T polymorphisms with Alzheimer's disease in the Chinese population: a meta-analysis of case-control studies. ACE, AD, CI, OR, PS1
42  2015 Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation. DCs
43  2015 Correlation of polymorphism of APOE and LRP genes to cognitive impairment and behavioral and psychological symptoms of dementia in Alzheimer's disease and vascular dementia. AD, APOE, BPSD, HAM-D, HAMA, MMSE, PCR-RFLP, VD
44  2015 Electroacupuncture at the governor vessel and bladder meridian acupoints improves postmenopausal osteoporosis through osteoprotegerin/RANKL/RANK and Wnt/beta-catenin signaling pathways. BL, BMD, EA, GV, OC, OPG, RANKL, TRACP-5b
45  2015 In vitro discrimination of the role of LRP1 at the BBB cellular level: focus on brain capillary endothelial cells and brain pericytes. AD, BBB, BCECs
46  2015 Novel receptors for bacterial protein toxins. ---
47  2015 Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment. DGL, DOX, GNP, MMP-2, TNBC
48  2015 The regulation of osteoclast differentiation by Wnt signals. ---
49  2015 Wnt co-receptor LRP5/6 overexpression confers protection against hydrogen peroxide-induced neurotoxicity and reduces tau phosphorylation in SH-SY5Y cells. AD
50  2015 Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3beta-Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System. BP, DKK1, GSK-3beta, IRS-1, NTS, SHRs
51  2014 A low-density lipoprotein receptor-related protein (LRP)-like molecule identified from Chlamys farreri participated in immune response against bacterial infection. AcLDL, LPS, LY, PGN, rCfLRP, SRCR
52  2014 APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease. APOE
53  2014 Elevated serum ApoE levels are associated with bacterial infections in pediatric patients. APOE, HSPG, LDLR, RT-PCR, SDC1
54  2014 Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling. HGF
55  2014 HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways. HAND, NMDARs, NOS, PKG, sGC, Tat
56  2014 HIV-1 Tat-induced changes in synaptically-driven network activity adapt during prolonged exposure. HAND, Tat
57  2014 Low-density lipoprotein receptor-related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction. DMM, IL-1beta, OA
58  2014 Reversing LRP5-dependent osteoporosis and SOST deficiency-induced sclerosing bone disorders by altering WNT signaling activity. OPPG
59  2014 Specific deletion of LDL receptor-related protein on macrophages has skewed in vivo effects on cytokine production by invariant natural killer T cells. alphaGC, APCs, iNKT, LDLR, LRP-cKO
60  2014 The role of the blood-brain barrier in the pathogenesis of senile plaques in Alzheimer's disease. BBB, eNOS, P-gp, RAGE, SP, ST, VEGF
61  2013 Angiopep-conjugated nanoparticles for targeted long-term gene therapy of Parkinson's disease. BBB, DGL, DPA, hGDNF, PD, PEG
62  2013 APP independent and dependent effects on neurite outgrowth are modulated by the receptor associated protein (RAP). APP, KO, RAP, WT
63  2013 Cripto-1 enhances the canonical Wnt/beta-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. TCF
64  2013 Development of a conditional Mesd (mesoderm development) allele for functional analysis of the low-density lipoprotein receptor-related family in defined tissues. ECM
65  2013 Expression of Shh and Wnt signaling pathway proteins in eyelid sebaceous gland carcinoma: clinicopathologic study. Shh
66  2013 Extracellular matrix structure and tissue stiffness control postnatal lung development through the lipoprotein receptor-related protein 5/Tie2 signaling system. ECM, LOX
67  2013 Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake. FVIII, PS
68  2013 Fell-Muir lecture: Connective tissue growth factor (CCN2) -- a pernicious and pleiotropic player in the development of kidney fibrosis. BMP4
69  2013 Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures. HAND, HIV, Syn-GFP, Tat
70  2013 Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture. AD, APOE4, KO, OE, RAP, WT
71  2013 Soy isoflavone alleviates Abeta1-42-induced impairment of learning and memory ability through the regulation of RAGE/LRP-1 in neuronal and vascular tissue. AD, IL-1beta, NF-kappaB p65, RAGE, SIF, TNF-alpha
72  2013 The anti-adipogenic effects of (-)epigallocatechin gallate are dependent on the WNT/beta-catenin pathway. C/EBP, Dvl, FABP, FASN, PPAR, si
73  2013 The monomeric receptor binding domain of tetrameric alpha2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades. alpha 2M, RBD
74  2013 Up-regulating blood brain barrier permeability of nanoparticles via multivalent effect. NIR
75  2012 Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles. ANG-PEG-NP, BBB, PEG-NP, PTX
76  2012 CDP-choline treatment induces brain plasticity markers expression in experimental animal stroke. GFAP, MRI, pMCAO, VEGF
77  2012 Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors. ---
78  2012 LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease. AD, ECD
79  2012 Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity. JAK, PAI-1, STAT, tPA, uPA
80  2012 Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation. CRT, PR3
81  2012 Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain. AD, APP, FA
82  2012 Shear stress is required for the endocytic uptake of the factor VIII-von Willebrand factor complex by macrophages. FVIII, LDL, RAP
83  2012 The multifunctional glycolytic protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a novel macrophage lactoferrin receptor. GAPDH, LF, Tf
84  2012 The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2. BBB, DOX, DOX-O-MWNTs-PEG-ANG, O-MWNTs
85  2012 Treatment of experimental brain metastasis with MTO-liposomes: impact of fluidity and LRP-targeting on the therapeutic result. MTO
86  2012 Two-order targeted brain tumor imaging by using an optical/paramagnetic nanoprobe across the blood brain barrier. BBB
87  2012 Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver. NEP
88  2012 WNT/beta-catenin pathway is modulated in asthma patients and LPS-stimulated RAW264.7 macrophage cell line. Dvl, GSK, LPS, NF-kappaB, siRNA
89  2012 [Evaluation for antithrombotic agents by a thrombotic model in animals]. ICH, MMPs, tPA
90  2011 A single lysine of the two-lysine recognition motif of the D3 domain of receptor-associated protein is sufficient to mediate endocytosis by low-density lipoprotein receptor-related protein. CR, LDL, RAP
91  2011 AICAR, an activator of AMPK, inhibits adipogenesis via the WNT/beta-catenin pathway in 3T3-L1 adipocytes. AICAR, AMPK, C/EPB, Dvl, FABP, LPL, PPAR, siRNA
92  2011 Amyloid-beta peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier. AD, i.c.v, RAP
93  2011 Angiopep-conjugated poly(ethylene glycol)-co-poly(epsilon-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma. ANG-NP, BBB
94  2011 C1 domain residues Lys 2092 and Phe 2093 are of major importance for the endocytic uptake of coagulation factor VIII. FVIII
95  2011 Complement receptor 3 (CD11b/CD18) is implicated in the elimination of beta-amyloid peptides. ---
96  2011 Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells. Fz, PCR, SFRP, UC
97  2011 Human neutrophil peptides mediate endothelial-monocyte interaction, foam cell formation, and platelet activation. HNPs
98  2011 Low-density lipoprotein receptor-related protein is decreased in optic neuropathy of Alzheimer disease. AD, NF
99  2011 LRP4 association to bone properties and fracture and interaction with genes in the Wnt- and BMP signaling pathways. BMD, BMP, FN, LS, SNPs, TB, Wnt
100  2011 MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. ---