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Abbreviation : LTD4
Long Form : leukotriene D4
No. Year Title Co-occurring Abbreviation
2020 Allergen challenge-induced changes in bone-marrow responses to leukotriene D4, nonsteroidal anti-inflammatory drugs and cytokines. CysLT, IL, NSAID, OVA
2020 Arachidonic acid metabolism is elevated in Mycoplasma gallisepticum and Escherichia coli co-infection and induces LTC4 in serum as the biomarker for detecting poultry respiratory disease. AA, E. coli, LTC4, MG
2020 RPTPepsilon promotes M2-polarized macrophage migration through ROCK2 signaling and podosome formation. CysLTs, HMDMs, PTPepsilon
2020 [Leukotriene D4 bronchial provocation test for detection of airway hyper-responsiveness in children]. AHR, BPT, MCh, ROC
2019 A novel therapeutic potential of cysteinyl leukotrienes and their receptors modulation in the neurological complications associated with Alzheimer's disease. 5-LOX, AD, CysLTs, LTC4, LTE4
2019 Anti-Inflammation Effect of Small Molecule Oligopeptides Prepared from Panax ginseng C. A. Meyer in Rats. GOPs, PGE2, TNF-alpha
2019 Role of Protein Tyrosine Phosphatase Epsilon (PTPepsilon) in Leukotriene D4-Induced CXCL8 Expression. GPCR, HEK293, MAPKs, PTPepsilon, PTPs
2018 Effects of leukotriene D4 and histamine nasal challenge on airway responsiveness and inflammation in persistent allergic rhinitis patients. AR, FeNO, NAR, VAS
2018 GPR17 mediates ischemia-like neuronal injury via microglial activation. OGD/R, UDP
10  2018 Leukotriene D4 induces cellular senescence in osteoblasts. CysLT, cysLT1R, PAI-1
11  2018 Lipid mediator Leukotriene D4-induces airway epithelial cells proliferation through EGFR/ERK1/2 pathway. CysLTs, EGF, SAECs
12  2018 New maresin conjugates in tissue regeneration pathway counters leukotriene D4-stimulated vascular responses. CysLT1, MCTR
13  2017 Chalcone Derivatives: Anti-inflammatory Potential and Molecular Targets Perspectives. COX, ICAM-1, IL, LOX, MCP-1, MOAs, NF- kappaB, NOS, PGs, SARs, VCAM-1
14  2017 M2-like macrophages induce colon cancer cell invasion via matrix metalloproteinases. EMT, M2-medium, MMP-9, TAMs, TNF-alpha
15  2016 Correlations of nasal responses to leukotriene D4 and histamine nasal provocation with quality of life in allergic rhinitis. AR, QOL, RQoLQ
16  2016 Effects of leukotriene D4 on adenoidal T cells in children with obstructive sleep apnea syndrome. AdMCs, JNK, PHA
17  2016 Leukotriene D4 nasal provocation test: Rationale, methodology and diagnostic value. AR, LT, ROC
18  2016 Responsiveness to methacholine, but not leukotriene D4, correlates with fractional exhaled nitric oxide in asthma. FeNO, MCh
19  2016 The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model. CICs, PGE2
20  2016 [The relationship between the key nasal symptoms and the level of histamineand leukotriene D4 in serum and nasal secretions in allergic rhinitis]. AR, ELISA
21  2015 Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. 5-LOX
22  2014 Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitro. IL-1beta
23  2014 Induced sputum eicosanoids during aspirin bronchial challenge of asthmatic patients with aspirin hypersensitivity. AERD, LTE4
24  2014 Leukotriene receptor antagonist as a novel tocolytic in an in vitro model of human uterine contractility. AUC, CysLTR1
25  2014 Multidrug resistance protein 4 (MRP4/ABCC4) regulates thrombus formation in vitro and in vivo. AC, GC, MRP4
26  2014 Protein kinase C-mediated phosphorylation of RKIP regulates inhibition of Na-alanine cotransport by leukotriene D(4) in intestinal epithelial cells. PKA, PKC, RKIP
27  2014 The inflammatory mediator leukotriene D₄ induces subcellular beta-catenin translocation and migration of colon cancer cells. ---
28  2014 [Effects of leukotriene D4 on proliferation and migration of lung epithelial A549 cells in vitro]. CysLT
29  2014 [The relevance of leukotriene D4 synthase gene A(-444)C polymorphism to clinical responsiveness of leukotriene receptor antagonist in patients with allergic rhinitis]. AR, ELISA, LTD4S A, PCR, RELP
30  2013 A contraction assay system using primary cultured mouse bronchial smooth muscle cells. BSMC
31  2013 HAMI 3379, a CysLT2 receptor antagonist, attenuates ischemia-like neuronal injury by inhibiting microglial activation. CysLTs, NMLTC4, OGD/R
32  2013 Leukotriene D4 induces amyloid-beta generation via CysLT(1)R-mediated NF-kappaB pathways in primary neurons. AD
33  2013 Leukotriene D4 induces cognitive impairment through enhancement of CysLT₁ R-mediated amyloid-beta generation in mice. AD, APP
34  2013 Responsiveness to leukotriene D4 and methacholine for predicting efficacy of montelukast in asthma. MCh
35  2013 [Leukotriene D4 activates BV2 microglia in vitro]. ---
36  2012 Interleukin-13 enhanced Ca2+ oscillations in airway smooth muscle cells. 2-APB, ASMCs, CysLT1R, IL-13, RyR, TRPC
37  2012 Leukotriene D4 bronchial provocation test: methodology and diagnostic value. ROC
38  2011 Circulating LTD4 in patients with hepatocellular carcinoma. CHB, HCC
39  2011 [Changes of leukotriene D4 in nasal discharge and plasma of patients with persistent allergic rhinitis and the effects of antihistamine]. AR, EIA, ELISA, IL-5
40  2010 Involvement of cysteinyl leukotriene receptors in angiogenesis in rat thoracic aortic rings. CysLTs
41  2008 Discovery of a potent and long-acting bronchorelaxing capsazepinoid, RESPIR 4-95. ACh, COPD, PGD2
42  2008 Elucidation of signaling and functional activities of an orphan GPCR, GPR81. CysLT2R, GPCR, IP
43  2008 Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. CM, CysLT, gpCysLT2, LTC4
44  2008 Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells. 5-LO, COX-2, TNF-alpha
45  2008 Synthesis of tenascin and laminin beta2 chain in human bronchial epithelial cells is enhanced by cysteinyl leukotrienes via CysLT1 receptor. CysLTs, LN, TN
46  2008 The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction. NKA
47  2006 CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation. ASMC, DCF, EGFR, HASMC, NAC, PI3K, PTX, ROS
48  2006 Cysteinyl-leukotrienes in the regulation of beta2-adrenoceptor function: an in vitro model of asthma. cysteinyl-LTs, PKC, PSS
49  2006 Differential effects of salbutamol and montelukast on eosinophil adhesion and superoxide anion generation. CysLTs, LTRA
50  2006 Effects of 1400W, a potent selective inducible NOS inhibitor, on histamine- and leukotriene D4-induced relaxation of isolated guinea pig nasal mucosa. iNOS, L-NMMA
51  2006 Inflammatory mediators in exhaled breath condensate of children with obstructive sleep apnea syndrome. AHI, EBC, LTB4, LTC4, LTE4, OSA, PGE2, SDB
52  2006 The inflammatory mediator leukotriene D4 induces beta-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells. ---
53  2006 [Effect of shuanglong capsule on content of leukotrienes compound of lung tissues in asthmatic rats]. LTB4, LTC4, RP-HPLC, SLC
54  2005 Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts. HFn, NHLF, PTX
55  2005 The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells. PI3K
56  2004 8-Bromo-cAMP decreases the Ca2+ sensitivity of airway smooth muscle contraction through a mechanism distinct from inhibition of Rho-kinase. 8-BrcAMP, cAMP, CCh, PDBu, PKA
57  2004 Leukotriene D4 activates alveolar epithelial Na,K-ATPase and increases alveolar fluid clearance. CysLT1, cysLT3
58  2004 Regulation of proteoglycan synthesis by leukotriene d4 and epidermal growth factor in bronchial smooth muscle cells. ASMCs, BSMCs, ECM, EGF
59  2004 Roxithromycin suppresses mucin gene expression in epithelial cells. LPS, LTA, PMA
60  2003 A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. CysLT2
61  2003 Identification of two additional members of the membrane-bound dipeptidase family. MBD-1, MBD-2, MBD-3
62  2003 Leukotriene D4 mediates survival and proliferation via separate but parallel pathways in the human intestinal epithelial cell line Int 407. CREB, PKC
63  2003 Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin. COX-2, PGE2
64  2002 Cysteinyl leukotriene receptors. CysLT, LTC4, LTE4
65  2002 Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells. GST, PLC-gamma1
66  2002 [Chronic obstructive pulmonary disease at the turn of the millennium]. COPD
67  2001 Acute effects of prostaglandin D2 to induce airflow obstruction and airway microvascular leakage in guinea pigs: role of thromboxane A2 receptors. EB dye, PGD2
68  2001 Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1. BM
69  2001 Intracellular signalling involved in activation of the volume-sensitive K+ current in Ehrlich ascites tumour cells. ChTX
70  2001 K+ conductance activated during regulatory volume decrease. The channels in Ehrlich cells and their possible molecular counterpart. RVD
71  2001 Regulation of cellular differentiation and apoptosis by fatty acids and their metabolites. AA, DHA, EPA, PGE1, PGE2
72  2000 K+ currents activated by leukotriene D4 or osmotic swelling in Ehrlich ascites tumour cells. ChTX
73  2000 Lectin affinity chromatography and electrophoretic properties of human platelet gamma-glutamyl transferase. LTC4, PAGE
74  1999 Characterization of the human cysteinyl leukotriene CysLT1 receptor. LTC4, LTE4
75  1999 Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects. AHR, PC20
76  1999 Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle. ASM, IGFBPs, IGFs, MMP-1
77  1999 Leukotriene D4 (LTD4) activates charybdotoxin-sensitive and -insensitive K+ channels in ehrlich ascites tumor cells. RVD
78  1999 Leukotriene D4 inhibits Na+ uptake through cAMP and PLC pathways in primary cultured renal proximal tubular cells. cAMP, PKC, PKI, PLC, PTCs
79  1999 Strain dependence of the airway response to dry-gas hyperpnea challenge in the rat. BN, NK
80  1998 A single dose of zafirlukast reduces LTD4-induced bronchoconstriction in patients on maintenance inhaled corticosteroid therapy. ICS, LTRAs
81  1998 Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig. OA, PDE4
82  1998 Antigen-induced responses in lung parenchymal strips during sinusoidal oscillation. ---
83  1998 Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. 5-LO, LTC4
84  1998 Dipeptidase inhibitor and epithelial removal potentiate leukotriene D4-induced human tracheal smooth muscle contraction. MDP
85  1998 Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. CysLTs, HASM
86  1998 Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro. ---
87  1998 gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. GGL, LTC4
88  1998 Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078. VCR
89  1998 Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells. MAP kinase, PTX
90  1998 Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. cys-bis-gly, LTE4
91  1998 Leukotriene D4 contractions in human airways are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. a-IgE
92  1998 Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. LES
93  1998 Leukotrienes antagonist-inhibitor and the bronchial response to inhaled antigen in actively sensitized guinea-pigs. AR, AS, Cdyn
94  1998 Montelukast. ---
95  1998 N-carbamoyl analogs of Zafirlukast: potent receptor antagonists of leukotriene D4. ---
96  1998 Pharmacological antagonism of Anchietia salutaris extracts on the contraction induced by prostaglandin D2 and U46619 in guinea-pig lung parenchymal strips. ADP, DR, PAF, PGD2, TXA2
97  1998 Possible contribution of leukotrienes in the arrhythmogenic effects of digoxin on isolated guinea-pig hearts. VPBs, VT
98  1998 Swelling-induced arachidonic acid release via the 85-kDa cPLA2 in human neuroblastoma cells. 3H-AA, AA, cPLA2, RVD
99  1998 The effect of a cysteinyl leukotriene antagonist, ONO-1078 (pranlukast) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs. OA
100  1998 The effect of leukotriene D4 on the patency of nasal passage in the guinea pig. AR, GPs