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Abbreviation : LTOT
Long Form : long-term opioid therapy
No. Year Title Co-occurring Abbreviation
2022 A Cluster-Randomized Clinical Trial to Decrease Prescription Opioid Misuse: Improving the Safety of Opioid Therapy (ISOT). ISOT
2022 Arguments for and Against a New Diagnostic Entity for Patients With Chronic Pain on Long-Term Opioid Therapy for Whom Harms Outweigh Benefits. DSM-5, OUD
2022 Association Between Exposure to Complementary and Integrative Therapies and Opioid Analgesic Daily Dose Among Patients on Long-term Opioid Therapy. CIH, VHA
2022 Complex Persistent Opioid Dependence-an Opioid-induced Chronic Pain Syndrome. CPOD, OICP
2022 Emotional distress and pain catastrophizing predict cue-elicited opioid craving among chronic pain patients on long-term opioid therapy. HRV
2022 Impact of Informed Consent and Education on Care Engagement After Opioid Initiation in the Veterans Health Administration. SIC, VHA
2022 Impact of transitioning from long-term to intermittent opioid therapy on the development of opioid-related adverse outcomes: A retrospective cohort study. SIPTW
2022 Mindfulness-Oriented Recovery Enhancement reduces opioid craving, pain, and negative affect among chronic pain patients on long-term opioid therapy: An analysis of within- and between-person state effects. MORE, SG
2022 Simulated opioid choice linked to opioid use disorder severity among veterans with chronic pain: initial validation of a novel paradigm. OUD
10  2021 Abrupt Discontinuation of Long-term Opioid Therapy Among Medicare Beneficiaries, 2012-2017. ---
11  2021 Association Between Pain Intensity and Discontinuing Opioid Therapy or Transitioning to Intermittent Opioid Therapy After Initial Long-Term Opioid Therapy: A Retrospective Cohort Study. ---
12  2021 Associations of opioid prescription dose and discontinuation with risk of substance-related morbidity in long-term opioid therapy. OR
13  2021 Cannabis use, pain interference, and prescription opioid receipt among persons with HIV: a target trial emulation study. PWH
14  2021 COVID-19 outcomes among adult patients treated with long-term opioid therapy for chronic non-cancer pain in the USA: a retrospective cohort study. RR
15  2021 Development and field testing of primary care screening tools for harms of long-term opioid therapy continuation and tapering to discontinuation: a study protocol. SET
16  2021 Do Formulation and Dose of Long-Term Opioid Therapy Contribute to Risk of Adverse Events among Older Adults? CNCP, MME, OIRD, SA
17  2021 Evaluation of Buprenorphine Rotation in Patients Receiving Long-term Opioids for Chronic Pain: A Systematic Review. GRADE, PRISMA
18  2021 Guideline adherence and reasons for recommending dose reduction in a primary care-based opioid management clinic. CDC, CSA, MEDD, POP, UDT
19  2021 Hazardous alcohol use is associated with greater pain interference and prescription opioid misuse among persons living with HIV and chronic pain. aMD, AUDIT, BPI, COMM, PLWH, TEACH
20  2021 How Patients and Providers Weigh the Risks and Benefits of Long-Term Opioid Therapy for Cancer Pain. ---
21  2021 Long-term opioid therapy tapering: Trends from 2014 to 2018 in a Midwestern State. CI, MME
22  2021 Long-term prescription opioid users' risk for new-onset depression increases with frequency of use. ---
23  2021 Management of cancer pain: challenging the evidence of the recent guidelines for opioid use in palliative care. ---
24  2021 Mind-body approaches targeting the psychological aspects of opioid use problems in patients with chronic pain: evidence and opportunities. OUD
25  2021 Opioid Policy and Chronic Pain Treatment Access Experiences: A Multi-Stakeholder Qualitative Analysis and Conceptual Model. ---
26  2021 Opioid Prescriptions in Chronic Pain Rehabilitation. A Prospective Study on the Prevalence and Association between Individual Patient Characteristics and Opioids. IMMR
27  2021 Prevalence of long-term opioid therapy in spine center outpatients the spinal pain opioid cohort (SPOC). SPOC
28  2021 Safety of opioid prescribing among older cancer survivors. ---
29  2021 STRategies to Improve Pain and Enjoy life (STRIPE): Protocol for a pragmatic randomized trial of pain coping skills training and opioid medication taper guidance for patients on long-term opioid therapy. STRIPE
30  2021 Trajectories of Opioid Coverage After Long-Term Opioid Therapy Initiation Among a National Cohort of US Veterans. AMME, CNCP
31  2021 Variations in Long-term Opioid Therapy Definitions: A Systematic Review of Observational Studies Using Routinely Collected Data (2000-2019). ---
32  2020 All-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors. HR, MEDD, PLWH
33  2020 All-cause mortality in patients with long-term opioid therapy compared with non-opioid analgesics for chronic non-cancer pain: a database study. CNCP, HRs, RD
34  2020 Benefits and Harms of Long-term Opioid Dose Reduction or Discontinuation in Patients with Chronic Pain: a Rapid Review. ---
35  2020 Complex Persistent Opioid Dependence with Long-term Opioids: a Gray Area That Needs Definition, Better Understanding, Treatment Guidance, and Policy Changes. CPOD
36  2020 Endogenous theta stimulation during meditation predicts reduced opioid dosing following treatment with Mindfulness-Oriented Recovery Enhancement. EEG, FMT, MORE
37  2020 Exploring Factors Associated With Long-Term Opioid Therapy in Cancer Survivors: An Integrative Review. ---
38  2020 Long-Term Opioid Therapy in Spine Center Outpatients: Protocol for the Spinal Pain Opioid Cohort (SPOC) Study. IRRID, SPOC
39  2020 Opioid dispensation among systemic lupus erythematosus patients who persistently frequent the emergency department. ED, SLE
40  2020 Opioid Prescribing and Opioid Risk Mitigation Strategies in the Veterans Health Administration. PEPReC, VHA
41  2020 Opioid prescribing history prior to heroin overdose among commercially insured adults. ---
42  2020 Outcomes in Long-term Opioid Tapering and Buprenorphine Transition: A Retrospective Clinical Data Analysis. ---
43  2020 Predictors of pain-related functional impairment among people living with HIV on long-term opioid therapy. BPI-I, PLWH
44  2020 Prospective Investigation of Factors Associated with Prescription Opioid Dose Escalation among Patients in Integrated Health Systems. CI, HR
45  2020 Reducing the Pain Behind Opioid Prescribing in Primary Care. MMEs
46  2020 Research methods and baseline findings of the improving the safety of opioid therapy (ISOT) cluster-randomized trial. ISOT, NCM, PCPs
47  2020 Salivary measurement and mindfulness-based modulation of prescription opioid cue-reactivity. ---
48  2019 Associations of mental health and family background with opioid analgesic therapy: a nationwide Swedish register-based study. SES
49  2019 Common and Challenging Behaviors Among Individuals on Long-term Opioid Therapy. DSM, OUD
50  2019 Disagreement and Uncertainty Among Experts About how to Respond to Marijuana Use in Patients on Long-term Opioids for Chronic Pain: Results of a Delphi Study. CUD
51  2019 Efficacy and harms of long-term opioid therapy in chronic non-cancer pain: Systematic review and meta-analysis of open-label extension trials with a study duration ≥26 weeks. CI, CNCP, SMD
52  2019 Long-term opioid therapy definitions and predictors: A systematic review. ---
53  2019 Setting Expectations, Following Orders, Safety, and Standardization: Clinicians' Strategies to Guide Difficult Conversations About Opioid Prescribing. VA
54  2019 Signature Informed Consent for Long-Term Opioid Therapy in Patients With Cancer: Perspectives of Patients and Providers. SIC
55  2019 Study protocol for the targeting effective analgesia in clinics for HIV (TEACH) study - a cluster randomized controlled trial and parallel cohort to increase guideline concordant care for long-term opioid therapy among people living with HIV. PLWH, TEACH
56  2019 Team-Based Clinic Redesign of Opioid Medication Management in Primary Care: Effect on Opioid Prescribing. MED
57  2019 The Influence of Allowable Refill Gaps on Detecting Long-Term Opioid Therapy: An Analysis of Population-Based Administrative Dispensing Data Among Patients with Knee Arthritis Awaiting Total Knee Arthroplasty. TKA
58  2018 Addressing Opioid-Related Chemical Coping in Long-Term Opioid Therapy for Chronic Noncancer Pain: A Multicenter, Observational, Cross-Sectional Study. CNCP, MEDD, OrCC, OUD
59  2018 Association Between Facility-Level Utilization of Non-pharmacologic Chronic Pain Treatment and Subsequent Initiation of Long-Term Opioid Therapy. ---
60  2018 Brief Report: The Association of Chronic Pain and Long-Term Opioid Therapy With HIV Treatment Outcomes. aOR, CI
61  2018 Changes in pain intensity after discontinuation of long-term opioid therapy for chronic noncancer pain. VA
62  2018 Clinical Strategies for the Treatment and Management of Patients Prescribed Long-term Opioid Therapy. VA
63  2018 Clinician Referrals for Non-opioid Pain Care Following Discontinuation of Long-term Opioid Therapy Differ Based on Reasons for Discontinuation. ---
64  2018 Correlates of Use and Perceived Effectiveness of Non-pharmacologic Strategies for Chronic Pain Among Patients Prescribed Long-term Opioid Therapy. NPTs
65  2018 Long-term opioid therapy of non-cancer pain : Prevalence and predictors of hospitalization in the event of possible misuse. CI, CNCP, OR
66  2018 Managing Chronic Pain in Cancer Survivors Prescribed Long-Term Opioid Therapy: A National Survey of Ambulatory Palliative Care Providers. ---
67  2018 Provider reasons for discontinuing long-term opioid therapy following aberrant urine drug tests differ based on the type of substance identified. OR, UDT, VA
68  2018 Racial disparities in discontinuation of long-term opioid therapy following illicit drug use among black and white patients. aOR, CI
69  2018 [Long-term opioid therapy of non-cancer pain : Prevalence and predictors of hospitalization in the event of possible misuse]. CI, CNCP, OR
70  2017 Attitudes Toward Opioids and Risk of Misuse/Abuse in Patients with Chronic Noncancer Pain Receiving Long-term Opioid Therapy. CNCP, DAI-M, ORT, STAR
71  2017 Guideline-recommended vs high-dose long-term opioid therapy for chronic noncancer pain is associated with better health outcomes: data from a representative sample of the German population. CNCP
72  2017 Long-term opioid therapy in Denmark: A disappointing journey. CNCP
73  2017 Managing Concerning Behaviors in Patients Prescribed Opioids for Chronic Pain: A Delphi Study. ---
74  2017 Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Systematic Review. ---
75  2017 Patterns and correlates of medical cannabis use for pain among patients prescribed long-term opioid therapy. ---
76  2017 Reasons for discontinuation of long-term opioid therapy in patients with and without substance use disorders. SUD
77  2017 Substance Use Disorder Treatment Following Clinician-Initiated Discontinuation of Long-Term Opioid Therapy Resulting from an Aberrant Urine Drug Test. SUD, UDTs
78  2017 Suicidal ideation and suicidal self-directed violence following clinician-initiated prescription opioid discontinuation among long-term opioid users. SI, SSV, VHA
79  2017 The conundrum of opioid tapering in long-term opioid therapy for chronic pain: A commentary. CPD
80  2017 The Evaluation of Medical Inpatients Who Are Admitted on Long-term Opioid Therapy for Chronic Pain. ---
81  2016 Management of problematic behaviours among individuals on long-term opioid therapy: protocol for a Delphi study. IRB, UAB
82  2016 The Association Between Receipt of Guideline-Concordant Long-Term Opioid Therapy and All-Cause Mortality. CI, HR, SUD
83  2016 The Effect of Substance Use Disorders on the Association Between Guideline-concordant Long-term Opioid Therapy and All-cause Mortality. aHR, CI, SUDs
84  2016 The opioid epidemic and the long-term opioid therapy for chronic noncancer pain revisited: a transatlantic perspective. CNCP
85  2015 Long-term opioid therapy for chronic non-cancer pain in Germany. CNCP
86  2014 National study of discontinuation of long-term opioid therapy among veterans. VHA