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Abbreviation : LXR
Long Form : liver X receptor
No. Year Title Co-occurring Abbreviation
2020 27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression. 27HC
2020 4beta-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters. 4betaHC, ABCA1, PXR
2020 7alpha,25-Dihydroxycholesterol Suppresses Hepatocellular Steatosis through GPR183/EBI2 in Mouse and Human Hepatocytes. GPR183, SREBP-1c
2020 African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. ---
2020 Apolipoprotein F: a natural inhibitor of cholesteryl ester transfer protein and a key regulator of lipoprotein metabolism. ApoF, CETP
2020 Approved LXR agonists exert unspecific effects on pancreatic beta-cell function. ---
2020 Axl receptor tyrosine kinase is a regulator of apolipoprotein E. ABCA1, AD, APOE
2020 Cerebral Ischemia-Reperfusion Injury: Lysophosphatidic Acid Mediates Inflammation by Decreasing the Expression of Liver X Receptor. LPA, MCAO, NF-kappaB, SD, TdT
2020 Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation. 25-HC, AM, CH25H
10  2020 Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-beta, and ERbeta: results from the EPIC-Heidelberg cohort. 27HC, CIs, EPIC, ERbeta, ORs, PR
11  2020 Combinations of LXR and RXR agonists induce triglyceride accumulation in human HepaRG cells in a synergistic manner. NR, RXR
12  2020 Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques. ---
13  2020 Differential Role of Liver X Receptor (LXR) alpha and LXRbeta in the Regulation of UDP-Glucuronosyltransferase 1A1 in Humanized UGT1 Mice. hUGT1, LXRs, TSB
14  2020 Dysregulation of LXR responsive genes contribute to ichthyosis in trichothiodystrophy. TTD
15  2020 Effect of Quercetin on Atherosclerosis Based on Expressions of ABCA1, LXR-alpha and PCSK9 in ApoE-/- Mice. ABCA1, AS, HDL-C, IL-6, LDL-C, PCSK9, TC, TG, TNF-alpha
16  2020 Exposure to hydrocarbons and chlorpyrifos alters the expression of nuclear receptors and antioxidant, detoxifying, and immune response proteins in the liver of the rainbow trout, Oncorhynchus mykiss. ABCC2, MRP2, AhR, AR, CPF, GGT, GR, IL, PR, WAF
17  2020 Hemistepsin A inhibits T0901317-induced lipogenesis in the liver. HsA
18  2020 Induction of fecal cholesterol excretion is not effective for the treatment of hyperbilirubinemia in Gunn rats. EZE, FXR, OCA, TICE, UCB
19  2020 Inhibition of notch enhances the anti-atherosclerotic effects of LXR agonists while reducing fatty liver development in ApoE-deficient mice. ICAM-1, RCT
20  2020 Lipid rafts as a therapeutic target. AIBP, CASMERs, iRafts
21  2020 Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine. FA, PE, PL
22  2020 Liver X Receptor Agonism Sensitizes a Subset of Hepatocellular Carcinoma to Sorafenib by Dual-Inhibiting MET and EGFR. EGFR, HCC, RTKs
23  2020 Liver X Receptor beta Related to Tumor Progression and Ribosome Gene Expression in Papillary Thyroid Cancer. ABCG8, APOC1, APOE, GSEA, KEGG, SREBP-1c
24  2020 Liver X receptor inhibits the growth of hepatocellular carcinoma cells via regulating HULC/miR-134-5p/FOXM1 axis. HCC, HULC
25  2020 Liver X receptor regulates Th17 and RORgammat+ Treg cells by distinct mechanisms. MLN, NRs, Th
26  2020 LncRNA-H19 silencing suppresses synoviocytes proliferation and attenuates collagen-induced arthritis progression by modulating miR-124a. AI, FLS, lncRNA H19, PT
27  2020 LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes. BCG
28  2020 Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1alpha-Induced PPARalpha/PPARgamma/FXR/LXR System. DEHP, FXR, HIF-1alpha, LYC
29  2020 Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non-alcoholic steatohepatitis model. HCC, NASH
30  2020 Pregnane X Receptor Activator Rifampin Increases Blood Pressure and Stimulates Plasma Renin Activity. 4betaHC, BP, PXR
31  2020 Reduced Sirtuin1 signalling exacerbates diabetic mice hindlimb ischaemia injury and inhibits the protective effect of a liver X receptor agonist. HLI, OS, PAD, SIRT1
32  2020 Retinoic acid induced cytokines are selectively modulated by liver X receptor activation in zebrafish. AhR, NRs, RAR
33  2020 Sophoricoside is a selective LXRbeta antagonist with potent therapeutic effects on hepatic steatosis of mice. DIO, NAFLD
34  2020 SULT2B1b inhibits reverse cholesterol transport and promotes cholesterol accumulation and inflammation in lymphocytes from AMI patients with low LDL-C levels. AMI, CAD, IFN-gamma, LDL-C, MACEs, SULT2B1b, TNF-alpha
35  2020 Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice. DPN, NOX4, ROS, SCs
36  2020 The effect of ursodeoxycholic acid on the relative expression of the lipid metabolism genes in mouse cholesterol gallstone models. ABCB11, CSI, CYP7A1, FXR, LD, PPAR-alpha, RT-PCR, UDCA
37  2020 The effects of LXR agonist T0901317 and LXR antagonist GSK2033 on morphogenesis and lipid properties in full thickness skin models. FTMs, NHS, SC, SCD-1
38  2020 The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy. PC, PNKP
39  2020 The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRalpha and PPARalpha. ABC, LDLR, TG
40  2019 5-HT3 Antagonist Ondansetron Increases apoE Secretion by Modulating the LXR-ABCA1 Pathway. ABCA1, AD, APOE, iPSC, OS
41  2019 A Stable Luciferase Reporter System to Characterize LXR Regulation by Oxysterols and Novel Ligands. NRs
42  2019 Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR. FXR, HDL, OCA
43  2019 Activation of liver X receptor promotes fatty acid synthesis in goat mammary epithelial cells via modulation of SREBP1 expression. GMEC, SREBP1, TAG
44  2019 Activation of Liver X Receptors by GW3965 Attenuated Deoxycorticosterone Acetate-Salt Hypertension-Induced Cardiac Functional and Structural Changes. 4-HNE, DOCA, GRP78, IkappaB-alpha, MMP-2, NF-kappaB p65, p-PERK, TAC
45  2019 Activation of Liver X Receptors by GW3965 attenuated DOCA-salt hypertension-induced cardiac functional and structural changes. 4-HNE, DOCA, GRP78, IkappaB-alpha, MMP-2, NF-kappaB p65, p-PERK, TAC
46  2019 Activation of LXR Receptors and Inhibition of TRAP1 Causes Synthetic Lethality in Solid Tumors. ATF4, GBM, PERK, TRAP1
47  2019 Activation of LXRbeta inhibits tumor respiration and is synthetically lethal with Bcl-xL inhibition. ISR
48  2019 Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma. CTX, PXR
49  2019 Anti-inflammatory effects of naturally occurring retinoid X receptor agonists isolated from Sophora tonkinensis Gagnep. via retinoid X receptor/liver X receptor heterodimers. AD, ATF3, IL, mRNA, NF-kappaB, RXR
50  2019 Apoptotic cell-mimicking gold nanocages loaded with LXR agonist for attenuating the progression of murine systemic lupus erythematosus. NP, PS, SLE
51  2019 Biological mechanisms and related natural modulators of liver X receptor in nonalcoholic fatty liver disease. NAFLD, NASH
52  2019 Characterization of Redox-Responsive LXR-Activating Nanoparticle Formulations in Primary Mouse Macrophages. ABCA1, NP, RR
53  2019 Characterization of the cholesterol efflux of apolipoprotein E-containing high-density lipoprotein in THP-1 cells. ABCA1, APOE, CEC, HDL
54  2019 Cholesterol-lowering potentials of Lactobacillus strain overexpression of bile salt hydrolase on high cholesterol diet-induced hypercholesterolemic mice. AI, BSH, BW, CYP7A1, FXR, HCD, LDL-C, LDLR, SHP, TC
55  2019 Cigarette Smoke Extract Modulates Functions of Peroxisome Proliferator-Activated Receptors. CSE, LDL, mPPARs, PPAR, PPARs
56  2019 Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency. ---
57  2019 Development of novel liver X receptor modulators based on a 1,2,4-triazole scaffold. HCV
58  2019 Discovery of tissue selective liver X receptor agonists for the treatment of atherosclerosis without causing hepatic lipogenesis. ---
59  2019 Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease. FXR, NAFLD, NPC1L1, PMN
60  2019 Each liver X receptor (LXR) type has a different purpose in different situations. ---
61  2019 ER-Negative Breast Cancer Is Highly Responsive to Cholesterol Metabolite Signalling. ---
62  2019 Exogenous Addition of 25-Hydroxycholesterol Reduces Level of Very Long-Chain Fatty Acids in X-Linked Adrenoleukodystrophy. 25-HC, CH25H, iPSCs, VLCFAs, X-ALD
63  2019 Expression of LXR‑beta, ABCA1 and ABCG1 in human triple‑negative breast cancer tissues. ABCA1, ABCG1, TNBC
64  2019 Fucoidan A2 from the Brown Seaweed Ascophyllum nodosum Lowers Lipid by Improving Reverse Cholesterol Transport in C57BL/6J Mice Fed a High-Fat Diet. ATP, CYP7A1, LDLR, NPC1L1, PCSK9, PPAR, RCT, SR-B1
65  2019 Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells. ABC, Adx, ADXR, apo, apoA-I, LDL, StAR, TSPO
66  2019 HSP70 induces liver X receptor pathway activation and cholesterol reduction invitro and invivo. HSPs
67  2019 Human Lupus Plasma Pro-Atherogenic Effects on Cultured Macrophages Are Not Mitigated by Statin Therapy: A Mechanistic LAPS Substudy. ABC, ABC, CD36, CVD, LAPS, PPAR, ScR
68  2019 Identification of an intrinsic lysophosphatidic acid acyltransferase activity in the lipolytic inhibitor G0/G1 switch gene 2 (G0S2). ATGL, G0S2, LPA, LPAAT, TG
69  2019 Identification of Macrophage Genotype and Key Biological Pathways in Circulating Angiogenic Cell Transcriptome. CAC, CAC, FXR, RXR, TAM
70  2019 Inhibition of microRNA-17-5p reduces the inflammation and lipid accumulation, and up-regulates ATP-binding cassette transporterA1 inatherosclerosis. 3'-UTR, ABCA1, AS, PBLs, PPAR
71  2019 Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice. PRMT3
72  2019 Involvement of G-Protein-Coupled Receptor 40 in the Inhibitory Effects of Docosahexaenoic Acid on SREBP1-Mediated Lipogenic Enzyme Expression in Primary Hepatocytes. DHA, FAS, GPR40, LD, SCD-1, SREBP
73  2019 Liver X receptor agonist T0901317 inhibits the migration and invasion of non-small-cell lung cancer cells in vivo and in vitro. EGFR-TKI
74  2019 LXR Signaling Regulates Macrophage Survival and Inflammation in Response to Ionizing Radiation. BMDMs
75  2019 LXRalpha limits TGFbeta-dependent hepatocellular carcinoma associated fibroblast differentiation. alpha-SMA, CAFs, FASN, HCC, TGF-beta
76  2019 Measuring Apoptotic Cell Engulfment (Efferocytosis) Efficiency. BMDM
77  2019 MicroRNA 7 Impairs Insulin Signaling and Regulates Abeta Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway. AD, CNS, hnRNP K, IDE, INSR, IRS2, miR-7, RBP
78  2019 Molecular characterization and homology modeling of liver X receptor in Asian seabass, Lates calcarifer: predicted functions in reproduction and lipid metabolism. AF-1, AF-2, DBD, LBD
79  2019 Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons. HSP
80  2019 Neuroprotective effect of naturally occurring RXR agonists isolated from Sophora tonkinensis Gagnep. on amyloid-beta-induced cytotoxicity in PC12 cells. ABCA1, AD, RXR
81  2019 Oxysterols and Gastrointestinal Cancers Around the Clock. FXR, OSBP, ROR
82  2019 Pharmacological activation of liver X receptor during cigarette smoke exposure adversely affects alveolar macrophages and pulmonary surfactant homeostasis. BAL
83  2019 PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells. ABCA1, HSCs, PNPLA3, PPARgamma, WT
84  2019 Programmed increases in LXRalpha induced by paternal alcohol use enhance offspring metabolic adaptation to high-fat diet induced obesity. ---
85  2019 Promoting intestinal lymphatic transport targets a liver-X receptor (LXR) agonist (WAY-252,623) to lymphocytes and enhances immunomodulation. ---
86  2019 Protective effect of lodoxamide on hepatic steatosis through GPR35. ---
87  2019 Regulation of Brain Cholesterol: What Role Do Liver X Receptors Play in Neurodegenerative Diseases? AD, ALS, CNS, MS
88  2019 Regulation of Macrophage Foam Cell Formation During Nitrogen Mustard (NM)-Induced Pulmonary Fibrosis by Lung Lipids. BAL, FXR, NM, PPAR, SREBP
89  2019 Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1-Mediated Cholesterol Removal. ---
90  2019 Rewiring of Lipid Metabolism and Storage in Ovarian Cancer Cells after Anti-VEGF Therapy. LC-MS, NMR, VEGF
91  2019 Selectivity in cornified envelop binding of ceramides in human skin and the role of LXR inactivation on ceramide binding. CLE, FTM, OdS, SC
92  2019 Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXRalpha) and Pregnane X Receptor (PXR). AMPK, LXRalpha, NAFLD, PXR
93  2019 Sirt1 counteracts decrease in membrane phospholipid unsaturation and diastolic dysfunction during saturated fatty acid overload. FA, KD, LV, MUFA, NMN, SCD1, SFA
94  2019 Structural requirements of cholenamide derivatives as the LXR ligands. ---
95  2019 Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed-forward loop between LXR and autophagy. ---
96  2019 Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives. ---
97  2019 Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist? ccRCC, FA, FASN, HDL, LDLR, SCD1, SREBP-1c
98  2019 The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells. DDA, NIS
99  2019 The fucoidan A3 from the seaweed Ascophyllum nodosum enhances RCT-related genes expression in hyperlipidemic C57BL/6J mice. ABC, CYP7A1, LDLR, PPAR, RCT, SR-B1, SREBP
100  2019 The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice. ABC, NPC1L1, PPAR, RCT, SR-B1, SREBP