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Abbreviation : MAPKs
Long Form : mitogen-activated protein kinases
No. Year Title Co-occurring Abbreviation
2020 (Z)-7,4'-dimethoxy-6-hydroxy-aurone-4-O-beta-glucopyranoside attenuates lipoteichoic acid-induced damage in rat cardiomyoblast cells. DHAG, LTA, NF-kappaB
2020 3,5-Dicaffeoyl-epi-quinic acid inhibits the PMA-stimulated activation and expression of MMP-9 but not MMP-2 via downregulation of MAPK pathway. DCEQA, MMPs, PMA
2020 3-Hydroxyolean-12-en-27-oic Acids Inhibit RANKL-Induced Osteoclastogenesis in Vitro and Inflammation-Induced Bone Loss in Vivo. AR-1, CtsK, LPS, NFATc1, RANKL, TRAP
2020 A comprehensive pathway map of IL-18-mediated signalling. IL-18, NF-kappaB, Th
2020 A selective p38alpha/beta MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse. AD
2020 A study on the protective effects of taxifolin on human umbilical vein endothelial cells and THP-1 cells damaged by hexavalent chromium: a probable mechanism for preventing cardiovascular disease induced by heavy metals. CVD, HUVECs, NF-kappaB
2020 Activation of JNK and p38 in MCF-7 Cells and the In Vitro Anticancer Activity of Alnus hirsuta Extract. ELISA
2020 Activation of RAW264.7 macrophage by Exopolysaccharide from Aphanothece halaphytica (EPSAH) and the underlying mechanisms. EPSAH
2020 Altered paracellular permeability in intestinal cell monolayer challenged with lipopolysaccharide: Modulatory effects of pterostilbene metabolites. ---
10  2020 Ameliorative effects of Qingganjiuwei powder, a traditional Mongolian medicine, against CCl4-induced liver fibrosis in rats. alpha-SMA, ERK, JNKs, MMP2, SIL, TIMP1
11  2020 Ampelopsin Induces DR5-Mediated Apoptotic Cell Death in EBV-Infected Cells through the p38 Pathway. AMP, EBV, TRAIL
12  2020 An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling. ---
13  2020 Angiotensin Converting Enzyme Inhibitors (ACEIs) Decrease the Progression of Cardiac Fibrosis in Rheumatic Heart Disease Through the Inhibition of IL-33/sST2. ACEIs, APC, DCs, GAS, RHD, TGF-beta
14  2020 Angiotensin III induces p38 Mitogen-activated protein kinase leading to proliferation of vascular smooth muscle cells. Ang, AT1, RAAS, SHRs, VSMCs
15  2020 Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-kappaB Pathway. IL, LPS, NO
16  2020 Anti-inflammatory potential of Trifolium pratense L. leaf extract in LPS-stimulated RAW264.7 cells and in a rat model of carrageenan-induced inflammation. COX-2, IL, iNOS, NF, NO, PGE2, TNF
17  2020 Apold1 deficiency associates with increased arterial thrombosis in vivo. PI3K, TF, WT
18  2020 Argania Spinosa Fruit Shell Extract-Induced Melanogenesis via cAMP Signaling Pathway Activation. AFSEE, cAMP, DCT, ERK, MITF, TRP-1, TRY
19  2020 Attenuation of Inflammatory Symptoms by Icariside B2 in Carrageenan and LPS-Induced Inflammation Models via Regulation of MAPK/NF-kappaB Signaling Cascades. CA, COX-2, ERK, IkappaBalpha, iNOS, NF-kappaB, NO, PGE2, RT-PCR
20  2020 Attenuation of paraquat-induced inflammation by inhibitors of phosphorylation of mitogen-activated protein kinases in BV2 microglial cells. PD, TLR4
21  2020 Bacteroides fragilis Enterotoxin Induces Sulfiredoxin-1 Expression in Intestinal Epithelial Cell Lines Through a Mitogen-Activated Protein Kinases- and Nrf2-Dependent Pathway, Leading to the Suppression of Apoptosis. IECs, Srx
22  2020 CaMKII(delta) regulates osteoclastogenesis through ERK, JNK, and p38 MAPKs and CREB signalling pathway. CaMKs, NFATc1, TRAP
23  2020 Can the AGE/RAGE/ERK signalling pathway and the epithelial-to-mesenchymal transition interact in the pathogenesis of chronic rhinosinusitis with nasal polyps? AGEs, CRSwNP, EMT, ERK, NP, RAGE
24  2020 Chemical composition of tetraploid Gynostemma pentaphyllum gypenosides and their suppression on inflammatory response by NF-kappaB/MAPKs/AP-1 signaling pathways. GP, JNK and ERK
25  2020 Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d-galactosamine induced acute liver injury. AMPK, AST, d-GalN, LPS, NF-kappaB, Nrf2
26  2020 Chinese liquor extract attenuates oxidative damage in HepG2 cells and extends lifespan of Caenorhabditis elegans. HOMO
27  2020 Clinical relevance of understanding mitogen-activated protein kinases involved in asthma. IgE
28  2020 Cloning, molecular and functional characterization by overexpression in Arabidopsis of MAPKK genes from grapevine (Vitis vinifera). ETH, MKK, SA
29  2020 Coixol Suppresses NF-kappaB, MAPK Pathways and NLRP3 Inflammasome Activation in Lipopolysaccharide-Induced RAW 264.7 Cells. COX, IL, iNOS, LPS, NF-kappaB, NLRP, NO, TNF
30  2020 Communication between Cyclin-dependent kinase Cdc2 and the Wis1-Spc1 MAPK pathway determines mitotic timing in Schizosaccharomyces pombe. CDKs
31  2020 Comprehensive comparison on the anti-inflammatory effects of three species of Sigesbeckia plants based on NF-kappaB and MAPKs signal pathways in vitro. COX-2, iNOS, LPS, NF-kappaB, SG, SH, SP
32  2020 Copper induces hepatic inflammatory responses by activation of MAPKs and NF-kappaB signalling pathways in the mouse. AKP, ALB, ASK1, AST, COX-2, GGT, ICR, IkappaB, IL-1beta, IL-2, IL-8, iNOS, JNK, NF-kappaB, NO, p38 MAPK, PGE2, TBIL, TGF-beta
33  2020 Current understanding of metal ions in the pathogenesis of Alzheimer's disease. AD, Cdk5, ER, GSK-3beta, PP2A
34  2020 Deep sea minerals ameliorate diabetic-induced inflammation via inhibition of TNFalpha signaling pathways. COX, DSW, iNOS, STZ
35  2020 Deletion of the PDZ-binding kinase (Pbk) gene does not affect male fertility in mice. JNK, KO, PBK, WT
36  2020 Discovery and development of ASK1 inhibitors. ASK1, JNK
37  2020 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. AFL, CYP2E1, EGF, MKP-1, PPARalpha, TG
38  2020 Doxorubicin-induces NFAT/Fas/FasL cardiac apoptosis in rats through activation of calcineurin and P38 MAPK and inhibition of mTOR signalling pathways. DOX
39  2020 Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia. BPD, DUSP, DUSPs, PH, SNPs
40  2020 Dysregulation of Dual-Specificity Phosphatases by Epstein-Barr Virus LMP1 and Its Impact on Lymphoblastoid Cell Line Survival. DUSPs, EBV, ERK, LCLs, LMP1
41  2020 Early high-frequency spinal cord stimulation treatment inhibited the activation of spinal mitogen-activated protein kinases and ameliorated spared nerve injury-induced neuropathic pain in rats. ERKs, HFSCS, JNKs, SCS, SNI
42  2020 Eckol from Ecklonia cava ameliorates TNF-alpha/IFN-gamma-induced inflammatory responses via regulating MAPKs and NF-kappaB signaling pathway in HaCaT cells. ELISA, IFN-gamma, NF-kappaB, RT-PCR, TNF-alpha
43  2020 Effect of BMS-470539 on lipopolysaccharide-induced neutrophil activation. IL, LPS, NF-kappaB
44  2020 Effects of peroxiredoxin 1 on nicotine induced apoptosis in mouse tongue. MEF, Prx1, Prx1
45  2020 Electrosprayed poly(lactic-co-glycolic acid) particles as a promising drug delivery system for the novel JNK inhibitor IQ-1. IQ-1, JNK, PLGA
46  2020 Endocytosis, signal transduction and proteolytic cleaving of human holotransferrin in Entamoeba histolytica. FAK, PI3K, Tf
47  2020 Ergosterol Peroxide from the Medicinal Mushroom Ganoderma lucidum Inhibits Differentiation and Lipid Accumulation of 3T3-L1 Adipocytes. ACC, FAS, FAT, MCE, PPARgamma, SREBP-1c
48  2020 ERK3/MAPK6 controls IL-8 production and chemotaxis. IL-8, LPS
49  2020 Exogenous Hydrogen Sulfide Regulates Mycoplasma pneumoniae Lipid-Associated Membrane Proteins to Induce Expression of Heme Oxygenase-1 and Proinflammatory Cytokines. ELISA, IL-6, IL-8, LAMPs, M. pneumoniae, NF-kappaB, Nrf2
50  2020 Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks. MAPK
51  2020 Expanding the Toolkit of Fluorescent Biosensors for Studying Mitogen Activated Protein Kinases in Plants. ---
52  2020 Fibroblast-Like-Synoviocytes Mediate Secretion of Pro-Inflammatory Cytokines via ERK and JNK MAPKs in Ti-Particle-Induced Osteolysis. ERK, FLS, JNK
53  2020 Fowlerstefin, a cysteine protease inhibitor of Naegleria fowleri, induces inflammatory responses in BV-2 microglial cells in vitro. PAM
54  2020 Functional interaction between Cdc42 and the stress MAPK signaling pathway during the regulation of fission yeast polarized growth. SAPK
55  2020 G721-0282 inhibits cell growth and induces apoptosis in human osteosarcoma through down-regulation of the STAT3 pathway. Chi3L1, OS
56  2020 Genome-wide identification of the mitogen-activated protein kinase (MAPK) family in cotton (Gossypium hirsutum) reveals GhMPK6 involved in fiber elongation. BR, IAA, MAPK
57  2020 Glycosyl flavones from Humulus japonicus suppress MMP-1 production via decreasing oxidative stress in UVB irradiated human dermal fibroblasts. AP-1, BDE, UV
58  2020 Histone H2B induces retinal ganglion cell death through toll-like receptor 4 in the vitreous of acute primary angle closure patients. APAC, DAMPs, GON, RGC, TLR4
59  2020 Human CCR6+ Th17 Lymphocytes Are Highly Sensitive to Radiation-Induced Senescence and Are a Potential Target for Prevention of Radiation-Induced Toxicity. IL-8, IR, mTOR, ROS, VEGF-A
60  2020 Identification of FOS as a Candidate Risk Gene for Liver Cancer by Integrated Bioinformatic Analysis. CALML3, GPCR, OS, TTR
61  2020 Identification of the MAPK Cascade and its Relationship with Nitrogen Metabolism in the Green Alga Chlamydomonasreinhardtii. NO, NR
62  2020 Impact of Conventional and Atypical MAPKs on the Development of Metabolic Diseases. ERK3, 4 and 7, ERK5, NLK
63  2020 Influence of bifentrin, a pyrethriod pesticide, on human colorectal HCT-116 cells attributed to alterations in oxidative stress involving mitochondrial apoptotic processes. BIF, ERK, MDA, ROS
64  2020 Inhibition of NK1R attenuates LPS-induced microglial inflammation and consequent death of PC12 cells. COX-2, IL-1beta, iNOS, LPS, NF-kappaB, NK-1, NK1R, PD, TNF-alpha
65  2020 Inhibition of nuclear factor kappa B as a mechanism of Danshensu during Toll-like receptor 2-triggered inflammation in macrophages. BMMs, CCR7, CXCL9, DEGs, DSS, ELISA, IFN-gamma, IL-12, IL-6, LTF, NF-kappaB, PPI, RT-qPCR, TF, TLR2
66  2020 Inhibition of RIPK1/RIPK3 ameliorates osteoclastogenesis through regulating NLRP3-dependent NF-kappaB and MAPKs signaling pathways. Nec-1, RIPKs
67  2020 Inhibitory Effects of Urtica thunbergiana Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice. AD, FLG, IL, UT
68  2020 Inhibitory Mechanisms of Water Extract of Oplopanax elatus on Lipopolysaccharide-Induced Inflammatory Responses in RAW 264.7 Murine Macrophage Cells. AP-1, COX-2, ERK, iNOS, LPS, PGE2, WOE
69  2020 Isolation, characterization and anti-inflammatory mechanism of probiotics in lipopolysaccharide-stimulated RAW 264.7 macrophages. COX-2, LAB, LPS
70  2020 Isosamidin from Peucedanum japonicum Roots Prevents Methylglyoxal-Induced Glucotoxicity in Human Umbilical Vein Endothelial Cells via Suppression of ROS-Mediated Bax/Bcl-2. AGEs, ERK, HUVECs, JNK, MGO, ROS
71  2020 Juglanin administration protects skin against UVB‑induced injury by reducing Nrf2‑dependent ROS generation. NF, Nrf2, UVB
72  2020 Lindera obtusiloba Attenuates Oxidative Stress and Airway Inflammation in a Murine Model of Ovalbumin-Challenged Asthma. AP, HO-1, LOL, MUC5AC, NF-kappaB, NQO1, Nrf2, OVA, TNF
73  2020 LmjMAPK10 offers protection against Leishmania donovani infection. ---
74  2020 Longxuetongluo capsule alleviates lipopolysaccharide-induced neuroinflammation by regulating multiple signaling pathways in BV2 microglia cells. CM, COX-2, ELISA, EMSA, ERK, iNOS, JAK/STAT, LDH, LPS, LTC, MTS, NF-kappaB, NO, OGD/R, PGE2, TNF-alpha
75  2020 Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK and calcium. LGE
76  2020 LRP1 knockdown aggravates Abeta1-42-stimulated microglial and astrocytic neuroinflammatory responses by modulating TLR4/NF-kappaB/MAPKs signaling pathways. AD, IL-1beta, IL-6, LRP1, MyD88, NF-kappaB, TLR4, TNF-alpha, TRAF6
77  2020 Lycorine Induces Apoptosis and G1 Phase Arrest Through ROS/p38 MAPK Signaling Pathway in Human Osteosarcoma Cells In Vitro and In Vivo. LY
78  2020 MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases. ---
79  2020 Mdivi-1 attenuates lipopolysaccharide-induced acute lung injury by inhibiting MAPKs, oxidative stress and apoptosis. ALI, LPS
80  2020 Mechanical stretching of pulmonary vein stimulates matrix metalloproteinase-9 and transforming growth factor-beta1 through stretch-activated channel/MAPK pathways in pulmonary hypertension due to left heart disease model rats. MLAP, MMP-9, PH-LHD, RVSP, SAC, TGF-beta1
81  2020 Mechanism Analysis of a Novel Angiotensin-I-Converting Enzyme Inhibitory Peptide from Isochrysis zhanjiangensis Microalgae for Suppressing Vascular Injury in Human Umbilical Vein Endothelial Cells. ACE, Ang II, HUVEC, NF-kappaB, Nrf2
82  2020 Mechanisms of Copper Tolerance, Accumulation, and Detoxification in the Marine Macroalga Ulva compressa (Chlorophyta): 20 Years of Research. ASC, CaMKs, CDPKs, MTs, NADPH, PCs
83  2020 Melanoma stem cell maintenance and chemo-resistance are mediated by CD133 signal to PI3K-dependent pathways. MSCs
84  2020 Melatonin Reduces Neuropathic Pain Behavior and Glial Activation through MT2 Melatonin Receptor Modulation in a Rat Model of Lysophosphatidylcholine-Induced Demyelination Neuropathy. CN, GFAP, LPC
85  2020 MerTK negatively regulates Staphylococcus aureus induced inflammatory response via SOCS1/SOCS3 and Mal. IL-1beta, IL-6, MerTK, NF-kappaB, S. aureus, TNF-alpha
86  2020 Metformin Suppresses LPS-Induced Inflammatory Responses in Macrophage and Ameliorates Allergic Contact Dermatitis in Mice via Autophagy. ACD, AKT, BMDMs, DNFB, IL, LPS, mTOR, NO, TNF
87  2020 Mg2+ in beta-TCP/Mg-Zn composite enhances the differentiation of human bone marrow stromal cells into osteoblasts through MAPK-regulated Runx2/Osx. BMSCs, CM, hBMSC
88  2020 Microglia mediated neuroinflammation - signaling regulation and therapeutic considerations with special reference to some natural compounds. AD, NF-kappaB, PD
89  2020 Mitogen-activated protein kinase phosphatase-2 deletion modifies ventral tegmental area function and connectivity and alters reward processing. MKPs, VTA
90  2020 Modulation of cell signaling pathways by Phyllanthus amarus and its major constituents: potential role in the prevention and treatment of inflammation and cancer. NF-kappaB
91  2020 Molecular action mechanism of anti-inflammatory hydrolysates obtained from brewers' spent grain. BSG, NF-kappaB, TLRs
92  2020 Molecular characterization and expression analysis of two crucial MAPKs- jnk1 and erk1 as cellular signal transducers in Labeo rohita in response to PAMPs stimulation and pathogenic invasion. LRG
93  2020 MusaMPK5, a mitogen activated protein kinase is involved in regulation of cold tolerance in banana. MBP
94  2020 Mycobacterium avium subsp. paratuberculosis MAP1889c Protein Induces Maturation of Dendritic Cells and Drives Th2-biased Immune Responses. CREB, DCs, IL, LPS, MAP, MHC, NF-kappaB, TLR, TNF
95  2020 Nicotine inhibits MAPK signaling and spheroid invasion in ovarian cancer cells. ERK, MLK3, nAChRs, OC
96  2020 Oleanolic acid inhibits mouse spinal cord injury through suppressing inflammation and apoptosis via the blockage of p38 and JNK MAPKs. IkappaBalpha, IKKalpha, LPS, NF-kappaB, OA, SCI
97  2020 Organophosphorus Compounds and MAPK Signaling Pathways. ERK, JNK, OPCs
98  2020 Ovarian status dictates the neuroinflammatory and behavioral consequences of sub-chronic stress exposure in middle-aged female mice. ERK
99  2020 p38 mitogen-activated protein kinases (MAPKs) are involved in intestinal immune response to bacterial muramyl dipeptide challenge in Ctenopharyngodon idella. MDP
100  2020 PEP-1-GLRX1 protein exhibits anti-inflammatory effects by inhibiting the activation of MAPK and NF-kappaB pathways in Raw 264.7 cells. COX-2, GLRX1, iNOS, LPS, NF-kappaB, TPA