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Abbreviation : MIC
Long Form : metabolic-intermediate complex
No. Year Title Co-occurring Abbreviation
2018 Evaluation of Strategies for the Assessment of Drug-Drug Interactions Involving Cytochrome P450 Enzymes. CO, DDIs, HLM, MDI
2017 Numerical analysis of time dependent inhibition kinetics: comparison between rat liver microsomes and rat hepatocyte data for mechanistic model fitting. DEX, MBI, RLM, SCRH, SRH, TDI
2013 Carbene generation by cytochromes and electronic structure of heme-iron-porphyrin-carbene complex: a quantum chemical study. CYP450, MBI, MDP
2013 Importance of H-abstraction in the final step of nitrosoalkane formation in the mechanism-based inactivation of cytochrome P450 by amine-containing drugs. DFT, MBI, MI, NMH, P450s
2013 Inhibition of cytochrome P450 enzymes and biochemical aspects of mechanism-based inactivation (MBI). DDI, MBI
2012 Metabolic-intermediate complex formation with cytochrome P450: theoretical studies in elucidating the reaction pathway for the generation of reactive nitroso intermediate. MBI
2008 Time-dependent inhibition of human drug metabolizing cytochromes P450 by tricyclic antidepressants. HLM, MBI, TCAs, TDI
2007 Computational approaches that predict metabolic intermediate complex formation with CYP3A4 (+b5). RP
2005 Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. ---
10  2002 Effects of olopatadine, a new antiallergic agent, on human liver microsomal cytochrome P450 activities. FMO
11  2002 Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites. ---
12  1999 Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation. CYP, DTZ