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Abbreviation : MTAP
Long Form : methylthioadenosine phosphorylase
No. Year Title Co-occurring Abbreviation
2019 A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis. DDR
2019 Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. PRMTs
2019 Hemizygous loss of NF2 detected by fluorescence in situ hybridization is useful for the diagnosis of malignant pleural mesothelioma. FISH, NF2
2019 Highly expressed EZH2 in combination with BAP1 and MTAP loss, as detected by immunohistochemistry, is useful for differentiating malignant pleural mesothelioma from reactive mesothelial hyperplasia. BAP1, EZH2, FISH, HD, IHC, MPM, PRC2, RMH
2019 Methods to Study the Role of Methionine-Restricted Diet and Methioninase in Cancer Growth Control. ---
2019 MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation. GBM, GSC
2019 Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. MTAN
2019 Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinoma. IGF-1R, MTA, RCC
2018 A combination of MTAP and BAP1 immunohistochemistry in pleural effusion cytology for the diagnosis of mesothelioma. BAP1, FISH, IHC, MPM, RMC
10  2018 A combination of MTAP and BAP1 immunohistochemistry is effective for distinguishing sarcomatoid mesothelioma from fibrous pleuritis. BAP1, FISH, HD, IHC, MPM
11  2018 Characterization of methylthioadenosin phosphorylase (MTAP) expression in colorectal cancer. ---
12  2018 Exploiting methionine restriction for cancer treatment. ---
13  2018 Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors. ESFT, OS
14  2018 Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine. 2FA, 6-TG, MTA
15  2018 Utility of Methylthioadenosine Phosphorylase Compared With BAP1 Immunohistochemistry, and CDKN2A and NF2 Fluorescence In Situ Hybridization in Separating Reactive Mesothelial Proliferations From Epithelioid Malignant Mesotheliomas. BAP1, CDKN2A, NF2
16  2017 Exosomes containing differential expression of microRNA and mRNA in osteosarcoma that can predict response to chemotherapy. Cdc5L, CIP4, mRNAs, OS, PEDF, WWOX
17  2017 Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase. AdoMet, MTA
18  2017 Immunohistochemical detection of MTAP and BAP1 protein loss for mesothelioma diagnosis: Comparison with 9p21 FISH and BAP1 immunohistochemistry. BAP1, FISH, HD, IHC, MPM, RMH, ROC
19  2017 Leishmania infantum 5'-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target. AS, EPs, HETA, huPNP, LiMTAP, MTA
20  2017 Schistosoma mansoni purine and pyrimidine biosynthesis: structures and kinetic experiments in the search for the best therapeutic target. UP
21  2017 The Transition-State Structure for Human MAT2A from Isotope Effects. BIE, Cf, KIE, QM, SAM
22  2016 Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma. MTA, PRMTs, SNP
23  2016 Continuous Fluorescence Assays for Reactions Involving Adenine. 2AMTA, MTA, MTAN
24  2016 Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. MTA
25  2016 Independent Loss of Methylthioadenosine Phosphorylase (MTAP) in Primary Cutaneous T-Cell Lymphoma. MF, SS
26  2016 Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease. ---
27  2016 Methionine and Kynurenine Activate Oncogenic Kinases in Glioblastoma, and Methionine Deprivation Compromises Proliferation. DRM, NHAs, SAM
28  2016 Methylthioadenosine (MTA) Regulates Liver Cells Proteome and Methylproteome: Implications in Liver Biology and Disease. MTA
29  2016 MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. PRMT5
30  2016 MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis. MTA, SAM
31  2016 The essential role of methylthioadenosine phosphorylase in prostate cancer. ---
32  2015 Characterization and Prognostic Significance of Methylthioadenosine Phosphorylase Deficiency in Nasopharyngeal Carcinoma. DMFS, DSS, LRFS, NPC, PCR
33  2015 Expression of Methylthioadenosine Phosphorylase (MTAP) in Pilocytic Astrocytomas. PAs
34  2015 Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination. 6-TG, T-cell ALL
35  2014 6-thioguanine: a drug with unrealized potential for cancer therapy. 6-TG, MTA
36  2014 Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance. ---
37  2014 Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function. MTA
38  2014 MTAP is an independent prognosis marker and the concordant loss of MTAP and p16 expression predicts short survival in non-small cell lung cancer patients. NSCLC
39  2014 Quantitation of cellular metabolic fluxes of methionine. LC-MS
40  2014 The metabolite 5'-methylthioadenosine signals through the adenosine receptor A2B in melanoma. AP-1, cAMP, MTA, PKC
41  2013 Association between rs10118757(A/G) in methylthioadenosine phosphorylase gene and coronary artery disease in Chinese Hans. CAD, MI
42  2013 Common genetic variants in the 9p21 region and their associations with multiple tumours. CA, CDKN2A, CRC, EC, ESCC, OS
43  2013 Deregulation of protein methylation in melanoma. ERK, MTA, PRMTs
44  2013 Expression and function of methylthioadenosine phosphorylase in chronic liver disease. HSCs
45  2013 Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice. ---
46  2013 Ocular expression and distribution of products of the POAG-associated chromosome 9p21 gene region. POAG, SNPs
47  2013 Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase. MTA, TS
48  2012 A corrected space group for Sulfolobus sulfataricus 5'-deoxy-5'-methylthioadenosine phosphorylase II. MTA
49  2012 Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells. 5-FU, 6-TG, MTA, PRPP
50  2012 Lack of expression of MTAP in uncommon T-cell lymphomas. AITL, ALCL, PTCL
51  2012 Methylthioadenosine phosphorylase inactivation depends on gene deletion in laryngeal squamous cell carcinoma. qPCR
52  2012 Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target. CRPC
53  2012 The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas. ATP, IHC, MPM, RP, WT1
54  2011 Chemical genetic screening for compounds that preferentially inhibit growth of methylthioadenosine phosphorylase (MTAP)-deficient Saccharomyces cerevisiae. ---
55  2011 Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA). HCC, MMP, MTA
56  2011 Downregulation of methylthioadenosin phosphorylase by homozygous deletion in gastric carcinoma. ---
57  2011 Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase. ---
58  2011 Expression of Chr9p21 genes CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and MTAP in human atherosclerotic plaque. Chr
59  2011 Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase. AdoMet, MTA, MTDIA
60  2011 Identification and characterization of two adenosine phosphorylase activities in Mycobacterium smegmatis. ADO, PNP
61  2011 Increased sensitivity to thiopurines in methylthioadenosine phosphorylase-deleted cancers. 6-MP, 6-TG, DNPS, meTIMP
62  2011 Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing. MTA, MTI, MTIP, PaMTIP, PfPNP, PNPs
63  2011 Polymorphisms in nevus-associated genes MTAP, PLA2G6, and IRF4 and the risk of invasive cutaneous melanoma. CIs, IRF4, ORs, PLA2G6
64  2011 Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies. MTA
65  2010 Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase. MTAN, SAM
66  2010 Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis. IAG-NH, IG-NH
67  2010 Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma. BAD, CDKN2A, IGF-1R
68  2010 Methylthioadenosine phosphorylase represents a predictive marker for response to adjuvant interferon therapy in patients with malignant melanoma. OS, RFS, STAT1
69  2010 Nucleolar targeting of coilin is regulated by its hypomethylation state. CBs, SMN, snRNPs
70  2010 Quantification of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry in cultured tumor cells and liver biopsies. ---
71  2010 Tumor suppressor gene alterations of spontaneously malignant transformed cells from human embryonic muscle in vitro. MSCs, PCR
72  2010 [Association between methylthioadenosine phosphorylase gene single nucleotide polymorphisms and myocardial infarction in Chinese Han ethnicity]. MI, SNP
73  2009 A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer. NSCLC
74  2009 Direct and tumor microenvironment mediated influences of 5'-deoxy-5'-(methylthio)adenosine on tumor progression of malignant melanoma. AP-1, bFGF, MMP
75  2009 Genetic mapping of the sex-linked barring gene in the chicken. CDKN2B, miRNA-31, TRIM36
76  2009 Immunohistochemical diagnosis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma. IHC, MTA, NSCLC
77  2009 Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma. ---
78  2009 MTAP and CDKN2B genes are associated with myocardial infarction in Chinese Hans. CDKN2A, CDKN2B, MI, tSNP
79  2009 MTAP gene is associated with ischemic stroke in Chinese Hans. GWA, tSNP
80  2009 Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy. 5-FU, 6-TG, APRT, DAP, F-Ade, HF, MeP, MTA, MTR-1-P, PRPP
81  2009 [Expression of methylthioadenosine phosphorylase (MTAP) gene and demethylation of its promoter in human colorectal cancer]. MSP
82  2008 Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. MTAN, PNP
83  2008 Methylthioadenosine phosphorylase expression in cutaneous squamous cell carcinoma. AI/LOH, SCC
84  2008 Quantitative analysis of 5'-deoxy-5'-methylthioadenosine in melanoma cells by liquid chromatography-stable isotope ratio tandem mass spectrometry. LLOQ, LOD, MTA
85  2008 Transition state analogues in quorum sensing and SAM recycling. MTA, MTAN, SAM
86  2007 A potential predictive marker for response to interferon in malignant melanoma. ---
87  2007 A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. MT-DADMe-ImmA, MTA
88  2007 Biochemical and structural characterization of mammalian-like purine nucleoside phosphorylase from the Archaeon Pyrococcus furiosus. PNP
89  2007 Methylthioadenosine phosphorylase (MTAP) in hearing: gene disruption by chromosomal rearrangement in a hearing impaired individual and model organism analysis. FISH
90  2007 Methylthioadenosine phosphorylase deficiency in Japanese osteosarcoma patients. IHC
91  2006 Circadian pharmacology of L-alanosine (SDX-102) in mice. ---
92  2006 EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. CFU-GMs, EFA, T-ALL
93  2006 Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma. CDKN2B, MLPA
94  2006 Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy. MCL
95  2006 Methylthioadenosine phosphorylase gene deletions are frequently detected by fluorescence in situ hybridization in conventional chondrosarcomas. FISH
96  2006 Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma. HCC, IFN
97  2006 The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity. GARFT, TS
98  2006 Tissue microarray analysis of methylthioadenosine phosphorylase protein expression in melanocytic skin tumors. ---
99  2006 Transition-state structure of human 5'-methylthioadenosine phosphorylase. KIEs, MTA
100  2005 Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implications. ---