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Abbreviation : MXC
Long Form : methoxychlor
No. Year Title Co-occurring Abbreviation
2020 Development of a Generic Physiologically Based Kinetic Model to Predict In Vivo Uterotrophic Responses Induced by Estrogenic Chemicals in Rats Based on In Vitro Bioassays. COU, DES, GEN, PBK
2019 Bioaccumulation and toxicity of methoxychlor on Chinese mitten crab (Eriocheir sinensis). ---
2019 Effect of prenatal exposure to combined immunosuppressive agrochemicals in a mouse model of allergic airway inflammation. BALF, PARA
2018 Comparative Studies on Enzyme Activity of Immobilized Horseradish Peroxidase in Silica Nanomaterials with Three Different Shapes and Methoxychlor Degradation of Vesicle-Like Mesoporous SiO₂ as Carrier. HRP
2018 Involvement of estrogen receptor alpha in pro-pruritic and pro-inflammatory responses in a mouse model of allergic dermatitis. DPN, ER, mBMDCs, PPT
2018 Methoxychlor metabolite HPTE alters viability and differentiation of embryonic thymocytes from C57BL/6 mice. EDC
2017 Effects of methoxychlor on IGF-I signaling pathway in rat ovary. IGF-I, IHC, PND
2017 N-acetyl cysteine-mediated effective attenuation of methoxychlor-induced granulosa cell apoptosis by counteracting reactive oxygen species generation in caprine ovary. NAC
2016 Effects of Methoxychlor and Its Metabolite Hydroxychlor on Human Placental 3beta-Hydroxysteroid Dehydrogenase 1 and Aromatase in JEG-3 Cells. HSD3B1
10  2016 Hepatocytes as in vitro test system to investigate metabolite patterns of pesticides in farmed rainbow trout and common carp: Comparison between in vivo and in vitro and across species. ---
11  2016 In utero methoxychlor exposure increases rat fetal Leydig cell number but inhibits its function. GD
12  2016 Methoxychlor and Vinclozolin Induce Rapid Changes in Intercellular and Intracellular Signaling in Liver Progenitor Cells. AR, ER, GJIC, MAPKs, PC-PLC, VIN
13  2016 Methoxychlor exposure induces oxidative stress and affects mouse oocyte meiotic maturation. ---
14  2016 Regulation of arcuate genes by developmental exposures to endocrine-disrupting compounds in female rats. ARC, BPA, DES, EDCs, PND
15  2016 USPIO assisting degradation of MXC by host/guest-type immobilized laccase in AOT reverse micelle system. GC-MS, NMR, USPIO
16  2015 Effects of methoxychlor and 2,2-bis ( p -hydroxyphenyl)-1,1,1-trichloroethane on cytochrome P450 enzyme activities in human and rat livers. HPTE
17  2015 Endocrine disrupters: the new players able to affect the epigenome. EDs, PCBs, VZ
18  2015 Exposure Duration-Dependent Ovarian Recovery in Methoxychlor-Treated Mice. ---
19  2015 Genome-Wide Locations of Potential Epimutations Associated with Environmentally Induced Epigenetic Transgenerational Inheritance of Disease Using a Sequential Machine Learning Prediction Approach. DDT, DMRs, i.e., toxicant
20  2015 Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors alpha and beta in the rat granulosa cell in vitro. GCs
21  2014 Effects of estradiol and methoxychlor on Leydig cell regeneration in the adult rat testis. EDS
22  2014 Effects of prior oral exposure to combinations of environmental immunosuppressive agents on ovalbumin allergen-induced allergic airway inflammation in Balb/c mice. BALF, OVA, PARA, PBO
23  2014 Effects of short-term oral combined exposure to environmental immunotoxic chemicals in mice. PARA, PBO, SRBC
24  2014 Endocrine disrupting effects of dichlorodiphenyltrichloroethane analogues on gonadotropin hormones in pituitary gonadotrope cells. DDT, ERK, FSH, LH, p,p'-DDE
25  2014 Fetal and neonatal exposure to the endocrine disruptor, methoxychlor, reduces lean body mass and bone mineral density and increases cortical porosity. BMD, EB, LBM, PND
26  2014 Methoxychlor and triclosan stimulates ovarian cancer growth by regulating cell cycle- and apoptosis-related genes via an estrogen receptor-dependent pathway. DDT, EDCs, MTT, TCS
27  2014 Perinatal exposure to low-dose methoxychlor impairs testicular development in C57BL/6 mice. ---
28  2014 Perinatal exposure to methoxychlor enhances adult cognitive responses and hippocampal neurogenesis in mice. ---
29  2014 The ameliorative effect of propolis against methoxychlor induced ovarian toxicity in rat. ---
30  2013 Developmental programming: impact of prenatal exposure to bisphenol-A and methoxychlor on steroid feedbacks in sheep. BPA, GnRH, LH
31  2013 Effects of methoxychlor and its metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 11beta-hydroxysteroid dehydrogenase activities in vitro. HPTE
32  2013 Immunotoxicity of the organochlorine pesticide methoxychlor in female ICR, BALB/c, and C3H/He mice. GC, PALS, PFC, SRBC
33  2013 Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor. mono-OH MXC
34  2013 Targeted genome-wide methylation and gene expression analyses reveal signaling pathways involved in ovarian dysfunction after developmental EDC exposure in rats. PND
35  2012 An environmental fate study of methoxychlor using water-sediment model system. de-Cl-MXC
36  2012 Distinct mechanisms of endocrine disruption of DDT-related pesticides toward estrogen receptor alpha and estrogen-related receptor gamma. DDD, DDE, DDT, ER, ERR, LBD, MD
37  2012 Estrogen receptor alpha overexpressing mouse antral follicles are sensitive to atresia induced by methoxychlor and its metabolites. ESRs
38  2012 Induced growth of BG-1 ovarian cancer cells by 17beta-estradiol or various endocrine disrupting chemicals was reversed by resveratrol via downregulation of cell cycle progression. BPA, CDK2, EDCs, HBCD, NP, OP
39  2012 Methoxychlor induces atresia by altering Bcl2 factors and inducing caspase activity in mouse ovarian antral follicles in vitro. ---
40  2012 Methoxychlor inhibits growth and induces atresia through the aryl hydrocarbon receptor pathway in mouse ovarian antral follicles. AhR, WT
41  2012 Methoxychlor-induced ovarian follicle toxicity in mice: dose and exposure duration-dependent effects. ---
42  2012 Treatment with bisphenol A and methoxychlor results in the growth of human breast cancer cells and alteration of the expression of cell cycle-related genes, cyclin D1 and p21, via an estrogen receptor-dependent signaling pathway. BPA, EDCs, ERs
43  2011 Bioconcentration and biotransformation of [⁴C]methoxychlor in the brackish water bivalve Corbicula japonica. ---
44  2011 Detection of thymocytes apoptosis in mice induced by organochlorine pesticides methoxychlor. PS
45  2011 Early life exposure to endocrine-disrupting chemicals causes lifelong molecular reprogramming of the hypothalamus and premature reproductive aging. EB, POA
46  2011 Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase-3 activities in human and rat testes. 3beta-HSD, HPTE
47  2011 Increased sensitivity of estrogen receptor alpha overexpressing antral follicles to methoxychlor and its metabolites. AhR, AR, DMSO, ESR1, MOH, mRNA, PR
48  2011 Methoxychlor affects multiple hormone signaling pathways in the largemouth bass (Micropterus salmoides) liver. AR
49  2011 Methoxychlor reduces estradiol levels by altering steroidogenesis and metabolism in mouse antral follicles in vitro. DMSO, ELISA, HSD17B1, Star
50  2011 Neonatal injections of methoxychlor decrease adult rat female reproductive behavior. ---
51  2011 Neuroendocrine impacts of endocrine-disrupting chemicals in birds: life stage and species sensitivities. AhR, EDC, EDI, NEQ, TEQ
52  2011 Specific transgenerational imprinting effects of the endocrine disruptor methoxychlor on male gametes. EDCs
53  2010 Adding insult to injury: effects of xenobiotic-induced preantral ovotoxicity on ovarian development and oocyte fusibility. MEN, VCD
54  2010 Developmental programming: impact of fetal exposure to endocrine-disrupting chemicals on gonadotropin-releasing hormone and estrogen receptor mRNA in sheep hypothalamus. BPA, EDCs, ESR, GnRH, LH
55  2010 Developmental reprogramming of reproductive and metabolic dysfunction in sheep: native steroids vs. environmental steroid receptor modulators. BPA
56  2010 Mono-hydroxy methoxychlor alters levels of key sex steroids and steroidogenic enzymes in cultured mouse antral follicles. DMSO, mono-OH
57  2009 Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38. BPA, EDCs, ER, ERE, ERK, MAPK, NP, OP
58  2009 Effects of the organochlorine pesticide methoxychlor on dopamine metabolites and transporters in the mouse brain. DAT, PD, VMAT2
59  2009 Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes. DNMT, ER
60  2009 Influence of dietary Coexposure to benzo(a)pyrene on the biotransformation and distribution of 14C-methoxychlor in the channel catfish (Ictalurus punctatus). BaP, HPTE, OH-MXC
61  2009 Methoxychlor inhibits growth of antral follicles by altering cell cycle regulators. CCND2, CDK4, NAC, PCNA
62  2009 Perinatal exposure to xenoestrogens affects pain in adult female rats. CNS, EE, PRE
63  2008 Developmental methoxychlor exposure affects multiple reproductive parameters and ovarian folliculogenesis and gene expression in adult rats. LH
64  2008 Effects of the pesticide methoxychlor on gene expression in the liver and testes of the male largemouth bass (Micropterus salmoides). StAR, VTG
65  2008 Glucuronidation and sulfonation, in vitro, of the major endocrine-active metabolites of methoxychlor in the channel catfish, Ictalurus punctatus, and induction following treatment with 3-methylcholanthrene. 3-MC, max
66  2008 Methoxychlor and estradiol induce oxidative stress DNA damage in the mouse ovarian surface epithelium. OSE
67  2008 Stimulation of transactivation of the largemouth bass estrogen receptors alpha, beta-a, and beta-b by methoxychlor and its mono- and bis-demethylated metabolites in HepG2 cells. ERs
68  2007 A proteomic (SELDI-TOF-MS) approach to estrogen agonist screening. BPA, CP, ES, TPP
69  2007 Determining the transrepression activity of xenoestrogen on nuclear factor-kappa B in Cos-1 cells by estrogen receptor-alpha. CMV, CMV MIEp, hERalpha, NF-kappaB, RBA
70  2007 Metabolic profiling of endocrine-disrupting compounds by on-line cytochrome p450 bioreaction coupled to on-line receptor affinity screening. ERalpha, HRS, SPE
71  2007 Methoxychlor and its metabolites inhibit growth and induce atresia of baboon antral follicles. ---
72  2007 Methoxychlor suppresses the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible CYP1A1 expression in murine Hepa-1c1c7 cells. Ah, DDT, DRE, EROD, TCDD
73  2007 The pesticide methoxychlor decreases myotube formation in cell culture by slowing myoblast proliferation. ---
74  2006 Altered mammary gland development in male rats exposed to genistein and methoxychlor. GE
75  2006 Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus): evidence for roles of CYP1 and CYP3A family isozymes. 3-MC
76  2006 Developmental programming: differential effects of prenatal exposure to bisphenol-A or methoxychlor on reproductive function. BPA
77  2006 Effect of methoxychlor and estradiol on cytochrome p450 enzymes in the mouse ovarian surface epithelium. ERalpha, GE, OSE
78  2006 Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary. CAT, GPx, ROS
79  2006 Methoxychlor induces atresia of antral follicles in ERalpha-overexpressing mice. ERalpha, FSH
80  2006 Methoxychlor inhibits growth and induces atresia of antral follicles through an oxidative stress pathway. CAT, DMSO, GPx, NAC
81  2006 Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways. ER
82  2006 Perinatal exposure to endocrine disrupting compounds alters behavior and brain in the female pine vole. DES, EDCs, OT
83  2006 Reproductive abnormalities in adult male mice following preimplantation exposures to estradiol or pesticide methoxychlor. ---
84  2005 A comparison of in vitro and in vivo EDSTAC test battery results for detecting antiandrogenic activity. AR, AST, BaP, FLUT, FP, LBD, TP
85  2005 Assessing the consequences of the pesticide methoxychlor: neuroendocrine and behavioral measures as indicators of biological impact of an estrogenic environmental chemical. EDCs
86  2005 Comparative in vitro metabolism of methoxychlor in male and female rats: metabolism of demethylated methoxychlor metabolites by precision-cut rat liver slices. ---
87  2005 Comparative in vitro metabolism of the suspected pro-oestrogenic compound, methoxychlor in precision-cut liver slices from male and female rats. ---
88  2005 Comparison of relative binding affinities of endocrine active compounds to fathead minnow and rainbow trout estrogen receptors. DES, fhmER, GEN, MT, p-NP, PTOP, RBA, rbtER, TAM
89  2005 Consequences of endocrine disrupting chemicals on reproductive endocrine function in birds: establishing reliable end points of exposure. EDCs
90  2005 Effects of selected xenoestrogens on liver peroxisomes, vitellogenin levels and spermatogenic cell proliferation in male zebrafish. AOX, DBP, OP
91  2005 Impact of maternal dietary exposure to endocrine-acting chemicals on progesterone receptor expression in microdissected hypothalamic medial preoptic areas of rat offspring. DINP, EE, ER, GEN, MPOAs, PR, SRC
92  2005 Methoxychlor directly affects ovarian antral follicle growth and atresia through Bcl-2- and Bax-mediated pathways. Bcl-2 OE, WT
93  2005 Methoxychlor disrupts uterine Hoxa10 gene expression. ER, ERE
94  2005 Methoxychlor induces proliferation of the mouse ovarian surface epithelium. HPTE, OSE, PCNA
95  2005 Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation. CNS, ELISA, pCREB, ROS
96  2005 Methoxychlor-induced inducible nitric oxide synthase and proinflammatory cytokines expression in macrophages via NF-kappaB, ERK, and p38 mitogen-activated protein kinases. NO
97  2005 Myelotoxicity in genistein-, nonylphenol-, methoxychlor-, vinclozolin- or ethinyl estradiol-exposed F1 generations of Sprague-Dawley rats following developmental and adult exposures. CFU, GEN, GM-CSF, M-CSF, NPh, PND, VCZ
98  2005 Validation study of OECD rodent uterotrophic assay for the assessment of estrogenic activity in Sprague-Dawley immature female rats. BPA, DBP, EE, GN, NP, OECD
99  2004 Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals. EE, FSH, LH, PRL
100  2004 Effects of methoxychlor exposure during perinatal period on reproductive function after maturation in rats. ---