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Abbreviation : MyD88
Long Form : myeloid differentiation factor 88
No. Year Title Co-occurring Abbreviation
2023 Gastroprotective effect of dapagliflozin in ethanol-induced gastric lesions in rats: Crosstalk between HMGB1/RAGE/PTX3 and TLR4/MyD88/VEGF/PDGF signaling pathways. DAPA, EtOH, HMGB1, OME, PDGF, PTX3, RAGE, TLR4, VEGF
2023 Ginsenoside Rg3 treats acute radiation proctitis through the TLR4/MyD88/NF-κB pathway and regulation of intestinal flora. ARP, GRg3, IL-1beta, NF-kappaB, TLR4
2023 Increased expression of the TLR7/9 signaling pathways in chronic active EBV infection. CAEBV, CBA, EBV, IM, NF-kappaB, TLR
2023 Inhibition of Mogroside IIIE on isoproterenol-induced myocardial fibrosis through the TLR4/MyD88/NF-κB signaling pathway. alpha-SMA, ISO, MGIIIE, TGF-beta1, TLR4
2023 Inhibitory Effects of Bacillus Coagulans TL3 on the Ileal Oxidative Stress and Inflammation Induced by Lipopolysaccharide in Rats. B. coagulans TL3, HBC, LBC, LPS, TLR4
2023 Inhibitory Mechanism of IL-6 Production by Orento in Oral Squamous Cell Carcinoma Cell Line CAL27 Stimulated by Pathogen-Associated Molecular Patterns from Periodontopathogenic Porphyromonas gingivalis. IL, JNK, LPS, MAPK, NF-kB, TLR
2023 Molecular Biomarker Exploration of Rituximab plus CHOP Therapy in Real-World Diffuse Large B-Cell Lymphoma Patients. BTG2, CARD11, CREBBP, DLBCL, ETV6, IPI, NGS, PDGFR, PDGFRA, PDGFRB, PFS, PFS
2023 Neuroprotection by Preconditioning in Mice is Dependent on MyD88-Mediated CXCL10 Expression in Endothelial Cells. CNS, CXCL10, LPS, TLR4
2023 Polystyrene microplastics induced inflammation with activating the TLR2 signal by excessive accumulation of ROS in hepatopancreas of carp (Cyprinus carpio). COX-2, IL-1beta, iNOS, PS-MPs, ROS, TLR2, TRAF6
10  2023 Porphyromonas gingivalis Lipopolysaccharides Promote Proliferation and Migration of Human Vascular Smooth Muscle Cells through the MAPK/TLR4 Pathway. HASMCs, MAPK, Pg-LPS, TLR4
11  2023 Tenebrio molitor Larva Trypsin Hydrolysate Ameliorates Atopic Dermatitis in C57BL/6 Mice by Targeting the TLR-Mediated MyD88-Dependent MAPK Signaling Pathway. AD, DNCB, ELISA, MAPK, TMTH
12  2022 A Dual-Action Molecule Suppresses S. aureus Infection as an Inhibitor Targeting Hla Pore Formation and TLR2 Signaling. S. aureus, TLR2
13  2022 Activation of cGAS-STING by Lethal Malaria N67C Dictates Immunity and Mortality through Induction of CD11b+ Ly6Chi Proinflammatory Monocytes. cGAS, IL, STING
14  2022 Activation of Inflammatory Networks in the Lungs Caused by Chronic Cold Stress Is Moderately Attenuated by Glucose Supplementation. HMGB1, NLRP3, TLR4
15  2022 Acute iron oxide nanoparticles exposure induced murine eosinophilic airway inflammation via TLR2 and TLR4 signaling. BALF, EMBP, IL, KC, MCP, NF, TLR, TNF, TRAF6, TSLP
16  2022 Adaptor protein MyD88 confers the susceptibility to stress via amplifying immune danger signals. COVID-19, CSDS, MDD, mPFC, SARS-CoV-2
17  2022 Aerobic exercise improves intestinal mucosal barrier dysfunction through TLR4/MyD88/NF-kappaB signaling pathway in diabetic rats. D-Lac, DAO, DC, DE, FBG, IL-6, INS, LPS, NC, NF-kappaB, TLR4, TNF-alpha
18  2022 Agrobacterium sp. ZX09 beta-Glucan Attenuates Enterotoxigenic Escherichia coli-Induced Disruption of Intestinal Epithelium in Weaned Pigs. BGL, CAT, DAO, ETEC, IL-6, NF-kappaB, T-SOD, TNF-alpha
19  2022 AIF-1 and RNASET2 are involved in the inflammatory response in the Mediterranean mussel Mytilus galloprovincialis following Vibrio infection. AIF-1, PAMPs, PRRs, TLR4
20  2022 Amentoflavone Exerts Anti-Neuroinflammatory Effects by Inhibiting TLR4/MyD88/NF-κB and Activating Nrf2/HO-1 Pathway in Lipopolysaccharide-Induced BV2 Microglia. HO-1, LPS, NF-kappaB, Nrf2, TLR4
21  2022 Anethole ameliorates inflammation induced by monosodium urate in an acute gouty arthritis model via inhibiting TLRs/MyD88 pathway. AGA, IL-1beta, IL-6, IL-8, MCP-1, MSU, NLRP3, TLRs, TNF-alpha
22  2022 Antiatherosclerotic effects of corilagin via suppression of the LOX-1/MyD88/NF-kappaB signaling pathway in vivo and in vitro. HFD, LOX-1, MCP-1, NF-kappaB, RT-PCR, TNF-alpha, VSMCs
23  2022 Apigenin and apigenin-7, 4'-O-dioctanoate protect against acrolein-aggravated inflammation via inhibiting the activation of NLRP3 inflammasome and HMGB1/MYD88/NF-kappaB signaling pathway in Human umbilical vein endothelial cells (HUVEC). GSH-Px, HMGB1, HUVEC, IL-18, IL-1beta, IL-6, LPS, NLRP3, P-P65, ROS, TLR4, TNF-alpha
24  2022 Apigenin attenuates inflammatory response in allergic rhinitis mice by inhibiting the TLR4/MyD88/NF-κB signaling pathway. AR, ECP, IgE, LPS, NF-kappaB, OVA, TLR4
25  2022 Apostichopus japonicus matrix metalloproteinase-16 might act as a pattern recognition receptor. DAP, MMPs, PGN
26  2022 Atorvastatin suppresses NLRP3 inflammasome activation in intracerebral hemorrhage via TLR4- and MyD88-dependent pathways. GFAP, Iba1, ICH, IL, NLRP3, TLR4, TNF
27  2022 Attenuation of Palmitic Acid-Induced Intestinal Epithelial Barrier Dysfunction by 6-Shogaol in Caco-2 Cells: The Role of MiR-216a-5p/TLR4/NF-kappaB Axis. FD-4, IL, NF-kappaB, PA, TEER, TJ, TLR4, TNF-alpha
28  2022 Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model. AU, NF-kappaB, SCI, TLR4
29  2022 Baicalein Ameliorates Myocardial Ischemia Through Reduction of Oxidative Stress, Inflammation and Apoptosis via TLR4/MyD88/MAPKS/NF-kappaB Pathway and Regulation of Ca2+ Homeostasis by L-type Ca2+ Channels. Bai, Bax, Bcl-2, CAT, CK, IL-6, LDH, MDA, MI, NF-kappaB, ROS, SOD, TLR4, TNF-alpha
30  2022 Baicalin inhibits inflammation of lipopolysaccharide-induced acute lung injury toll like receptor-4/myeloid differentiation primary response 88/nuclear factor-kappa B signaling pathway. ALI, LPS, MAPK, NF-kappaB, NLRP3, TLR4
31  2022 Baicalin Mitigates the Neuroinflammation through the TLR4/MyD88/NF-kappaB and MAPK Pathways in LPS-Stimulated BV-2 Microglia. BA, MAPK, NF-kappaB, TLR4
32  2022 BDNF-modified human umbilical cord mesenchymal stem cells-derived dopaminergic-like neurons improve rotation behavior of Parkinson's disease rats through neuroprotection and anti-neuroinflammation. BDNF, DAergic, GFAP, HSP60, hUCMSCs, Iba1, Nurr1, p-Akt, PD, PI3K, Pitx3, SN, TH, TLR4, TrkB
33  2022 Bioinformatic Analysis and Cellular Assays Identify Substance P Influencing Th17/Treg Differentiation via the MyD88 Pathway as a Potential Contributor to the Progression of Asthma and Allergic Rhinitis. AR, ELISA, GEO, GSVA, SP
34  2022 Blockade of Myd88 signaling by a novel MyD88 inhibitor prevents colitis-associated colorectal cancer development by impairing myeloid-derived suppressor cells. CAC, MDSCs, TLR
35  2022 Blockage of MyD88 in cardiomyocytes alleviates cardiac inflammation and cardiomyopathy in experimental diabetic mice. TLRs
36  2022 Brain-gut-liver axis: Chronic psychological stress promotes liver injury and fibrosis via gut in rats. IL-1, LPS, NF-kappabeta, TLR4, TNF-alpha
37  2022 Bupivacaine inhibits the TLR4- and TLR2-Myd88/NF-kappaB pathways in human leukocytes. hPBMCs, LPS, MAP kinase, MD-2, PGE2, TLR4, TNF-alpha
38  2022 Catalpol relieved angiotensin II-induced blood-brain barrier destruction via inhibiting the TLR4pathway in brain endothelial cells. Ang II, BBB, BSA-FITC, Cav-1, CSVD, iNOS, NF-kappaB, TLR4, TNF-alpha
39  2022 CD38 deficiency protects the retina from ischaemia/reperfusion injury partly via suppression of TLR4/MyD88/NF-kappaB signalling. I/R, KO, NF-kappaB p-p65, Sirt1, TLR4
40  2022 Characterization and functional analysis of a myeloid differentiation factor 88 in Ostrinia furnacalis Guenee larvae infected by Bacillus thuringiensis. Bt, DD, OfMyD88, PPO2
41  2022 Characterization and macrophages immunomodulatory activity of two water-soluble polysaccharides from Abrus cantoniensis. MAPKs, TLR4
42  2022 Characterization of immunomodulatory responses induced by manuka honey. i.p, IL-1beta, IL-6, iNOS, LPS, MH, MHC, PECs, TLR4, TNF-alpha
43  2022 Chlorogenic Acid as a Positive Regulator in LPS-PG-Induced Inflammation via TLR4/MyD88-Mediated NF-kappaB and PI3K/MAPK Signaling Cascades in Human Gingival Fibroblasts. CGA, COX-2, ERK, HGF, iNOS, JNK, NO, PGE2, PI3K, TLR4
44  2022 CircUBE3B High Expression Participates in Sevoflurane-Induced Human Hippocampal Neuron Injury via Targeting miR-326 and Regulating MYD88 Expression. circUBE3B, POCD, qPCR, SEVO
45  2022 Circular RNA MELK Promotes Chondrocyte Apoptosis and Inhibits Autophagy in Osteoarthritis by Regulating MYD88/NF-kappaB Signaling Axis through MicroRNA-497-5p. circMELK, NF-kappaB, OA
46  2022 Clostridium butyricum inhibits the progression of colorectal cancer and alleviates intestinal inflammation via the myeloid differentiation factor 88 (MyD88)-nuclear factor-kappa B (NF-kappaB) signaling pathway. AOM, CFU, CRC, CTRL, DSS, ELISA, FISH, NF-kappaB, PBS, RT-qPCR, TUNEL
47  2022 Compound Gaoziban tablet alleviates depression toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B pathway. COX-2, CUMS, Iba1, IL, p-NF-kappaB, TLR4, TNF-alpha
48  2022 Dangshen Erling Decoction Ameliorates Myocardial Hypertrophy via Inhibiting Myocardial Inflammation. DSELD, G-CSF, GM-CSF, HF, IL, ISO, LDH, MMP-9, TLR, TNF
49  2022 Deletion of MyD88 in astrocytes prevents β-amyloid-induced neuropathology in mice. AD
50  2022 Diagnosing Vitreoretinal Lymphomas-An Analysis of the Sensitivity of Existing Tools. IgH, PCR, TCR, VRL
51  2022 Diet-Induced High Serum Levels of Trimethylamine-N-oxide Enhance the Cellular Inflammatory Response without Exacerbating Acute Intracerebral Hemorrhage Injury in Mice. HMGB1, ICH, IL-1beta, P38-MAPK, TMAO
52  2022 Dietary Galla Chinensis tannic acid supplementation in the diets improves growth performance, immune function and liver health status of broiler chicken. NF-kappaB, NLRP3, TA, TLR4
53  2022 Dietary Glucose Ameliorates Impaired Intestinal Development and Immune Homeostasis Disorders Induced by Chronic Cold Stress in Pig Model. HMGB1, NLRP3, TLR4
54  2022 Dietary ingredient change induces a transient MyD88-dependent mucosal enteric glial cell response and promotes obesity. EGC, GFAP, HFD, qRT-PCR
55  2022 Distinct Cell-specific Roles of NOX2 and MyD88 in Epileptogenesis. NADPH, scRNA-seq, TLE
56  2022 Effect of Berberine on Activation of TLR4-NFκB Signaling Pathway and NLRP3 Inflammasome in Patients with Gout. BBR, CASP1, ELISA, HC, IL-1beta, NF, PBMCs, TLR4
57  2022 Effect of TLR4/MyD88/NF-kB axis in paraventricular nucleus on ventricular arrhythmias induced by sympathetic hyperexcitation in post-myocardial infarction rats. HRV, MI, NE, NF-kB, P-V loop, PES, PVN, RSNA, SCD, TLR4, VAs
58  2022 Effects of acupuncture on microglial polarization and the TLR4/TRIF/MyD88 pathway in a rat model of traumatic brain injury. Co-IP, mNSS, SD, TBI, TIR, TLR4
59  2022 Effects of penehyclidine hydrochloride on myocardial ischaemia-reperfusion injury in rats by inhibiting TLR4/MyD88/NF-kappaB pathway via miR-199a-3p. LAD, MI/RI, NF-kappaB, PHC, TLR4
60  2022 Effects of substituting soybean meal with corn on immune function and gene expression of gut TLR4 pathway of growing goats. AP-1, EOS, IFN-beta, IgG, IL-4, IRAK1, IRF3, LYM, MAPK1, MON, NEU, TNF-alpha, TRAF6, WBC
61  2022 Effects of TLR9/NF-kappaB on oxidative stress and inflammation in IPEC-J2 cells. MDA, NF-kappaB, SOD, TLR9
62  2022 Efficacy of Sishen Wan on dinitrobenzene sulfonic acid-induced ulcerative colitis and its effect on toll-like receptor 2/interleukin-1 receptor-associated kinase-4/nuclear factor-kappaB signal pathway. CMDI, DAI, DNBS, IL-1beta, TNF-alpha, UC
63  2022 Electroacupuncture at Zusanli Alleviates Sepsis by Regulating the TLR4-MyD88-NF-Kappa B Pathway and Diversity of Intestinal Flora. EA, IL-1beta, LDH, NF-kappaB, TNF-alpha, TUNEL
64  2022 Engineered Bacteria EcN-MT Alleviate Liver Injury in Cadmium-Exposed Mice via its Probiotics Characteristics and Expressing of Metallothionein. Bax, Bcl-2, CAT, Cd, MDA, MT, NF-kappaB, SOD, TLR4
65  2022 Enterobacter cloacae aggravates metabolic disease by inducing inflammation and lipid accumulation. AMPK, E. cloacae, NAFLD, NF-kappaB, SREBP-1c, TLR4
66  2022 Evaluation of Ammonia Nitrogen Exposure in Immune Defenses Present on Spleen and Head-Kidney of Wuchang Bream (Megalobrama amblycephala). IgM, IL-1beta, TLRs, TNF-alpha
67  2022 Exercise Alleviates the Apolipoprotein A5-Toll-Like Receptor 4 Axis Impairment in Mice With High-Fat Diet-Induced Non-alcoholic Steatohepatitis. APOA5, HFD, LPS, NASH, NF-kappaB, TLR4
68  2022 Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity. AT, BMI, IRAK1, IRFs, NF-kappaB, SRA1, T2D, TLRs
69  2022 Extracellular HSP90alpha Induces MyD88-IRAK Complex-Associated IKKalpha/beta-NF-kappaB/IRF3 and JAK2/TYK2-STAT-3 Signaling in Macrophages for Tumor-Promoting M2-Polarization. eHSP90alpha, IL, IRF3, JAK2, STAT-3, TLR4, TYK2
70  2022 Forsythiaside A improves Influenza A virus infection through TLR7 signaling pathway in the lungs of mice. NF-kappaB, TLR7
71  2022 Forsythiasides: A review of the pharmacological effects. HO-1, NF-kappaB, Nrf2, TLR4
72  2022 Genetic resilience in chickens against bacterial, viral and protozoal pathogens. IFN, MHC, NRAMP1, RIP2, SNP
73  2022 Genistein attenuates LPS-induced inflammatory injury of rat dorsal root ganglion neuron via down-regulating HDAC6. DRGN, GEN, LPS, NP, TLR4, TSA
74  2022 Heme Oxygenase-1 may Mediate Early Inflammatory Response of Intracerebral Hemorrhage through Toll-like Receptor 4 Signaling Pathway. HO-1, ICH, TIR, TLR4, ZnPP
75  2022 Herbal extracts that induce type I interferons through Toll-like receptor 4 signaling. BMDMs, EMCV, IFNs, INT, LPS, TIR, TLR4
76  2022 HMGB1/TLR4 induces autophagy and promotes neuroinflammation after intracerebral hemorrhage. 3-MA, HMGB1, ICH, siRNA, TLR4
77  2022 Hovenia Monofloral Honey can Attenuate Enterococcus faecalis Mediated Biofilm Formation and Inflammation. HMH, IL-8, MAPKs, TLR2
78  2022 Identification, functional characterization and expression pattern of myeloid differentiation factor 88 (MyD88) in Nibea albiflora. IL
79  2022 IL-1beta-Triggered Long Non-coding RNA CHRF Induces Non-Small Cell Lung Cancer by Modulating the microRNA-489/Myd88 Axis. CHRF, IL-1beta, LncRNAs, miR-489, NSCLC
80  2022 Inflammation Induced by Lipopolysaccharide and Palmitic Acid Increases Cholesterol Accumulation via Enhancing Myeloid Differentiation Factor 88 Expression in HepG2 Cells. LPS, PA, SREBP-2, TLR4
81  2022 Inhalation of Salvianolic Acid B Prevents Fine Particulate Matter-Induced Acute Airway Inflammation and Oxidative Stress by Downregulating the LTR4/MyD88/NLRP3 Pathway. KC, NLRP3, Sal B, TLR4, TRAF-6
82  2022 Inhibition of MyD88 attenuates angiotensin II-induced hypertensive kidney disease via regulating renal inflammation. Ang II, NF-kappaB, TLRs
83  2022 Inhibitory Effects of Dutasteride on TLR4: An In vitro Pain Study. IL-1beta, LPS, NF-kappaB, NO, TLR4
84  2022 Insomnia and depressive behavior of MyD88-deficient mice: Relationships with altered microglial functions. PFC, ZT
85  2022 Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea. GI, TLR, UGT
86  2022 Ketogenic Diet Modulates Neuroinflammation via Metabolites from Lactobacillus reuteri After Repetitive Mild Traumatic Brain Injury in Adolescent Mice. 3-IAA, AhR, betaHB, KD, L. reuteri, rmTBI, SPF, TBI, TLR4
87  2022 Knockdown of phosphoinositide-dependent kinase 1 (PDK1) inhibits fibrosis and inflammation in lipopolysaccharide-induced acute lung injury rat model by attenuating NF-kappaB/p65 pathway activation. ALI, alpha-SMA, ELISA, IL-6, iNOS, LPS, MCP-1, mRNA, NF-kappaB, PDK1, RT-PCR, SD, TGF-beta, TLR4, TNF-alpha
88  2022 Long Noncoding RNA MEG3-205/Let-7a/MyD88 Axis Promotes Renal Inflammation and Fibrosis in Diabetic Nephropathy. AGEs, DN, lncRNA, MEG3, MMCs
89  2022 LPS- and LTA-Induced Expression of TLR4, MyD88, and TNF-alpha in Lymph Nodes of the Akkaraman and Romanov Lambs. LPS, LTA, TLR, TNF-alpha
90  2022 LXR agonist inhibits inflammation through regulating MyD88 mRNA alternative splicing. LXRs
91  2022 Macroglobulinemia and Autoinflammatory Disease. NOD2, SchS, WM
92  2022 Macrophage-specific MyD88 deletion and pharmacological inhibition prevents liver damage in non-alcoholic fatty liver disease via reducing inflammatory response. HFD, NAFLD, TLRs
93  2022 Melatonin decreases IRF-3 protein expression in the gastrocnemius muscle, reduces IL-1β and LPS plasma concentrations, and improves the lipid profile in rats with apical periodontitis fed on a high-fat diet. AP, GM, HFD, IL-1beta, IRF3, LPS, MEL, NF-kappaB, TLR4, TRIF
94  2022 Membrane orthologs of TLR5 of tongue sole Cynoglossus semilaevis: Expression patterns, signaling pathway and antibacterial property. ECD, PBLs, rCsTLR5M, TIR, TLR5, TMD
95  2022 MicroRNA-885-3p alleviates bronchial epithelial cell injury induced by lipopolysaccharide via toll-like receptor 4. Bax, Bcl-2, CCK-8, IL-6, IL-8, LPS, miR-885-3p, miRNAs, NF-kappaB, TLR4, TNF-alpha
96  2022 miR-30e-5p attenuates neuronal deficit and inflammation of rats with intracerebral hemorrhage by regulating TLR4. ICH, TLR, TRIF
97  2022 Molecular characterization and functional analysis of DIGIRR from golden pompano (Trachinotus ovatus). Co-IP, DIGIRR, Ig, LPS, ORF, TIR, TRIF
98  2022 Molecular Characterization of MyD88 in Anodonta woodiana and Its Involvement in the Innate Immune Response to Bacterial Infection. DD, LPS, qRT-PCR, TIR
99  2022 Moringa oleifera leaf polysaccharide alleviates experimental colitis by inhibiting inflammation and maintaining intestinal barrier. DSS, FTIR, IL-10, M. oleifera, MW, NF-kappaB, PPARgamma, TLR4, UC, XRD, ZO-1
100  2022 Mulberry Leaf Flavonoids Inhibit Liver Inflammation in Type 2 Diabetes Rats by Regulating TLR4/MyD88/NF-kappaB Signaling Pathway. FINS, HFD, MLF, NF-kappaB, T2DM, TLR4, TRAF6