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Abbreviation : NAC
Long Form : N-acetylcysteine
No. Year Title Co-occurring Abbreviation
2020 A Combination of N-Acetylcysteine and Prednisone Has No Benefit Over Prednisone Alone in Severe Alcoholic Hepatitis: A Retrospective Analysis. DF
2020 A prospective randomized controlled trial comparing simethicone, N-acetylcysteine, sodium bicarbonate and peppermint for visualization in upper gastrointestinal endoscopy. EGD, TCTR, TVS
2020 Acetaldehyde induces phosphorylation of dynamin-related protein 1 and mitochondrial dysfunction via elevating intracellular ROS and Ca2+ levels. AD, CaMKII, Drp1, JNK, MAPK, PD, ROS
2020 Activation of MIP-2 and MCP-5 Expression in Methylmercury-Exposed Mice and Their Suppression by N-Acetyl-L-Cysteine. BW, CNS
2020 Acute N-Acetylcysteine Administration Ameliorates Loss of Olfactory Neurons Following Experimental Injury In Vivo. OE
2020 AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. AhR, ROS, TCE
2020 alpha-Mangostin reduced the viability of A594 cells in vitro by provoking ROS production through downregulation of NAMPT/NAD. MAN, NMN, ROS
2020 An acute lytic cell death induced by xanthohumol obstructed ROS detecting in HL-60 cells. ROS, XN
2020 Anti-inflammatory effects of Aureusidin in LPS-stimulated RAW264.7 macrophages via suppressing NF-kappaB and activating ROS- and MAPKs-dependent Nrf2/HO-1 signaling pathways. LPS, MAPK, NF-kappaB, NO, NQO1, Nrf2, PGE2, ROS, SnPP, TNF-alpha
10  2020 Antioxidant supplementation partially rescues accelerated ovarian follicle loss, but not oocyte quality, of glutathione deficient mice†. ALA, eCG, Gclm, PND
11  2020 Antiproliferative Effect of Acridine Chalcone Is Mediated by Induction of Oxidative Stress. MAPK, ROS/RNS
12  2020 Application of non-invasive low-intensity pulsed electric field with thermal cycling-hyperthermia for synergistically enhanced anticancer effect of chlorogenic acid on PANC-1 cells. LIPEF, ROS, TC-HT
13  2020 Artichoke Polyphenols Sensitize Human Breast Cancer Cells to Chemotherapeutic Drugs via a ROS-Mediated Downregulation of Flap Endonuclease 1. ADR, AEs, DDR, FEN1, PTX
14  2020 Assessment of Cell Viability of Fresh Osteochondral Allografts in N-Acetylcysteine-Enriched Medium. PBS
15  2020 Bardoxolone-Methyl (CDDO-Me) Suppresses Androgen Receptor and Its Splice-Variant AR-V7 and Enhances Efficacy of Enzalutamide in Prostate Cancer Cells. ADT, AR, CRPC, ENZ, PC, ROS
16  2020 Bisphenol A and its substitutes regulate human B cell survival via Nrf2 expression. BPA, CHDM, DMT, HO, ISO, KD, Nrf2, ROS, SOD, TMCD
17  2020 Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo. BD, ROS
18  2020 Calcitonin gene-related peptide attenuates angiotensin II-induced ROS-dependent apoptosis in vascular smooth muscle cells by inhibiting the CaMKII/CREB signalling pathway. Ang, ROS, VSMCs
19  2020 Can PBDEs affect the pathophysiologic complex of epithelium in lung diseases? ALI, PBDEs, pHBEC, TEER, TJ, ZO-1
20  2020 Co-administration of N-acetylcysteine and dexmedetomidine plays a synergistic effect on protection of LPS-induced acute lung injury via correcting Th1/Th2/Th17 cytokines imbalance. ALI, BALF, DEX, LPS, MPO
21  2020 Cobalt nanoparticles trigger ferroptosis-like cell death (oxytosis) in neuronal cells: Potential implications for neurodegenerative disease. Co, GPX4, NPs
22  2020 Cocoa tea (Camellia ptilophylla) induces mitochondria-dependent apoptosis in HCT116 cells via ROS generation and PI3K/Akt signaling pathway. GCG, MMP, PI3K, ROS
23  2020 Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury. AILI, NE
24  2020 Combined treatment with N-acetylcysteine and gefitinib overcomes drug resistance to gefitinib in NSCLC cell line. CI, NSCLC, qRT-PCR
25  2020 Comparison of N-ethyl maleimide and N-(1-phenylethyl) maleimide for derivatization of biological thiols using liquid chromatography-mass spectrometry. Cys, LC-HRMS, NEM
26  2020 Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models. ATP, CNT, DPI, IMQ, LDH, PI, ROS, TPA
27  2020 Cr(VI) induces ROS-mediated mitochondrial-dependent apoptosis in neuronal cells via the activation of Akt/ERK/AMPK signaling pathway. AMPK, ERK, MMP, ROS
28  2020 Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. ATA, CLU, HG, HS, Nec, TCC
29  2020 Cytotoxic effects of thioxanthone derivatives as photoinitiators on isolated rat hepatocytes. ATP, DETX, ROS, UV
30  2020 Depressive symptoms and cannabis use in a placebo-controlled trial of N-Acetylcysteine for adult cannabis use disorder. CUD
31  2020 Differentiation agents increase the potential AraC therapy of AML by reactivating cell death pathways without enhancing ROS generation. AML, AraC, CD, ECD, ROS, VDR
32  2020 Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways. ALDH, alpha-SMA, CAFs, FACS, IHC, NPC
33  2020 DNA hypermethylation: A novel mechanism of CREG gene suppression and atherosclerogenic endothelial dysfunction. 5-aza-dC, DNMT, HCAECs, HUVECs, oxLDL
34  2020 Dopamine attenuates lipopolysaccharide-induced expression of proinflammatory cytokines by inhibiting the nuclear translocation of NF-kappaB p65 through the formation of dopamine quinone in microglia. LPS, NF-kappaB
35  2020 Effect of Cysteine on Methylglyoxal-Induced Renal Damage in Mesangial Cells. AG, AGEs, GLO-I, MGO, ROS
36  2020 Effect of Formulation Factors and Oxygen Levels on the Stability of Aqueous Injectable Solution Containing Pemetrexed. DO
37  2020 Effect of single dose N-acetylcysteine administration on resting state functional connectivity in schizophrenia. ACC, DMN, rs-fMRI, RSFC, SN
38  2020 EGCG regulates CTR1 expression through its pro-oxidative property in non-small-cell lung cancer cells. CTR1, EGCG, NEAT1, NSCLC, ROS
39  2020 Endothelin-1 Downregulates Sulfur Dioxide/Aspartate Aminotransferase Pathway via Reactive Oxygen Species to Promote the Proliferation and Migration of Vascular Smooth Muscle Cells. AAT, ET-1, ROS, VSMC
40  2020 Enhancer of zeste homolog 2 modulates oxidative stress-mediated pyroptosis in vitro and in a mouse kidney ischemia-reperfusion injury model. EZH2, I/R, ROS
41  2020 Epigenetic modification of H3K4 and oxidative stress are involved in MC-LR-induced apoptosis in testicular cells of SD rats. MC-LR, MTA, ROS, SD
42  2020 Ergolide, a potent sesquiterpene lactone induces cell cycle arrest along with ROS-dependent apoptosis and potentiates vincristine cytotoxicity in ALL cell lines. ALL
43  2020 EV71 infection induces cell apoptosis through ROS generation and SIRT1 activation. EV71, IL-1beta, ROS, SIRT1
44  2020 Evidence for oxidative and not reductive stress in the aged rabbit heart. CF, DP, EDP, FDPL, gamma-GCS, GSH-Px, LMWI, PC
45  2020 Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway. LDH, micro-PS, MP, SDH
46  2020 Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte. CHOP
47  2020 Generating stem-like memory T cells with antioxidants for adoptive cell transfer immunotherapy of cancer. ACT
48  2020 Glsnf1-mediated metabolic rearrangement participates in coping with heat stress and influencing secondary metabolism in Ganoderma lucidum. AMPK, GAs, HS, Snf1
49  2020 High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes. cyt c, DeltaPsim, HG, mtDNA, ROS
50  2020 Impact of Comorbidities and Commonly Used Drugs on Mortality in COPD - Real-World Data from a Primary Care Setting. ASA, CI, COPD, HR, ICS, LAMA
51  2020 Improvement of cognitive function in schizophrenia with N-acetylcysteine: A theoretical review. ---
52  2020 Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRalpha/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-alpha-Induced Lung Inflammation. Akt, APO, ARE, ChIP, DPI, HMG-CoA, HO-1, HPAEpiCs, ICAM, MVS, NOX, PDFGR, ROS, siRNA, TNF
53  2020 Inhibition of Gap Junction-Mediated Intercellular Communication by Poly(I:C) in Cultured Human Corneal Fibroblasts. Cx43, GJIC, HCFs, JNK, MAPK, SOD
54  2020 Inhibition of ROS-NF-kappaB-dependent autophagy enhances Hypocrellin A united LED red light-induced apoptosis in squamous carcinoma A431 cells. cSCC, HA, NF-kappaB, ROS
55  2020 Inorganic mercury-induced MIP-2 expression is suppressed by N-acetyl-L-cysteine in RAW264.7 macrophages. ---
56  2020 Interplay between oxidative stress and autophagy function and its role in inflammatory cytokine expression induced by palmitate in skeletal muscle cells. ROS
57  2020 Isoflavones Isolated from the Seeds of Millettia ferruginea Induced Apoptotic Cell Death in Human Ovarian Cancer Cells. DMI, ROS
58  2020 Knock-down of LncRNA-XIST induced glioma cell death and inhibited tumorigenesis by regulating miR-137/SLC1A5 axis-mediated ROS production. NHAs
59  2020 Lawsone, a 2-hydroxy-1,4-naphthoquinone from Lawsonia inermis (henna), produces mitochondrial dysfunctions and triggers mitophagy in Saccharomyces cerevisiae. MIC
60  2020 Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-kappaB signaling pathway. ERK, HCC, JNK, LIQ, NF-kappaB, STAT3
61  2020 Low-cost management of mushroom poisoning in a limited-resource area: a 12-year retrospective study. ---
62  2020 Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators. DMD, ECC
63  2020 MiR-130a alleviated high-glucose induced retinal pigment epithelium (RPE) death by modulating TNF-alpha/SOD1/ROS cascade mediated pyroptosis. NSA, ROS, RPE, SOD, TNF
64  2020 Mixed methods analysis of Health-Related Quality of Life in ambulant individuals affected with RYR1-related myopathies pre-post-N-acetylcysteine therapy. HRQoL, MMR
65  2020 Myristica fragrans seed extract reverses scopolamine-induced cortical injury via stimulation of HO-1 expression in male rats. HMOX1
66  2020 N-acetyl cysteine ameliorates depression-induced cognitive deficits by restoring the volumes of hippocampal subfields and associated neurochemical changes. CLI, DG
67  2020 N-acetyl cysteine protects against chlorine-induced tissue damage in an ex vivo model. PCLS
68  2020 N-Acetyl-cysteine and Mechanisms Involved in Resolution of Chronic Wound Biofilm. EPS
69  2020 N-acetyl-l-cysteine protects porcine oocytes undergoing meiotic resumption from heat stress. ERK, HS
70  2020 N-Acetyl-L-Cysteine Reduces Fibrosis and Improves Muscle Function After Acute Compartment Syndrome Injury. ---
71  2020 N-acetyl-L-cysteine reduces Leishmania amazonensis-induced inflammation in BALB/c mice. ---
72  2020 N-acetylcysteine (NAC) alleviates the peripheral neuropathy associated with liver cirrhosis via modulation of neural MEG3/PAR2/ NF-ҡB axis. OS, PAR2, TAA, vF
73  2020 N-acetylcysteine and ascorbic acid therapy for acute hepatic injury after hexavalent chromium ingestion. ---
74  2020 N-Acetylcysteine Attenuates Lipopolysaccharide-Induced Osteolysis by Restoring Bone Remodeling Balance via Reduction of Reactive Oxygen Species Formation During Osteoclastogenesis. Acp5, CTSK, DC-STAMP, LPS, NFATc1, Oc-stamp, OCs, pre-OCs, ROS
75  2020 N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression. CLDN, FEV1, OVA, p-Akt, p-PDK1
76  2020 N-Acetylcysteine for Pediatric Obsessive-Compulsive Disorder: A Small Pilot Study. CY-BOCS, OCD
77  2020 N-acetylcysteine for the treatment of comorbid alcohol use disorder and posttraumatic stress disorder: Design and methodology of a randomized clinical trial. AUD, fMRI, PTSD
78  2020 N-acetylcysteine inhibits thrombosis in a murine model of myeloproliferative neoplasm. MPNs
79  2020 N-acetylcysteine mitigates acute opioid withdrawal behaviors and CNS oxidative stress in neonatal rats. NAS, PND
80  2020 N-acetylcysteine prevents oxidized low-density lipoprotein-induced reduction of MG53 and enhances MG53 protective effect on bone marrow stem cells. MAPCs, oxLDL
81  2020 N-acetylcysteine reduces amphotericin B deoxycholate nephrotoxicity and improves the outcome of murine cryptococcosis. AmB, ROS
82  2020 N-acetylcysteine yields sex-specific efficacy for cue-induced reinstatement of nicotine seeking. ---
83  2020 Neuroprotective effects of N-acetylcysteine via inhibition of matrix metalloproteinase in a mouse model of transient global cerebral ischemia. MMP, TUNEL
84  2020 New quinoline-2-one/pyrazole derivatives; design, synthesis, molecular docking, anti-apoptotic evaluation, and caspase-3 inhibition assay. ---
85  2020 NF-kappaB/Cartilage Acidic Protein 1 Promotes Ultraviolet B Irradiation-Induced Apoptosis of Human Lens Epithelial Cells. CRTAC1, HLECs, NF-kappaB, PDTC, ROS, UVB
86  2020 Noise-induced loss of sensory hair cells is mediated by ROS/AMPKalpha pathway. AC, AMP, cAMP, NIHL, OHC, ROS
87  2020 Non-Thermal Atmospheric Pressure Bio-Compatible Plasma Stimulates Apoptosis via p38/MAPK Mechanism in U87 Malignant Glioblastoma. MAPK, RONS, ROS
88  2020 Novel Therapeutic Approaches against Acetaminophen-induced Liver Injury and Acute Liver Failure. ---
89  2020 One Step Synthesis of Fmoc-Aminoacyl-N-alkylcysteine via the Ugi Four-Component Condensation Reaction. ---
90  2020 Oral N-acetylcysteine improves cone function in retinitis pigmentosa patients in phase I trial. BCVA, EZ, RP
91  2020 Oxidative and nitrosative stress in the neurotoxicity of polybrominated diphenyl ether-153: possible mechanism and potential targeted intervention. L-NNA, LDH, MDA, nNOS, NO, PBDEs, Prx I, ROS, SOD
92  2020 Oxidative stress facilitates cell death by inhibiting Orai1-mediated Ca2+ entry in brain capillary endothelial cells. 2-APB, BBB, BCECs, ROS
93  2020 Oxidative stress mediates heat-induced changes of tight junction proteins in porcine sertoli cells via inhibiting CaMKKbeta-AMPK pathway. CAT, GSH-Px, MDA, SOD
94  2020 Pharmacokinetic profile of N-acetylcysteine amide and its main metabolite in mice using new analytical method. LC-MS, NACA
95  2020 Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-kappaB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer. NSA, NSCLC, PPVI, ROS, TTM
96  2020 Prophylaxis of implant-related infections by local release of vancomycin from a hydrogel in rabbits. BAG
97  2020 Protective effect of N-acetyl cysteine against radiotherapy-induced cardiac damage. MDA, RT
98  2020 Protective effect of N-acetylcysteine on the toxicity of silver nanoparticles: Bioavailability and toxicokinetics in Enchytraeus crypticus. NPs
100  2020 Randomized controlled trial of N-acetylcysteine therapy for RYR1-related myopathies. 6MWT, CI, RYR1-RM