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Abbreviation : NAC
Long Form : N-acetylcysteine
No. Year Title Co-occurring Abbreviation
2020 1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42), a novel ALK inhibitor, induces apoptosis and protective autophagy in H2228 cells. AO/EB, AV/PI, EML4-ALK, MDC, PI, Rh123, ROS
2020 13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity Against Oral Cancer Cells Through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts. 13-AC, MMP, ROS
2020 15-Deoxy-Delta12,14-prostaglandin J2 Induces Apoptosis in Ha-ras-transformed Human Breast Epithelial Cells by Targeting IkappaB kinase-NF-kappaB Signaling. IKKbeta, ROS
2020 4-Aminobiphenyl inhibits the DNA homologous recombination repair in human liver cells: The role of miR-630 in downregulating RAD18 and MCM8. 4-ABP, DSBs, HR, ROS
2020 A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent. FHF
2020 A Chinese Herbal Formula Suppresses Colorectal Cancer Migration and Vasculogenic Mimicry Through ROS/HIF-1alpha/MMP2 Pathway in Hypoxic Microenvironment. AAM, MMP2, ROS, VM
2020 A combination of an antioxidant with a prebiotic exerts greater efficacy than either as a monotherapy on cognitive improvement in castrated-obese male rats. HFD, ND
2020 A Combination of N-Acetylcysteine and Prednisone Has No Benefit Over Prednisone Alone in Severe Alcoholic Hepatitis: A Retrospective Analysis. DF
2020 A knack for "NAC": Treatment for heat stroke induced acute liver injury. ALI
10  2020 A multi-centre, double-blind, 12-week, randomized, placebo-controlled trial to assess the efficacy of adjunctive N-Acetylcysteine for treatment-resistant PTSD: a study protocol. PTSD
11  2020 A novel coordination complex of platinum (PT) induces cell death in colorectal cancer by altering redox balance and modulating MAPK pathway. CRC, Pt, PT, PT, ROS
12  2020 A prospective randomized controlled trial comparing simethicone, N-acetylcysteine, sodium bicarbonate and peppermint for visualization in upper gastrointestinal endoscopy. EGD, TCTR, TVS
13  2020 A Randomized Controlled Trial of Intravenous N-acetylcysteine in the Management of Anti-tuberculosis Drug-Induced Liver Injury. ATDILI
14  2020 A steroidal saponin form Paris vietnamensis (Takht.) reverses temozolomide resistance in glioblastoma cells via inducing apoptosis through ROS/PI3K/Akt pathway. CCK-8, MGMT, NF-kappaB p65, PI3K, ROS, TEM, TMZ, TUNEL
15  2020 Accelerated habitual learning resulting from L-dopa exposure in rats is prevented by N-acetylcysteine. ---
16  2020 Accelerated transsulfuration metabolically defines a discrete subclass of amyotrophic lateral sclerosis patients. ---
17  2020 Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior. GFAP, NAcore, TNF-alpha
18  2020 Acetaldehyde induces phosphorylation of dynamin-related protein 1 and mitochondrial dysfunction via elevating intracellular ROS and Ca2+ levels. AD, CaMKII, Drp1, JNK, MAPK, PD, ROS
19  2020 Activation of MIP-2 and MCP-5 Expression in Methylmercury-Exposed Mice and Their Suppression by N-Acetyl-L-Cysteine. BW, CNS
20  2020 Activation of PPARgamma reduces N-acetyl-cysteine -induced hypercorticoidism by down-regulating MC2R expression into adrenal glands. ACTH, HPA, PPAR, StAR
21  2020 Activity of Sodium Lauryl Sulfate, Rhamnolipids, and N-Acetylcysteine Against Biofilms of Five Common Pathogens. MICs, RHL, SDS
22  2020 Acute N-Acetylcysteine Administration Ameliorates Loss of Olfactory Neurons Following Experimental Injury In Vivo. OE
23  2020 Advances in the understanding of poor graft function following allogeneic hematopoietic stem-cell transplantation. allo-HSCT, GVHD, PGF, ROS, SCB
24  2020 Adverse outcome pathways induced by 3,4-dimethylmethcathinone and 4-methylmethcathinone in differentiated human SH-SY5Y neuronal cells. 4-MMC, METH, ROS
25  2020 Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects. BM, HSC, HSPC, MSC, ROS
26  2020 AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. AhR, ROS, TCE
27  2020 AHR-mediated ROS production contributes to the cardiac developmental toxicity of PM2.5 in zebrafish embryos. AHR, EOM, ROS
29  2020 Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS. ACE, ACE2, ALA, Ang II, AT1R, HSCs, MrgD, NOX, RAS, ROS, siRNA
30  2020 Alleviating Cellular Oxidative Stress through Treatment with Superoxide-Triggered Persulfide Prodrugs. PMA, ROS, SOPD-Pep
31  2020 alpha-Mangostin reduced the viability of A594 cells in vitro by provoking ROS production through downregulation of NAMPT/NAD. MAN, NMN, ROS
32  2020 Alpha-neoendorphin can reduce UVB-induced skin photoaging by activating cellular autophagy. p-ERK, p-JNK, p-mTOR, p-p38, ROS, UV, UVB
33  2020 An acute lytic cell death induced by xanthohumol obstructed ROS detecting in HL-60 cells. ROS, XN
34  2020 An Observational Study: Is N-Acetylcysteine Helpful in Performance Improvement of Mycoplasma IST2 Testing through Sample Homogenization? ---
35  2020 Antagonistic effect of N-acetyl-L-cysteine against cadmium-induced cytotoxicity and abnormal immune response on chicken peritoneal macrophages. LPS
36  2020 Antenatal N-acetylcysteine to improve outcomes of premature infants with intra-amniotic infection and inflammation (Triple I): randomized clinical trial. CI, FDA, PTB
37  2020 Anti-inflammatory effects of Aureusidin in LPS-stimulated RAW264.7 macrophages via suppressing NF-kappaB and activating ROS- and MAPKs-dependent Nrf2/HO-1 signaling pathways. LPS, MAPK, NF-kappaB, NO, NQO1, Nrf2, PGE2, ROS, SnPP, TNF-alpha
38  2020 Anticancer activity of functional polysuccinates with N-acetyl-cysteine in side chains. HaCaT
39  2020 Antifibrotic effect of curcumin, n-acetyl cysteine and propolis against bisphenol A-induced hepatotoxicity in rats: Prophylaxis versus co-treatment. BPA
40  2020 Antimycin A shows selective antiproliferation to oral cancer cells by oxidative stress-mediated apoptosis and DNA damage. 8-oxodG, AMA, MitoMP, MitoSOX, ROS
41  2020 Antioxidant Antagonises Chemotherapeutic Drug Effect in Lung Cancer Cell Line A549. 6-TG
42  2020 Antioxidant Effects of N-Acetylcysteine Prevent Programmed Metabolic Disease in Mice. HFD, WAT
43  2020 Antioxidant supplementation partially rescues accelerated ovarian follicle loss, but not oocyte quality, of glutathione-deficient mice†. ALA, eCG, Gclm, PND
44  2020 Antioxidants Reduce Muscular Dystrophy in the dy2J/dy2J Mouse Model of Laminin alpha2 Chain-Deficient Muscular Dystrophy. ROS
45  2020 Antiproliferative Effect of Acridine Chalcone Is Mediated by Induction of Oxidative Stress. MAPK, ROS/RNS
46  2020 Antitumorigenic Effect of Hsp90 Inhibitor SNX-2112 on Tongue Squamous Cell Carcinoma is Enhanced by Low-Intensity Ultrasound. ERS
47  2020 Application of non-invasive low-intensity pulsed electric field with thermal cycling-hyperthermia for synergistically enhanced anticancer effect of chlorogenic acid on PANC-1 cells. LIPEF, ROS, TC-HT
48  2020 Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways. TJ
49  2020 Artichoke Polyphenols Sensitize Human Breast Cancer Cells to Chemotherapeutic Drugs via a ROS-Mediated Downregulation of Flap Endonuclease 1. ADR, AEs, DDR, FEN1, PTX
50  2020 Assessment of Cell Viability of Fresh Osteochondral Allografts in N-Acetylcysteine-Enriched Medium. PBS
51  2020 Bardoxolone-Methyl (CDDO-Me) Suppresses Androgen Receptor and Its Splice-Variant AR-V7 and Enhances Efficacy of Enzalutamide in Prostate Cancer Cells. ADT, AR, CRPC, ENZ, PC, ROS
52  2020 Benefits of N-acetylcysteine on liver functions in living donor hepatectomy. ICU
53  2020 beta-Escin alleviates cobalt chloride-induced hypoxia-mediated apoptotic resistance and invasion via ROS-dependent HIF-1alpha/TGF-beta/MMPs in A549 cells. HIF-1alpha
54  2020 Bisphenol A aggravates renal ischemia-reperfusion injury by disrupting mitochondrial homeostasis and N-acetylcysteine mitigates the injurious outcomes. AMPK, BPA, Drp1, Mfn2, p-DRP1, PINK, RIR, SIRT3
55  2020 Bisphenol A and its substitutes regulate human B cell survival via Nrf2 expression. BPA, CHDM, DMT, HO, ISO, KD, Nrf2, ROS, SOD, TMCD
56  2020 Blue light-emitting diode irradiation promotes transcription factor EB-mediated lysosome biogenesis and lysosomal cell death in murine photoreceptor-derived cells. LEDs, LMP, TFEB
57  2020 Bmi deficiency causes oxidative stress and intervertebral disc degeneration which can be alleviated by antioxidant treatment. GPx, SOD
58  2020 Bmi-1 determines the stemness of renal stem or progenitor cells. OS, RSCs, WT
59  2020 BRAF Mutant Melanoma Adjusts to BRAF/MEK Inhibitors via Dependence on Increased Antioxidant SOD2 and Increased Reactive Oxygen Species Levels. BRAF, FDA, MEK, NF, ROS, SOD2, TDR
60  2020 Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo. BD, ROS
61  2020 Calcitonin gene-related peptide attenuates angiotensin II-induced ROS-dependent apoptosis in vascular smooth muscle cells by inhibiting the CaMKII/CREB signalling pathway. Ang, ROS, VSMCs
62  2020 Can PBDEs affect the pathophysiologic complex of epithelium in lung diseases? ALI, PBDEs, pHBEC, TEER, TJ, ZO-1
63  2020 Cannabidiol Promotes Endothelial Cell Survival by Heme Oxygenase-1-Mediated Autophagy. CBD, HO-1, HUVEC, Nrf2, ROS
64  2020 CEES-induced ROS accumulation regulates mitochondrial complications and inflammatory response in keratinocytes. CEES, DeltaPsim, ETC, HydHCl, IRF3, MnSOD, mtDNA, NAME, OXPHOS, PI3K, ROS, SOD, TFAM
65  2020 Chronic impairment of mitochondrial bioenergetics and beta-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. AKI, CKD, FA
66  2020 Cigarette smoke extract inhibits cell migration and contraction via the reactive oxygen species/adenosine monophosphate-activated protein kinase pathway in nasal fibroblasts. AMPK, CSE, ROS, siRNA
67  2020 Cilostazol alleviate nicotine induced cardiomyocytes hypertrophy through modulation of autophagy by CTSB/ROS/p38MAPK/JNK feedback loop. CTSB, NRVMs
68  2020 Co-administration of everolimus and N-acetylcysteine attenuates hepatic stellate cell activation and hepatic fibrosis. mTOR
69  2020 Co-administration of N-acetylcysteine and dexmedetomidine plays a synergistic effect on protection of LPS-induced acute lung injury via correcting Th1/Th2/Th17 cytokines imbalance. ALI, BALF, DEX, LPS, MPO
70  2020 Cobalt nanoparticles trigger ferroptosis-like cell death (oxytosis) in neuronal cells: Potential implications for neurodegenerative disease. Co, GPX4, NPs
71  2020 Cocoa tea (Camellia ptilophylla) induces mitochondria-dependent apoptosis in HCT116 cells via ROS generation and PI3K/Akt signaling pathway. GCG, MMP, PI3K, ROS
72  2020 Coinfection with PCV2 and SS2 enhances the survival of SS2 in swine tracheal epithelial cells by decreasing reactive oxygen species production. PCV2, ROS, SS2, STEC
73  2020 Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury. AILI, NE
74  2020 Combination Therapy of Gabapentin and N-Acetylcysteine Against Posttraumatic Epilepsy in Rats. GBP, LEV, PTE, PTZ, TBI
75  2020 Combination Therapy with Cinnamaldehyde and Hyperthermia Induces Apoptosis of A549 Non-Small Cell Lung Carcinoma Cells via Regulation of Reactive Oxygen Species and Mitogen-Activated Protein Kinase Family. CNM, MAPK, NSCLC, ROS
76  2020 Combined treatment with N-acetylcysteine and gefitinib overcomes drug resistance to gefitinib in NSCLC cell line. CI, NSCLC, qRT-PCR
77  2020 Comparison of N-ethyl maleimide and N-(1-phenylethyl) maleimide for derivatization of biological thiols using liquid chromatography-mass spectrometry. Cys, LC-HRMS, NEM
78  2020 Comparison of the effect of clarithromycin triple therapy with or without N-acetylcysteine in the eradication of Helicobacter pylori: a randomized controlled trial. CI, ITT
79  2020 Comparison of the efficacy between NAC and metformin in treating PCOS patients: a meta-analysis. PCOS, RCTs
80  2020 Compression stress induces nucleus pulposus cell autophagy by inhibition of the PI3K/AKT/mTOR pathway and activation of the JNK pathway. IVDD, NP, ROS
81  2020 Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models. ATP, CNT, DPI, IMQ, LDH, PI, ROS, TPA
82  2020 Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis. ER, PBA, ROS, UPR
83  2020 Copper Oxide Nanoparticles Induce Oxidative DNA Damage and Cell Death via Copper Ion-Mediated P38 MAPK Activation in Vascular Endothelial Cells. GCLM, HO-1, HUVECs, MAPK, MDA, TTM
84  2020 Coupled electronic states in CdTe quantum dot assemblies fabricated by utilizing chemical bonding between ligands. PL, QDSLs
85  2020 COVID-19: The Potential Role of Copper and N-acetylcysteine (NAC) in a Combination of Candidate Antiviral Treatments Against SARS-CoV-2. NEJM, NO, SARS-CoV-2, WHO
86  2020 Cr(VI) induces ROS-mediated mitochondrial-dependent apoptosis in neuronal cells via the activation of Akt/ERK/AMPK signaling pathway. AMPK, ERK, MMP, ROS
87  2020 Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. ATA, CLU, HG, HS, Nec, TCC
88  2020 Curcumin induced apoptosis is mediated through oxidative stress in mutated p53 and wild type p53 colon adenocarcinoma cell lines. ROS
89  2020 Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity. JNK, mTOR, NAPQI, NF
90  2020 Cytotoxic activity of dimeric acridone alkaloids derived from Citrus plants towards human leukaemia HL-60 cells. ROS
91  2020 Cytotoxic effects of thioxanthone derivatives as photoinitiators on isolated rat hepatocytes. ATP, DETX, ROS, UV
92  2020 Cytotoxicity of Saikosaponin A targets HEKa cell through apoptosis induction by ROS accumulation and inflammation suppression via NF-kappaB pathway. IMQ, MMP, PASI, ROS, SSA
93  2020 Deferiprone (DFP) Targets Cancer Stem Cell (CSC) Propagation by Inhibiting Mitochondrial Metabolism and Inducing ROS Production. CSC, CSCs, DFP, ECAR, ROS
94  2020 Delayed peaks of acetaminophen in overdose patients with concomitant abdominal trauma. ---
95  2020 Depressive symptoms and cannabis use in a placebo-controlled trial of N-Acetylcysteine for adult cannabis use disorder. CUD
96  2020 Development of chitosan-coated liposome for pulmonary delivery of N-acetylcysteine. CH
97  2020 Diesel particulate matter2.5 promotes epithelial-mesenchymal transition of human retinal pigment epithelial cells via generation of reactive oxygen species. EMT, ROS, RPE, TGF-beta
98  2020 Dietary antioxidants significantly reduced phorbol myristate acetate induced oxidative stress of peripheral blood mononuclear cells of patients with rheumatoid arthritis. PBML, PBML, PMS, RA
99  2020 Differential Effects of Reactive Oxygen Species on IgG versus IgM Levels in TLR-Stimulated B Cells. NOX, ROS
100  2020 Differentiation agents increase the potential AraC therapy of AML by reactivating cell death pathways without enhancing ROS generation. AML, AraC, CD, ECD, ROS, VDR