1 |
2019 |
Loss of the Na+/H+ Exchange Regulatory Factor 1 Increases Susceptibility to Cisplatin-Induced Acute Kidney Injury. |
AKI |
2 |
2019 |
NHERF3 is necessary for Escherichia coli heat-stable enterotoxin-induced inhibition of NHE3: differences in signaling in mouse small intestine and Caco-2 cells. |
ETEC, ST |
3 |
2017 |
Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol. |
DAG, PLC |
4 |
2017 |
FGF23-Klotho signaling axis in the kidney. |
FGF23, SGK1 |
5 |
2017 |
Na+/H+ exchange regulatory factor 1 is required for ROMK1 K+ channel expression in the surface membrane of cultured M-1 cortical collecting duct cells. |
CCD |
6 |
2017 |
PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs. |
PBMs, PM |
7 |
2016 |
Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24. |
CRC, LPA2 |
8 |
2016 |
NHERF1 regulates actin cytoskeleton organization through modulation of alpha-actinin-4 stability. |
F-actin |
9 |
2015 |
Drug Transporters and Na+/H+ Exchange Regulatory Factor PSD-95/Drosophila Discs Large/ZO-1 Proteins. |
PDZ |
10 |
2015 |
The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity. |
EBRS, ERM, OK |
11 |
2014 |
Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCdelta signaling. |
BB, EGFR, LPA, MV, NHE3, OK, ROCK |
12 |
2013 |
Differential association of the Na+/H+ Exchanger Regulatory Factor (NHERF) family of adaptor proteins with the raft- and the non-raft brush border membrane fractions of NHE3. |
BBM |
13 |
2013 |
Ezrin, a membrane cytoskeletal cross-linker, is essential for the regulation of phosphate and calcium homeostasis. |
--- |
14 |
2013 |
NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells. |
ERM, PDZ |
15 |
2012 |
FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway. |
FGF23 |
16 |
2011 |
NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity. |
BB, cGK, HA, KD, NHE3, shRNA, siRNA |
17 |
2011 |
Regulation of G protein-coupled receptor function by Na+/H+ exchange regulatory factors. |
GPCR, PTB, SH3 |
18 |
2009 |
GABARAP deficiency modulates expression of NaPi-IIa in renal brush-border membranes. |
BBM, GABARAP, TRL |
19 |
2008 |
The epithelial brush border Na+/H+ exchanger NHE3 associates with the actin cytoskeleton by binding to ezrin directly and via PDZ domain-containing Na+/H+ exchanger regulatory factor (NHERF) proteins. |
BB |
20 |
2007 |
Canonical transient receptor potential 5. |
PI |
21 |
2007 |
NHERF links the N-cadherin/catenin complex to the platelet-derived growth factor receptor to modulate the actin cytoskeleton and regulate cell motility. |
PDGFRbeta, PDZ |
22 |
2007 |
NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands. |
EBP50, ERM |
23 |
2006 |
Structural basis for NHERF recognition by ERM proteins. |
--- |
24 |
2005 |
Beyond the brush border: NHERF4 blazes new NHERF turf. |
--- |
25 |
2005 |
Expression of TRPC4 channel protein that interacts with NHERF-2 in rat descending vasa recta. |
DVR, TRPC |
26 |
2005 |
Ezrin controls the macromolecular complexes formed between an adapter protein Na+/H+ exchanger regulatory factor and the cystic fibrosis transmembrane conductance regulator. |
CFTR |
27 |
2005 |
Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells. |
PDZ |
28 |
2004 |
Control of epithelial ion transport by Cl- and PDZ proteins. |
CFTR, ENaC |
29 |
2004 |
Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor. |
EGFR, GRK2, PDGFRbeta |
30 |
2004 |
The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface. |
EGFRs, RTKs |
31 |
2003 |
A kinase-regulated mechanism controls CFTR channel gating by disrupting bivalent PDZ domain interactions. |
CFTR, PDZ, Po |
32 |
2003 |
Crystallographic characterization of the radixin FERM domain bound to the C-terminal region of the human Na+/H+-exchanger regulatory factor (NHERF). |
NHERFs |
33 |
2003 |
Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. |
--- |
34 |
2003 |
Stimulation of beta 2-adrenergic receptor increases cystic fibrosis transmembrane conductance regulator expression in human airway epithelial cells through a cAMP/protein kinase A-independent pathway. |
CFTR, HAEC, PDZ |
35 |
2003 |
The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia. |
CFTR, PDZ |
36 |
2002 |
Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. |
PTH1R, PTHrP |
37 |
2002 |
Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors. |
--- |
38 |
2002 |
Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. |
PDZ |
39 |
2001 |
Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains. |
CFTR, PDGFR |
40 |
2001 |
Crystallographic characterization of the PDZ1 domain of the human Na+/H+ exchanger regulatory factor. |
--- |
41 |
2001 |
Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. |
NHE3 |
42 |
2001 |
Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells. |
PKA |
43 |
2001 |
Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. |
8-BrcAMP, NHE3, OK |
44 |
2001 |
NHERF: targeting and trafficking membrane proteins. |
NHE3 |
45 |
2001 |
Phosphorylation and cell cycle-dependent regulation of Na+/H+ exchanger regulatory factor-1 by Cdc2 kinase. |
--- |
46 |
2001 |
Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction. |
CFTR |
47 |
2001 |
Structural basis of the Na+/H+ exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator. |
CFTR |
48 |
2000 |
Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity. |
ERK, PDGF, PDGFR, PDGFR-CT |
49 |
1999 |
G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. |
HEK293 |
50 |
1998 |
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. |
--- |
51 |
1998 |
The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. |
NHE, NHE3 |