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Abbreviation : OPA1
Long Form : optic atrophy type 1
No. Year Title Co-occurring Abbreviation
2020 Effects of Diabetes on Mitochondrial Morphology and Its Implications in Diabetic Retinopathy. EM, HG, RRECs, WB
2019 Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization. cAMP, dbcAMP, Drp1, Mfn, ONH, PKA
2019 MCU Up-regulation contributes to myocardial ischemia-reperfusion Injury through calpain/OPA-1-mediated mitochondrial fusion/mitophagy Inhibition. I/R, MCU
2018 Overexpression of Optic Atrophy Type 1 Protects Retinal Ganglion Cells and Upregulates Parkin Expression in Experimental Glaucoma. IOP, RGCs
2018 Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion 56Fe radiation induced brain injury in mice. cyto c, Mfn2, ROS
2016 Molecular Impairment Mechanisms of Novel OPA1 Mutations Predicted by Molecular Modeling in Patients With Autosomal Dominant Optic Atrophy and Auditory Neuropathy Spectrum Disorder. ADOA, ANSD
2016 OPA1-related disorders: Diversity of clinical expression, modes of inheritance and pathophysiology. ---
2016 Phyllanthus urinaria's Inhibition of Human Osteosarcoma Xenografts Growth in Mice is Associated with Modulation of Mitochondrial Fission/Fusion Machinery. Bcl-2, CD31, Drp1, PCNA, TUNEL
2016 Recessive optic atrophy, sensorimotor neuropathy and cataract associated with novel compound heterozygous mutations in OPA1. ---
10  2015 Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics. Drp1, Fis1, LDH, MMP, PD, ROS
11  2015 Analysis of opa1 isoforms expression and apoptosis regulation in autosomal dominant optic atrophy (ADOA) patients with mutations in the opa1 gene. ADOA
12  2015 Changes in Mitochondrial Morphology and Bioenergetics in Human Lymphoblastoid Cells With Four Novel OPA1 Mutations. ADOA
13  2015 Improved locus-specific database for OPA1 mutations allows inclusion of advanced clinical data. ADOA, LSDB
14  2015 The cap-translation inhibitor 4EGI-1 induces mitochondrial dysfunction via regulation of mitochondrial dynamic proteins in human glioma U251 cells. Drp1, Mfn1, MMP, NAC, ROS
15  2014 A recurrent deletion mutation in OPA1 causes autosomal dominant optic atrophy in a Chinese family. ADOA, CNGS
16  2014 Phyllanthus urinaria induces mitochondrial dysfunction in human osteosarcoma 143B cells associated with modulation of mitochondrial fission/fusion proteins. ATP, Fis1, Mfn1, MnSOD, NAC, P. urinaria
17  2012 High frequency of OPA1 mutations causing high ADOA prevalence in south-eastern Sicily, Italy. PCR
18  2011 A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics. ADOA, NMDA, RGCs, SOD2
19  2011 Down-regulation of OPA1 in patients with primary open angle glaucoma. POAG
20  2011 Identification of p.A684V missense mutation in the WFS1 gene as a frequent cause of autosomal dominant optic atrophy and hearing impairment. OA, SNHL
21  2010 Autosomal dominant optic neuropathy and sensorineual hearing loss associated with a novel mutation of WFS1. LHON
22  2010 Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma. AAV2, RGC, WT
23  2009 Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. GTPase, RGC, TUNEL
24  2009 Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis. CTMP, LETM1
25  2008 Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve. EM, IOP, ON, ONH
26  2008 Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential. L-OPA1, S-OPA1, SPG7
27  2007 No association between OPA1 polymorphisms and primary open-angle glaucoma in three different populations. POAG
28  2006 OPA1 expression in the human retina and optic nerve. ---
29  2005 OPA1 expression in the normal rat retina and optic nerve. DOA
30  2004 Dominant optic atrophy, sensorineural hearing loss, ptosis, and ophthalmoplegia: a syndrome caused by a missense mutation in OPA1. ---
31  2002 A novel mutation of the OPA1 gene in a Japanese family with optic atrophy type 1. ---