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Abbreviation : OSC
Long Form : oxidosqualene cyclase
No. Year Title Co-occurring Abbreviation
2019 Cloning and characterization of oxidosqualene cyclases involved in taraxasterol, taraxerol, and bauerenol triterpene biosynthesis in Taraxacum coreanum. ---
2019 Friedelane-type triterpene cyclase in celastrol biosynthesis from Tripterygium wilfordii and its application for triterpenes biosynthesis in yeast. ---
2019 Functional characterization of an oxidosqualene cyclase (PdFRS) encoding a monofunctional friedelin synthase in Populus davidiana. ORF
2019 Identification of triterpene biosynthetic genes from Momordica charantia using RNA-seq analysis. ---
2019 Virtual screening and drug repositioning as strategies for the discovery of new antifungal inhibitors of oxidosqualene cyclase. CaOSC
2018 Comparative Transcriptome Analysis Identifies Putative Genes Involved in Steroid Biosynthesis in Euphorbia tirucalli. DEGs, nr
2018 NMR Biochemical Assay for Oxidosqualene Cyclase: Evaluation of Inhibitor Activities on Trypanosoma cruzi and Human Enzymes. ---
2018 Productive Amyrin Synthases for Efficient alpha-Amyrin Synthesis in Engineered Saccharomyces cerevisiae. alpha-AS
2018 Selection of reliable reference genes for RT-qPCR during methyl jasmonate, salicylic acid and hydrogen peroxide treatments in Ganoderma lucidum. MeJA, PP2A, SA
10  2017 beta-Amyrin synthase from Conyzablinii expressed in Saccharomycescerevisiae. ---
11  2017 Design strategies of oxidosqualene cyclase inhibitors: Targeting the sterol biosynthetic pathway. ---
12  2017 Functional Characterization of CYP716 Family P450 Enzymes in Triterpenoid Biosynthesis in Tomato. GC-MS, P450s, qPCR
13  2017 Gamma irradiation of medicinally important plants and the enhancement of secondary metabolite production. CHS, PAL, PHB, SE, SS
14  2017 Identification of Putative Genes Involved in Limonoids Biosynthesis in Citrus by Comparative Transcriptomic Analysis. CYP450s, VIGS
15  2017 Pathway engineering for the production of beta-amyrin and cycloartenol in Escherichia coli-a method to biosynthesize plant-derived triterpene skeletons in E. coli. FPP
16  2016 An Intronless beta-amyrin Synthase Gene is More Efficient in Oleanolic Acid Accumulation than its Paralog in Gentiana straminea. betaAS, betaASs
17  2016 Arylpiperidines as a new class of oxidosqualene cyclase inhibitors. HEI
18  2016 Lactobacillus acidophilus K301 Inhibits Atherogenesis via Induction of 24 (S), 25-Epoxycholesterol-Mediated ABCA1 and ABCG1 Production and Cholesterol Efflux in Macrophages. ABCA1, ABCG1, LXR, PMA, SQLE
19  2016 Sterol Synthesis in Diverse Bacteria. ---
20  2016 The Oxidosqualene Cyclase from the Oomycete Saprolegnia parasitica Synthesizes Lanosterol as a Single Product. CA, LA
21  2015 2,3-Oxidosqualene cyclase protects liver cells from the injury of intermittent hypoxia by regulating lipid metabolism. CCK-8, IH, mRNA, OSA, OSC-EGFP
22  2015 Biosynthetic Mechanism of Lanosterol: Cyclization. ---
23  2015 Characterisation of two oxidosqualene cyclases responsible for triterpenoid biosynthesis in Ilex asprella. GC, GC-MS
24  2015 Characterization of the 2,3-Oxidosqualene Cyclase Gene from Antrodia cinnamomea and Enhancement of Cytotoxic Triterpenoid Compound Production. DEA, DSA, OS, PCA
25  2015 Expression patterns, molecular markers and genetic diversity of insect-susceptible and resistant Barbarea genotypes by comparative transcriptome analysis. DBM, G-type, P-type, SNPs, SSRs
26  2015 The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination. 5-FU
27  2014 Cholesterol synthesis inhibitor RO 48-8071 suppresses transcriptional activity of human estrogen and androgen receptor. AR, ERalpha, RO
28  2014 Concerted Cyclization of Lanosterol C-Ring and D-Ring Under Human Oxidosqualene Cyclase Catalysis: An ab Initio QM/MM MD Study. ---
29  2014 Isolation and characterization of an oxidosqualene cyclase gene encoding a beta-amyrin synthase involved in Polygala tenuifolia Willd. saponin biosynthesis. ---
30  2014 Potential synergistic effects of Chinese herbal prescription FTZ components detected in blood towards hepatic lipid-modulating targets. CETP, FXR, HMGR, LXR, RC, SQS, TCM
31  2013 Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway. ---
32  2013 Molecular characterization and differential expression studies of an oxidosqualene cyclase (OSC) gene of Brahmi (Bacopa monniera). ORF, OSCs, qRT-PCR
33  2013 Purification, kinetics, inhibitors and CD for recombinant beta-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases. ---
34  2012 Divergent evolution of oxidosqualene cyclases in plants. ---
35  2012 Identification of marneral synthase, which is critical for growth and development in Arabidopsis. MRN1, OS
36  2012 Inhibitors of human 2,3-oxidosqualene cyclase (OSC) discovered by virtual screening. ---
37  2012 Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. MIA
38  2012 The triterpene cyclase protein family: a systematic analysis. SHC, TTCED
39  2011 An inverse docking approach for identifying new potential anti-cancer targets. ---
40  2011 Investigation of the potential for triterpene synthesis in rice through genome mining and metabolic engineering. ---
41  2011 Squalene-hopene cyclases. SHC
42  2010 Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids. ---
43  2010 Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts. HSD17B7
44  2010 Methyl jasmonate induces ganoderic acid biosynthesis in the basidiomycetous fungus Ganoderma lucidum. dw, FPS, GA, hmgr, hmgs, MeJA, mvd, SQS, UD
45  2010 Novel pyrrole- and 1,2,3-triazole-based 2,3-oxidosqualene cyclase inhibitors. SAR
46  2009 Biosynthesis of steroidal antibiotic fusidanes: functional analysis of oxidosqualene cyclase and subsequent tailoring enzymes from Aspergillus fumigatus. P450s, SDR
47  2009 Expression of terpenoid synthase mRNA and terpenoid content in salt stressed mangrove. ---
48  2009 Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: a model for the development of novel antiparasitic agents. ---
49  2009 Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. HF, LXRs, SREBP-1c
50  2008 Biosynthesis of baccharis oxide, a triterpene with a 3,10-oxide bridge in the A-ring. ---
51  2008 GRIND-based 3D-QSAR to predict inhibitory activity for similar enzymes, OSC and SHC. SHC
52  2007 Cloning and functional expression of cycloartenol synthases from mangrove species Rhizophora stylosa Griff. and Kandelia candel (L.) Druce. ---
53  2007 Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase. ---
54  2007 Influence of conformation on GRIND-based three-dimensional quantitative structure-activity relationship (3D-QSAR). ---
55  2007 Origin of structural diversity in natural triterpenes: direct synthesis of seco-triterpene skeletons by oxidosqualene cyclase. ---
56  2007 Production of triterpene acids by cell suspension cultures of Olea europaea. ---
57  2006 Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng. ---
58  2005 Analogs of squalene and oxidosqualene inhibit oxidosqualene cyclase of Trypanosoma cruzi expressed in Saccharomyces cerevisiae. ---
59  2005 Analysis of transcripts in methyl jasmonate-treated ginseng hairy roots to identify genes involved in the biosynthesis of ginsenosides and other secondary metabolites. ESTs, MeJA, SE, SS
60  2005 Histopathologic findings after treatment with different oxidosqualene cyclase (OSC) inhibitors in hamsters and dogs. ---
61  2004 Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra. ---
62  2004 Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor. ---
63  2004 Farnesyloxycoumarins, a new class of squalene-hopene cyclase inhibitors. SHC
64  2004 Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. ---
65  2004 Novel squalene-hopene cyclase inhibitors derived from hydroxycoumarins and hydroxyacetophenones. SHC
66  2004 The monotopic membrane protein human oxidosqualene cyclase is active as monomer. hOSC
67  2004 Umbelliferone aminoalkyl derivatives as inhibitors of oxidosqualene cyclases from Saccharomyces cerevisiae, Trypanosoma cruzi, and Pneumocystis carinii. ---
68  2004 Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors. SHC
69  2003 Mechanistic insights into oxidosqualene cyclizations through homology modeling. SHC
70  2003 Oxidosqualene cyclase inhibitors as antimicrobial agents. ---
71  2003 Up-regulation of soyasaponin biosynthesis by methyl jasmonate in cultured cells of Glycyrrhiza glabra. bAS, MeJA, SQS
72  2002 Crystal structure of a squalene cyclase in complex with the potential anticholesteremic drug Ro48-8071. SHC
73  2002 Molecular cloning and functional expression of cDNAs encoding oxidosqualene cyclases from Costus speciosus. CASs
74  2002 Structure activity relationships of new inhibitors of mammalian 2,3-oxidosqualene cyclase designed from isoquinoline derivatives. ---
75  2001 Toxicologic lesions associated with two related inhibitors of oxidosqualene cyclase in the dog and mouse. HMG-CoA
76  2001 Vinyl sulfide derivatives of truncated oxidosqualene as selective inhibitors of oxidosqualene and squalene-hopene cyclases. SHC
77  2000 Rationally designed inhibitors as tools for comparing the mechanism of squalene-hopene cyclase with oxidosqualene cyclase. SHC
78  2000 Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution. SHC
79  1999 19-Azasqualene-2,3-epoxide and its N-oxide: metabolic fate and inhibitory effect on sterol biosynthesis in Saccharomyces cerevisiae. ---
80  1997 Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. ---
81  1997 Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. OS
82  1995 2,3-Oxidosqualene cyclase: from azasqualenes to new site-directed inhibitors. OS
83  1995 Identification of the active site of vertebrate oxidosqualene cyclase. ---
84  1995 Molecular cloning of cDNA encoding human lanosterol synthase. RACE
85  1994 Active site mapping of affinity-labeled rat oxidosqualene cyclase. ---
86  1992 Affinity labeling of vertebrate oxidosqualene cyclases with a tritiated suicide substrate. ---
87  1992 Epoxidation of 2,3-oxidosqualene to 2,3;22,23-squalene dioxide by squalene epoxidase. SE, SQ