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Abbreviation : PA
Long Form : phenylacetate
No. Year Title Co-occurring Abbreviation
2018 Safety, tolerability, and pharmacokinetics of l-ornithine phenylacetate in patients with acute liver injury/failure and hyperammonemia. AEs, ALF, ALI, OPA, PAGN
2017 An update on the use of benzoate, phenylacetate and phenylbutyrate ammonia scavengers for interrogating and modifying liver nitrogen metabolism and its implications in urea cycle disorders and liver disease. PB
2017 Identification of enzymes involved in oxidation of phenylbutyrate. PB
2017 Quantitation of phenylbutyrate metabolites by UPLC-MS/MS demonstrates inverse correlation of phenylacetate:phenylacetylglutamine ratio with plasma glutamine levels. ARG, ASL, NAGS, OTC, PAG, PB, UCDs
2015 Serum biomarkers of oxidative stress in cats with feline infectious peritonitis. FIP, pNA, PON1, TAC, TBBL
2015 Serum paraoxonase type-1 activity in pigs: assay validation and evolution after an induced experimental inflammation. APP, PON1, TBBL
2015 Structural Organization of Enzymes of the Phenylacetate Catabolic Hybrid Pathway. ---
2013 The determination of Q192R polymorphism of paraoxonase 1 by using non-toxic substrate p-nitrophenylacetate. NIA, PO, PON1
2012 Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease. AD, SNPs, TBBL
10  2010 Identification of phenylbutyrate-generated metabolites in Huntington disease patients using parallel liquid chromatography/electrochemical array/mass spectrometry and off-line tandem mass spectrometry. HD, HDAC, SPB, UV
11  2010 Oligodendrocyte development and myelinogenesis are not impaired by high concentrations of phenylalanine or its metabolites. MBP, PAH, Phe, PKU, PP
12  2009 Sodium phenylacetate inhibits the Ras/MAPK signaling pathway to induce reduction of the c-Raf-1 protein in human and canine breast cancer cells. MEK, Ser
13  2008 Differentiation of EDTA-sensitive from EDTA-insensitive human serum esterases hydrolysing phenylacetate. ---
14  2007 Modulation by phenylacetate of early estrogen-mediated events in MCF-7 breast cancer cells. ER, EREs, PR
15  2007 Plasma phenylacetate and 1-naphthyl acetate hydrolyzing activities of wild birds as possible non-invasive biomarkers of exposure to organophosphorus and carbamate insecticides. NA
16  2005 Down-regulation of Skp2 is correlated with p27-associated cell cycle arrest induced by phenylacetate in human prostate cancer cells. AIDL
17  2005 Increases in NMR-visible lipid and glycerophosphocholine during phenylbutyrate-induced apoptosis in human prostate cancer cells. NMR, PB
18  2004 Multisite inhibition by phenylacetate of PC-3 cell growth. MPD
19  2004 Pharmacokinetics of sodium phenylacetate and sodium benzoate following intravenous administration as both a bolus and continuous infusion to healthy adult volunteers. BZ, HIP, PAG
20  2004 Phenylacetylglycine, a putative biomarker of phospholipidosis: its origins and relevance to phospholipid accumulation using amiodarone treated rats as a model. LBPA, PAG, PAH, PROD
21  2004 Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells. PB
22  2003 A study of a different dose-intense infusion schedule of phenylacetate in patients with recurrent primary brain tumors consortium report. ---
23  2003 In vitro and in vivo effects of easily administered, low-toxic retinoid and phenylacetate compounds on human neuroblastoma cells. 4-CPA, RA, RAG
24  2003 Phenylacetate inhibits growth and modulates cell cycle gene expression in renal cancer cell lines. Rb
25  2003 Phenylbutyrate inhibits growth of cervical carcinoma cells independent of HPV type and copy number. Cip1, PB
26  2002 4-Fluoro-N-butylphenylacetamide: a synthetic phenylacetate derivative that upregulates Bcl-X(S), activates caspase cascade and induces apoptosis in human squamous lung cancer CH27 cells. DAPI
27  2002 Effects of cryopreservation and phenylacetate on biological characters of adherent LAK cells from patients with hepatocellular carcinoma. A-LAK, HCC, NA-LAK, PBMCs, PME
28  2002 [Up regulation of phenylacetate to glioma homeobox gene expression]. RER, RT-PCR
29  2001 Assay of serum arylesterase activity by fitting to the reaction curve with an integrated rate equation. ArE, PNPA
30  2001 Differentiation of human neuroblastoma by phenylacetate is mediated by peroxisome proliferator-activated receptor gamma. PPAR, RARbeta
31  2001 Inhibition of estrogen-dependent breast cell responses with phenylacetate. 4-CPA, ER
32  2001 Pharmacokinetics and cerebrospinal fluid penetration of phenylacetate and phenylbutyrate in the nonhuman primate. AUC, CL, CSF, i.v, PB
33  2001 Phenylacetate enhances the antiproliferative effect of retinoic acid in follicular thyroid cancer. RA
34  2001 The differentiation inducers phenylacetate and phenylbutyrate modulate camptothecin sensitivity in colon carcinoma cells in vitro by intracellular acidification. CPTs, PB
35  2001 [Determination of paraoxonase activities in serum and HDL]. HDL, PON
36  2000 Biochemical and molecular characterization of phenylacetate-coenzyme A ligase, an enzyme catalyzing the first step in aerobic metabolism of phenylacetic acid in Azoarcus evansii. PACoA, Phe
37  2000 Induction of apoptosis in malignant B cells by phenylbutyrate or phenylacetate in combination with chemotherapeutic agents. PB
38  2000 p27Kip1 is the key mediator of phenylacetate induced cell cycle arrest in human prostate cancer cells. pRb
39  1999 Phenylbutyrate-induced G1 arrest and apoptosis in myeloid leukemia cells: structure-function analysis. BA, PB
40  1999 Radiopotentiation of human brain tumor cells by sodium phenylacetate. ---
41  1998 [Age related decrease of high density lipoproteins (HDL) in women after menopause. Quantification of HDL with genetically determined HDL arylesterase in women with healthy coronary vessels and in women with angiographically verified coronary heart disease]. CAD, HDL, PO
42  1997 Identification of the 4-hydroxyphenylacetate transport gene of Escherichia coli W: construction of a highly sensitive cellular biosensor. 2-HPA, 3,4-DHPA, 3-HPA, 4-HPA
43  1997 Impact of the putative differentiating agents sodium phenylbutyrate and sodium phenylacetate on proliferation, differentiation, and apoptosis of primary neoplastic myeloid cells. PB
44  1997 Modulation of radiation response of human tumour cells by the differentiation inducers, phenylacetate and phenylbutyrate. PB
45  1996 Control of LNCaP proliferation and differentiation: actions and interactions of androgens, 1alpha,25-dihydroxycholecalciferol, all-trans retinoic acid, 9-cis retinoic acid, and phenylacetate. 9cRA, ATRA, PSA
46  1996 Phenylacetate is an inhibitor of prostatic growth and development in organ culture. BPH
47  1996 Phenylbutyrate induces apoptosis in human prostate cancer and is more potent than phenylacetate. PB
48  1996 Up-regulation and functional role of p21Waf1/Cip1 during growth arrest of human breast carcinoma MCF-7 cells by phenylacetate. pRb
49  1996 Vulnerability of multidrug-resistant tumor cells to the aromatic fatty acids phenylacetate and phenylbutyrate. MDR, PB
50  1995 Increased susceptibility of ras-transformed cells to phenylacetate is associated with inhibition of p21ras isoprenylation and phenotypic reversion. ---
51  1995 Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate. TGF
52  1995 Transcriptional upregulation of TGF-alpha by phenylacetate and phenylbutyrate is associated with differentiation of human melanoma cells. PB, TGF-alpha
53  1993 Differentiation of esterases reacting with organophosphorus compounds. BNA, POX
54  1993 Effect of excess phenylacetate diet during pregnancy on fetal brain growth in rats. ---
55  1986 Substrate-ligand interactions with acetylcholinesterase and energetics of binding. ACh, IPA
56  1983 A quantitative ultrastructural study of the effects of phenylacetate on synaptic organization in the developing rat cerebral cortex. ---
57  1983 Experimental maternal phenylketonuria: an examination of two animal models. pClPhe, Phe, PKU