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Abbreviation : PBP2a
Long Form : penicillin-binding protein 2a
No. Year Title Co-occurring Abbreviation
2023 Brazilian red propolis in combination with β-lactams exerts an efficient antibacterial action over methicillin-resistant Staphylococcus aureus (MRSA) strains. BPE, CEFO, ERTA, IMI, MRSA, RPE
2022 Molecular Basis of Non-beta-Lactam Antibiotics Resistance in Staphylococcus aureus. MRSA
2022 Molecular docking and proteomics reveals the synergistic antibacterial mechanism of theaflavin with beta-lactam antibiotics against MRSA. FICI, S. aureus, TF
2022 Targeted inhibition of methicillin-resistant Staphylococcus aureus biofilm formation by a graphene oxide-loaded aptamer/berberine bifunctional complex. agr, GO, MRSA, SELEX
2021 Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics. Atl, MRSA, succinyl-CoA, TCA
2021 Design, synthesis of pyridine coupled pyrimidinone/pyrimidinthione as anti-MRSA agent: Validation by molecular docking and dynamics simulation. MRSA
2021 Discovery of novel Staphylococcus aureus penicillin binding protein 2a inhibitors by multistep virtual screening and biological evaluation. MD, MRSA, SPR
2021 Improved Detection of mecA-Mediated beta-Lactam Resistance in Staphylococcus lugdunensis Using a New Oxacillin Salt Agar Screen. CA, DD
2021 Mutation-Based Antibiotic Resistance Mechanism in Methicillin-Resistant Staphylococcus aureus Clinical Isolates. MRSA
10  2021 Rapid MRSA detection via tandem mass spectrometry of the intact 80 kDa PBP2a resistance protein. MRSA, MS
11  2021 Study on Demethoxycurcumin as a Promising Approach to Reverse Methicillin-Resistance of Staphylococcus aureus. DMC, MICs, MRSA
12  2020 Eleutheroside K isolated from Acanthopanax henryi (Oliv.) Harms suppresses methicillin resistance of Staphylococcus aureus. ETSK, MIC, Oliv, OXA
13  2020 Flavonoids as Potential anti-MRSA Agents through Modulation of PBP2a: A Computational and Experimental Study. IVS, MRSA
14  2020 Inhibition of penicillin-binding protein 2a (PBP2a) in methicillin resistant Staphylococcus aureus (MRSA) by combination of oxacillin and a bioactive compound from Ramalinaroesleri. MICs, MRSA, SEM
15  2020 Methicillin-resistant Staphylococcus aureus (MRSA) isolated from raw milk and nasal swabs of small ruminants in Abeokuta, Nigeria. MRSA
16  2020 The Mechanism of Bisdemethoxycurcumin Enhances Conventional Antibiotics against Methicillin-Resistant Staphylococcus aureus. BDMC, MRSA
17  2019 Evaluation of disc diffusion tests and agar screening for predicting mecA-mediated oxacillin resistance in Staphylococcus lugdunensis revealed a cefoxitin-susceptible, mecA-positive S. lugdunensis clonal complex 27 clone. CA, CLSI, ME, MRSA, S. lugdunensis, VME
18  2019 Genomic identification of cryptic susceptibility to penicillins and beta-lactamase inhibitors in methicillin-resistant Staphylococcus aureus. MRSA
19  2019 Improved Performance of a Rapid Immunochromatographic Assay for Detection of PBP2a in Non-Staphylococcus aureus Staphylococcal Species. CI, non-SASS
20  2019 Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus. DNA, HSA, MRSA
21  2019 Label-free detection of nosocomial bacteria using a nanophotonic interferometric biosensor. BiMW, LOD, MRSA, MSSA, S/N
22  2019 Recombinant PBP2a of methicillin-resistant S. aureus formulation in Alum and Montanide ISA266 adjuvants induced cellular and humoral immune responses with protection in Balb/C mice. Ni-NTA
23  2019 Tellimagrandin II, A Type of Plant Polyphenol Extracted from Trapa bispinosa Inhibits Antibiotic Resistance of Drug-Resistant Staphylococcus aureus. MRSA, TEM, TGII
24  2019 The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus. MRSA
25  2019 [Evaluation of a rapid assay for detection of PBP2a Staphylococcus aureus]. MRSA
26  2018 Aspermerodione, a novel fungal metabolite with an unusual 2,6-dioxabicyclo[2.2.1]heptane skeleton, as an inhibitor of penicillin-binding protein 2a. ECD, MRSA
27  2018 Cationic Branched Polyethylenimine (BPEI) Disables Antibiotic Resistance in Methicillin-Resistant Staphylococcus epidermidis (MRSE). BPEI, MRSA, MRSE, MRSE, WTA
28  2018 Ceftaroline Resistance by Clone-Specific Polymorphism in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus. MRSA, NPBD, PBD
29  2018 Evaluation of the Revised Ceftaroline Disk Diffusion Breakpoints When Testing a Challenge Collection of Methicillin-Resistant Staphylococcus aureus Isolates. CLSI, Ma, Mi, MRSA, PBD, SDD, VM
30  2018 Punicalagin suppresses methicillin resistance of Staphylococcus aureus to oxacillin. MRSA, PGN
31  2017 Antimicrobial activity and synergism of ursolic acid 3-O-alpha-L-arabinopyranoside with oxacillin against methicillin-resistant Staphylococcus aureus. MIC, MRSA, OD600, Oliv, OXA, TEM, URS
32  2017 BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A beta-Lactamases. BLIP-II, MRSA
33  2017 Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis. ---
34  2017 Synergistic antibacterial effects of herbal extracts and antibiotics on methicillin-resistant Staphylococcus aureus: A computational and experimental study. FIC, MRSA
35  2016 Improving time to optimal Staphylococcus aureus treatment using a penicillin-binding protein 2a assay. ---
36  2016 PBP 4 Mediates High-Level Resistance to New-Generation Cephalosporins in Staphylococcus aureus. MRSA
37  2016 Prevalence of Panton-Valentine leukocidin genes in community-associated methicillin-resistant Staphylococcus aureus in the District of Pomoravlje. CA-MRSA, CLSI, PCR, PVL
38  2016 Studies on antimicrobial activity of Poncirus trifoliata ethyl extract fraction against methicillin-resistant Staphylococcus aureus and to elucidate its antibacterial mechanism. EA08, MIC, MRSA
39  2016 The Global Regulon sarA Regulates beta-Lactam Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus In Vitro and in Endovascular Infections. MRSA
40  2015 Evaluation of an Immunochromatographic Assay for Rapid Detection of Penicillin-Binding Protein 2a in Human and Animal Staphylococcus intermedius Group, Staphylococcus lugdunensis, and Staphylococcus schleiferi Clinical Isolates. ---
41  2015 In Vitro Activity of Ceftaroline against Staphylococcus aureus Isolated in 2012 from Asia-Pacific Countries as Part of the AWARE Surveillance Program. AWARE, MRSA, ST5
42  2015 Inhibition of penicillin-binding protein 2a (PBP2a) in methicillin resistant Staphylococcus aureus (MRSA) by combination of ampicillin and a bioactive fraction from Duabanga grandiflora. HPLC, MIC, MRSA
43  2015 Inhibitory effect of Duabanga grandiflora on MRSA biofilm formation via prevention of cell-surface attachment and PBP2a production. MRSA
44  2015 Old Drugs To Treat Resistant Bugs: Methicillin-Resistant Staphylococcus aureus Isolates with mecC Are Susceptible to a Combination of Penicillin and Clavulanic Acid. blaZLGA251, MRSA, SCCmec
45  2015 Prevention of cell-surface attachment and reduction of penicillin-binding protein 2a (PBP2a) level in methicillin-resistant Staphylococcus aureus biofilms by Acalypha wilkesiana. HPLC, MRSA
46  2015 Synergistic, collaterally sensitive beta-lactam combinations suppress resistance in MRSA. MRSA
47  2015 The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureus. MRSA
48  2015 The Association of Panton-Valentine leukocidin and mecA Genes in Methicillin-Resistant Staphylococcus aureus Isolates From Patients Referred to Educational Hospitals in Ahvaz, Iran. MRSA, PVL
49  2014 Analysis of Staphylococcus aureus clinical isolates with reduced susceptibility to ceftaroline: an epidemiological and structural perspective. MRSA
50  2014 beta-Lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease. CA, MRSA
51  2014 Ceftaroline is active against heteroresistant methicillin-resistant Staphylococcus aureus clinical strains despite associated mutational mechanisms and intermediate levels of resistance. HeR, HoR, MRSA
52  2014 Development of an immunoaffinity solid phase microextraction method for the identification of penicillin binding protein 2a. BSA, MRSA, SPME
53  2014 Discovery of a new class of non-beta-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity. MRSA
54  2014 Disruption of allosteric response as an unprecedented mechanism of resistance to antibiotics. MRSA
55  2014 PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates. MRSA
56  2014 Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. MRSA
57  2014 The mecA homolog mecC confers resistance against beta-lactams in Staphylococcus aureus irrespective of the genetic strain background. MRSA, SCCmec
58  2014 The mechanism of antibacterial activity of phlorofucofuroeckol-A against methicillin-resistant Staphylococcus aureus. MRSA, PFF
59  2013 Cloning, Expression and Purification of Penicillin Binding Protein2a (PBP2a) from Methicillin Resistant Staphylococcus aureus: A Study on Immunoreactivity in Balb/C Mouse. IPTG, S. aureus
60  2013 Evaluation and use of a rapid Staphylococcus aureus assay by an antimicrobial stewardship program. MRSA, MSSA
61  2013 How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function. MRSA, PBPs
62  2013 The differential detection of methicillin-resistant, methicillin-susceptible and borderline oxacillin-resistant Staphylococcus aureus by surface plasmon resonance. BORSA, MRSA, MSSA
63  2013 Wound infections caused by inducible meticillin-resistant Staphylococcus aureus strains. MRSA
64  2012 Analysis of borderline oxacillin-resistant Staphylococcus aureus (BORSA) strains isolated in Tunisia. BORSA
65  2012 Ceftaroline in complicated skin and skin-structure infections. cSSSIs, MRSA
66  2012 Community-acquired methicillin-resistant Staphylococcus aureus from skin and soft tissue infections (in a sample of Egyptian population): analysis of mec gene and staphylococcal cassette chromosome. CA-MRSA, HA-MRSA, PVL, SCCmec, SSTIs
67  2012 Evaluation of Clearview Exact PBP2a, a new immunochromatographic assay, for detection of low-level methicillin-resistant Staphylococcus aureus (LL-MRSA). ICA, LL-MRSA
68  2012 Methicillin resistance alters the biofilm phenotype and attenuates virulence in Staphylococcus aureus device-associated infections. HeR, MSSA, PIA/PNAG
69  2011 Artesunate in combination with oxacillin protect sepsis model mice challenged with lethal live methicillin-resistant Staphylococcus aureus (MRSA) via its inhibition on proinflammatory cytokines release and enhancement on antibacterial activity of oxacillin. MRSA
70  2011 Computational studies of bacterial resistance to beta-lactam antibiotics: mechanism of covalent inhibition of the penicillin-binding protein 2a (PBP2a). MRSA
71  2011 Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus. CC130, ccr, DRs, MRSA, ORFs, SCCmec, SCCmec XI
72  2011 Genotypic relatedness and phenotypic characterization of Staphylococcus schleiferi subspecies in clinical samples from dogs. PFGE
73  2011 Microtiter plate-based assay for inhibitors of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus. MRSA
74  2010 Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2. CM, ECg, MRSA, PBP
75  2008 Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics. MRSA
76  2008 In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus. BPR, MRSA
77  2007 Characterization of the beta-lactam antibiotic sensor domain of the MecR1 signal sensor/transducer protein from methicillin-resistant Staphylococcus aureus. MRSA
78  2007 Surveillance of healthy cats and cats with inflammatory skin disease for colonization of the skin by methicillin-resistant coagulase-positive staphylococci and Staphylococcus schleiferi ssp. schleiferi. ISD, MR, PCR, PFGE, SCCmec
79  2007 [Clone, expression and identification of penicillin binding protein 2a of methicillin-resistant Staphylococcus aureus isolated from patients]. IPTG, MRSA
80  2007 [Preparation, characterization and preliminary application of monoclonal antibody against the transpeptidase domain of MRSA-PBP2a]. mAb
81  2005 Beta-lactam resistance in Staphylococcus aureus: the adaptive resistance of a plastic genome. MRSA
82  2005 Correlation of penicillin Binding protein 2a detection with oxacillin resistance in Staphylococcus aureus and discovery of a novel penicillin binding protein 2a mutation. LAT
83  2004 Evaluation of penicillin binding protein 2a latex agglutination assay for identification of methicillin-resistant Staphylococcus aureus directly from blood cultures. ---
84  2004 LB11058, a new cephalosporin with high penicillin-binding protein 2a affinity and activity in experimental endocarditis due to homogeneously methicillin-resistant Staphylococcus aureus. MRSA
85  2004 Methicillin resistance of staphylococci isolated from the skin of dogs with pyoderma. PCR
86  2004 The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. MRSA
87  2003 A novel strategy for in vitro selection of peptide-drug conjugates. ---
88  2003 Rapid MRSA detection by a latex kit. MRSA, MSSA
89  2003 Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus. BlaR
90  2003 RWJ-54428 (MC-02,479), a new cephalosporin with high affinity for penicillin-binding proteins, including PBP 2a, and stability to staphylococcal beta-lactamases. MRSA, MSSA
91  2002 Detection and expression of methicillin/oxacillin resistance in multidrug-resistant and non-multidrug-resistant Staphylococcus aureus in Central Sydney, Australia. MDR, MRSA, NMDR
92  2002 Detection of methicillin and mupirocin resistance in Staphylococcus aureus isolates using conventional and molecular methods: a descriptive study from a burns unit with high prevalence of MRSA. MIC, MRSA, PCR
93  2002 Detection of methicillin resistance in primary blood culture isolates of coagulase-negative staphylococci by PCR, slide agglutination, disk diffusion, and a commercial method. LA
94  2002 Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. MRSA
95  2000 Evaluation of a latex agglutination assay for rapid detection of oxacillin resistant Staphylococcus aureus. LA, PCR
96  2000 Identification and characterization of the penicillin-binding protein 2a of Streptococcus pneumoniae and its possible role in resistance to beta-lactam antibiotics. ---
97  1999 Penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus: kinetic characterization of its interactions with beta-lactams using electrospray mass spectrometry. MRSA
98  1999 Rapid detection of methicillin resistance in Staphylococcus aureus isolates by the MRSA-screen latex agglutination test. MRSA
99  1998 Identification of the active site serine of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by electrospray mass spectrometry. LC/MS, MRSA
100  1998 Soluble penicillin-binding protein 2a: beta-lactam binding and inhibition by non-beta-lactams using a 96-well format. ---