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Abbreviation : PD
Long Form : polydatin
No. Year Title Co-occurring Abbreviation
2019 MALAT1 Up-Regulator Polydatin Protects Brain Microvascular Integrity and Ameliorates Stroke Through C/EBPbeta/MALAT1/CREB/PGC-1alpha/PPARgamma Pathway. BBB, MALAT1, OGD, tMCAO
2019 Polydatin attenuates reactive oxygen species-induced airway remodeling by promoting Nrf2-mediated antioxidant signaling in asthma mouse model. EMT, NOX, Nrf2, OVA, ROS, TGF
2019 Polydatin Increases Radiosensitivity by Inducing Apoptosis of Stem Cells in Colorectal Cancer. AOM, BMP, CRC, CSCs, DSS
2019 Polydatin suppresses the development of lung inflammation and fibrosis by inhibiting activation of the NACHT domain-, leucine-rich repeat-, and pyd-containing protein 3 inflammasome and the nuclear factor-kappaB pathway after Mycoplasma pneumoniae infection. MP, MPP, NF-kappaB, NLRP3
2019 Prophylactic Dermatologic Treatment of Afatinib-Induced Skin Toxicities in Patients with Metastatic Lung Cancer: A Pilot Study. NSCLC
2019 Targeting the ROS/PI3K/AKT/HIF-1alpha/HK2 axis of breast cancer cells: Combined administration of Polydatin and 2-Deoxy-d-glucose. 2-DG
2018 In vivo assessment of polydatin, a natural polyphenol compound, on arsenic-induced free radical overproduction, gene expression, and genotoxicity. IL-1beta, NF-kappaB, TNF-alpha
2018 Polydatin Alleviates Radiation-Induced Testes Injury by Scavenging ROS and Inhibiting Apoptosis Pathways. HE, IR
2018 Polydatin effectively attenuates disease activity in lupus-prone mouse models by blocking ROS-mediated NET formation. CYC, MMF, NET, PBS, PIL, PMA, ROS, SLE
10  2018 Polydatin inhibits the IL-1beta-induced inflammatory response in human osteoarthritic chondrocytes by activating the Nrf2 signaling pathway and ameliorates murine osteoarthritis. COX-2, DMM, ECM, IL, iNOS, MMP13, NO, OA, PGE2, siRNA, TNF-alpha
11  2018 Polydatin protects against acetaminophen-induced hepatotoxicity in mice via anti-oxidative and anti-apoptotic activities. ALT, Apaf-1, AST, cyt c, GSH-Px, iNOS, MDA, NO, NOX2, ROS
12  2018 Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats. ECM, IVDD, NPCs
13  2018 Protective effect of polydatin on radiation-induced injury of intestinal epithelial and endothelial cells. IR
14  2018 Protective effects of polydatin and grape seed extract in rats exposed to cadmium. CD, GSEs, MDA, TOS
15  2018 Stable isotope labeling and 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside biosynthetic pathway characterization in Fallopia multiflora. L-Phe, SB, SP, THSG
16  2017 Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial-mesenchymal transition. RILI
17  2017 Polydatin ameliorates diabetic cardiomyopathy via Sirt3 activation. MI, STZ, WT
18  2017 Polydatin ameliorates Staphylococcus aureus-induced mastitis in mice via inhibiting TLR2-mediated activation of the p38 MAPK/NF-kappaB pathway. mMECs
19  2017 Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell. CREB
20  2017 Polydatin impairs mitochondria fitness and ameliorates podocyte injury by suppressing Drp1 expression. DN, Drp1, HG, ROS
21  2017 Polydatin improves the developmental competence of bovine embryos in vitro via induction of sirtuin 1 (Sirt1). COX, NF, ROS, SIRT1
22  2017 Polydatin inhibits cell proliferation and induces apoptosis in laryngeal cancer and HeLa cells via suppression of the PDGF/AKT signaling pathway. p-AKT, PDGF
23  2017 Polydatin inhibits mast cell-mediated allergic inflammation by targeting PI3K/Akt, MAPK, NF-kappaB and Nrf2/HO-1 pathways. PCA, PSA
24  2017 Polydatin Prevents Methylglyoxal-Induced Apoptosis through Reducing Oxidative Stress and Improving Mitochondrial Function in Human Umbilical Vein Endothelial Cells. HUVECs, MGO, MMP, ROS
25  2017 Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys. ARE, CKIP-1, DN, FN, GMCs, HG, ICAM-1, Nrf2
26  2017 Polydatin protects cardiomyocytes against myocardial infarction injury by activating Sirt3. CS, LAD, LV, MI, WT
27  2017 Polydatin Protects Rat Liver against Ethanol-Induced Injury: Involvement of CYP2E1/ROS/Nrf2 and TLR4/NF-kappaB p65 Pathway. ADH, ALDH, ALP, AST, CAT, CYP2E1, GSH-Px, HO-1, LDH, MDA, NF-kappaB, Nrf2, ROS, SOD, TG, TLR4
28  2017 Polydatin protects the respiratory system from PM2.5 exposure. aPM2.5, BALF, OP
29  2017 Polydatin reduces Staphylococcus aureus lipoteichoic acid-induced injury by attenuating reactive oxygen species generation and TLR2-NFkappaB signalling. LTA, ROS, S. aureus
30  2017 Polydatin regulates proliferation, apoptosis and autophagy in multiple myeloma cells through mTOR/p70s6k pathway. 3-MA, CCK-8, MM
31  2017 Protective effects of polydatin on experimental testicular torsion and detorsion injury in rats. CAT, GPx, MDA, SOD, TUNEL
32  2017 Resveratrol and polydatin as modulators of Ca2+ mobilization in the cardiovascular system. RES
33  2016 Ameliorative effect of polydatin on oxidative stress-mediated testicular damage by chronic arsenic exposure in rats. ---
34  2016 Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury. Bcl-2, I/R, MCAO, mNSS, TUNEL
35  2016 Polydatin ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3 activation-mediated mitochondrial protection. HS, SI, SIRT
36  2016 Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. AP-1, DN, FN, GMCs, HG, S1P, SphK1, WT
37  2016 Polydatin attenuates d-galactose-induced liver and brain damage through its anti-oxidative, anti-inflammatory and anti-apoptotic effects in mice. AST, d-gal
38  2016 Polydatin Induces Apoptosis and Inhibits Growth of Acute Monocytic Leukemia Cells. ---
39  2016 Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux. 3-MA, EF, I/R, IS, LCA, LVFS, NRCs, RES, ROS
40  2016 Polydatin promotes apoptosis through upregulation the ratio of Bax/Bcl-2 and inhibits proliferation by attenuating the beta-catenin signaling in human osteosarcoma cells. ---
41  2016 Polydatin Protecting Kidneys against Hemorrhagic Shock-Induced Mitochondrial Dysfunction via SIRT1 Activation and p53 Deacetylation. DeltaPsim, MD, RTECs
42  2016 Polydatin-induced cell apoptosis and cell cycle arrest are potentiated by Janus kinase 2 inhibition in leukemia cells. Bcl-2, JAK2
43  2015 Inhibitory Effects of Polydatin on Lipopolysaccharide-Stimulated RAW 264.7 Cells. COX-2, ELISA, ERK, iNOS, JNK, LPS, MAPK, mRNA, NF-kappaB, NO, PGE2
44  2015 Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator. ---
45  2015 Polydatin Inhibits Mitochondrial Dysfunction in the Renal Tubular Epithelial Cells of a Rat Model of Sepsis-Induced Acute Kidney Injury. CLP, RTEC
46  2015 Polydatin prevents hypertrophy in phenylephrine induced neonatal mouse cardiomyocytes and pressure-overload mouse models. ANP, TAC
47  2015 Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-beta1 in rat glomerular messangial cells. AGEs, DN, HO-1, Nrf2, SOD1
48  2015 Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2 pathway. DeltaPsim, RES
49  2015 Polydatin: a new therapeutic agent against multiorgan dysfunction. AOPPs, Bcl-2, MODS
50  2014 Pharmacokinetics and bioavailability study of polydatin in rat plasma by using a LC-MS/MS method. MRM
51  2014 Polydatin attenuates cardiac hypertrophy through modulation of cardiac Ca2+ handling and calcineurin-NFAT signaling pathway. beta-MHC, NRVMs, PO, TAC
52  2014 Polydatin attenuates ipopolysaccharide-induced acute lung injury in rats. ALI, LPS
53  2014 Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest. ---
54  2014 Protective effect of polydatin against burn-induced lung injury in rats. BALF, IL, MPO, PMNs
55  2014 Protective effect of polydatin, a natural precursor of resveratrol, against cisplatin-induced toxicity in rats. CIS, i.p
56  2013 Polydatin attenuated food allergy via store-operated calcium channels in mast cell. ELISA, IgE, IL-4, OVA, RPMCs, SOCs
57  2013 Polydatin--a new mitochondria protector for acute severe hemorrhagic shock treatment. CsA, DeltaPsi, LPO, NS, RES
58  2013 Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1. COX-2, IL-6, iNOS, TNF-alpha
59  2012 Plant polyphenols regulate chemokine expression and tissue repair in human keratinocytes through interaction with cytoplasmic and nuclear components of epidermal growth factor receptor system. AP-1, EGFR, ERK, IL-8, IP-10, MCP-1, PPs, QR, RV, T/I, TGF-alpha, VB
60  2012 Polydatin (PD) inhibits IgE-mediated passive cutaneous anaphylaxis in mice by stabilizing mast cells through modulating Ca⁺ mobilization. CRACs, PCA, TG
61  2012 Polydatin modulates Ca(2+) handling, excitation-contraction coupling and beta-adrenergic signaling in rat ventricular myocytes. AR, E-C, NOS, RyRs
62  2012 Polydatin protects against lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice. AST, D-GalN, ECAM-1, FHF, ICAM-1, LPS, MPO, NF-kB, TNF-alpha
63  2012 The progress of the research on cardio-vascular effects and acting mechanism of polydatin. ---
64  2011 Inhibition of TNF-alpha-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4'-trimethoxystilbene. RSV, TMS
65  2011 Polydatin up-regulates Clara cell secretory protein to suppress phospholipase A2 of lung induced by LPS in vivo and in vitro. ALI, ARDS, CCSP, LPS, PLA2
66  2011 [Effects of polydatin on bleomycin-induced pulmonary fibrosis in rats]. BALF, DXM, ELISA, LTC4, PGE2, TGF-beta1
67  2009 [The regulative effects of polydatin on toll-like receptor 4 signal transduction pathway in lung ischemia/reperfusion injury in rabbits]. ET, HE, I/R, ICAM-1, NF, TLR4
68  2008 [Protective effects of polydatin against lung ischemia/reperfusion injury and the initial exploration for its mechanism]. C group, I/R, IAR, LI/RI, MDA, PMB, SOD
69  2006 HPLC determination of polydatin in rat biological matrices: application to pharmacokinetic studies. RPHPLC
70  2003 [Effect of polydatin on lipopolysaccharide-induced leucocyte chemotaxis]. LPS
71  1999 Protective effects of polydatin against CCl(4)-induced injury to primarily cultured rat hepatocytes. ---